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1. 发明申请

US20080245716A1 Separation column and liquid chromatography system with this column 审中-公开
标题翻译：分离柱和液相色谱系统
公开(公告)号：US20080245716A1
公开(公告)日：2008-10-09
申请号：US12076754
申请日：2008-03-21
申请人： Takeshi Ohura , Tomohiro Shoji , Daizo Tokinaga , Tomonari Morioka , Yoshihiro Nagaoka , Yoshitaka Kodama
发明人： Takeshi Ohura , Tomohiro Shoji , Daizo Tokinaga , Tomonari Morioka , Yoshihiro Nagaoka , Yoshitaka Kodama
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01J2220/82 , G01N30/52 , G01N30/54 , G01N30/6052 , G01N30/606 , G01N30/88 , G01N2030/027 , G01N2030/528
摘要： A monolithic separation column and a liquid chromatography system using the same are provided by which the pressure tightness is improved, and the manufacturing is enabled at a low temperature, thus preventing the degradation of the separation performance. A monolithic rod 118 is made of a porous body and has a cylindrical shape. A coat material 116 coats an outer circumference of the monolithic rod 118 and includes an uneven portion 116R on an outer face thereof A holder 112, into which the monolithic rod 118 coated with the coat material 116 is inserted, includes a taper portion 112T on an inner face thereof. A potting media 114 is fitted or filled between the coat material 116 and the holder 112.
摘要翻译：提供了一种整体式分离柱和使用其的液相色谱系统，通过其提高了压力密封性，并且可以在低温下进行制造，从而防止分离性能的劣化。整体式杆118由多孔体制成并具有圆柱形状。涂层材料116涂覆整体式杆118的外周，并且在其外表面上包括不平坦部分116R，涂覆有涂层材料116的整体式杆118插入其中的保持器112包括锥形部分112T 在其内表面上。灌封介质114装配或填充在涂层材料116和保持器112之间。

2. 发明授权

US07811451B2 Separation column and liquid chromatograph using the same 有权
标题翻译：分离柱和液相色谱仪使用
公开(公告)号：US07811451B2
公开(公告)日：2010-10-12
申请号：US11877944
申请日：2007-10-24
申请人： Yoshihiro Nagaoka , Masahito Ito , Daizo Tokinaga , Tomohiro Shoji , Tomonari Morioka
发明人： Yoshihiro Nagaoka , Masahito Ito , Daizo Tokinaga , Tomohiro Shoji , Tomonari Morioka
IPC分类号： B01D15/08 , C02F1/28 , G01N30/02
CPC分类号： B01D15/22 , B01J2220/82 , G01N30/6026 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： The flow rate of a solvent is reduced as a separation column and the separation performance is improved even under high-pressure conditions. There is provided a separation column including a monolith rod into which a sample and a mobile phase flow, the separation column comprising: a coating material coated on the outer circumference of a monolith rod; a support member into which the monolith rod coated with the coating material is inserted, and a rod fixing material fitted into or filled a gap between the coating material and the support member; wherein the upper end face of the rod fixing material is sealed, the upper end face being the inflow-side end when the separation column is assembled.
摘要翻译：溶剂的流量作为分离塔减少，即使在高压条件下也提高了分离性能。提供了一种分离柱，其包括样品和流动相流入其中的整料棒，所述分离柱包括：涂覆在整料棒外圆周上的涂料; 插入涂覆有涂料的整料棒的支撑构件，以及装配到涂料和支撑构件之间或填充涂层材料和支撑构件之间的间隙的杆固定材料; 其中杆固定材料的上端面被密封，当组装分离柱时，上端面是流入侧端。

3. 发明申请

US20080099389A1 SEPARATION COLUMN AND LIQUID CHROMATOGRAPH USING THE SAME 有权
标题翻译：使用相同的分离柱和液相色谱
公开(公告)号：US20080099389A1
公开(公告)日：2008-05-01
申请号：US11877944
申请日：2007-10-24
申请人： Yoshihiro Nagaoka , Masahito Ito , Daizo Tokinaga , Tomohiro Shoji , Tomonari Morioka
发明人： Yoshihiro Nagaoka , Masahito Ito , Daizo Tokinaga , Tomohiro Shoji , Tomonari Morioka
IPC分类号： B01D15/10
CPC分类号： B01D15/22 , B01J2220/82 , G01N30/6026 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： The flow rate of a solvent is reduced as a separation column and the separation performance is improved even under high-pressure conditions. There is provided a separation column including a monolith rod into which a sample and a mobile phase flow, the separation column comprising: a coating material coated on the outer circumference of a monolith rod; a support member into which the monolith rod coated with the coating material is inserted, and a rod fixing material fitted into or filled a gap between the coating material and the support member; wherein the upper end face of the rod fixing material is sealed, the upper end face being the inflow-side end when the separation column is assembled.
摘要翻译：溶剂的流量作为分离塔减少，即使在高压条件下也提高了分离性能。提供了一种分离柱，其包括样品和流动相流入其中的整料棒，所述分离柱包括：涂覆在整料棒外圆周上的涂料; 插入涂覆有涂料的整料棒的支撑构件，以及装配到涂料和支撑构件之间或填充涂层材料和支撑构件之间的间隙的杆固定材料; 其中杆固定材料的上端面被密封，当组装分离柱时，上端面是流入侧端。

4. 发明申请

US20120127469A1 FLOW CELL, DETECTOR, AND LIQUID CHROMATOGRAPH 审中-公开
标题翻译：流动池，检测器和液相色谱
公开(公告)号：US20120127469A1
公开(公告)日：2012-05-24
申请号：US13388765
申请日：2010-06-18
申请人： Nobuhiro Tsukada , Shigenori Togashi , Yoshihiro Nagaoka , Tomohiro Shoji
发明人： Nobuhiro Tsukada , Shigenori Togashi , Yoshihiro Nagaoka , Tomohiro Shoji
IPC分类号： G01N21/59
CPC分类号： G01N30/74 , G01N2030/746
摘要： In a liquid chromatograph, a flow cell, in which a direction of detecting light and a flow direction of a sample fluid are parallel to each other, and in which the flow direction of the sample fluid changes at the moment of the sample fluid flowing out of a detecting portion into an outflow channel and at the moment of the sample fluid flowing into the detecting portion from an inflow channel, is capable of suppressing a peak broadening of a chromatogram. A plurality of outflow channels are provided, which shorten a distance between a flow outlet and a flow bend in the sample flow. A plurality of inflow channels are also provided, some of which collide jets flowing into the detecting portion from the inflow channels and others of which produce a swirl of jets flowing into the detecting portion from the inflow channels.
摘要翻译：在液相色谱仪中，流动池中检测光的方向和样品流体的流动方向彼此平行，并且样品流体流动方向在样品流体流出时变化的流动池的检测部分流入流出通道，并且在样品流体从流入通道流入检测部分的时刻能够抑制色谱图的峰值变宽。提供了多个流出通道，其缩短了流出口和样品流中的流动弯曲之间的距离。还设置有多个流入通道，其中一些流入通道从流入通道碰撞流入检测部分的射流，其中一些从流入通道产生流入检测部分的喷流漩涡。

5. 发明授权

US09150911B2 Nucleic acid analysis reaction cell and nucleic acid analyzer 有权
标题翻译：核酸分析反应池和核酸分析仪
公开(公告)号：US09150911B2
公开(公告)日：2015-10-06
申请号：US13696962
申请日：2011-04-20
申请人： Taro Nakazawa , Masatoshi Narahara , Ryoji Inaba , Yoshihiro Nagaoka , Shigenori Togashi
发明人： Taro Nakazawa , Masatoshi Narahara , Ryoji Inaba , Yoshihiro Nagaoka , Shigenori Togashi
IPC分类号： C12Q1/68 , B01L3/00 , G01N27/447 , G01N35/10
CPC分类号： C12Q1/6844 , B01L3/502746 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2400/086 , G01N27/447 , G01N35/1095
摘要： A nucleic acid analysis reaction cell and a nucleic acid analyzer are provided, in which a uniform flow rate is realized, so that a portion where a flow rate is low is removed and washing time for reagent removal is shortened.A flow path (103) is provided which includes a detection area (108) for detecting sequence information of a nucleic acid fragment and detection outer areas (107) disposed at both ends of the detection area (108). An inflow port (105) is provided in one of the detection outer areas (107) and a discharge port (106) is provided in the other of the detection outer areas (107). The detection outer areas (107) disposed at both the ends of the detection area (108) are areas whose widths become narrow toward ends, and guides (104) for branching a liquid are provided in at least the detection outer area (107) in which the inflow port (105) is provided.
摘要翻译：提供了一种核酸分析反应池和核酸分析仪，其中实现了均匀的流速，从而消除了流速低的部分，缩短了除去试剂的洗涤时间。提供了一种流路（103），其包括用于检测核酸片段的序列信息的检测区域（108）和设置在检测区域（108）两端的检测外部区域（107）。在一个检测外部区域（107）中设置有流入口（105），并且在另一个检测外部区域（107）中设置有排出口（106）。设置在检测区域（108）的两端的检测外部区域（107）是宽度朝向端部变窄的区域，并且至少在检测外部区域（107）中设置用于分支液体的引导件（104）其中设置有流入口（105）。

6. 发明授权

US08551423B2 Liquid supply device using check valve and reactive liquid chromatography system 失效
标题翻译：液体供应装置采用止回阀和反应液相色谱系统
公开(公告)号：US08551423B2
公开(公告)日：2013-10-08
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： B01L3/02
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

7. 发明申请

US20060153735A1 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析仪和化学分析盒
公开(公告)号：US20060153735A1
公开(公告)日：2006-07-13
申请号：US11319977
申请日：2005-12-29
申请人： Yoshihiro Nagaoka , Nobuyuki Maki , Noriyo Nishijima , Michihiro Saito , Hiroki Ihara
发明人： Yoshihiro Nagaoka , Nobuyuki Maki , Noriyo Nishijima , Michihiro Saito , Hiroki Ihara
IPC分类号： G01N31/22 , G01N35/00
CPC分类号： G01N21/07 , G01N35/025 , G01N2035/00148 , G01N2035/00495 , Y10T436/11 , Y10T436/111666 , Y10T436/25
摘要： A chemical analysis apparatus comprises a motor, a holding disk that can be rotated by the motor, a plurality of examination cartridges arranged on the holding disk, a perforator that perforates the examination cartridges, a heating device, and a detection device. The examination cartridge comprises a substrate including a vessel and a flow channel, which are defined by recesses, and a cover that covers the vessel and the flow channel. A centrifugal force generated by rotation of the holding disk is made use of to move a solution from a vessel on an inner peripheral side relative to an axis of rotation to a vessel on an outer peripheral side relative to the axis of rotation through the flow channel.
摘要翻译：化学分析装置包括电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查盒，对检查筒进行穿孔的穿孔器，加热装置和检测装置。检查筒包括由凹部限定的容器和流路的基板和覆盖容器和流路的盖。通过保持盘的旋转而产生的离心力用于将溶液从相对于旋转轴线的内周侧的容器移动到通过流动通道相对于旋转轴线的外周侧上的容器。

8. 发明授权

US06290460B1 Centrifugal fluid machine 失效
标题翻译：离心流体机
公开(公告)号：US06290460B1
公开(公告)日：2001-09-18
申请号：US09636739
申请日：2000-08-11
申请人： Yoshihiro Nagaoka , Sadashi Tanaka , Yukiji Iwase , Michiaki Ida , Hirotoshi Ishimaru , Saburo Iwasaki , Yoshiharu Ueyama , Tetuya Yoshida
发明人： Yoshihiro Nagaoka , Sadashi Tanaka , Yukiji Iwase , Michiaki Ida , Hirotoshi Ishimaru , Saburo Iwasaki , Yoshiharu Ueyama , Tetuya Yoshida
IPC分类号： F01D102
CPC分类号： F04D29/669 , F04D1/06 , F04D29/2216 , F04D29/422 , F04D29/428 , F04D29/444 , F04D29/448 , F04D29/661 , F04D29/663 , F05B2260/96 , F05D2240/121 , F05D2240/304 , F05D2250/52
摘要： At a vaned diffuser or a volute casing of a centrifugal fluid machine, pressure pulsation and vibrating forces acting upon the diffuser or the volute casing are mitigated or cancelled so as to abate the noise from the centrifugal fluid machine. The fluid machine having an impeller 3 rotating about a rotating. shaft 2 within a casing 1 and having a vaned diffuser 4 or volute 12 fixed to the casing 1 is constructed such that radius of the vane trailing edge of the impeller 3 and radius of the vane leading edge of the diffuser 4 or radius of the volute tongue is varied in the direction of axis of rotation and inclinations, on a meridional plane, of the vane trailing edge of the impeller 3 and the vane leading edge of the diffuser 4 or the volute tongue are set in the same orientation, thereby reduction in head and efficiency or occurrence of an axial thrust may be restrained to the extent possible to optimally abate the noise and pressure pulsation of the centrifugal fluid machine.
摘要翻译：在离心式流体机械的叶片式扩散器或蜗壳上，作用在扩散器或蜗壳上的压力脉动和振动力被减轻或消除，从而减轻离心流体机器的噪音。流体机器具有围绕旋转的旋转的叶轮3。壳体1内的轴2和具有固定到壳体1上的叶片扩散器4或蜗壳12的轴2被构造成使得叶轮3的叶片后缘的半径和扩散器4的叶片前缘的半径或蜗壳的半径舌部在旋转轴线的方向上变化，并且在经向平面上，叶轮3的叶片后缘和扩散器4的叶片前缘或蜗形舌片的倾斜被设置在相同的取向上，从而减少头部和效率或轴向推力的发生可以在可能的程度上被限制，以最佳地减轻离心式流体机械的噪声和压力脉动。

9. 发明授权

US09128071B2 Liquid mixing device and liquid chromatograph 有权
标题翻译：液体混合装置和液相色谱仪
公开(公告)号：US09128071B2
公开(公告)日：2015-09-08
申请号：US13704247
申请日：2011-05-18
申请人： Nobuhiro Tsukada , Yoshihiro Nagaoka , Hironori Kaji , Daisuke Akieda
发明人： Nobuhiro Tsukada , Yoshihiro Nagaoka , Hironori Kaji , Daisuke Akieda
IPC分类号： G01N30/02 , B01F5/06 , G01N30/34
CPC分类号： G01N30/02 , B01F5/0646 , G01N30/34
摘要： A liquid mixing device that decreases a concentration non-uniformity in the flow direction of a mobile phase and a liquid chromatograph that uses the liquid mixing device are provided. The liquid mixing device is configured to include a flow channel unit that is made from an introduction channel, a branch portion that is positioned in a downstream of the introduction channel, multiple branched flow channels that branch from the branch portion, a junction portion in which the multiple branched flow channels join together, and a discharge channel of the downstream of the junction portion. The multiple branched flow channels are different in terms of any one of, or several of width, depth, and length that are associated with an external shape, and a structure filling the inside of the flow channel and thus the times for the liquid to pass through the branched flow channels are different from each other.
摘要翻译：提供了降低流动相的流动方向的浓度不均匀性和使用液体混合装置的液相色谱仪的液体混合装置。液体混合装置被构造成包括由引入通道制成的流动通道单元，位于引入通道下游的分支部分，从分支部分分支的多个分支流动通道，其中连接部分多个分支流动通道连接在一起，以及连接部分下游的排出通道。多个分支流动通道在与外部形状相关联的宽度，深度和长度中的任何一个或几个方面是不同的，以及填充流动通道内部的结构，因此液体通过的时间通过分支流动通道彼此不同。

10. 发明申请

US20130084629A1 Nucleic Acid Analysis Reaction Cell and Nucleic Acid Analyzer 有权
标题翻译：核酸分析反应池和核酸分析仪
公开(公告)号：US20130084629A1
公开(公告)日：2013-04-04
申请号：US13696962
申请日：2011-04-20
申请人： Taro Nakazawa , Masatoshi Narahara , Ryoji Inaba , Yoshihiro Nagaoka , Shigenori Togashi
发明人： Taro Nakazawa , Masatoshi Narahara , Ryoji Inaba , Yoshihiro Nagaoka , Shigenori Togashi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , B01L3/502746 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2400/086 , G01N27/447 , G01N35/1095
摘要： A nucleic acid analysis reaction cell and a nucleic acid analyzer are provided, in which a uniform flow rate is realised, so that a portion where a flow rate is low is removed and washing time for reagent removal is shortened.A flow path (103) is provided which includes a detection area (108) for detecting sequence information of a nucleic acid fragment and detection outer areas (107) disposed at both ends of the detection area (108). An inflow port (105) is provided in one of the detection outer areas (107) and a discharge port (106) is provided in the other of the detection outer areas (107). The detection outer areas (107) disposed at both the ends of the detection area (108) are areas whose widths become narrow toward ends, and guides (104) for branching a liquid are provided in at least the detection outer area (107) in which the inflow port (105) is provided.
摘要翻译：提供了一种核酸分析反应池和核酸分析仪，其中实现了均匀的流速，从而消除了流速低的部分，缩短了除去试剂的洗涤时间。提供了一种流路（103），其包括用于检测核酸片段的序列信息的检测区域（108）和设置在检测区域（108）两端的检测外部区域（107）。在一个检测外部区域（107）中设置有流入口（105），并且在另一个检测外部区域（107）中设置有排出口（106）。设置在检测区域（108）的两端的检测外部区域（107）是宽度朝向端部变窄的区域，并且至少在检测外部区域（107）中设置用于分支液体的引导件（104）其中设置有流入口（105）。

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