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1. 发明申请

US20080245716A1 Separation column and liquid chromatography system with this column 审中-公开
标题翻译：分离柱和液相色谱系统
公开(公告)号：US20080245716A1
公开(公告)日：2008-10-09
申请号：US12076754
申请日：2008-03-21
申请人： Takeshi Ohura , Tomohiro Shoji , Daizo Tokinaga , Tomonari Morioka , Yoshihiro Nagaoka , Yoshitaka Kodama
发明人： Takeshi Ohura , Tomohiro Shoji , Daizo Tokinaga , Tomonari Morioka , Yoshihiro Nagaoka , Yoshitaka Kodama
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01J2220/82 , G01N30/52 , G01N30/54 , G01N30/6052 , G01N30/606 , G01N30/88 , G01N2030/027 , G01N2030/528
摘要： A monolithic separation column and a liquid chromatography system using the same are provided by which the pressure tightness is improved, and the manufacturing is enabled at a low temperature, thus preventing the degradation of the separation performance. A monolithic rod 118 is made of a porous body and has a cylindrical shape. A coat material 116 coats an outer circumference of the monolithic rod 118 and includes an uneven portion 116R on an outer face thereof A holder 112, into which the monolithic rod 118 coated with the coat material 116 is inserted, includes a taper portion 112T on an inner face thereof. A potting media 114 is fitted or filled between the coat material 116 and the holder 112.
摘要翻译：提供了一种整体式分离柱和使用其的液相色谱系统，通过其提高了压力密封性，并且可以在低温下进行制造，从而防止分离性能的劣化。整体式杆118由多孔体制成并具有圆柱形状。涂层材料116涂覆整体式杆118的外周，并且在其外表面上包括不平坦部分116R，涂覆有涂层材料116的整体式杆118插入其中的保持器112包括锥形部分112T 在其内表面上。灌封介质114装配或填充在涂层材料116和保持器112之间。

2. 发明申请

US20090211911A1 CAPILLARY ELECTROPHORESIS APPARATUS 有权
标题翻译：毛细管电泳装置
公开(公告)号：US20090211911A1
公开(公告)日：2009-08-27
申请号：US12344053
申请日：2008-12-24
申请人： Takeshi Ohura , Ryoji Inaba , Yoshitaka Kodama , Hiromi Yamashita , Manabu Akiba , Tomohiro Shoji
发明人： Takeshi Ohura , Ryoji Inaba , Yoshitaka Kodama , Hiromi Yamashita , Manabu Akiba , Tomohiro Shoji
IPC分类号： G01N27/26
CPC分类号： G01N35/00732 , G01N27/44743 , G01N2035/00316
摘要： The invention provides a capillary electrophoresis apparatus which can improve the operability and measuring speed. According to the invention, a sensor for identifying the type of sample containers is fixed at the position away from a capillary anode electrode. The sensor is made to be closer to the sample containers by moving a moving stage so that the sample containers disposed on the moving stage can be identified by the sensor. A fixing apparatus for fixing at least a pair of sample containers is provided on the moving stage.
摘要翻译：本发明提供一种可以提高可操作性和测量速度的毛细管电泳装置。根据本发明，用于识别样品容器类型的传感器固定在远离毛细管阳极电极的位置。通过移动移动台使传感器更靠近样品容器，使得可以通过传感器识别设置在移动台上的样品容器。用于固定至少一对样本容器的定影装置设置在移动台上。

3. 发明授权

US08685220B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US08685220B2
公开(公告)日：2014-04-01
申请号：US13559445
申请日：2012-07-26
申请人： Takeshi Ohura , Ryoji Inaba , Yoshitaka Kodama , Hiromi Yamashita , Manabu Akiba , Tomohiro Shoji
发明人： Takeshi Ohura , Ryoji Inaba , Yoshitaka Kodama , Hiromi Yamashita , Manabu Akiba , Tomohiro Shoji
IPC分类号： C02F1/40 , C02F1/48 , C02F11/00 , G01N27/00 , C25B13/00 , C25B11/00 , C25B9/00
CPC分类号： G01N35/00732 , G01N27/44743 , G01N2035/00316
摘要： The invention provides a capillary electrophoresis apparatus which can improve the operability and measuring speed. According to the invention, a sensor for identifying the type of sample containers is fixed at the position away from a capillary anode electrode. The sensor is made to be closer to the sample containers by moving a moving stage so that the sample containers disposed on the moving stage can be identified by the sensor. A fixing apparatus for fixing at least a pair of sample containers is provided on the moving stage.
摘要翻译：本发明提供一种可以提高可操作性和测量速度的毛细管电泳装置。根据本发明，用于识别样品容器类型的传感器固定在远离毛细管阳极电极的位置。通过移动移动台使传感器更靠近样品容器，使得可以通过传感器识别设置在移动台上的样品容器。用于固定至少一对样本容器的定影装置设置在移动台上。

4. 发明授权

US08252162B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US08252162B2
公开(公告)日：2012-08-28
申请号：US12344053
申请日：2008-12-24
申请人： Takeshi Ohura , Ryoji Inaba , Yoshitaka Kodama , Hiromi Yamashita , Manabu Akiba , Tomohiro Shoji
发明人： Takeshi Ohura , Ryoji Inaba , Yoshitaka Kodama , Hiromi Yamashita , Manabu Akiba , Tomohiro Shoji
IPC分类号： C02F1/40 , C02F1/48 , C02F11/00 , G01N27/00 , C25B13/00 , C25B11/00 , C25B9/00
CPC分类号： G01N35/00732 , G01N27/44743 , G01N2035/00316
摘要： The invention provides a capillary electrophoresis apparatus which can improve the operability and measuring speed. According to the invention, a sensor for identifying the type of sample containers is fixed at the position away from a capillary anode electrode. The sensor is made to be closer to the sample containers by moving a moving stage so that the sample containers disposed on the moving stage can be identified by the sensor. A fixing apparatus for fixing at least a pair of sample containers is provided on the moving stage.
摘要翻译：本发明提供一种可以提高可操作性和测量速度的毛细管电泳装置。根据本发明，用于识别样品容器类型的传感器固定在远离毛细管阳极电极的位置。通过移动移动台使传感器更靠近样品容器，使得可以通过传感器识别设置在移动台上的样品容器。用于固定至少一对样本容器的定影装置设置在移动台上。

5. 发明授权

US07943027B2 Electrophoresis unit and electrophoretic analysis method 有权
标题翻译：电泳单元和电泳分析方法
公开(公告)号：US07943027B2
公开(公告)日：2011-05-17
申请号：US11979570
申请日：2007-11-06
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , C07K1/26 , G01N27/44721 , G01N27/44782
摘要： The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased.An irradiation time to the samples is adjusted during analysis without changing a sampling time. By shortening the irradiation time, a fluorescence amount of the samples is reduced to cause signal intensity detected by a detector to physically decrease. If the irradiation time is very short (several 100 msec), the irradiation time and fluorescence intensity are in a direct proportional relationship. It is known that, if the irradiation time is reduced to 1/n, the fluorescence intensity, that is, signal intensity to be detected will be 1/n. Thus, for data whose irradiation time is reduced to 1/n during analysis, data obtained by multiplying a substantially measured value by n is used for data analysis as a true value to be originally acquired.
摘要翻译：本发明的目的是在电泳单元中扩展动态范围，同时增加多个样本之间的浓度差。在分析过程中调整样品的照射时间，而不改变采样时间。通过缩短照射时间，减少样品的荧光量，使得由检测器检测出的信号强度物理降低。如果照射时间非常短（几百毫秒），照射时间和荧光强度成正比关系。已知如果照射时间减少到1 / n，则荧光强度即被检测信号强度为1 / n。因此，对于在分析期间其照射时间减少到1 / n的数据，将通过将基本上测量的值乘以n获得的数据用作数据分析作为最初获取的真实值。

6. 发明申请

US20080217177A1 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US20080217177A1
公开(公告)日：2008-09-11
申请号：US12073296
申请日：2008-03-04
申请人： Ryoji Inaba , Motohiro Yamazaki , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Ryoji Inaba , Motohiro Yamazaki , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： G01N27/26
CPC分类号： G01N27/447
摘要： There is provided a capillary electrophoresis apparatus wherein coupling efficiency of exciting irradiation light to a capillary array does not decline even if any one capillary array of two capillary arrays is removed.Light emission generated by capillaries of each capillary array of 2n (n is a positive integer) capillary arrays radiating exciting light from one side is detected by one optical detection system.
摘要翻译：提供了一种毛细管电泳装置，其中激光照射光与毛细管阵列的耦合效率即使去除两个毛细管阵列的任何一个毛细管阵列也不会下降。通过一个光学检测系统检测由一个辐射来自一侧的激发光的2μs（n是正整数）毛细管阵列的毛细管阵列的毛细管产生的发光。

7. 发明授权

US08262888B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US08262888B2
公开(公告)日：2012-09-11
申请号：US12073296
申请日：2008-03-04
申请人： Ryoji Inaba , Motohiro Yamazaki , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Ryoji Inaba , Motohiro Yamazaki , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/447
摘要： There is provided a capillary electrophoresis apparatus wherein coupling efficiency of exciting irradiation light to a capillary array does not decline even if any one capillary array of two capillary arrays is removed.Light emission generated by capillaries of each capillary array of 2n (n is a positive integer) capillary arrays radiating exciting light from one side is detected by one optical detection system.
摘要翻译：提供了一种毛细管电泳装置，其中激光照射光与毛细管阵列的耦合效率即使去除两个毛细管阵列的任何一个毛细管阵列也不会下降。通过一个光学检测系统检测由辐射来自一侧的激发光的2n（n是正整数）毛细管阵列的毛细管阵列的毛细管产生的发光。

8. 发明申请

US20120043211A1 CAPILLARY ELECTROPHORESIS APPARATUS 审中-公开
标题翻译：毛细管电泳装置
公开(公告)号：US20120043211A1
公开(公告)日：2012-02-23
申请号：US13263958
申请日：2010-04-08
申请人： Yasutaka Otsuka , Toshiyuki Sakurai , Tomohiro Shoji , Takeshi Ohura
发明人： Yasutaka Otsuka , Toshiyuki Sakurai , Tomohiro Shoji , Takeshi Ohura
IPC分类号： G01N27/447 , C25B15/02
CPC分类号： G01N27/44743 , G01N27/44713
摘要： Provided is a capillary electrophoresis apparatus capable of avoiding electric discharge even when a conductive component is arranged near a cathode end of a capillary. The capillary electrophoresis apparatus of the present invention has a structure in which a spatial distance and a creeping distance between an electrode attached to the cathode end of the capillary and the conductive component are large even when the conductive component is arranged near the cathode end of the capillary. That is to say, the capillary electrode, which protrudes from a lower surface of the load header, penetrates through a space between the load header and an anti-evaporation film and further penetrates through a capillary hole formed on the anti-evaporation film to extend into a container. At least a portion exposed to the space between the load header and the anti-evaporation film of the capillary electrode is covered with an insulating member.
摘要翻译：提供一种毛细管电泳装置，即使在导电性成分配置在毛细管的阴极端附近也能够避免放电。本发明的毛细管电泳装置具有这样的结构，即使在导电部件靠近阴极端附近的情况下，附着于毛细管的阴极端的电极与导电部件之间的空间距离和蠕变距离也较大毛细管。也就是说，从负载集管的下表面突出的毛细管电极穿过负载集管和防蒸发膜之间的空间，并且进一步穿透形成在防蒸发膜上的毛细孔，以延伸进入容器暴露于负载集管和毛细管电极的防蒸发膜之间的空间的至少一部分被绝缘部件覆盖。

9. 发明申请

US20080110756A1 Electrophoresis unit and electrophoretic analysis method 有权
标题翻译：电泳单元和电泳分析方法
公开(公告)号：US20080110756A1
公开(公告)日：2008-05-15
申请号：US11979570
申请日：2007-11-06
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , C07K1/26 , G01N27/44721 , G01N27/44782
摘要： The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased.An irradiation time to the samples is adjusted during analysis without changing a sampling time. By shortening the irradiation time, a fluorescence amount of the samples is reduced to cause signal intensity detected by a detector to physically decrease. If the irradiation time is very short (several 100 msec), the irradiation time and fluorescence intensity are in a direct proportional relationship. It is known that, if the irradiation time is reduced to 1/n, the fluorescence intensity, that is, signal intensity to be detected will be 1/n. Thus, for data whose irradiation time is reduced to 1/n during analysis, data obtained by multiplying a substantially measured value by n is used for data analysis as a true value to be originally acquired.
摘要翻译：本发明的目的是在电泳单元中扩展动态范围，同时增加多个样本之间的浓度差。在分析过程中调整样品的照射时间，而不改变采样时间。通过缩短照射时间，减少样品的荧光量，使得由检测器检测出的信号强度物理降低。如果照射时间非常短（几百毫秒），照射时间和荧光强度成正比关系。已知如果照射时间减少到1 / n，则荧光强度即被检测信号强度为1 / n。因此，对于在分析期间照射时间减少到1 / n的数据，将通过将基本上测量的值乘以n获得的数据用作数据分析，作为最初获取的真实值。

10. 发明授权

US09562809B2 Biopolymer optical analysis device and method 有权
标题翻译：生物聚合物光学分析装置及方法
公开(公告)号：US09562809B2
公开(公告)日：2017-02-07
申请号：US13812801
申请日：2011-07-21
申请人： Satoshi Ozawa , Takashi Anazawa , Rena Akahori , Satoshi Takahashi , Takeshi Ohura , Masashi Kiguchi
发明人： Satoshi Ozawa , Takashi Anazawa , Rena Akahori , Satoshi Takahashi , Takeshi Ohura , Masashi Kiguchi
IPC分类号： G01J3/02 , B82Y5/00 , B82Y15/00 , G01N33/487 , G01N21/65
CPC分类号： G01J3/0267 , B82Y5/00 , B82Y15/00 , C12Q1/6869 , G01N21/658 , G01N33/48721 , C12Q2565/631 , C12Q2565/632
摘要： The present invention provides a device and method for analyzing the characteristics of a biopolymer with excellent mechanical stability, high spatial resolution and sensitivity using a simple device construction. Specifically, the Raman scattered light of a biopolymer is measured and the properties of monomer units forming the biopolymer are analyzed by using a biopolymer property analysis chip (100a) characterized by comprising: a solid substrate (110); at least one nanopore (120) disposed in the solid substrate (110); and one or more electrically conductive thin films (130a, 130b) disposed on the solid substrate (110). The biopolymer property analysis chip (100a) is characterized in that the electrically conductive thin films (130a, 130b) are disposed partially on the solid substrate (110) where the nanopore (120) is formed and a biopolymer which has penetrated into the nanopore (120) is caused to generate Raman scattered light by means of irradiation with external light.
摘要翻译：本发明提供一种使用简单的装置结构分析具有优异机械稳定性，高空间分辨率和灵敏度的生物聚合物的特性的装置和方法。具体地，测量生物聚合物的拉曼散射光，并通过使用生物聚合物性质分析芯片（100a）分析形成生物聚合物的单体单元的性质，其特征在于包括：固体基材（110）; 设置在所述固体基板（110）中的至少一个纳米孔（120）; 以及设置在固体基板（110）上的一个或多个导电薄膜（130a，130b）。生物聚合物性质分析芯片（100a）的特征在于，导电薄膜（130a，130b）部分地设置在形成有纳米孔（120）的固体基板（110）上，并且已经渗透到纳米孔中的生物聚合物 120）通过外部光照射产生拉曼散射光。

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