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1. 发明授权

US08546072B2 Substrate for assaying β-glucan and/or endotoxin and assay method 有权
标题翻译：用于测定β-葡聚糖和/或内毒素的底物和测定方法
公开(公告)号：US08546072B2
公开(公告)日：2013-10-01
申请号：US12918724
申请日：2009-02-20
申请人： Takeshi Kitagawa , Naoyuki Yamamoto , Mutsuhiro Date
发明人： Takeshi Kitagawa , Naoyuki Yamamoto , Mutsuhiro Date
IPC分类号： A61K38/00 , A61K38/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12Q1/00 , G01N33/53
CPC分类号： C07K5/1013 , C07K5/0606 , C07K5/06095 , C07K5/0808 , C07K5/081 , C07K5/101 , G01N33/5308 , G01N2400/24
摘要： An object of the present invention is to provide a peptide derivative for determining β-glucan or endotoxin which allows high sensitivity measurement, and a method for determining β-glucan and/or endotoxin using the same. The present invention relates to (1) a peptide derivative represented by the following general formula [1]: X-A1-Gly-Arg-A2-E-D [1], (2) a reagent for determining β-glucan and/or endotoxin comprising the above-described peptide derivative, (3) a method for determining β-glucan and/or endotoxin, characterized in that a sample containing β-glucan and/or endotoxin, an amebocyte lysate of a horseshoe crab and the above-described peptide derivative are reacted each other, then the resulting released compound represented by the following general formula [2]: H-A2-E-D [2] is separated from unreacted substance and quantified, and the determination is made based on this value, and (4) a reagent kit for determining β-glucan and/or endotoxin, comprising an amebocyte lysate of a horseshoe crab and the above-described peptide derivative as constituents thereof.
摘要翻译：本发明的目的是提供一种用于测定允许高灵敏度测定的β-葡聚糖或内毒素的肽衍生物，以及使用该衍生物测定β-葡聚糖和/或内毒素的方法。本发明涉及（1）由以下通式[1]表示的肽衍生物：X-A1-Gly-Arg-A2-ED [1]，（2）用于测定β-葡聚糖和/或内毒素的试剂其包含上述肽衍生物，（3）β-葡聚糖和/或内毒素的测定方法，其特征在于，含有β-葡聚糖和/或内毒素的样品，马蹄蟹的血小板裂解物和上述肽衍生物彼此反应，然后将由以下通式[2]表示的所得释放化合物：H-A2-ED [2]与未反应物质分离并定量，并基于该值进行测定，和（4 ）用于测定β-葡聚糖和/或内毒素的试剂盒，其包含鲎的微血管裂解物和上述肽衍生物作为其组成。

2. 发明申请

US20100330700A1 SUBSTRATE FOR ASSAYING BETA-GLUCAN AND/OR ENDOTOXIN AND ASSAY METHOD 有权
标题翻译：用于测定β-葡萄糖和/或内毒素和测定方法的基质
公开(公告)号：US20100330700A1
公开(公告)日：2010-12-30
申请号：US12918724
申请日：2009-02-20
申请人： Takeshi Kitagawa , Naoyuki Yamamoto , Mutsuhiro Date
发明人： Takeshi Kitagawa , Naoyuki Yamamoto , Mutsuhiro Date
IPC分类号： G01N33/567 , C07K7/06 , C07K5/10 , C07K5/103 , G01N27/447
CPC分类号： C07K5/1013 , C07K5/0606 , C07K5/06095 , C07K5/0808 , C07K5/081 , C07K5/101 , G01N33/5308 , G01N2400/24
摘要： An object of the present invention is to provide a peptide derivative for determining β-glucan or endotoxin which allows high sensitivity measurement, and a method for determining β-glucan and/or endotoxin using the same. The present invention relates to (1) a peptide derivative represented by the following general formula [1]: X-A1-Gly-Arg-A2-E-D [1], (2) a reagent for determining β-glucan and/or endotoxin comprising the above-described peptide derivative, (3) a method for determining β-glucan and/or endotoxin, characterized in that a sample containing β-glucan and/or endotoxin, an amebocyte lysate of a horseshoe crab and the above-described peptide derivative are reacted each other, then the resulting released compound represented by the following general formula [2]: H-A2-E-D [2] is separated from unreacted substance and quantified, and the determination is made based on this value, and (4) a reagent kit for determining β-glucan and/or endotoxin, comprising an amebocyte lysate of a horseshoe crab and the above-described peptide derivative as constituents thereof.
摘要翻译：本发明的目的是提供一种用于测定能够进行高灵敏度测定的葡聚糖或内毒素的肽衍生物，以及使用其的β-葡聚糖和/或内毒素测定方法。本发明涉及（1）由以下通式[1]表示的肽衍生物：X-A1-Gly-Arg-A2-ED [1]，（2）用于测定葡聚糖和/或包含上述肽衍生物的内毒素，（3）确定葡萄糖和/或内毒素的方法，其特征在于，含有葡聚糖和/或内毒素的样品，马蹄蟹的血小板裂解物和上述描述的肽衍生物彼此反应，然后将由以下通式[2]表示的所得释放化合物：H-A2-ED [2]与未反应物质分离并定量，并基于该值进行测定，和（4）用于测定葡萄糖和/或内毒素的试剂盒，其包含马蹄蟹的血小板裂解物和上述肽衍生物作为其组成。

3. 发明申请

US20090069546A1 PYRAZOLE-BASED CYANINE DYE 有权
公开(公告)号：US20090069546A1
公开(公告)日：2009-03-12
申请号：US12295189
申请日：2007-03-30
申请人： Mutsuhiro Date , Satoshi Hasaba , Naoyuki Yamamoto
发明人： Mutsuhiro Date , Satoshi Hasaba , Naoyuki Yamamoto
IPC分类号： C07K16/00 , C07D403/02 , C07H1/00 , C07K1/13 , C07H21/00
CPC分类号： C09B23/06 , C07D403/06 , C07D403/14 , C07D487/04 , C07D487/14 , C09B23/083 , G01N33/533 , G01N33/582
摘要： Problem Provided is a novel cyanine dye derivative with a pyrazole skeleton and an indole skeleton, having high sensitivity performance in a shorter wavelength region as compared with a conventional optical system, and showing high water solubility. Solution The invention provides (1) a compound represented by the following general formula [50] and a salt thereof: [wherein R1 to R6 each independently represent a substituted or unsubstituted alkyl group which may have an amide bond; R7 to R10 each independently represent alkyl group, alkenyl group, alkynyl group, aryl group, alkoxy group, aryloxy group, alkylthio group, arylthio group, alkylsulfonyl group, arylsulfonyl group, carbamoyl group, sulfamoyl group, ureido group or amino group, those groups being able to have substituents; a group represented by the general formula [2]: —COOR12 [2] (wherein R12 represents hydrogen atom, C1 to C10 alkyl group, alkali metal atom, organic ammonium ion, ammonium ion or anion); a group represented by the general formula [3]: —SO3R13 [3] (wherein R13 represents hydrogen atom, alkali metal atom, organic ammonium ion, ammonium ion or anion), halogen atom, aromatic heterocyclic thio group, hydrogen atom, hydroxyl group, cyano group, formyl group, thiol group or nitro group; R11 represents hydrogen atom, or alkyl group, alkenyl group, alkynyl group or aryl group, those groups being able to have substituents; and n represents an integer of from 0 to 3, provided that any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4 may form a bivalent group with a group selected from —O— group, —S— group, —COO— group and groups represented by the general formulae [52] to [54]: (wherein R50 represents hydrogen atom, alkyl group, alkenyl group or aryl group, those groups being able to have substituents), and substituted or unsubstituted alkylene group; and in the case where said bivalent group is formed, at least one of R1 to R11, along with the bivalent group formed by any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4, has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group; and in the case where said bivalent group is not formed, at least one of R1 to R11 has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group]; (2) a labeled compound obtained by subjecting the above compound to direct or indirect binding to a substance to be labeled, and (3) a method for labeling a substance to be labeled, comprising subjecting the above compound to direct or indirect binding to the substance to be labeled.

4. 发明授权

US09797886B2 Agglutination enhancer 有权
公开(公告)号：US09797886B2
公开(公告)日：2017-10-24
申请号：US14123899
申请日：2012-06-04
申请人： Naoyuki Yamamoto , Tsutomu Masuda
发明人： Naoyuki Yamamoto , Tsutomu Masuda
IPC分类号： G01N33/53 , C08F220/36 , C08F220/60 , G01N33/542
CPC分类号： G01N33/5306 , C08F220/36 , C08F220/60 , G01N33/542
摘要： The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.

5. 发明授权

US08918044B2 Image heating apparatus and recording material feeding apparatus 有权
标题翻译：图像加热装置和记录材料供给装置
公开(公告)号：US08918044B2
公开(公告)日：2014-12-23
申请号：US13530812
申请日：2012-06-22
申请人： Koji Takematsu , Kazuaki Aoki , Shouhei Takeda , Yasuo Nami , Naoyuki Yamamoto , Masahiro Nawa
发明人： Koji Takematsu , Kazuaki Aoki , Shouhei Takeda , Yasuo Nami , Naoyuki Yamamoto , Masahiro Nawa
IPC分类号： G03G15/20 , G03G15/01
CPC分类号： G03G15/2053 , G03G15/0189 , G03G2215/0129
摘要： An image heating apparatus includes a hollow image heating roller having a through hole at one axial end portion side thereof; a bearing fitted around the roller; a heat insulating bush fitted around the roller between the roller and the bearing; a retaining ring for preventing the heat insulating bush from moving relative to the roller; an annular spacer provided between the heat insulating bush and the retaining ring, the annular spacer being provided with an inwardly protruded key portion engageable with the through hole.
摘要翻译：图像加热装置包括：中空图像加热辊，其具有在其一个轴向端部侧的通孔; 围绕辊子安装的轴承; 安装在滚子和滚子之间的绝热衬套; 用于防止绝热衬套相对于辊移动的保持环; 设置在所述绝热衬套和所述保持环之间的环形间隔件，所述环形间隔件设置有与所述通孔接合的向内突出的键部。

6. 发明授权

US08580557B2 Casein hydrolyzate, process for producing the same and use thereof 有权
标题翻译：酪蛋白水解物，其制备方法及其用途
公开(公告)号：US08580557B2
公开(公告)日：2013-11-12
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda , Hideo Nishimura
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C12N1/00 , C12N9/62 , A61K38/00 , A61K38/05 , A61K38/06 , C12N9/50 , C12N9/48 , A61K47/00 , A61K38/55 , A23C9/12 , C12P21/06 , A61P9/12
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译：本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法，及其用途。本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。

7. 发明申请

US20120200198A1 Surface-Mount Piezoelectric Device 有权
标题翻译：表面贴装压电器件
公开(公告)号：US20120200198A1
公开(公告)日：2012-08-09
申请号：US13356043
申请日：2012-01-23
申请人： Naoyuki Yamamoto
发明人： Naoyuki Yamamoto
IPC分类号： H01L41/053
CPC分类号： H03H9/02 , H01L23/04 , H01L2924/0002 , H03H9/1021 , H03H9/15 , H01L2924/00
摘要： The present invention provides piezoelectric surface mount devices in which the area of the mounting terminals is reduced, leading to reduction of manufacturing cost. A piezoelectric device comprises a package base (120) including a bottom surface having a long edge and a short edge and a pair of mounting terminals formed on respective short edges of the package base. The pair of mounting terminals are separated by a predetermined longitudinal distance (X3) and are arranged as close as possible to the longitudinal center line of the package base. The predetermined distance is sufficient to prevent electrical short when mounting the piezoelectric device onto the printed substrate. The maximum width (Z2) of each mounting terminal measured in a direction parallel with the short edges of the package base is less than one half the width of the short edge (Z1).
摘要翻译：本发明提供了压电表面贴装装置，其中安装端子的面积减小，导致制造成本的降低。一种压电装置，包括：包装底座（120），包括具有长边缘和短边缘的底表面和形成在封装基座的相应短边缘上的一对安装端子。一对安装端子以预定的纵向距离（X3）分开，并且尽可能靠近包装基座的纵向中心线。当将压电元件安装在印刷基板上时，预定距离足以防止电气短路。在与封装基座的短边缘平行的方向上测量的每个安装端子的最大宽度（Z2）小于短边（Z1）的宽度的一半。

8. 发明申请

US20110082281A1 CASEIN HYDROLYZATE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF 有权
标题翻译： CASEIN水解产物，其生产方法和用途
公开(公告)号：US20110082281A1
公开(公告)日：2011-04-07
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C07K5/08 , C07K5/06 , C12P21/00
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译：本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法，及其用途。本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。

9. 发明授权

US07599642B2 Image forming apparatus including a heater positioned between a photosensitive member and a corona charger 失效
标题翻译：图像形成装置包括位于感光构件和电晕充电器之间的加热器
公开(公告)号：US07599642B2
公开(公告)日：2009-10-06
申请号：US11836983
申请日：2007-08-10
申请人： Masanobu Nakajima , Takahiro Nakase , Naoyuki Yamamoto
发明人： Masanobu Nakajima , Takahiro Nakase , Naoyuki Yamamoto
IPC分类号： G03G15/02
CPC分类号： G03G15/0291 , G03G15/751 , G03G2215/027
摘要： An image forming apparatus is constituted by an image bearing member; a corona charging member including a wire; a heat generating member for generating heat by energization; a shielding member, including the heat generating member, capable of shielding a portion of the corona charging member opposing to the image bearing member from the image bearing member by being moved between the corona charging member and the image bearing member; an energization control member for controlling energization of the heat generating member; and moving member for moving the shielding member to a first position at which the shielding member shields the portion and a second position retracted from the first position. When the shielding member is located at the first position, at least a part of the heat generating member is disposed between the corona charging member and the image bearing member.
摘要翻译：图像形成装置由图像承载部件构成; 包括线的电晕充电部件; 通过通电产生热量的发热部件; 包括所述发热元件的屏蔽部件能够通过在所述电晕充电部件和所述图像承载部件之间移动而将与所述图像承载部件相对的所述电晕充电部件的一部分从所述图像承载部件屏蔽起来; 通电控制部件，用于控制发热部件的通电; 以及用于将屏蔽构件移动到屏蔽构件遮蔽该部分的第一位置和从第一位置缩回的第二位置的移动构件。当屏蔽构件位于第一位置时，发热构件的至少一部分设置在电晕充电构件和图像承载构件之间。

10. 发明申请

US20080130061A1 IMAGE FORMING APPARATUS AND LINE WIDTH CORRECTION METHOD THEREFOR 有权
标题翻译：图像形成装置及其宽度校正方法
公开(公告)号：US20080130061A1
公开(公告)日：2008-06-05
申请号：US11950504
申请日：2007-12-05
申请人： Takahiro Nakase , Naoyuki Yamamoto , Masanobu Nakajima
发明人： Takahiro Nakase , Naoyuki Yamamoto , Masanobu Nakajima
IPC分类号： H04N1/04
CPC分类号： H04N1/00002 , H04N1/00015 , H04N1/00031 , H04N1/00045 , H04N1/00063 , H04N1/00066 , H04N1/00087
摘要： This invention provides an image forming apparatus capable of outputting, without using any special device, an image which is free from changes in density and tint even upon crisscross rotation and exhibits good proportion of a small character. To accomplish this, the pulse width of a laser emission signal is controlled at 16 levels for one dot at 600 dpi, controlling an actual image in the main scanning direction. When adjusting vertical and horizontal line widths, patch data are created by rotating an anisotropic pattern through 0° and 90° (S1 in FIG. 5). Then, a reader/scanner (15) reads each patch as density data (S2 in FIG. 5). A pulse width, that is, line width correction value at which the densities of the patch patterns rotated through 0° and 90° become equal to each other is obtained (S3 in FIG. 5).
摘要翻译：本发明提供了一种图像形成装置，即使在使用任何特殊装置的情况下，也能够即使在十字形旋转时也能够输出密度变化和色调的图像，并且具有小的特征的较小比例。为了实现这一点，激光发射信号的脉冲宽度以600dpi的一个点被控制在16个等级，控制主扫描方向上的实际图像。当调整垂直和水平线宽时，通过将各向异性图案旋转0°和90°（图5中的S1）来创建贴片数据。然后，读取器/扫描器（15）读取每个贴片作为密度数据（图5中的S 2）。获得脉冲宽度，即，通过0°和90°旋转的贴片图案的密度彼此相等的线宽校正值（图5中的S 3）。

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