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1. 发明申请

US20110082281A1 CASEIN HYDROLYZATE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF 有权
标题翻译： CASEIN水解产物，其生产方法和用途
公开(公告)号：US20110082281A1
公开(公告)日：2011-04-07
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C07K5/08 , C07K5/06 , C12P21/00
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译：本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法，及其用途。本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。

2. 发明申请

US20070299014A1 Casein hydrolyzate, process for producing the same and use thereof 审中-公开
标题翻译：酪蛋白水解物，其制备方法及其用途
公开(公告)号：US20070299014A1
公开(公告)日：2007-12-27
申请号：US10565497
申请日：2004-07-30
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： A61K38/06 , A61K38/04 , C12P21/06 , A61K38/05
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译：本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法，及其用途。本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。

3. 发明授权

US08580557B2 Casein hydrolyzate, process for producing the same and use thereof 有权
标题翻译：酪蛋白水解物，其制备方法及其用途
公开(公告)号：US08580557B2
公开(公告)日：2013-11-12
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda , Hideo Nishimura
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C12N1/00 , C12N9/62 , A61K38/00 , A61K38/05 , A61K38/06 , C12N9/50 , C12N9/48 , A61K47/00 , A61K38/55 , A23C9/12 , C12P21/06 , A61P9/12
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译：本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法，及其用途。本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。

4. 发明申请

US20100151080A1 PROCESS FOR PRODUCTION OF FERMENTED MILK AND FERMENTED MILK BEVERAGE/FOOD 审中-公开
标题翻译：生产发酵奶和发酵牛奶饮料的过程
公开(公告)号：US20100151080A1
公开(公告)日：2010-06-17
申请号：US11996854
申请日：2006-07-25
申请人： Mariko Yasuda , Tadashi Shinoda , Naoyuki Yamamoto
发明人： Mariko Yasuda , Tadashi Shinoda , Naoyuki Yamamoto
IPC分类号： A23C9/127
CPC分类号： C12Y304/00 , A23C9/1209 , A23C9/1275 , A23L2/38 , A23L33/18 , A23V2002/00 , A23Y2220/39 , C12P21/06 , A23V2200/326
摘要： The invention provides a method for producing a fermented milk that conveniently gives excellent taste and flavor or functionalities, such as antihypertensive effect, to fermented food and beverages. The method enables effective production of particular peptides having useful functions, such as antihypertensive effect, in the resulting fermented milk. The invention also provides fermented milk food and beverages utilizing the fermented milk, which have excellent taste and flavor and even functionality. The present method includes the steps of (A) enzymatically digesting animal milk casein with protease (1) containing particular proteases such as papain, and (B) fermenting animal milk casein or the like with lactic acid bacteria, to thereby produce VPP, IPP, and YP in the resulting fermented milk. The fermented milk food and beverages of the present invention contain the fermented milk obtained by the present method or a concentrate thereof, and VPP, IPP, and YP at or over particular contents.
摘要翻译：本发明提供一种生产发酵乳的方法，其方便地对发酵的食物和饮料提供优异的味道和风味或功能，例如抗高血压作用。该方法能够在所得的发酵乳中有效地制备具有有用功能的特定肽，例如抗高血压作用。本发明还提供利用发酵乳的发酵乳食品和饮料，其具有优异的味道和风味，甚至功能性。本发明的方法包括以下步骤：（A）用含有特异性蛋白酶如木瓜蛋白酶的蛋白酶（1）酶促消化动物乳酪蛋白，（B）用乳酸菌发酵动物乳酪蛋白等，从而产生VPP，IPP，和YP在所得的发酵乳中。本发明的发酵乳食品和饮料含有通过本发明方法获得的发酵乳或其浓缩物，以及特定内容物上的VPP，IPP和YP。

5. 发明授权

US07029670B2 Medicines for relieving intestinal disorders 失效
标题翻译：减轻肠道疾病的药物
公开(公告)号：US07029670B2
公开(公告)日：2006-04-18
申请号：US10250382
申请日：2001-12-25
申请人： Naoyuki Yamamoto , Osamu Masuda , Kyouko Kaneko , Nagisa Ikeda , Yuu Ishida , Daisuke Kusuda , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Osamu Masuda , Kyouko Kaneko , Nagisa Ikeda , Yuu Ishida , Daisuke Kusuda , Tadashi Shinoda
IPC分类号： A01N63/00 , C12N1/20
CPC分类号： A61K35/20 , A61K35/747 , Y10S514/892 , A61K2300/00
摘要： An agent for relieving intestinal disorders which contain live cells of a strain belonging to Lactobacillus helveticus. This strain is preferably characterized by a resistance to a specific bile acid, adhesiveness to intestinal epithelial cells, etc. A method of controlling intestinal functions which involves the step of administering such a medicine to a subject with a need for the control of intestinal functions. When administered to humans or the like, these agents exert effects of elevating defecation frequency, etc., thereby efficaciously improving the intestinal environment.
摘要翻译：用于缓解肠道病症的药剂，其含有属于瑞士乳杆菌属的菌株的活细胞。该菌株的特征在于对特定胆汁酸的抗性，对肠上皮细胞的粘附性等。一种控制肠功能的方法，其涉及向受试者施用这种药物以控制肠功能的步骤。当施用于人类等时，这些药剂施加提高排便频率等的作用，从而有效地改善肠道环境。

6. 发明授权

US08877483B2 Dioxin elimination promoter 有权
标题翻译：二恶英消除促进剂
公开(公告)号：US08877483B2
公开(公告)日：2014-11-04
申请号：US10514555
申请日：2003-05-30
申请人： Tadashi Shinoda , Akihiro Masuyama , Hidetoshi Morita , Hiroshi Yoshikawa
发明人： Tadashi Shinoda , Akihiro Masuyama , Hidetoshi Morita , Hiroshi Yoshikawa
IPC分类号： C12N1/20 , A61K49/00 , A61K39/07 , C12R1/225 , A61K35/74 , A23L1/30 , C12R1/125 , A23K1/00
CPC分类号： C12R1/225 , A23K10/18 , A23L33/135 , A61K35/742 , A61K35/744 , C12R1/125
摘要： An accelerating agent for elimination of dioxins which comprises, as an active ingredient, a microorganism having an activity of accelerating elimination of dioxins in the body to the outside of the body.
摘要翻译：一种用于消除二恶英的促进剂，其包含作为活性成分的微生物，其具有将体内二恶英的消除作用加快至身体外部的活性成分。

7. 发明授权

US4309731A Recording and playing system for magnetic tape from a cassette 失效
标题翻译：从磁带录制和播放磁带的系统
公开(公告)号：US4309731A
公开(公告)日：1982-01-05
申请号：US72315
申请日：1979-09-04
申请人： Masashi Yoshida , Hideyuki Kawase , Tadashi Shinoda
发明人： Masashi Yoshida , Hideyuki Kawase , Tadashi Shinoda
IPC分类号： G11B15/29 , G11B15/665 , G11B15/66 , G03B1/04
CPC分类号： G11B15/6656 , G11B15/29
摘要： A motor-driven mechanism for pulling magnetic tape from a cassette and winding same around a rotary head cylinder for a circumferential extent of a predetermined angle is utilized for causing the pinch roller to force the magnetic tape against the capstan following tape loading.
摘要翻译：用于从盒子拉动磁带并围绕旋转磁头圆筒缠绕预定角度的周边程度的电机驱动机构被用来使夹紧辊在磁带加载之后将磁带强制地压靠在绞盘上。

8. 发明申请

US20050201997A1 Dioxin elimination promoter 有权
标题翻译：二恶英消除促进剂
公开(公告)号：US20050201997A1
公开(公告)日：2005-09-15
申请号：US10514555
申请日：2003-05-30
申请人： Tadashi Shinoda , Akihiro Masuyama , Hidetoshi Morita , Hiroshi Yoshikawa
发明人： Tadashi Shinoda , Akihiro Masuyama , Hidetoshi Morita , Hiroshi Yoshikawa
IPC分类号： A23K1/00 , A23L1/30 , A61P39/02 , A61P43/00 , A61K45/00
CPC分类号： C12R1/225 , A23K10/18 , A23L33/135 , A61K35/742 , A61K35/744 , C12R1/125
摘要： An accelerating agent for elimination of dioxins which comprises, as an active ingredient, a microorganism having an activity of accelerating elimination of dioxins in the body to the outside of the body.
摘要翻译：一种用于消除二恶英的促进剂，其包含作为活性成分的微生物，其具有将体内二恶英的消除作用加速至身体外部。

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