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1. 发明申请

US20090069546A1 PYRAZOLE-BASED CYANINE DYE 有权
公开(公告)号：US20090069546A1
公开(公告)日：2009-03-12
申请号：US12295189
申请日：2007-03-30
申请人： Mutsuhiro Date , Satoshi Hasaba , Naoyuki Yamamoto
发明人： Mutsuhiro Date , Satoshi Hasaba , Naoyuki Yamamoto
IPC分类号： C07K16/00 , C07D403/02 , C07H1/00 , C07K1/13 , C07H21/00
CPC分类号： C09B23/06 , C07D403/06 , C07D403/14 , C07D487/04 , C07D487/14 , C09B23/083 , G01N33/533 , G01N33/582
摘要： Problem Provided is a novel cyanine dye derivative with a pyrazole skeleton and an indole skeleton, having high sensitivity performance in a shorter wavelength region as compared with a conventional optical system, and showing high water solubility. Solution The invention provides (1) a compound represented by the following general formula [50] and a salt thereof: [wherein R1 to R6 each independently represent a substituted or unsubstituted alkyl group which may have an amide bond; R7 to R10 each independently represent alkyl group, alkenyl group, alkynyl group, aryl group, alkoxy group, aryloxy group, alkylthio group, arylthio group, alkylsulfonyl group, arylsulfonyl group, carbamoyl group, sulfamoyl group, ureido group or amino group, those groups being able to have substituents; a group represented by the general formula [2]: —COOR12 [2] (wherein R12 represents hydrogen atom, C1 to C10 alkyl group, alkali metal atom, organic ammonium ion, ammonium ion or anion); a group represented by the general formula [3]: —SO3R13 [3] (wherein R13 represents hydrogen atom, alkali metal atom, organic ammonium ion, ammonium ion or anion), halogen atom, aromatic heterocyclic thio group, hydrogen atom, hydroxyl group, cyano group, formyl group, thiol group or nitro group; R11 represents hydrogen atom, or alkyl group, alkenyl group, alkynyl group or aryl group, those groups being able to have substituents; and n represents an integer of from 0 to 3, provided that any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4 may form a bivalent group with a group selected from —O— group, —S— group, —COO— group and groups represented by the general formulae [52] to [54]: (wherein R50 represents hydrogen atom, alkyl group, alkenyl group or aryl group, those groups being able to have substituents), and substituted or unsubstituted alkylene group; and in the case where said bivalent group is formed, at least one of R1 to R11, along with the bivalent group formed by any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4, has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group; and in the case where said bivalent group is not formed, at least one of R1 to R11 has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group]; (2) a labeled compound obtained by subjecting the above compound to direct or indirect binding to a substance to be labeled, and (3) a method for labeling a substance to be labeled, comprising subjecting the above compound to direct or indirect binding to the substance to be labeled.

2. 发明授权

US08546072B2 Substrate for assaying β-glucan and/or endotoxin and assay method 有权
标题翻译：用于测定β-葡聚糖和/或内毒素的底物和测定方法
公开(公告)号：US08546072B2
公开(公告)日：2013-10-01
申请号：US12918724
申请日：2009-02-20
申请人： Takeshi Kitagawa , Naoyuki Yamamoto , Mutsuhiro Date
发明人： Takeshi Kitagawa , Naoyuki Yamamoto , Mutsuhiro Date
IPC分类号： A61K38/00 , A61K38/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12Q1/00 , G01N33/53
CPC分类号： C07K5/1013 , C07K5/0606 , C07K5/06095 , C07K5/0808 , C07K5/081 , C07K5/101 , G01N33/5308 , G01N2400/24
摘要： An object of the present invention is to provide a peptide derivative for determining β-glucan or endotoxin which allows high sensitivity measurement, and a method for determining β-glucan and/or endotoxin using the same. The present invention relates to (1) a peptide derivative represented by the following general formula [1]: X-A1-Gly-Arg-A2-E-D [1], (2) a reagent for determining β-glucan and/or endotoxin comprising the above-described peptide derivative, (3) a method for determining β-glucan and/or endotoxin, characterized in that a sample containing β-glucan and/or endotoxin, an amebocyte lysate of a horseshoe crab and the above-described peptide derivative are reacted each other, then the resulting released compound represented by the following general formula [2]: H-A2-E-D [2] is separated from unreacted substance and quantified, and the determination is made based on this value, and (4) a reagent kit for determining β-glucan and/or endotoxin, comprising an amebocyte lysate of a horseshoe crab and the above-described peptide derivative as constituents thereof.
摘要翻译：本发明的目的是提供一种用于测定允许高灵敏度测定的β-葡聚糖或内毒素的肽衍生物，以及使用该衍生物测定β-葡聚糖和/或内毒素的方法。本发明涉及（1）由以下通式[1]表示的肽衍生物：X-A1-Gly-Arg-A2-ED [1]，（2）用于测定β-葡聚糖和/或内毒素的试剂其包含上述肽衍生物，（3）β-葡聚糖和/或内毒素的测定方法，其特征在于，含有β-葡聚糖和/或内毒素的样品，马蹄蟹的血小板裂解物和上述肽衍生物彼此反应，然后将由以下通式[2]表示的所得释放化合物：H-A2-ED [2]与未反应物质分离并定量，并基于该值进行测定，和（4 ）用于测定β-葡聚糖和/或内毒素的试剂盒，其包含鲎的微血管裂解物和上述肽衍生物作为其组成。

3. 发明申请

US20100330700A1 SUBSTRATE FOR ASSAYING BETA-GLUCAN AND/OR ENDOTOXIN AND ASSAY METHOD 有权
标题翻译：用于测定β-葡萄糖和/或内毒素和测定方法的基质
公开(公告)号：US20100330700A1
公开(公告)日：2010-12-30
申请号：US12918724
申请日：2009-02-20
申请人： Takeshi Kitagawa , Naoyuki Yamamoto , Mutsuhiro Date
发明人： Takeshi Kitagawa , Naoyuki Yamamoto , Mutsuhiro Date
IPC分类号： G01N33/567 , C07K7/06 , C07K5/10 , C07K5/103 , G01N27/447
CPC分类号： C07K5/1013 , C07K5/0606 , C07K5/06095 , C07K5/0808 , C07K5/081 , C07K5/101 , G01N33/5308 , G01N2400/24
摘要： An object of the present invention is to provide a peptide derivative for determining β-glucan or endotoxin which allows high sensitivity measurement, and a method for determining β-glucan and/or endotoxin using the same. The present invention relates to (1) a peptide derivative represented by the following general formula [1]: X-A1-Gly-Arg-A2-E-D [1], (2) a reagent for determining β-glucan and/or endotoxin comprising the above-described peptide derivative, (3) a method for determining β-glucan and/or endotoxin, characterized in that a sample containing β-glucan and/or endotoxin, an amebocyte lysate of a horseshoe crab and the above-described peptide derivative are reacted each other, then the resulting released compound represented by the following general formula [2]: H-A2-E-D [2] is separated from unreacted substance and quantified, and the determination is made based on this value, and (4) a reagent kit for determining β-glucan and/or endotoxin, comprising an amebocyte lysate of a horseshoe crab and the above-described peptide derivative as constituents thereof.
摘要翻译：本发明的目的是提供一种用于测定能够进行高灵敏度测定的葡聚糖或内毒素的肽衍生物，以及使用其的β-葡聚糖和/或内毒素测定方法。本发明涉及（1）由以下通式[1]表示的肽衍生物：X-A1-Gly-Arg-A2-ED [1]，（2）用于测定葡聚糖和/或包含上述肽衍生物的内毒素，（3）确定葡萄糖和/或内毒素的方法，其特征在于，含有葡聚糖和/或内毒素的样品，马蹄蟹的血小板裂解物和上述描述的肽衍生物彼此反应，然后将由以下通式[2]表示的所得释放化合物：H-A2-ED [2]与未反应物质分离并定量，并基于该值进行测定，和（4）用于测定葡萄糖和/或内毒素的试剂盒，其包含马蹄蟹的血小板裂解物和上述肽衍生物作为其组成。

4. 发明申请

US20120046474A1 PYRAZOLE-BASED CYANINE DYE CONTAINING QUATERNARY AMMONIUM CATION 有权
公开(公告)号：US20120046474A1
公开(公告)日：2012-02-23
申请号：US13318089
申请日：2010-04-27
申请人： Naoyuki Yamamoto , Tatsuo Kurosawa , Satoshi Hasaba , Matsuhiro Date
发明人： Naoyuki Yamamoto , Tatsuo Kurosawa , Satoshi Hasaba , Matsuhiro Date
IPC分类号： C07D403/06
CPC分类号： C07D403/06 , C09B23/083
摘要： ProblemProvided is a novel cyanine dye derivative having high fluorescence intensity in a short wavelength region, a structure where a pyrazole skeleton and an indole skeleton are bound to a polymethine chain, and also a controllable migration velocity by further introducing a quaternary ammonium cation into a molecule having said structure.SolutionThe present invention is the invention of a compound represented by the general formula [1] or a salt thereof: [wherein R1 to R6 each independently represent an alkyl group having, as a substituent, a group represented by the general formula [101]: (wherein R101 to R104 each independently represent a hydrogen atom or an alkyl group of C1 to C3 and m represents an integer from 2 to 6, and two or three of R102 to R104 together with a nitrogen atom to which they are bound may form a heterocyclic ammonium cation); or a group derived from a carboxylic acid represented by the general formula [2] which may have an amide bond: —COOR12 [2] (wherein R12 represents a hydrogen atom, an alkyl group of C1 to C10, an alkali metal atom, an organic ammonium ion, an ammonium ion or anion); or an alkyl group which may have, as a substituent, a group derived from a sulfonic acid represented by the general formula [3] which may have an amide bond: —SO3R13 [3] (wherein R13 represents a hydrogen atom, an alkali metal atom, an organic ammonium ion, an ammonium ion or anion); R7 to R10 each independently represent an alkyl group, an alkynyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylsulfonyl group, an arylsulfonyl group, an amino group, a group derived from a carboxylic acid represented by the general formula [2], a group derived from a sulfonic acid represented by the general formula [3], a halogen atom, a hydrogen atom, a hydroxyl group, a cyano group or a nitro group; R11 represents a hydrogen atom, an alkyl group, an alkynyl group or an aryl group, and n represents an integer from 0 to 3, and at least one of R1 to R6 is an alkyl group having, as a substituent, a group represented by the general formula [101]].

5. 发明授权

US08921124B2 Pyrazole-based cyanine dye 有权
公开(公告)号：US08921124B2
公开(公告)日：2014-12-30
申请号：US12295189
申请日：2007-03-30
申请人： Matsuhiro Date , Satoshi Hasaba , Naoyuki Yamamoto
发明人： Matsuhiro Date , Satoshi Hasaba , Naoyuki Yamamoto
IPC分类号： G01N33/533 , C09B23/06 , C07D487/02 , G01N33/58 , C07D403/06 , C07D403/14 , C07D487/04 , C07D487/14 , C09B23/08
CPC分类号： C09B23/06 , C07D403/06 , C07D403/14 , C07D487/04 , C07D487/14 , C09B23/083 , G01N33/533 , G01N33/582
摘要： PROBLEMProvided is a novel cyanine dye derivative with a pyrazole skeleton and an indole skeleton, having high sensitivity performance in a shorter wavelength region as compared with a conventional optical system, and showing high water solubility.SOLUTIONThe invention provides (1) a compound represented by the following general formula [50] and a salt thereof: [wherein R1 to R6 each independently represent a substituted or unsubstituted alkyl group which may have an amide bond; R7 to R10 each independently represent alkyl group, alkenyl group, alkynyl group, aryl group, alkoxy group, aryloxy group, alkylthio group, arylthio group, alkylsulfonyl group, arylsulfonyl group, carbamoyl group, sulfamoyl group, ureido group or amino group, those groups being able to have substituents; a group represented by the general formula [2]: —COOR12 [2] (wherein R12 represents hydrogen atom, C1 to C10 alkyl group, alkali metal atom, organic ammonium ion, ammonium ion or anion); a group represented by the general formula [3]: —SO3R13 [3] (wherein R13 represents hydrogen atom, alkali metal atom, organic ammonium ion, ammonium ion or anion), halogen atom, aromatic heterocyclic thio group, hydrogen atom, hydroxyl group, cyano group, formyl group, thiol group or nitro group; R11 represents hydrogen atom, or alkyl group, alkenyl group, alkynyl group or aryl group, those groups being able to have substituents; and n represents an integer of from 0 to 3, provided that any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4 may form a bivalent group with a group selected from —O— group, —S— group, —COO— group and groups represented by the general formulae [52] to [54]: (wherein R50 represents hydrogen atom, alkyl group, alkenyl group or aryl group, those groups being able to have substituents), and substituted or unsubstituted alkylene group; and in the case where said bivalent group is formed, at least one of R1 to R11, along with the bivalent group formed by any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4, has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group; and in the case where said bivalent group is not formed, at least one of R1 to R11 has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group]; (2) a labeled compound obtained by subjecting the above compound to direct or indirect binding to a substance to be labeled, and (3) a method for labeling a substance to be labeled, comprising subjecting the above compound to direct or indirect binding to the substance to be labeled.

6. 发明授权

US08546586B2 Pyrazole-based cyanine dye containing quaternary ammonium cation 有权
标题翻译：含有季铵阳离子的吡唑类花青染料
公开(公告)号：US08546586B2
公开(公告)日：2013-10-01
申请号：US13318089
申请日：2010-04-27
申请人： Naoyuki Yamamoto , Tatsuo Kurosawa , Satoshi Hasaba , Matsuhiro Date
发明人： Naoyuki Yamamoto , Tatsuo Kurosawa , Satoshi Hasaba , Matsuhiro Date
IPC分类号： C07D403/06
CPC分类号： C07D403/06 , C09B23/083
摘要： A cyanine dye derivative having high fluorescence intensity in a short wavelength region, and also a controllable migration velocity by further introducing a quaternary ammonium cation. A compound having general formula [1] or a salt thereof: wherein R1 to R6 each independently represent an alkyl group having, as a substituent, a group represented by the general formula [101]:
摘要翻译：在短波长区域具有高荧光强度的花青染料衍生物，并且通过进一步引入季铵阳离子也可控制迁移速度。具有通式[1]的化合物或其盐：其中R 1至R 6各自独立地表示具有由通式[101]表示的基团作为取代基的烷基：

7. 发明授权

US09797886B2 Agglutination enhancer 有权
公开(公告)号：US09797886B2
公开(公告)日：2017-10-24
申请号：US14123899
申请日：2012-06-04
申请人： Naoyuki Yamamoto , Tsutomu Masuda
发明人： Naoyuki Yamamoto , Tsutomu Masuda
IPC分类号： G01N33/53 , C08F220/36 , C08F220/60 , G01N33/542
CPC分类号： G01N33/5306 , C08F220/36 , C08F220/60 , G01N33/542
摘要： The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.

8. 发明授权

US08918044B2 Image heating apparatus and recording material feeding apparatus 有权
标题翻译：图像加热装置和记录材料供给装置
公开(公告)号：US08918044B2
公开(公告)日：2014-12-23
申请号：US13530812
申请日：2012-06-22
申请人： Koji Takematsu , Kazuaki Aoki , Shouhei Takeda , Yasuo Nami , Naoyuki Yamamoto , Masahiro Nawa
发明人： Koji Takematsu , Kazuaki Aoki , Shouhei Takeda , Yasuo Nami , Naoyuki Yamamoto , Masahiro Nawa
IPC分类号： G03G15/20 , G03G15/01
CPC分类号： G03G15/2053 , G03G15/0189 , G03G2215/0129
摘要： An image heating apparatus includes a hollow image heating roller having a through hole at one axial end portion side thereof; a bearing fitted around the roller; a heat insulating bush fitted around the roller between the roller and the bearing; a retaining ring for preventing the heat insulating bush from moving relative to the roller; an annular spacer provided between the heat insulating bush and the retaining ring, the annular spacer being provided with an inwardly protruded key portion engageable with the through hole.
摘要翻译：图像加热装置包括：中空图像加热辊，其具有在其一个轴向端部侧的通孔; 围绕辊子安装的轴承; 安装在滚子和滚子之间的绝热衬套; 用于防止绝热衬套相对于辊移动的保持环; 设置在所述绝热衬套和所述保持环之间的环形间隔件，所述环形间隔件设置有与所述通孔接合的向内突出的键部。

9. 发明授权

US08580557B2 Casein hydrolyzate, process for producing the same and use thereof 有权
标题翻译：酪蛋白水解物，其制备方法及其用途
公开(公告)号：US08580557B2
公开(公告)日：2013-11-12
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda , Hideo Nishimura
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C12N1/00 , C12N9/62 , A61K38/00 , A61K38/05 , A61K38/06 , C12N9/50 , C12N9/48 , A61K47/00 , A61K38/55 , A23C9/12 , C12P21/06 , A61P9/12
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译：本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法，及其用途。本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。

10. 发明申请

US20120200198A1 Surface-Mount Piezoelectric Device 有权
标题翻译：表面贴装压电器件
公开(公告)号：US20120200198A1
公开(公告)日：2012-08-09
申请号：US13356043
申请日：2012-01-23
申请人： Naoyuki Yamamoto
发明人： Naoyuki Yamamoto
IPC分类号： H01L41/053
CPC分类号： H03H9/02 , H01L23/04 , H01L2924/0002 , H03H9/1021 , H03H9/15 , H01L2924/00
摘要： The present invention provides piezoelectric surface mount devices in which the area of the mounting terminals is reduced, leading to reduction of manufacturing cost. A piezoelectric device comprises a package base (120) including a bottom surface having a long edge and a short edge and a pair of mounting terminals formed on respective short edges of the package base. The pair of mounting terminals are separated by a predetermined longitudinal distance (X3) and are arranged as close as possible to the longitudinal center line of the package base. The predetermined distance is sufficient to prevent electrical short when mounting the piezoelectric device onto the printed substrate. The maximum width (Z2) of each mounting terminal measured in a direction parallel with the short edges of the package base is less than one half the width of the short edge (Z1).
摘要翻译：本发明提供了压电表面贴装装置，其中安装端子的面积减小，导致制造成本的降低。一种压电装置，包括：包装底座（120），包括具有长边缘和短边缘的底表面和形成在封装基座的相应短边缘上的一对安装端子。一对安装端子以预定的纵向距离（X3）分开，并且尽可能靠近包装基座的纵向中心线。当将压电元件安装在印刷基板上时，预定距离足以防止电气短路。在与封装基座的短边缘平行的方向上测量的每个安装端子的最大宽度（Z2）小于短边（Z1）的宽度的一半。

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