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1. 发明授权

US06602195B1 Medical ultrasonic imaging pulse transmission method 有权
标题翻译：医用超声波成像脉冲传输方法
公开(公告)号：US06602195B1
公开(公告)日：2003-08-05
申请号：US09767158
申请日：2001-01-22
申请人： Sriram Krishnan , Patrick J. Phillips , Gregory L. Holley , Ismayil M. Guracar
发明人： Sriram Krishnan , Patrick J. Phillips , Gregory L. Holley , Ismayil M. Guracar
IPC分类号： A61B800
CPC分类号： G01S15/8959 , A61B8/00 , G01S7/52039 , G01S7/52041 , G01S7/52085 , G01S15/8927 , G01S15/8961 , G01S15/8963
摘要： A medical ultrasound imaging pulse transmission method transmits at least three pulses, including at least two pulses of different amplitude and at least two pulses of differing phase. The larger-amplitude pulse is transmitted with a larger aperture and the smaller-amplitude pulses are transmitted with respective smaller subapertures. The subapertures are arranged such that the sum of the subapertures used for the smaller-amplitude pulses is equal to the aperture used for the larger-amplitude pulse. In this way, pulses of differing amplitudes are obtained without varying the power level of individual transducer elements, and precise control over pulse amplitude is provided.
摘要翻译：医疗超声波成像脉冲传输方法传输至少三个脉冲，包括不同相位的不同振幅和至少两个脉冲的至少两个脉冲。较大幅度的脉冲以较大的孔径传输，较小幅度的脉冲用相应较小的子孔径传输。子孔径被布置成使得用于较小幅度脉冲的子孔径的总和等于用于较大幅度脉冲的孔径。以这种方式，在不改变各个换能器元件的功率电平的情况下获得不同幅度的脉冲，并且提供对脉冲幅度的精确控制。

2. 发明授权

US06413218B1 Medical diagnostic ultrasound imaging system and method for determining an acoustic output parameter of a transmitted ultrasonic beam 有权
标题翻译：医学诊断超声成像系统和用于确定发射超声波束的声输出参数的方法
公开(公告)号：US06413218B1
公开(公告)日：2002-07-02
申请号：US09501443
申请日：2000-02-10
申请人： John W. Allison , Lewis J. Thomas , Sriram Krishnan , Gregory L. Holley
发明人： John W. Allison , Lewis J. Thomas , Sriram Krishnan , Gregory L. Holley
IPC分类号： A61B800
CPC分类号： A61B8/4281 , A61B8/461 , A61B8/469 , A61B8/56 , G01S7/52036 , G01S7/5205 , G01S7/52074 , G01S7/52076 , G01S7/52084
摘要： The preferred embodiments described herein provide a medical diagnostic ultrasound imaging system and method for determining an acoustic output parameter of a transmitted ultrasonic beam. In one preferred embodiment, the ultrasound system determines an acoustic output parameter of a transmitted ultrasonic beam in a user-selected region. In another preferred embodiment, the ultrasound system achieves a specified acoustic output parameter of a transmitted ultrasonic beam in a selected region by automatically adjusting an operating parameter of the ultrasound imaging system. In yet another preferred embodiment, a region is selected in the ultrasound image that does not contain a peak acoustic output parameter of a transmitted ultrasonic beam. The system then determines an acoustic output parameter of the transmitted ultrasonic beam in that region and provides an indication of the determined acoustic output parameter.
摘要翻译：本文描述的优选实施例提供了用于确定发射超声波束的声输出参数的医学诊断超声成像系统和方法。在一个优选实施例中，超声系统在用户选择的区域中确定发射的超声波束的声输出参数。在另一个优选实施例中，超声系统通过自动调节超声成像系统的操作参数来实现选定区域中的发射超声波束的指定声输出参数。在另一优选实施例中，在超声波图像中选择不包含发射超声波束的峰值声输出参数的区域。然后，该系统确定该区域中发射的超声波束的声输出参数，并提供所确定的声输出参数的指示。

3. 发明授权

US06340348B1 Contrast agent imaging with destruction pulses in diagnostic medical ultrasound 有权
标题翻译：在诊断医学超声中具有破坏脉冲的造影剂成像
公开(公告)号：US06340348B1
公开(公告)日：2002-01-22
申请号：US09348246
申请日：1999-07-02
申请人： Sriram Krishnan , Gregory L. Holley , Edward A. Gardner , Samuel H. Maslak
发明人： Sriram Krishnan , Gregory L. Holley , Edward A. Gardner , Samuel H. Maslak
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B8/543 , A61B17/22004 , A61B2017/22008
摘要： The invention is directed to improvements in diagnostic medical ultrasound contrast agent imaging. In a preferred embodiment, high pulse repetition frequency (HPRF) destruction pulses are fired at a rate higher than necessary for receiving returning echoes. Pulse parameters can also be changed between the plurality of contrast agent-destroying pulses. Other preferred embodiments of the invention are directed to simultaneous transmission of multiple beams of destruction pulses. Destruction frames that consist of a plurality of destruction pulses can be triggered and swept over the entire region of tissue being imaged and at a variety of focal depths from the transmitter. The destruction frames are fired at some time triggered from a timer or some fixed part of a physiological signal, such as an ECG signal. Other preferred embodiments of the invention are directed to continuous low power imaging pulses alternating with destruction pulses triggered at a fixed point of a physiological signal, and a comparison of the received signals from imaging pulses fired before and after the destruction pulses. Alternatively, destruction pulses are triggered at a fixed point on a physiological signal different from the fixed point of a physiological signal used to trigger imaging pulses. In another embodiment, triggered destruction frames are used to enable a comparison of imaging frames in order to determine physiological functions, such as perfusion of blood in cardiac tissue. Finally, in another embodiment, destruction pulses are combined with subharmonic imaging.
摘要翻译：本发明涉及诊断医学超声造影剂成像的改进。在优选实施例中，高脉冲重复频率（HPRF）破坏脉冲以高于接收返回回波所需的速率被发射。也可以在多个造影剂破坏脉冲之间改变脉冲参数。本发明的其它优选实施例涉及同时传输多束破坏脉冲。由多个破坏脉冲组成的破坏帧可以被触发并扫过被成像的组织的整个区域并且在来自发射器的各种焦深处扫过。在由定时器或生理信号的某些固定部分（例如ECG信号）触发的某个时间触发破坏帧。本发明的其它优选实施例涉及与生理信号的固定点触发的破坏脉冲交替的连续低功率成像脉冲，以及在破坏脉冲之前和之后激发的成像脉冲的接收信号的比较。或者，在与用于触发成像脉冲的生理信号的固定点不同的生理信号上的固定点触发销毁脉冲。在另一个实施例中，触发的破坏帧用于使成像帧的比较能够确定生理功能，例如心脏组织中血液的灌注。最后，在另一个实施例中，销毁脉冲与次谐波成像组合。

4. 发明授权

US06213951B1 Medical diagnostic ultrasound method and system for contrast specific frequency imaging 有权
标题翻译：医学诊断超声方法和系统对比特定频率成像
公开(公告)号：US06213951B1
公开(公告)日：2001-04-10
申请号：US09253089
申请日：1999-02-19
申请人： Sriram Krishnan , Edward A. Gardner , Gregory L Holley
发明人： Sriram Krishnan , Edward A. Gardner , Gregory L Holley
IPC分类号： A61B814
CPC分类号： A61B8/481 , A61B8/06 , A61B8/13 , A61B8/488 , G01S7/52026 , G01S7/52038 , G01S7/52041
摘要： A medical diagnostic ultrasound imaging method and system insonify a tissue containing a contrast agent with ultrasonic transmit signals at a fundamental frequency f. Backscattered ultrasonic receive signals are acquired and filtered to emphasize frequency components between the fundamental frequency f and the second harmonic frequency 2f, and the filtered receive signals are processed for display. This filtering enhances the ability of the method and system to discriminate between contrast agent and adjacent tissue.
摘要翻译：医学诊断超声成像方法和系统以含有基本频率f的超声波发射信号对含有造影剂的组织进行增强。后向散射超声波接收信号被采集和滤波，以强调基频f和第二谐波频率2f之间的频率分量，并且滤波的接收信号被处理以进行显示。该过滤增强了方法和系统区分造影剂和相邻组织的能力。

5. 发明授权

US06174287B1 Medical diagnostic ultrasound system and method for continuous M-mode imaging and periodic imaging of contrast agents 有权
标题翻译：医学诊断超声系统和连续M模式成像和造影剂定期成像的方法
公开(公告)号：US06174287B1
公开(公告)日：2001-01-16
申请号：US09330547
申请日：1999-06-11
申请人： Jeffrey R. Resnick , Sriram Krishnan , Richard M. Bennett , Gregory L. Holley , Joan C. Main , John A. Davidson
发明人： Jeffrey R. Resnick , Sriram Krishnan , Richard M. Bennett , Gregory L. Holley , Joan C. Main , John A. Davidson
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B8/08 , A61B8/543
摘要： A method and system for imaging contrast agent within human or animal tissue, organs and/or blood is provided. Contrast agents, such as perfluorocarbon gas-filled albumin microbubbles which exhibit momentary contrast enhancement when exposed to high intensity ultrasound are injected into a patient. Periodic images are generated to avoid reduction in the contrast provided by the contrast agents due to ultrasound destruction. Between the periodic images, an M-mode image is substantially continuously updated to allow the user to better locate and maintain imaging of a region of interest, determine dynamic movement within the region of interest, access attenuation, determine an appropriate trigger point, and view perfusion of the contrast agent between the periodic images while minimizing destruction of contrast agent. In one embodiment, an ultrasound system alternates between triggered firings of a two-dimensional B-mode image and substantially continuous updating of an M-mode image. The M-mode image is displayed as a strip revealing the time course of reflected ultrasound echoes along a scan line within the B-mode image plane. The B-mode image is displayed adjacent to the M-mode image. In a second embodiment, two-dimensional B-mode and color Doppler images are triggered. The Doppler energy parameter is used for generating the adjacent and substantially continuous M-mode image.
摘要翻译：提供了用于在人或动物组织，器官和/或血液中成像造影剂的方法和系统。将暴露于高强度超声波时显示瞬间对比度增强的全氟化碳气体填充的白蛋白微泡的对比剂注射到患者体内。产生周期性图像以避免由于超声破坏造成的对比度降低。在周期性图像之间，M模式图像基本上连续更新，以允许用户更好地定位和维持感兴趣区域的成像，确定感兴趣区域内的动态移动，访问衰减，确定适当的触发点和观看在周期性图像之间灌注造影剂，同时最小化造影剂的破坏。在一个实施例中，超声系统在二维B模式图像的触发发射和M模式图像的基本连续更新之间交替。 M模式图像显示为沿着B模式图像平面内的扫描线显示反射超声回波的时间过程的条带。 B模式图像显示在与M模式图像相邻的位置。在第二实施例中，触发二维B模式和彩色多普勒图像。多普勒能量参数用于产生相邻和基本上连续的M模式图像。

6. 发明授权

US6132377A Medical diagnostic ultrasonic imaging system and method using differential sub-band detection techniques 有权
标题翻译：医学诊断超声成像系统和使用差分子带检测技术的方法
公开(公告)号：US6132377A
公开(公告)日：2000-10-17
申请号：US282402
申请日：1999-03-31
申请人： Mirsaid S. Bolorforosh , Edward A. Gardner , Gregory L. Holley , Ting Lan Ji , Sriram Krishnan , Bhaskar S. Ramamurthy
发明人： Mirsaid S. Bolorforosh , Edward A. Gardner , Gregory L. Holley , Ting Lan Ji , Sriram Krishnan , Bhaskar S. Ramamurthy
IPC分类号： A61B8/00 , G01S7/52
CPC分类号： A61B8/481 , G01S15/8988 , G01S7/52038 , G01N2291/02491
摘要： A medical diagnostic ultrasound imaging system and method modulate the image signal as a function of the ratio of the harmonic receive signal to the fundamental receive signal. Tissue harmonic backscatter differs substantially in spectral shape as compared to contrast agent backscatter, and this method allows improved discrimination between contrast agent and tissue backscatter.
摘要翻译：医学诊断超声成像系统和方法根据谐波接收信号与基本接收信号的比率调制图像信号。与造影剂反向散射相比，组织谐波反向散射在光谱形状上显着不同，并且该方法允许改善对比剂和组织反向散射之间的区别。

7. 发明授权

US08977825B1 Techniques for abstract profile definition to support information hiding 有权
标题翻译：抽象配置文件定义技术支持信息隐藏
公开(公告)号：US08977825B1
公开(公告)日：2015-03-10
申请号：US13435907
申请日：2012-03-30
申请人： Eric Scott Lewine , Neil Schutzman , Scott D. Von Rhee , Sriram Krishnan , Mario Wurzl
发明人： Eric Scott Lewine , Neil Schutzman , Scott D. Von Rhee , Sriram Krishnan , Mario Wurzl
IPC分类号： G06F12/00 , G06F13/00 , G06F13/28
CPC分类号： G06F13/28 , G06F3/0605 , G06F3/0631 , G06F3/0665 , G06F3/067 , G06F13/00 , G06F17/30
摘要： A method performed by a storage management computer includes (a) receiving a set of storage profile definitions (SPDs) from an administrator of a data storage system over a user interface, each SPD of the set of SPDs including (1) a storage profile name and (2) a set of storage policies assigned to that SPD, (b) providing the storage profile names from the set of SPDs to an environment management application, the environment management application being configured to manage environments that use storage from the data storage system, (c) in response to providing, receiving a selection of a particular SPD from the environment management application to be used in connection with a particular environment, and (d) provisioning a unit of storage from the data storage system to the particular environment in accordance with the set of storage policies assigned to the particular SPD.
摘要翻译：由存储管理计算机执行的方法包括（a）通过用户接口从数据存储系统的管理员接收一组存储简档定义（SPD），所述SPD组的每个SPD包括（1）存储简档名称以及（2）分配给该SPD的一组存储策略，（b）将该SPD的存储简档名称提供给环境管理应用，所述环境管理应用被配置为管理使用来自数据存储系统的存储的环境（c）响应于提供，从环境管理应用中接收特定SPD的选择以与特定环境结合使用，以及（d）将数据存储系统中的存储单元提供给特定环境中的特定环境根据分配给特定SPD的一组存储策略。

8. 发明授权

US08579784B2 Personalized prognosis modeling in medical treatment planning 有权
标题翻译：医疗策划中的个性化预后建模
公开(公告)号：US08579784B2
公开(公告)日：2013-11-12
申请号：US12944288
申请日：2010-11-11
申请人： Sriram Krishnan , R. Bharat Rao , Christopher Jude Amies
发明人： Sriram Krishnan , R. Bharat Rao , Christopher Jude Amies
IPC分类号： A61N5/00
CPC分类号： A61N5/103 , A61N2005/1041 , G06F19/00 , G06F19/3481 , G16H50/30 , G16H50/50
摘要： Automated treatment planning is provided with individual specific consideration. One or more prognosis models indicate survivability as a function of patient specific information for a given dose. By determining survivability for a plurality of doses, the biological model represented by survivability as a function of dose is determined from the specific patient. Similarly, the chances of complications or side effects are determined. The chance of survivability and chance of complication are used as or instead of the tumor control probability and normal tissue complications probability, respectively. The desired tumor dosage and tolerance dosage are selected as a function of the patient specific dose distributions. The selected dosages are input to an inverse treatment planning system for establishing radiation treatment parameters.
摘要翻译：提供自动化治疗计划，具体考虑。一个或多个预后模型表明作为给定剂量的患者特异性信息的函数的存活率。通过确定多个剂量的存活率，从特定患者确定作为剂量的函数的存活率所表示的生物学模型。类似地，确定并发症或副作用的机会。生存能力和并发症的机会分别被用作肿瘤控制概率和正常组织并发症概率。选择所需的肿瘤剂量和耐受剂量作为患者具体剂量分布的函数。选择的剂量被输入到用于建立放射治疗参数的反向治疗计划系统。

9. 发明申请

US20110286654A1 Segmentation of Biological Image Data 审中-公开
标题翻译：生物图像数据分割
公开(公告)号：US20110286654A1
公开(公告)日：2011-11-24
申请号：US13109457
申请日：2011-05-17
申请人： Sriram Krishnan
发明人： Sriram Krishnan
IPC分类号： G06K9/00
CPC分类号： G06K9/0014 , G06T7/12 , G06T7/155 , G06T2207/30024
摘要： Described herein are systems and methods for automated segmentation of image data. According to one aspect of the present technology, systems and methods are provided for detecting regions of interest within biological images. In particular, first and second images of first and second biological samples are received, wherein one or more routine stains have previously been applied to the first biological sample. A region of interest in the first image may be segmented to generate a boundary. The boundary may then be transferred to the second image to segment a corresponding region of interest in the second image.
摘要翻译：这里描述了用于图像数据的自动分割的系统和方法。根据本技术的一个方面，提供了用于检测生物图像内的感兴趣区域的系统和方法。特别地，接收第一和第二生物样品的第一和第二图像，其中一个或多个常规染料先前已经施加到第一生物样品。可以对第一图像中的感兴趣区域进行分割以产生边界。然后可以将边界传送到第二图像以分割第二图像中的对应的感兴趣区域。

10. 发明授权

US07805385B2 Prognosis modeling from literature and other sources 有权
标题翻译：文献和其他来源的预后建模
公开(公告)号：US07805385B2
公开(公告)日：2010-09-28
申请号：US11735736
申请日：2007-04-16
申请人： Harald Steck , Sriram Krishnan , R. Bharat Rao , Philippe Lambin , Cary Dehing-Oberije
发明人： Harald Steck , Sriram Krishnan , R. Bharat Rao , Philippe Lambin , Cary Dehing-Oberije
IPC分类号： G06E1/00 , G06F15/00 , G06G7/00 , G06N99/00
CPC分类号： G16H50/20 , G06F19/00 , G16H50/70
摘要： A predictor of medical treatment outcome is developed and applied. A prognosis model is developed from literature. The model is determined by reverse engineering the literature reported quantities. A relationship of a given variable to a treatment outcome is derived from the literature. A processor may then use individual patient values for one or more variables to predict outcome. The accuracy may be increased by including a data driven model in combination with the literature driven model.
摘要翻译：开发并应用了治疗结果的预测因子。从文献开发预后模型。该模型通过逆向工程文献报道的量来确定。给定变量与治疗结果的关系来源于文献。然后，处理器可以使用单个患者值用于一个或多个变量来预测结果。通过将数据驱动模型与文献驱动模型相结合，可以提高精度。

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