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    • 2. 发明授权
    • Personalized prognosis modeling in medical treatment planning
    • 医疗策划中的个性化预后建模
    • US08579784B2
    • 2013-11-12
    • US12944288
    • 2010-11-11
    • Sriram KrishnanR. Bharat RaoChristopher Jude Amies
    • Sriram KrishnanR. Bharat RaoChristopher Jude Amies
    • A61N5/00
    • A61N5/103A61N2005/1041G06F19/00G06F19/3481G16H50/30G16H50/50
    • Automated treatment planning is provided with individual specific consideration. One or more prognosis models indicate survivability as a function of patient specific information for a given dose. By determining survivability for a plurality of doses, the biological model represented by survivability as a function of dose is determined from the specific patient. Similarly, the chances of complications or side effects are determined. The chance of survivability and chance of complication are used as or instead of the tumor control probability and normal tissue complications probability, respectively. The desired tumor dosage and tolerance dosage are selected as a function of the patient specific dose distributions. The selected dosages are input to an inverse treatment planning system for establishing radiation treatment parameters.
    • 提供自动化治疗计划,具体考虑。 一个或多个预后模型表明作为给定剂量的患者特异性信息的函数的存活率。 通过确定多个剂量的存活率,从特定患者确定作为剂量的函数的存活率所表示的生物学模型。 类似地,确定并发症或副作用的机会。 生存能力和并发症的机会分别被用作肿瘤控制概率和正常组织并发症概率。 选择所需的肿瘤剂量和耐受剂量作为患者具体剂量分布的函数。 选择的剂量被输入到用于建立放射治疗参数的反向治疗计划系统。
    • 3. 发明申请
    • Segmentation of Biological Image Data
    • 生物图像数据分割
    • US20110286654A1
    • 2011-11-24
    • US13109457
    • 2011-05-17
    • Sriram Krishnan
    • Sriram Krishnan
    • G06K9/00
    • G06K9/0014G06T7/12G06T7/155G06T2207/30024
    • Described herein are systems and methods for automated segmentation of image data. According to one aspect of the present technology, systems and methods are provided for detecting regions of interest within biological images. In particular, first and second images of first and second biological samples are received, wherein one or more routine stains have previously been applied to the first biological sample. A region of interest in the first image may be segmented to generate a boundary. The boundary may then be transferred to the second image to segment a corresponding region of interest in the second image.
    • 这里描述了用于图像数据的自动分割的系统和方法。 根据本技术的一个方面,提供了用于检测生物图像内的感兴趣区域的系统和方法。 特别地,接收第一和第二生物样品的第一和第二图像,其中一个或多个常规染料先前已经施加到第一生物样品。 可以对第一图像中的感兴趣区域进行分割以产生边界。 然后可以将边界传送到第二图像以分割第二图像中的对应的感兴趣区域。
    • 7. 发明授权
    • Resolving multiple master node conflict in a DDB
    • 解决DDB中的多个主节点冲突
    • US07730180B1
    • 2010-06-01
    • US11880325
    • 2007-07-20
    • Sriram KrishnanGregory W. Lazar
    • Sriram KrishnanGregory W. Lazar
    • G06F15/173
    • G06F17/30575
    • In a multinode computer network, a directory database (DDB) in each of the nodes, contents of the DDB being replicated throughout the network through use of one of its nodes having been appointed as master node. The master node updates each DDB in each node in its network or domain configuration when the configuration changes. A global administrator has authority to replace or select a master node and to configure a domain, and performs these and other functions by way of computer terminal screen dialogs offered by a graphical user interface (GUI) associated with the computer network. In the case of multiple master nodes attempting to be master for the same nodes in the same network at the same time, this conflict is resolved in one embodiment of the present invention by allowing the most recently selected purported master node to be the actual master node. After resolution of this conflict the result is communicated by the prevailing master node to all nodes in the network. This resolution takes into account a global network with varying time zones, and further takes into account the remote possibility of a simultaneous appointment of two masters.
    • 在多节点计算机网络中,每个节点中的目录数据库(DDB),DDB的内容通过使用其节点中的一个被指定为主节点而在整个网络中复制。 主节点在配置更改时更新其网络或域配置中每个节点中的每个DDB。 全局管理员有权替换或选择主节点并配置域,并通过与计算机网络相关联的图形用户界面(GUI)提供的计算机终端屏幕对话来执行这些和其他功能。 在多个主节点同时尝试对相同网络中的相同节点进行主机的情况下,通过允许最近选择的所声称的主节点是实际主节点来解决本发明的一个实施例中的这种冲突 。 解决此冲突后,结果将由主节点传送到网络中的所有节点。 该决议考虑到具有不同时区的全球网络,并进一步考虑到同时预约两位主人的远程可能性。