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1. 发明授权

US06413218B1 Medical diagnostic ultrasound imaging system and method for determining an acoustic output parameter of a transmitted ultrasonic beam 有权
标题翻译：医学诊断超声成像系统和用于确定发射超声波束的声输出参数的方法
公开(公告)号：US06413218B1
公开(公告)日：2002-07-02
申请号：US09501443
申请日：2000-02-10
申请人： John W. Allison , Lewis J. Thomas , Sriram Krishnan , Gregory L. Holley
发明人： John W. Allison , Lewis J. Thomas , Sriram Krishnan , Gregory L. Holley
IPC分类号： A61B800
CPC分类号： A61B8/4281 , A61B8/461 , A61B8/469 , A61B8/56 , G01S7/52036 , G01S7/5205 , G01S7/52074 , G01S7/52076 , G01S7/52084
摘要： The preferred embodiments described herein provide a medical diagnostic ultrasound imaging system and method for determining an acoustic output parameter of a transmitted ultrasonic beam. In one preferred embodiment, the ultrasound system determines an acoustic output parameter of a transmitted ultrasonic beam in a user-selected region. In another preferred embodiment, the ultrasound system achieves a specified acoustic output parameter of a transmitted ultrasonic beam in a selected region by automatically adjusting an operating parameter of the ultrasound imaging system. In yet another preferred embodiment, a region is selected in the ultrasound image that does not contain a peak acoustic output parameter of a transmitted ultrasonic beam. The system then determines an acoustic output parameter of the transmitted ultrasonic beam in that region and provides an indication of the determined acoustic output parameter.
摘要翻译：本文描述的优选实施例提供了用于确定发射超声波束的声输出参数的医学诊断超声成像系统和方法。在一个优选实施例中，超声系统在用户选择的区域中确定发射的超声波束的声输出参数。在另一个优选实施例中，超声系统通过自动调节超声成像系统的操作参数来实现选定区域中的发射超声波束的指定声输出参数。在另一优选实施例中，在超声波图像中选择不包含发射超声波束的峰值声输出参数的区域。然后，该系统确定该区域中发射的超声波束的声输出参数，并提供所确定的声输出参数的指示。

2. 发明授权

US06602195B1 Medical ultrasonic imaging pulse transmission method 有权
标题翻译：医用超声波成像脉冲传输方法
公开(公告)号：US06602195B1
公开(公告)日：2003-08-05
申请号：US09767158
申请日：2001-01-22
申请人： Sriram Krishnan , Patrick J. Phillips , Gregory L. Holley , Ismayil M. Guracar
发明人： Sriram Krishnan , Patrick J. Phillips , Gregory L. Holley , Ismayil M. Guracar
IPC分类号： A61B800
CPC分类号： G01S15/8959 , A61B8/00 , G01S7/52039 , G01S7/52041 , G01S7/52085 , G01S15/8927 , G01S15/8961 , G01S15/8963
摘要： A medical ultrasound imaging pulse transmission method transmits at least three pulses, including at least two pulses of different amplitude and at least two pulses of differing phase. The larger-amplitude pulse is transmitted with a larger aperture and the smaller-amplitude pulses are transmitted with respective smaller subapertures. The subapertures are arranged such that the sum of the subapertures used for the smaller-amplitude pulses is equal to the aperture used for the larger-amplitude pulse. In this way, pulses of differing amplitudes are obtained without varying the power level of individual transducer elements, and precise control over pulse amplitude is provided.
摘要翻译：医疗超声波成像脉冲传输方法传输至少三个脉冲，包括不同相位的不同振幅和至少两个脉冲的至少两个脉冲。较大幅度的脉冲以较大的孔径传输，较小幅度的脉冲用相应较小的子孔径传输。子孔径被布置成使得用于较小幅度脉冲的子孔径的总和等于用于较大幅度脉冲的孔径。以这种方式，在不改变各个换能器元件的功率电平的情况下获得不同幅度的脉冲，并且提供对脉冲幅度的精确控制。

3. 发明授权

US06340348B1 Contrast agent imaging with destruction pulses in diagnostic medical ultrasound 有权
标题翻译：在诊断医学超声中具有破坏脉冲的造影剂成像
公开(公告)号：US06340348B1
公开(公告)日：2002-01-22
申请号：US09348246
申请日：1999-07-02
申请人： Sriram Krishnan , Gregory L. Holley , Edward A. Gardner , Samuel H. Maslak
发明人： Sriram Krishnan , Gregory L. Holley , Edward A. Gardner , Samuel H. Maslak
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B8/543 , A61B17/22004 , A61B2017/22008
摘要： The invention is directed to improvements in diagnostic medical ultrasound contrast agent imaging. In a preferred embodiment, high pulse repetition frequency (HPRF) destruction pulses are fired at a rate higher than necessary for receiving returning echoes. Pulse parameters can also be changed between the plurality of contrast agent-destroying pulses. Other preferred embodiments of the invention are directed to simultaneous transmission of multiple beams of destruction pulses. Destruction frames that consist of a plurality of destruction pulses can be triggered and swept over the entire region of tissue being imaged and at a variety of focal depths from the transmitter. The destruction frames are fired at some time triggered from a timer or some fixed part of a physiological signal, such as an ECG signal. Other preferred embodiments of the invention are directed to continuous low power imaging pulses alternating with destruction pulses triggered at a fixed point of a physiological signal, and a comparison of the received signals from imaging pulses fired before and after the destruction pulses. Alternatively, destruction pulses are triggered at a fixed point on a physiological signal different from the fixed point of a physiological signal used to trigger imaging pulses. In another embodiment, triggered destruction frames are used to enable a comparison of imaging frames in order to determine physiological functions, such as perfusion of blood in cardiac tissue. Finally, in another embodiment, destruction pulses are combined with subharmonic imaging.
摘要翻译：本发明涉及诊断医学超声造影剂成像的改进。在优选实施例中，高脉冲重复频率（HPRF）破坏脉冲以高于接收返回回波所需的速率被发射。也可以在多个造影剂破坏脉冲之间改变脉冲参数。本发明的其它优选实施例涉及同时传输多束破坏脉冲。由多个破坏脉冲组成的破坏帧可以被触发并扫过被成像的组织的整个区域并且在来自发射器的各种焦深处扫过。在由定时器或生理信号的某些固定部分（例如ECG信号）触发的某个时间触发破坏帧。本发明的其它优选实施例涉及与生理信号的固定点触发的破坏脉冲交替的连续低功率成像脉冲，以及在破坏脉冲之前和之后激发的成像脉冲的接收信号的比较。或者，在与用于触发成像脉冲的生理信号的固定点不同的生理信号上的固定点触发销毁脉冲。在另一个实施例中，触发的破坏帧用于使成像帧的比较能够确定生理功能，例如心脏组织中血液的灌注。最后，在另一个实施例中，销毁脉冲与次谐波成像组合。

4. 发明授权

US06174287B1 Medical diagnostic ultrasound system and method for continuous M-mode imaging and periodic imaging of contrast agents 有权
标题翻译：医学诊断超声系统和连续M模式成像和造影剂定期成像的方法
公开(公告)号：US06174287B1
公开(公告)日：2001-01-16
申请号：US09330547
申请日：1999-06-11
申请人： Jeffrey R. Resnick , Sriram Krishnan , Richard M. Bennett , Gregory L. Holley , Joan C. Main , John A. Davidson
发明人： Jeffrey R. Resnick , Sriram Krishnan , Richard M. Bennett , Gregory L. Holley , Joan C. Main , John A. Davidson
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B8/08 , A61B8/543
摘要： A method and system for imaging contrast agent within human or animal tissue, organs and/or blood is provided. Contrast agents, such as perfluorocarbon gas-filled albumin microbubbles which exhibit momentary contrast enhancement when exposed to high intensity ultrasound are injected into a patient. Periodic images are generated to avoid reduction in the contrast provided by the contrast agents due to ultrasound destruction. Between the periodic images, an M-mode image is substantially continuously updated to allow the user to better locate and maintain imaging of a region of interest, determine dynamic movement within the region of interest, access attenuation, determine an appropriate trigger point, and view perfusion of the contrast agent between the periodic images while minimizing destruction of contrast agent. In one embodiment, an ultrasound system alternates between triggered firings of a two-dimensional B-mode image and substantially continuous updating of an M-mode image. The M-mode image is displayed as a strip revealing the time course of reflected ultrasound echoes along a scan line within the B-mode image plane. The B-mode image is displayed adjacent to the M-mode image. In a second embodiment, two-dimensional B-mode and color Doppler images are triggered. The Doppler energy parameter is used for generating the adjacent and substantially continuous M-mode image.
摘要翻译：提供了用于在人或动物组织，器官和/或血液中成像造影剂的方法和系统。将暴露于高强度超声波时显示瞬间对比度增强的全氟化碳气体填充的白蛋白微泡的对比剂注射到患者体内。产生周期性图像以避免由于超声破坏造成的对比度降低。在周期性图像之间，M模式图像基本上连续更新，以允许用户更好地定位和维持感兴趣区域的成像，确定感兴趣区域内的动态移动，访问衰减，确定适当的触发点和观看在周期性图像之间灌注造影剂，同时最小化造影剂的破坏。在一个实施例中，超声系统在二维B模式图像的触发发射和M模式图像的基本连续更新之间交替。 M模式图像显示为沿着B模式图像平面内的扫描线显示反射超声回波的时间过程的条带。 B模式图像显示在与M模式图像相邻的位置。在第二实施例中，触发二维B模式和彩色多普勒图像。多普勒能量参数用于产生相邻和基本上连续的M模式图像。

5. 发明授权

US6132377A Medical diagnostic ultrasonic imaging system and method using differential sub-band detection techniques 有权
标题翻译：医学诊断超声成像系统和使用差分子带检测技术的方法
公开(公告)号：US6132377A
公开(公告)日：2000-10-17
申请号：US282402
申请日：1999-03-31
申请人： Mirsaid S. Bolorforosh , Edward A. Gardner , Gregory L. Holley , Ting Lan Ji , Sriram Krishnan , Bhaskar S. Ramamurthy
发明人： Mirsaid S. Bolorforosh , Edward A. Gardner , Gregory L. Holley , Ting Lan Ji , Sriram Krishnan , Bhaskar S. Ramamurthy
IPC分类号： A61B8/00 , G01S7/52
CPC分类号： A61B8/481 , G01S15/8988 , G01S7/52038 , G01N2291/02491
摘要： A medical diagnostic ultrasound imaging system and method modulate the image signal as a function of the ratio of the harmonic receive signal to the fundamental receive signal. Tissue harmonic backscatter differs substantially in spectral shape as compared to contrast agent backscatter, and this method allows improved discrimination between contrast agent and tissue backscatter.
摘要翻译：医学诊断超声成像系统和方法根据谐波接收信号与基本接收信号的比率调制图像信号。与造影剂反向散射相比，组织谐波反向散射在光谱形状上显着不同，并且该方法允许改善对比剂和组织反向散射之间的区别。

6. 发明授权

US07887487B2 Ultrasound diagnostic flow imaging with coded excitation 有权
标题翻译：超声诊断流程成像与编码激励
公开(公告)号：US07887487B2
公开(公告)日：2011-02-15
申请号：US11303622
申请日：2005-12-15
申请人： Xiaohui Hao , Kutay F. Ustuner , Gregory L. Holley , Seshadri Srinivasan , Albert Gee
发明人： Xiaohui Hao , Kutay F. Ustuner , Gregory L. Holley , Seshadri Srinivasan , Albert Gee
IPC分类号： A61B8/00
CPC分类号： A61B8/06 , A61B8/488 , G01S7/52038 , G01S15/8954 , G01S15/8959 , G01S15/8979
摘要： Diagnostic ultrasound flow imaging is performed with coded excitation pulses. Due to the use of frequency coded excitation pulses, flow information may suffer from spatial misregistration and estimate errors. Spatial position shift in flow data is offset for alignment with B-mode or other imaging. The flow estimates are compensated for the imaging center frequency variation with depth. The wide bandwidth information available due to coded excitation may allow anti-aliasing by estimating velocities from two frequency bands.
摘要翻译：用编码的激发脉冲进行诊断超声波成像。由于使用频率编码的激励脉冲，流量信息可能会受到空间重合失调和估计误差的困扰。流量数据中的空间位置偏移偏移以与B模式或其他成像对齐。影像中心频率随深度的变化而补偿流量估计值。由于编码激励可用的宽带宽信息可以通过估计来自两个频带的速度来允许抗混叠。

7. 发明授权

US06679846B2 Diagnostic ultrasound imaging method and system with improved frame rate 有权
公开(公告)号：US06679846B2
公开(公告)日：2004-01-20
申请号：US10081978
申请日：2002-02-21
申请人： David J. Napolitano , Christopher R. Cole , Gregory L. Holley , John A. Hossack , Charles E. Bradley , Patrick Phillips
发明人： David J. Napolitano , Christopher R. Cole , Gregory L. Holley , John A. Hossack , Charles E. Bradley , Patrick Phillips
IPC分类号： B60R2500
CPC分类号： G01S15/8963 , A61B8/00 , G01S7/52039 , G01S7/52046 , G01S7/52085 , G01S7/52095 , G01S15/8927 , G01S15/8959 , G01S15/8977
摘要： A medical diagnostic ultrasonic imaging system acquires receive beams from spatially distinct transmit beams. The receive beams alternate in type between at least first and second types across the region being imaged. The first and second types of receive beams differ in at least one scan parameter other than transmit and receive line geometry, and can for example differ in transmit phase, transmit or receive aperture, system frequency, transmit focus, complex phase angle, transmit code or transmit gain. Receive beams associated with spatially distinct ones of the transmit beams (including at least one beam of the first type and at least one beam of the second type) are then combined. In this way, many two-pulse techniques, including, for example, phase inversion techniques, synthetic aperture techniques, synthetic frequency techniques, and synthetic focus techniques, can be used while substantially reducing the frame rate penalty normally associated with such techniques.

8. 发明授权

US5902243A Ultrasonic imaging method with multiple pulse cancellation 失效
标题翻译：超声波成像方法多脉冲消除
公开(公告)号：US5902243A
公开(公告)日：1999-05-11
申请号：US61083
申请日：1998-04-15
申请人： Gregory L. Holley , David J. Hedberg , David J. Napolitano
发明人： Gregory L. Holley , David J. Hedberg , David J. Napolitano
IPC分类号： G01S7/52 , G01S15/89 , A61B8/00
CPC分类号： G01S15/8963 , G01S15/895 , G01S7/52038
摘要： An ultrasound imaging method includes the step of transmitting two ultrasonic transmit pulses into a region. First components of the transmit pulses are inverted with respect to each other while second components of the transmit pulses are not. Received ultrasound pulses associated with the transmit pulses are summed to selectively cancel the harmonic or fundamental components. By properly selecting the inverted and noninverted portions of the transmit pulses, the transmit pulses may be made unipolar, or they may be pre-distorted to further reduce second harmonic energy associated with system or tissue non-linearities.
摘要翻译：超声波成像方法包括将两个超声波发射脉冲发射到区域中的步骤。发送脉冲的第一分量相对于彼此反转，而发送脉冲的第二分量不是。与发射脉冲相关联的接收超声脉冲被相加以选择性地消除谐波或基波分量。通过适当地选择发射脉冲的反相和非反相部分，发射脉冲可以是单极的，或者它们可以被预失真以进一步减少与系统或组织非线性相关联的二次谐波能量。

9. 发明授权

US5551433A Method and apparatus for a geometric aberration transform in an adaptive focusing ultrasound beamformer system 失效
标题翻译：自适应聚焦超声波波束形成系统中几何像差变换的方法和装置
公开(公告)号：US5551433A
公开(公告)日：1996-09-03
申请号：US286664
申请日：1994-08-05
申请人： J. Nelson Wright , Gregory L. Holley , Donald R. Langdon
发明人： J. Nelson Wright , Gregory L. Holley , Donald R. Langdon
IPC分类号： G01N29/06 , A61B8/00 , G01S7/52 , G01S15/89 , G01N29/00
CPC分类号： G01S7/52049 , G01S15/8927 , G01S15/8918
摘要： A method and an apparatus are provided for storage and retrieval of measured aberration correction values used in adaptive focus ultrasound imaging. The aberration correction values, corresponding to an aberration region in an imaged subject, are measured at a transmit focal depth. The measured aberration correction values, typically delays, from a measurement depth are stored in a geometric aberration transform (GAT.TM.) table and transformed to aberration correction values at other focal depths for correcting the focus of both transmit and receive beamformers. The transformation is accomplished by using a geometric aberration transform (GAT.TM.) index table which retrieves one or more aberration correction values in the table for any desired depth.
摘要翻译：提供了一种用于存储和检索在自适应聚焦超声成像中使用的测量的像差校正值的方法和装置。对应于成像对象中的像差区域的像差校正值在发射焦点深度处被测量。测量的像差校正值（通常来自测量深度的延迟）被存储在几何像差变换（GAT TM）表中，并被转换成在其它焦深处的像差校正值，用于校正发射和接收波束形成器的焦点。通过使用几何像差变换（GAT TM）索引表来完成变换，该表索取表中任何所需深度的一个或多个像差校正值。

10. 发明授权

US06494841B1 Medical diagnostic ultrasound system using contrast pulse sequence imaging 有权
标题翻译：医学诊断超声系统使用对比脉冲序列成像
公开(公告)号：US06494841B1
公开(公告)日：2002-12-17
申请号：US09514803
申请日：2000-02-29
申请人： Lewis Jones Thomas , Samuel H. Maslak , Patrick Phillips , Gregory L. Holley
发明人： Lewis Jones Thomas , Samuel H. Maslak , Patrick Phillips , Gregory L. Holley
IPC分类号： A61B800
CPC分类号： G01S15/8961 , A61B8/481 , G01S7/52036 , G01S7/52039 , G01S7/52041 , G01S15/8959 , G01S15/8981
摘要： A medical diagnostic ultrasound imaging method fires a sequence of pulses into a body and then receives, beamforms, weights and sums the resulting echo signals to suppress first order echoes. The sequence of pulses includes at least two pulses that differ in amplitude and phase. In one form, no two pulses of the sequence have the same amplitude and opposite phase. In another form, only linear echoes are suppressed. In a third form, second and third order echoes are preserved while linear echoes are suppressed.
摘要翻译：医学诊断超声成像方法将一序列的脉冲发射到体内，然后接收波束成形，加权并对所得到的回波信号进行加和，以抑制一阶回波。脉冲序列包括幅度和相位不同的至少两个脉冲。在一种形式中，序列中没有两个脉冲具有相同的幅度和相反的相位。在另一种形式中，只有线性回波被抑制。在第三种形式中，第二和第三阶回波被保留，而线性回波被抑制。

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