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    • 1. 发明授权
    • Modified xanthan gum and method for modifying xanthan gum
    • 改性黄原胶和改性黄原胶的方法
    • US5416206A
    • 1995-05-16
    • US984215
    • 1992-11-30
    • Shigehiro NaguraKanji MurofushiKazumasa Maruyama
    • Shigehiro NaguraKanji MurofushiKazumasa Maruyama
    • A23L29/20C08B37/00C07H1/00C07H3/06
    • C08B37/0033
    • A modified xanthan gum has a viscosity of not less than 800 cP as determined on a 0.5% by weight solution thereof in a 12% by weight aqueous sodium chloride solution at 20.degree. C. and a ratio of this viscosity to that determined on a 0.5% by weight solution thereof in distilled water of not less than 1.5. The modified xanthan gum can be prepared by a method comprising the steps of mixing an organic solvent which does not dissolve xanthan gum and is hydrophilic with an aqueous solution of xanthan gum in a mixer, cutting, into fine fibrous materials, deposites formed in the mixed solution together with the mixed solution with a cutter, separating and recovering the suspended fine fibrous materials from the mixed solution and then drying the materials at a temperature of not more than 80.degree. C. The modified xanthan gum can directly be dissolved in aqueous solutions of salts such as common salt even at room temperature and can thus easily show a desired effect of thickening the aqueous salt solutions.
    • 改性黄原胶具有不低于800cP的粘度,其在20重量%的12重量%氯化钠水溶液中的0.5重量%溶液测得,并且该粘度与在0.5 其重量百分比在蒸馏水中的溶液不低于1.5。 改性黄原胶可以通过以下方法制备,该方法包括以下步骤:在混合器中混合不溶于黄原胶并且与黄原胶水溶液亲水的有机溶剂,将其切割成细纤维材料,混合形成的沉积物 溶液与混合溶液与切割器​​一起分离并从混合溶液中回收悬浮的细纤维材料,然后在不高于80℃的温度下干燥材料。改性的黄原胶可以直接溶于 即使在室温下也可以使用盐,例如盐,因此可容易地显示出使盐水溶液变稠的期望效果。
    • 2. 发明授权
    • Method for purifying polysaccharides
    • 多糖纯化方法
    • US5602241A
    • 1997-02-11
    • US403450
    • 1995-03-14
    • Kazumasa MaruyamaKazuyuki YamamotoShigehiro NaguraTaira Homma
    • Kazumasa MaruyamaKazuyuki YamamotoShigehiro NaguraTaira Homma
    • C08B37/00C07G17/00C07H1/06
    • C08B37/0003
    • A method for continuously precipitating a polysaccharide dissolved in an aqueous solution wherein a non-solvent for the polysaccharide is admixed with the aqueous solution to cause the polysaccharide to precipitate from the solution. The method includes the step of simultaneously feeding the aqueous solution containing the dissolved polysaccharide and the non-solvent through respective constant flow rate-pumps to produce non-pulsating metered first and second streams which are unaffected by pressure changes in the aqueous solution or the non-solvent fed to the respective pumps. The metered streams are simultaneously introduced from the respective pumps into a rotary turbine to mix the solution and the non-solvent and precipitate the polysaccharide. The precipitated polysaccharide is cut with an interlocking cutter which comprises a fixed cutter and a rotary cutter, and a suspension of finely cut polysaccharide particles is continuously withdrawn.
    • 将溶解在水溶液中的多糖连续沉淀的方法,其中将多糖的非溶剂与水溶液混合,使多糖从溶液中沉淀出来。 该方法包括通过相应的恒定流量泵同时进料含有溶解的多糖和非溶剂的水溶液的步骤,以产生不受水溶液或非水溶液中的压力变化影响的非脉动计量的第一和第二流 - 供应到相应的泵。 将计量流从各泵同时引入旋转涡轮机以混合溶液和非溶剂并沉淀多糖。 沉淀的多糖用包括固定切割机和旋转切割机的互锁切割机切割,并且连续地取出细切多糖颗粒的悬浮液。
    • 4. 发明授权
    • Method for providing enteric coating on solid dosage forms and aqueous
compositions therefor
    • 在固体剂型及其含水组合物上提供肠溶衣的方法
    • US4385078A
    • 1983-05-24
    • US71298
    • 1979-08-30
    • Yoshiro OndaHiroaki MutoHiroshi SuzukiKazumasa MaruyamaAtsushi Hatayama
    • Yoshiro OndaHiroaki MutoHiroshi SuzukiKazumasa MaruyamaAtsushi Hatayama
    • A61K47/38A61K9/28C08L1/10C08L1/14
    • A61K9/282A61K9/2866
    • A novel aqueous coating composition is proposed for providing enteric coating on solid dosage forms such as tablets. The aqueous coating composition of the invention comprises a fine powder of an enterosoluble cellulose derivative such as hydroxypropylmethylcellulose phthalate and hydroxypropylmethylcellulose acetate succinate, which is insoluble in water but can be plasticized and solubilized with certain plasticizing agents, as dispersed in an aqueous dispersing medium and a plasticizing agent having compatibility with the enterosoluble cellulose derivative and dissolved in the aqueous dispersing medium. The particle size of the enterosoluble cellulose derivative and the boiling point of the plasticizing agent is the key parameters and should be finer than 100 .mu.m in an average particle diameter and not lower than 100.degree. C., respectively. Upon application of the aqueous coating composition to the solid dosage forms, water as the dispersing medium is first evaporated leaving the cellulose derivative and the plasticizing agent, which latter solubilizes the former to form a continuous coating layer on the solid dosage forms imparting good and satisfactory enterosolubility thereto.
    • 提出了一种新颖的水性涂料组合物,用于在诸如片剂的固体剂型上提供肠溶衣。 本发明的水性涂料组合物包括不溶于水但可以用某些增塑剂增塑和溶解的分散在水分散介质中的肠溶性纤维素衍生物如羟丙基甲基纤维素邻苯二甲酸酯和羟丙基甲基纤维素乙酸酯琥珀酸盐的细粉末, 增塑剂与肠溶性纤维素衍生物具有相容性并溶于水分散介质中。 肠溶性纤维素衍生物的粒径和增塑剂的沸点是关键参数,平均粒径分别小于100μm,不低于100℃。 当将水性涂料组合物施用于固体剂型时,首先蒸发作为分散介质的水,留下纤维素衍生物和增塑剂,后者溶解前者,在固体剂型上形成连续涂层,赋予良好和令人满意的效果 肠溶性。
    • 5. 发明授权
    • Ether-ester derivatives of cellulose and their applications
    • 纤维素的醚酯衍生物及其应用
    • US4226981A
    • 1980-10-07
    • US944177
    • 1978-09-20
    • Yoshiro OndaHiroaki MutoKazumasa Maruyama
    • Yoshiro OndaHiroaki MutoKazumasa Maruyama
    • A61K9/28A61K9/36C08B13/00G03C1/835B44D1/50G03C1/92
    • A61K9/2866C08B13/00G03C1/835
    • A novel cellulose derivative provided in this invention is a mixed ester of an alkoxy or hydroxyalkoxy substituted cellulose ether, prepared by the esterification reaction of the ether with succinic anhydride and an anhydride of an aliphatic monocarboxylic acid. The cellulose derivatives are advantageous because of their capability of producing enteric coatings having sufficient flexibility without the use of a plasticizer as well as by their chemical and physical stability against moisture, and also by easy purification after completion of the esterification reaction. The coatings produced from the derivatives have a similar chemical and physical stability. The cellulose derivatives are useful for the enteric coating of pharmaceutical dosage forms and also for providing halation-preventing layers on photographic films.
    • 本发明提供的新型纤维素衍生物是通过醚与琥珀酸酐的酯化反应和脂族一元羧酸的酸酐制备的烷氧基或羟基烷氧基取代的纤维素醚的混合酯。 纤维素衍生物是有利的,因为它们具有在不使用增塑剂的情况下具有足够柔韧性的肠溶衣的能力,以及它们对水分的化学和物理稳定性以及酯化反应完成后容易的纯化。 由衍生物生产的涂料具有相似的化学和物理稳定性。 纤维素衍生物可用于药物剂型的肠溶包衣以及用于在照相胶片上提供防晕层。