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    • 3. 发明授权
    • Aqueous pharmaceutical compositions
    • 水性药物组合物
    • US07612115B2
    • 2009-11-03
    • US11374450
    • 2006-03-13
    • Hidekazu SuzukiTakahiro WadaMasanobu KiritaMasanobu Takeuchi
    • Hidekazu SuzukiTakahiro WadaMasanobu KiritaMasanobu Takeuchi
    • A61K47/00A61K31/715A61K31/47
    • A61K31/5383A61K9/0048A61K47/10A61K47/12A61K47/38
    • The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when new quinolone antibacterial agents such as ofloxacin as the active ingredient and can be retained at the administration site for a long time by virtue of rapid viscosity increase after administration in spite of their being liquid at administration and thereby attain high availability of pharmaceutical agent.The present invention relates to an antibacterial aqueous pharmaceutical composition which comprises: 2.8 to 4 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa·s or below at 20° C.; 1.5 to 2.3 w/v % of citric acid; 2 to 4 w/v % of polyethylene glycol; and 0.1 to 0.5 w/v % of ofloxacin.
    • 本发明的目的在于提供一种抗菌水性药物组合物和含水药物组合物,即使新的喹诺酮类抗菌剂如氧氟沙星作为活性成分,也能够在施用部位长时间保留,具有足够低的凝胶化温度 由于施用后的粘度快速增加,尽管它们在施用时是液体,从而获得药剂的高可用性。 本发明涉及一种抗菌水性药物组合物,其包含:2.8〜4w / v%的甲基纤维素,其2w / v%水溶液在20℃下的粘度为12mPa·s或更低。 1.5至2.3w / v%的柠檬酸; 2至4w / v%的聚乙二醇; 和0.1至0.5w / v%的氧氟沙星。
    • 8. 发明授权
    • Heat accumulating material
    • 蓄热材料
    • US4406804A
    • 1983-09-27
    • US303985
    • 1981-09-21
    • Takahiro WadaShoichi IshiharaRyoichi Yamamoto
    • Takahiro WadaShoichi IshiharaRyoichi Yamamoto
    • C09K5/06C09K3/34C09K5/00
    • C09K5/063
    • The heat accumulating material provided according to this invention makes use of the latent heat of fusion of sodium acetate trihydrate, and it comprises, as blended in a system consisting of sodium acetate and water, at least one nucleation catalyst selected from the group of compounds consisting of tetrasodium pyrophosphate, trisodium monohydrogenpyrophosphate, disodium dihydrogenpyrophosphate and monosodium trihydrogenpyrophosphate. In use of this heat accumulating material, the sodium acetate trihydrate would not be overcooled owing to the overcooling preventing function of the nucleation catalyst but is unfailingly crystallized at a temperature close to the fusion point thereof to radiate latent heat of fusion. The overcooling preventing performance of the nucleation catalyst is not deteriorated even if it is subjected to more than 1,000 cycles of repetition of fusion and solidification, and thus the heat accumulating material maintains a very stabilized heat absorbing and radiating capacity.
    • 根据本发明提供的蓄热材料利用乙酸钠三水合物的融合潜热,并且包括在由乙酸钠和水组成的体系中共混的至少一种成核催化剂,所述成核催化剂选自: 焦磷酸四钠,一氢焦磷酸三钠,焦磷酸二氢二钠和焦磷酸三钠。 在使用这种蓄热材料时,由于成核催化剂的过冷预防功能,乙酸钠三水合物不会过冷,而是在接近其熔点的温度下不断地结晶,从而辐射潜热融化。 成核催化剂的过冷预防性能即使经历1000次以上的熔融和凝固重复循环也不会劣化,因此蓄热材料保持非常稳定的吸热和辐射能力。