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    • 2. 发明授权
    • Stable lipid emulsion
    • 稳定的脂质乳剂
    • US5693337A
    • 1997-12-02
    • US500087
    • 1995-07-10
    • Hidekazu SuzukiSatoshi YamazakiYoshikazu NaitoKenji EndoTouru OgumaMakoto Maeda
    • Hidekazu SuzukiSatoshi YamazakiYoshikazu NaitoKenji EndoTouru OgumaMakoto Maeda
    • A61K9/00A61K9/107A61K47/18A61K9/127
    • A61K9/0029A61K47/183A61K9/0014A61K9/0019A61K9/0048A61K9/1075Y10S514/937Y10S514/943
    • A lipid emulsion which comprises (A) an oil component, (B) an emulsifying agent containing yolk lecithin and/or soybean lecithin, and (C) water, wherein the lipid emulsion further comprises citric acid or a pharmaceutically acceptable salt thereof and at least one member selected from the group consisting of methionine, phenylalanine, serine, histidine and pharmaceutically acceptable salts thereof, provided that it does not simultaneously contain methionine and phenylalanine. The addition of citric acid and histidine, methionine, phenylalanine and/or serine to a lipid emulsion containing natural lecithin as an emulsifying agent permits the prevention of change of color and formation of oil drops associated with the conventional natural lecithin-containing lipid emulsion due to the synergistic effect of the foregoing additives. The drug-containing lipid emulsion is also excellent in storage stability and thus the foregoing lipid emulsion can be applied to drugs such as injections, eye drops, nasal drops, lotions or liniments, inhalants and drugs for oral administration or cosmetics such as humectants.
    • 一种脂质乳剂,其包含(A)油组分,(B)含有卵黄卵磷脂和/或大豆卵磷脂的乳化剂和(C)水,其中所述脂质乳液还包含柠檬酸或其药学上可接受的盐,至少 选自甲硫氨酸,苯丙氨酸,丝氨酸,组氨酸及其药学上可接受的盐中的一种,条件是其不同时含有甲硫氨酸和苯丙氨酸。 将柠檬酸和组氨酸,甲硫氨酸,苯丙氨酸和/或丝氨酸加入到含有天然卵磷脂作为乳化剂的脂质乳剂中,可以防止与常规含天然卵磷脂的脂质乳液相关的颜色变化和油滴的形成,这是由于 上述添加剂的协同效应。 含药物的脂质乳剂的储存稳定性也优异,因此上述脂质乳剂可以用于药物如注射剂,滴眼剂,滴鼻剂,洗剂或搽剂,用于口服给药的吸入剂和药物,或诸如保湿剂的化妆品。
    • 3. 发明授权
    • O/W emulsion composition
    • O / W乳液组合物
    • US06432439B1
    • 2002-08-13
    • US09541682
    • 2000-04-03
    • Hidekazu SuzukiSatoshi YamazakiYoshikazu NaitoMasanobu TakeuchiYoshiaki Saito
    • Hidekazu SuzukiSatoshi YamazakiYoshikazu NaitoMasanobu TakeuchiYoshiaki Saito
    • A61K3156
    • A61K9/0048A61K9/107Y10S514/912Y10S514/914Y10S514/938Y10S514/939Y10S514/943
    • An O/W emulsion composition comprising fluorometholone or clobetasone butyrate, a phospholipid, an oil, a nonionic water-soluble cellulose derivative, and water. The O/W composition has advantages that fluorometholone or clobetasone butyrate contained therein is highly bioavailable and that the solubility of fluorometholone or clobetasone butyrate and the concentration thereof present in the composition can be kept stable. Thus, this composition is usable for the treatment of various inflammatory diseases by the generalized or local administration thereof. It provides a drug which shows an anti-inflammatory activity equal or higher than that of commercially available eye drops comprising a suspension of such an active ingredient even when it is applied in a smaller dose than that of commercially available one and further provides a drug having excellent storability, which reduces apprehension of systemic side effects of fluorometholone or clobetasone butyrate when it is applied to the eyes.
    • 包含氟美托隆或丁酸氯倍他松,磷脂,油,非离子水溶性纤维素衍生物和水的O / W乳液组合物。 O / W组合物的优点在于其中所含的氟米龙或丁酸氯倍他松具有高度的生物利用度,并且可以保持氟代米尔龙或丁酸氯倍他松的溶解度及其在组合物中的浓度。 因此,该组合物可用于通过其广泛或局部施用治疗各种炎性疾病。 它提供了一种药物,其显示的抗炎活性等于或高于包含这种活性成分的悬浮液的市售眼药水的抗炎活性,即使其施用量小于可商购的滴眼剂,并且还提供具有 优异的保存性,减少了当应用于眼睛时,氟米龙或丁酸氯倍他松的全身副作用的忧虑。
    • 5. 发明授权
    • Navigation apparatus having screen changing function
    • 具有屏幕改变功能的导航装置
    • US09212928B2
    • 2015-12-15
    • US12693924
    • 2010-01-26
    • Satoshi YamazakiKaori Amano
    • Satoshi YamazakiKaori Amano
    • G01C21/36G06F3/0481G06F3/0488
    • G01C21/3664G06F3/0481G06F3/0488
    • There is provided a navigation apparatus including: a display unit having a display screen; a touch panel provided to the display screen; and a display controller that selectively changes first, second, and third screens in response to contacting the touch panel to be displayed, wherein each of the screens has a manipulation-button display area for displaying a screen-changing button, and wherein, the display controller performs a first displaying operation of circulatingly changing the screens in a predetermined order to be displayed at each time of contacting the manipulation-button display area, a second displaying operation of displaying a pop-up menu including first, second, and third screen-selecting buttons for directly selecting the screens at the same time of the first displaying operation, and a third displaying operation of displaying on the display screen one screen selected among the screens in response to contacting the screen-selecting buttons displayed by the second displaying operation.
    • 提供了一种导航装置,包括:具有显示屏的显示单元; 提供给显示屏的触摸面板; 以及显示控制器,其响应于要接触要显示的触摸面板选择性地改变第一屏幕,第二屏幕和第三屏幕,其中每个屏幕具有用于显示屏幕改变按钮的操纵按钮显示区域,并且其中,所述显示器 控制器执行以预定顺序循环改变屏幕以在每次接触操作按钮显示区域时显示的第一显示操作,显示包括第一,第二和第三屏幕显示区域的弹出菜单的第二显示操作, 选择用于在第一显示操作的同时直接选择屏幕的按钮;以及第三显示操作,响应于接触由第二显示操作显示的屏幕选择按钮,在显示屏幕上显示选择的屏幕中的一个屏幕。