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1. 发明授权

US07563811B2 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof 有权
标题翻译： 1,2-二氢吡啶化合物及其制备方法和用途
公开(公告)号：US07563811B2
公开(公告)日：2009-07-21
申请号：US11174514
申请日：2005-07-06
申请人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terence Smith
发明人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terence Smith
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D213/70 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/1804
摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
摘要翻译：本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。由下式表示的化合物，其盐或其水合物。在该式中，Q表示NH，O或S; 并且R 1，R 2，R 3，R 4和R 5彼此相同或不同，各自表示氢原子，卤素原子，C 1-6烷基或由式-XA表示的基团（其中X表示单键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等）。

2. 发明授权

US06949571B2 1,2-dihydropyridine compounds, process for preparation of the same and use thereof 有权
标题翻译： 1,2-二氢吡啶化合物，其制备方法及其用途
公开(公告)号：US06949571B2
公开(公告)日：2005-09-27
申请号：US10296719
申请日：2001-06-08
申请人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Anthony John Groom , Leanne Rivers , Terence Smith
发明人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Anthony John Groom , Leanne Rivers , Terence Smith
IPC分类号： A61K20060101 , A61P20060101 , A61P1/08 , A61P9/10 , A61P13/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D20060101 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/18 , C07D401/02 , A61K31/44
CPC分类号： C07D213/70 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/1804
摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
摘要翻译：本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。由下式表示的化合物，其盐或其水合物。在该式中，Q表示NH，O或S; 和R 1，R 2，R 3，R 4和R 5，各自表示氢原子，卤素原子，C 1-6烷基或式-XA表示的基团（其中，X表示单键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等。）。

3. 发明申请

US20060189622A1 Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations 审中-公开
标题翻译：哒嗪酮和三嗪酮化合物及其作为药物制剂的用途
公开(公告)号：US20060189622A1
公开(公告)日：2006-08-24
申请号：US11408078
申请日：2006-04-21
申请人： Satoshi Nagato , Koki Kawano , Koichi Ito , Yoshihiko Norimine , Kohshi Ueno , Takahisa Hanada , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Masataka Ueno , Anthony Groom , Leanne Rivers , Terence Smith
发明人： Satoshi Nagato , Koki Kawano , Koichi Ito , Yoshihiko Norimine , Kohshi Ueno , Takahisa Hanada , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Masataka Ueno , Anthony Groom , Leanne Rivers , Terence Smith
IPC分类号： A61K31/506 , A61K31/501 , A61K31/50 , C07D409/02 , C07D403/02 , C07D405/02
CPC分类号： C07D237/24 , C07D237/14 , C07D401/04 , C07D491/04
摘要： The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, A1, A2 and A3 are independent of each other and each represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may be substituted; Q represents O, S or NH; Z represents C or N; X1, X2 and X3 are independent of each other and each represents a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, —NH—, —O—, —NHCO—, —CONH—, —SO0-2—, etc.; R1 and R2 are independent of each other and each represents a hydrogen atom or an optionally substituted C1-6 alkyl group, or R1 and R2 may be bound together such that CR2-ZR1 forms C═C; and R3 represents a hydrogen atom or an optionally substituted C1-6 alkyl group etc., or may be bound to any atom in A1 or A3 to form, together with the atom, an optionally substituted C5-8 hydrocarbon ring or an optionally substituted 5- to 8-membered heterocyclic ring.
摘要翻译：本发明提供了对AMPA受体和/或红藻氨酸受体具有优异抑制作用的新化合物。也就是说，它提供由下式表示的化合物，其盐或它们的水合物。在该式中，A 1，A 2和A 3彼此独立，并且各自表示C 3-8，环烷基，C 3-8环烯基，5至14元非芳族杂环基，C 6-14芳族烃环基或5〜14元芳族杂环基，其各自可以被取代; Q表示O，S或NH; Z表示C或N; X 1，X 2和X 3 3彼此独立，各自表示单键，任选取代的C 1〜 6个亚烷基，任选取代的C 2-6亚烯基，任选取代的C 2-6亚炔基，-NH-，-O-， -NHCO - ， - CONH - ， - SO 2 - 等; R 1和R 2彼此独立，各自表示氢原子或任选取代的C 1-6烷基，或R 可以将“1”和“R”2结合在一起，使得CR 2 -ZR 1'形成CC; 和R 3表示氢原子或任选取代的C 1-6烷基等，或者可以与A 1〜O 2中的任何原子结合 >或A <3>，以与原子一起形成任选取代的C 5 -C 8烃环或任选取代的5至8元杂环。

4. 发明申请

US20050245581A1 1, 2-Dihydropyridine compounds, manufacturing method thereof and use thereof 有权
标题翻译： 1,2-二氢吡啶化合物及其制备方法及其用途
公开(公告)号：US20050245581A1
公开(公告)日：2005-11-03
申请号：US11174514
申请日：2005-07-06
申请人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony Groom , Leanne Rivers , Terence Smith
发明人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony Groom , Leanne Rivers , Terence Smith
IPC分类号： A61K20060101 , A61P20060101 , A61P1/08 , A61P9/10 , A61P13/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D20060101 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/18 , A61K31/44
CPC分类号： C07D213/70 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/1804
摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally sbutituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
摘要翻译：本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。由下式表示的化合物，其盐或其水合物。在该式中，Q表示NH，O或S; 和R 1，R 2，R 3，R 4和R 5，各自表示氢原子，卤素原子，C 1-6烷基或式-XA表示的基团（其中，X表示单键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等。）。

5. 发明申请

US20090275751A1 1,2-DIHYDROPYRIDINE COMPOUNDS, MANUFACTURING METHOD THEREOF AND USE THEREOF 有权
标题翻译： 1,2-二羟基吡啶化合物及其制备方法及其用途
公开(公告)号：US20090275751A1
公开(公告)日：2009-11-05
申请号：US12395378
申请日：2009-02-27
申请人： Satoshi NAGATO , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takaisa Hanada , Masatake Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terrence Smith
发明人： Satoshi NAGATO , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takaisa Hanada , Masatake Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terrence Smith
IPC分类号： C07D401/04 , C07D417/04 , C07D213/63 , C07D401/14
CPC分类号： C07D213/70 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/1804
摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
摘要翻译：本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。由下式表示的化合物，其盐或其水合物。在该式中，Q表示NH，O或S; 并且R 1，R 2，R 3，R 4和R 5彼此相同或不同，各自表示氢原子，卤素原子，C 1-6烷基或由式-XA表示的基团（其中X表示单键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等）。

6. 发明申请

US20090090161A1 UNDERDRIVE-TYPE PRESS 审中-公开
标题翻译：下压式压力机
公开(公告)号：US20090090161A1
公开(公告)日：2009-04-09
申请号：US12298321
申请日：2007-05-08
申请人： Hiroyuki Amino
发明人： Hiroyuki Amino
IPC分类号： B21J9/18
CPC分类号： B21D22/22 , B21D24/12 , B30B1/103 , B30B1/14 , B30B15/007 , B30B15/061 , B30B15/148
摘要： [Object] An underdrive-type single action press capable of saving energy, saving space, and realizing high-precision formability in a well-balanced manner is provided. Particularly, a press capable of shortening a forming stroke, reducing overall height, exactly correcting the deflection of the slide or dies to improve adhesion of the dies to a workpiece, and realizing pressure equalization of a wrinkle holder is provided.[Means for Resolution] An underdrive-type press includes a forming press unit including a lower die located inside an annular wrinkle holder fixedly disposed on a bed, and a drive mechanism disposed within the bed to raise or lower a slide supporting the lower die, a slide raised or lowered by a drive mechanism loaded on the side of a crown, a die-clamping press unit including an upper die having a clamping portion pinching a workpiece in cooperation with the wrinkle holder at its peripheral edge, and a device applying a pressing force to the upper die from its back after the last stage of the descent of the slide of the die-clamping press unit and the upper die for improvements in forming precision.
摘要翻译：提供了一种能够节省能量，节省空间，并且以良好平衡的方式实现高精度可加工性的欠驱动型单作用按压机。特别地，提供了能够缩短成形冲程，降低整体高度，精确地校正滑块或模具的偏转以提高模具对工件的粘合性以及实现褶皱保持器的压力平衡的压力机。 [解决方法]欠驱动型压力机包括：成形压制单元，包括位于固定地设置在床上的环形褶皱保持器内的下模，以及设置在床内以提升或降低支撑下模的滑块的驱动机构，通过装载在冠部侧面的驱动机构升高或降低的滑块，包括上模具的上模具，所述上模具具有在其周缘处与所述褶皱保持件协作地夹持工件的夹紧部分，以及施加在模具夹紧压机单元和上模的滑块的最后阶段之后从其背面向上模具施加压力，以提高成形精度。

7. 发明申请

US20060261519A1 Method for producing formed wooden article 失效
标题翻译：成型木制品的制造方法
公开(公告)号：US20060261519A1
公开(公告)日：2006-11-23
申请号：US11371656
申请日：2006-03-08
申请人： Tatsuya Suzuki , Hisashi Nishimura , Hiroyuki Amino
发明人： Tatsuya Suzuki , Hisashi Nishimura , Hiroyuki Amino
IPC分类号： B29C59/02 , B28B1/14
CPC分类号： B27M1/02
摘要： A method for producing a formed wooden article by cutting out a primary blank member from a raw wood and forming the same into a final three-dimensional shape having a substantially uniform thickness, comprises: a primary compression step in which the primary blank member is compressed by primary molding dies, and the primary blank member is processed into a primary compressed article having a high compression portion in a vicinity of portions of the primary blank member corresponding to a die surface; a secondary blank processing step in which the primary compressed article is cut and processed into a secondary blank member; and a secondary compression step in which the secondary blank member is compressed by using secondary molding dies and the final three-dimensional shape is transferred onto the secondary blank member.
摘要翻译：一种用于通过从原木切割初级坯料并将其形成具有基本上均匀厚度的最终三维形状的成型木制品的方法包括：初级压缩步骤，其中主坯料被压缩通过一次成型模具将主坯料加工成相当于模具表面的主要坯料部分附近具有高压缩部分的一次压缩制品; 第二坯料加工步骤，其中将一次压缩制品切割并加工成二次坯料; 以及二次压缩步骤，其中通过使用二次成型模具对二次坯料进行压缩，并将最终的三维形状转印到二次坯料上。

8. 发明授权

US07670531B2 Method for producing formed wooden article 失效
标题翻译：成型木制品的制造方法
公开(公告)号：US07670531B2
公开(公告)日：2010-03-02
申请号：US11371656
申请日：2006-03-08
申请人： Tatsuya Suzuki , Hisashi Nishimura , Hiroyuki Amino
发明人： Tatsuya Suzuki , Hisashi Nishimura , Hiroyuki Amino
IPC分类号： B28B3/00
CPC分类号： B27M1/02
摘要： A method for producing a formed wooden article by cutting out a primary blank member from a raw wood and forming the same into a final three-dimensional shape having a substantially uniform thickness, comprises: a primary compression step in which the primary blank member is compressed by primary molding dies, and the primary blank member is processed into a primary compressed article having a high compression portion in a vicinity of portions of the primary blank member corresponding to a die surface; a secondary blank processing step in which the primary compressed article is cut and processed into a secondary blank member; and a secondary compression step in which the secondary blank member is compressed by using secondary molding dies and the final three-dimensional shape is transferred onto the secondary blank member.
摘要翻译：一种用于通过从原木切割初级坯料并将其形成具有基本上均匀厚度的最终三维形状的成型木制品的方法包括：初级压缩步骤，其中主坯料被压缩通过一次成型模具将主坯料加工成相当于模具表面的主要坯料部分附近具有高压缩部分的一次压缩制品; 第二坯料加工步骤，其中将一次压缩制品切割并加工成二次坯料; 以及二次压缩步骤，其中通过使用二次成型模具对二次坯料进行压缩，并将最终的三维形状转印到二次坯料上。

9. 发明授权

US07536892B2 Method and apparatus for forming sheet metal 有权
标题翻译：用于形成金属板的方法和装置
公开(公告)号：US07536892B2
公开(公告)日：2009-05-26
申请号：US11446997
申请日：2006-06-05
申请人： Hiroyuki Amino , Shigeo Matsubara , Yan Lu
发明人： Hiroyuki Amino , Shigeo Matsubara , Yan Lu
IPC分类号： B21D11/02 , B21D7/00
CPC分类号： B21D22/16 , B21D22/185
摘要： In order to provide a method and apparatus for forming a sheet metal, in which a three-dimensional product such as a prototype for commercialized press-forming can be formed in short time without limitations as to the shape and with high accuracy, preventing body wrinkles or reduction of the sheet thickness, a process of: performing drawing-forming to a predetermine height by pushing the forming punch having a desired shape in the sheet thickness direction with the edges of the blank workpiece being clamped; performing shape-forming with the shaping tool in the opposite side to the forming punch by increasing a clamping pressure to lock movement of a material with the forming punch being pushed; performing drawing-forming again by decreasing the clamping pressure and raising the forming punch by a desired height; and performing shape-forming with the shaping tool by increasing the clamping pressure to lock movement of a material, is repeated at least once.
摘要翻译：为了提供用于形成金属板的方法和装置，其中可以在短时间内形成诸如用于商业压制成型的原型的三维产品，而不限于形状和高精度，防止体皱纹或减少片材厚度的方法;以下步骤：通过在坯料工件的边缘被夹持的同时将具有期望形状的成形冲头沿片材厚度方向推压到预定高度; 通过增加夹紧压力来与成型冲头的相对侧的成形工具进行成形，以锁定成形冲头被推动的材料的运动; 通过减小夹紧压力并将成形冲头提高希望的高度来再次进行拉伸成形; 并且通过增加夹持压力以锁定材料的运动，通过成形工具进行成形，至少重复一次。

10. 发明申请

US20060272378A1 Method and apparatus for forming sheet metal 有权
公开(公告)号：US20060272378A1
公开(公告)日：2006-12-07
申请号：US11446997
申请日：2006-06-05
申请人： Hiroyuki Amino , Shigeo Matsubara , Yan Lu
发明人： Hiroyuki Amino , Shigeo Matsubara , Yan Lu
IPC分类号： B21D11/00
CPC分类号： B21D22/16 , B21D22/185
摘要： In order to provide a method and apparatus for forming a sheet metal, in which a three-dimensional product such as a prototype for commercialized press-forming can be formed in short time without limitations as to the shape and with high accuracy, preventing body wrinkles or reduction of the sheet thickness, a process of: performing drawing-forming to a predetermine height by pushing the forming punch having a desired shape in the sheet thickness direction with the edges of the blank workpiece being clamped; performing shape-forming with the shaping tool in the opposite side to the forming punch by increasing a clamping pressure to lock movement of a material with the forming punch being pushed; performing drawing-forming again by decreasing the clamping pressure and raising the forming punch by a desired height; and performing shape-forming with the shaping tool by increasing the clamping pressure to lock movement of a material, is repeated at least once.

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