专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07563811B2 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof 有权
标题翻译： 1,2-二氢吡啶化合物及其制备方法和用途
公开(公告)号：US07563811B2
公开(公告)日：2009-07-21
申请号：US11174514
申请日：2005-07-06
申请人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terence Smith
发明人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terence Smith
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D213/70 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/1804
摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
摘要翻译：本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。由下式表示的化合物，其盐或其水合物。在该式中，Q表示NH，O或S; 并且R 1，R 2，R 3，R 4和R 5彼此相同或不同，各自表示氢原子，卤素原子，C 1-6烷基或由式-XA表示的基团（其中X表示单键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等）。

2. 发明申请

US20050245581A1 1, 2-Dihydropyridine compounds, manufacturing method thereof and use thereof 有权
标题翻译： 1,2-二氢吡啶化合物及其制备方法及其用途
公开(公告)号：US20050245581A1
公开(公告)日：2005-11-03
申请号：US11174514
申请日：2005-07-06
申请人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony Groom , Leanne Rivers , Terence Smith
发明人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony Groom , Leanne Rivers , Terence Smith
IPC分类号： A61K20060101 , A61P20060101 , A61P1/08 , A61P9/10 , A61P13/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D20060101 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/18 , A61K31/44
CPC分类号： C07D213/70 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/1804
摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally sbutituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
摘要翻译：本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。由下式表示的化合物，其盐或其水合物。在该式中，Q表示NH，O或S; 和R 1，R 2，R 3，R 4和R 5，各自表示氢原子，卤素原子，C 1-6烷基或式-XA表示的基团（其中，X表示单键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等。）。

3. 发明申请

US20090275751A1 1,2-DIHYDROPYRIDINE COMPOUNDS, MANUFACTURING METHOD THEREOF AND USE THEREOF 有权
标题翻译： 1,2-二羟基吡啶化合物及其制备方法及其用途
公开(公告)号：US20090275751A1
公开(公告)日：2009-11-05
申请号：US12395378
申请日：2009-02-27
申请人： Satoshi NAGATO , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takaisa Hanada , Masatake Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terrence Smith
发明人： Satoshi NAGATO , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takaisa Hanada , Masatake Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terrence Smith
IPC分类号： C07D401/04 , C07D417/04 , C07D213/63 , C07D401/14
CPC分类号： C07D213/70 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/1804
摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
摘要翻译：本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。由下式表示的化合物，其盐或其水合物。在该式中，Q表示NH，O或S; 并且R 1，R 2，R 3，R 4和R 5彼此相同或不同，各自表示氢原子，卤素原子，C 1-6烷基或由式-XA表示的基团（其中X表示单键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等）。

4. 发明授权

US08772497B2 Method for producing 1, 2-dihydropyridine-2-one compound 有权
标题翻译： 1,2-二氢吡啶-2-酮化合物的制备方法
公开(公告)号：US08772497B2
公开(公告)日：2014-07-08
申请号：US12870507
申请日：2010-08-27
申请人： Itaru Arimoto , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Kayano , Katsutoshi Nishiura
发明人： Itaru Arimoto , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Kayano , Katsutoshi Nishiura
IPC分类号： C07D401/04
CPC分类号： C07D213/64
摘要： The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one and production processes therefore.
摘要翻译：本发明提供了一种商业生产下式（III-a）表示的1,2-二氢吡啶-2-酮化合物的方法，其中环A表示任选取代的2-吡啶基，环B表示任选取代的苯基，环C表示任选取代的苯基。此外，本发明提供3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮的晶体及其制备方法。

5. 发明申请

US20100324297A1 METHOD FOR PRODUCING 1, 2-DIHYDROPYRIDINE-2-ONE COMPOUND 有权
标题翻译： 1,1-二羟基吡啶-2-酮化合物的制备方法
公开(公告)号：US20100324297A1
公开(公告)日：2010-12-23
申请号：US12870507
申请日：2010-08-27
申请人： Itaru ARIMOTO , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Yayano , Katsutoshi Nishiura
发明人： Itaru ARIMOTO , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Yayano , Katsutoshi Nishiura
IPC分类号： C07D401/04
CPC分类号： C07D213/64
摘要： The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one and production processes therefore.
摘要翻译：本发明提供了一种商业生产下式（III-a）表示的1,2-二氢吡啶-2-酮化合物的方法，其中环A表示任选取代的2-吡啶基，环B表示任选取代的苯基，环C表示任选取代的苯基。此外，本发明提供3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮的晶体及其制备方法。

6. 发明申请

US20070142640A1 Method for producing 1, 2-dihydropyridine-2-one compound 有权
标题翻译： 1,2-二氢吡啶-2-酮化合物的制备方法
公开(公告)号：US20070142640A1
公开(公告)日：2007-06-21
申请号：US11649299
申请日：2007-01-04
申请人： Itaru Arimoto , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Kayano , Katsutoshi Nishiura
发明人： Itaru Arimoto , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Kayano , Katsutoshi Nishiura
IPC分类号： A61K31/444 , C07D401/02
CPC分类号： C07D213/64
摘要： The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one and production processes therefor.
摘要翻译：本发明提供了一种商业生产下式（III-a）表示的1,2-二氢吡啶-2-酮化合物的方法，其中环A表示任选取代的2-吡啶基，环B表示任选取代的苯基，环C表示任选取代的苯基。此外，本发明提供3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮的晶体及其制备方法。

7. 发明授权

US5583229A Process for the preparation of imidazopyridine derivatives 失效
标题翻译：咪唑并吡啶衍生物的制备方法
公开(公告)号：US5583229A
公开(公告)日：1996-12-10
申请号：US256869
申请日：1994-08-05
申请人： Yoshio Urawa , Ken Furukawa , Toshikazu Shimizu , Yoji Yamagishi , Tomio Tsurugi , Tomio Ichino
发明人： Yoshio Urawa , Ken Furukawa , Toshikazu Shimizu , Yoji Yamagishi , Tomio Tsurugi , Tomio Ichino
IPC分类号： C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/73 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04
CPC分类号： C07D213/73 , C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04 , Y02P20/55
摘要： The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: ##STR1##
摘要翻译： PCT No.PCT / JP93 / 01776 Sec。 371日期：1994年8月5日 102（e）日期1994年8月5日PCT 1993年12月7日PCT公布。公开号WO94 / 13666 日期：1994年6月23日本发明提供了制备由下式（II）表示的2-烷基-3-（联苯-4-基）甲基-3H-咪唑并[4,5-b]吡啶衍生物的工业上有利的方法），其是用作抗高血压药物的血管紧张素II受体的拮抗剂的前体，作为吡啶衍生物的取代基的前体的联苯衍生物，其制备方法和可用于制备联苯衍生物：（II）

8. 发明授权

US5245060A Terpene derivatives and process for preparing the same 失效
标题翻译： TERPENE衍生物及其制备方法
公开(公告)号：US5245060A
公开(公告)日：1993-09-14
申请号：US849967
申请日：1992-03-12
申请人： Kimio Hamamura , Yoshio Urawa , Yukio Narabe , Yoshihiko Hisatake , Shizumasa Kijima
发明人： Kimio Hamamura , Yoshio Urawa , Yukio Narabe , Yoshihiko Hisatake , Shizumasa Kijima
IPC分类号： B01J31/12 , C07B61/00 , C07C249/02 , C07C251/12
CPC分类号： C07C251/12 , C07C2101/14
摘要： A terpene derivative represented by the general formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl group; R.sup.2 represents an alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an arylalkyl group or a heteroaryl group; n is 0 or 1 or 2; and the symbol " " represents a single or double bond with the proviso that both of the linkages adjacent to each other are not simultaneously single bonds or double bonds which are useful for the preparation of drug, food, perfume and so on, and a process for preparing thereof.

9. 发明授权

US07557217B2 Process for production of benzimidazole derivative salt precipitate 失效
标题翻译：苯并咪唑衍生物盐沉淀物的制备方法
公开(公告)号：US07557217B2
公开(公告)日：2009-07-07
申请号：US11597743
申请日：2005-06-29
申请人： Yoshio Urawa
发明人： Yoshio Urawa
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a process for the production of a 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1 H-benzimidazole alkali metal salt (1), which is a drug or an intermediate for the production of a drug, the process not requiring large-scale equipment and being excellent in terms of workability, operability and energy conservation. According to the present invention, there is disclosed a process for the production of a salt precipitate represented by formula (1) (wherein B represents an alkali metal ion), the process comprising the steps of: dissolving the compound represented by formula (2) in a first organic solvent and adding an alkali metal hydroxide, or dissolving the alkali metal hydroxide in the first organic solvent and adding the compound represented by formula (2); and further adding a second organic solvent to a reaction mixture obtained.
摘要翻译：本发明提供了制备2 - [{4-（3-甲氧基丙氧基）-3-甲基吡啶-2-基}甲基亚磺酰基] -1H-苯并咪唑碱金属盐（1）的方法，该方法是药物或生产药物的中间体，不需要大型设备并且在可加工性，可操作性和节能方面优异的方法。根据本发明，公开了由式（1）表示的盐沉淀物（其中B表示碱金属离子）的方法，该方法包括以下步骤：将由式（2）表示的化合物在第一有机溶剂中加入碱金属氢氧化物，或将碱金属氢氧化物溶解在第一有机溶剂中，并加入由式（2）表示的化合物; 并进一步向获得的反应混合物中加入第二有机溶剂。

10. 发明申请

US20070225502A1 Process for Production of Benzimidazole Derivative Salt Precipitate 失效
标题翻译：苯并咪唑衍生物沉淀物的制备方法
公开(公告)号：US20070225502A1
公开(公告)日：2007-09-27
申请号：US11597743
申请日：2005-06-29
申请人： Yoshio Urawa
发明人： Yoshio Urawa
IPC分类号： C07D401/02
CPC分类号： C07D401/12
摘要： The present invention provides a process for the production of a 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1 H-benzimidazole alkali metal salt (1), which is a drug or an intermediate for the production of a drug, the process not requiring large-scale equipment and being excellent in terms of workability, operability and energy conservation. According to the present invention, there is disclosed a process for the production of a salt precipitate represented by formula (1) (wherein B represents an alkali metal ion), the process comprising the steps of: dissolving the compound represented by formula (2) in a first organic solvent and adding an alkali metal hydroxide, or dissolving the alkali metal hydroxide in the first organic solvent and adding the compound represented by formula (2); and further adding a second organic solvent to a reaction mixture obtained.
摘要翻译：本发明提供了制备2 - [{4-（3-甲氧基丙氧基）-3-甲基吡啶-2-基}甲基亚磺酰基] -1H-苯并咪唑碱金属盐（1）的方法，其为药物或生产药物的中间体，不需要大型设备并且在可加工性，可操作性和节能方面优异的方法。根据本发明，公开了由式（1）表示的盐沉淀物（其中B表示碱金属离子）的方法，该方法包括以下步骤：将由式（2）表示的化合物在第一有机溶剂中加入碱金属氢氧化物，或将碱金属氢氧化物溶解在第一有机溶剂中，并加入由式（2）表示的化合物; 并进一步向获得的反应混合物中加入第二有机溶剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式