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    • 5. 发明授权
    • Microfluidic particle-analysis systems
    • 微流控粒子分析系统
    • US08658418B2
    • 2014-02-25
    • US12501982
    • 2009-07-13
    • Antoine Daridon
    • Antoine Daridon
    • C12M1/34C12M3/00
    • C12M1/34B01L3/502738B01L3/502746B01L3/502753B01L3/502761B01L2200/0636B01L2200/0647B01L2200/0652B01L2200/0668B01L2200/10B01L2200/12B01L2200/16B01L2300/06B01L2300/0636B01L2300/0645B01L2300/0681B01L2300/0861B01L2300/0867B01L2300/087B01L2300/088B01L2300/0887B01L2300/0893B01L2300/123B01L2400/0409B01L2400/0415B01L2400/0481B01L2400/0622B01L2400/0655C12M21/06C12M23/16G01N15/1484G01N33/4833G01N2015/008G01N2015/0288G01N2015/149G01N2015/1493G02B21/32
    • The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analysis. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analysis, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
    • 本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置,方法和试剂盒的系统。 本发明提供了用于微粒操作和/或分析颗粒例如细胞,病毒,细胞器,珠粒和/或囊泡的装置,方法和试剂盒的系统。 本发明还提供了用于进行这些操作和分析的微流体机构。 这些机制可以实现颗粒的控制输入,运动/定位,保留/定位,处理,测量,释放和/或输出。 此外,这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。 因此,这些组合可以允许将粒子分类,培养,混合,处理和/或测定为单粒子,粒子的混合组,粒子阵列,非均匀粒子组和/或均匀粒子组,其中 其他,串联和/或并行。 此外,这些组合可以使微流体系统能够重复使用。 此外,这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。 因此,本发明的系统可以允许广泛范围的细胞和颗粒测定,例如药物筛选,细胞特征化,研究研究和/或临床分析等等,以缩小至微流体大小。 这种按比例缩小的测定可能使用较少的样品和试剂,可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。
    • 7. 发明申请
    • MICROFLUIDIC PARTICLE-ANALYSIS SYSTEMS
    • 微流化粒子分析系统
    • US20100120077A1
    • 2010-05-13
    • US12501982
    • 2009-07-13
    • Antoine Daridon
    • Antoine Daridon
    • C12Q1/02C12M1/34
    • C12M1/34B01L3/502738B01L3/502746B01L3/502753B01L3/502761B01L2200/0636B01L2200/0647B01L2200/0652B01L2200/0668B01L2200/10B01L2200/12B01L2200/16B01L2300/06B01L2300/0636B01L2300/0645B01L2300/0681B01L2300/0861B01L2300/0867B01L2300/087B01L2300/088B01L2300/0887B01L2300/0893B01L2300/123B01L2400/0409B01L2400/0415B01L2400/0481B01L2400/0622B01L2400/0655C12M21/06C12M23/16G01N15/1484G01N33/4833G01N2015/008G01N2015/0288G01N2015/149G01N2015/1493G02B21/32
    • The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
    • 本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置,方法和试剂盒的系统。 本发明提供了用于微粒操作和/或分析颗粒例如细胞,病毒,细胞器,珠粒和/或囊泡的装置,方法和试剂盒的系统。 本发明还提供用于进行这些操作和分析的微流体机理。 这些机制可以实现颗粒的控制输入,运动/定位,保留/定位,处理,测量,释放和/或输出。 此外,这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。 因此,这些组合可以允许将粒子分类,培养,混合,处理和/或测定为单粒子,粒子的混合组,粒子阵列,非均匀粒子组和/或均匀粒子组,其中 其他,串联和/或并行。 此外,这些组合可以使微流体系统能够重复使用。 此外,这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。 因此,本发明的系统可以允许广泛范围的细胞和颗粒测定,例如药物筛选,细胞特征化,研究研究和/或临床分析等,以缩小到微流体大小。 这种按比例缩小的测定可能使用较少的样品和试剂,可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。
    • 8. 发明申请
    • Devices and methods for microfluidic chromatography
    • 微流体色谱的装置和方法
    • US20070138076A1
    • 2007-06-21
    • US11305833
    • 2005-12-16
    • Antoine DaridonJiang HuangOai PhiAndy May
    • Antoine DaridonJiang HuangOai PhiAndy May
    • B01D15/08
    • G01N30/6004B01D15/14B01D15/18G01N30/6026G01N30/603G01N30/6047G01N30/6095G01N30/72
    • Embodiments of the invention provide devices, methods and systems for performing microfluidic chromatography. Particular embodiments provide microfluidic chromatography column devices which can perform chemical separation using small sample volumes and low pressure differentials across the column. One embodiment provides a microfluidic chromatography column device comprising a first, second and third capillary tube. A chromatographic packing is disposed in the second tube with a first and second support layer disposed on opposite ends of the second tube. The support layers are disposed in a substantially flat orientation within the tube. An external coupling joins the tubes such that the tubes are fluidically sealed. The device is configured to have a fluidic resistance such that a pressure differential across the column of less than about 10 psi produces a flow rate through the device of at least about 0.5 ml/min for a liquid solution.
    • 本发明的实施方案提供用于进行微流体色谱的装置,方法和系统。 具体实施方案提供了可以使用小样品体积和穿过该柱的低压差进行化学分离的微流体色谱柱装置。 一个实施方案提供了包含第一,第二和第三毛细管的微流体色谱柱装置。 色谱填料设置在第二管中,第一和第二支撑层设置在第二管的相对端上。 支撑层在管内以基本平坦的方向设置。 外部联接器连接管子,使得管子是流体密封的。 该装置被配置为具有流体阻力,使得小于约10psi的柱上的压力差产生液体溶液通过装置的流速为至少约0.5ml / min。