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1. 发明授权

US08206593B2 Microfluidic chemical reaction circuits 有权
标题翻译：微流控化学反应电路
公开(公告)号：US08206593B2
公开(公告)日：2012-06-26
申请号：US11792168
申请日：2005-12-05
申请人： Chung-cheng Lee , Guodong Sui , Arkadij Elizarov , Hartmuth C. Kolb , Jiang Huang , James R. Heath , Michael E. Phelps , Stephen R. Quake , Hsian-rong Tseng , Paul Wyatt , Antoine Daridon
发明人： Chung-cheng Lee , Guodong Sui , Arkadij Elizarov , Hartmuth C. Kolb , Jiang Huang , James R. Heath , Michael E. Phelps , Stephen R. Quake , Hsian-rong Tseng , Paul Wyatt , Antoine Daridon
IPC分类号： B01D11/00 , B01J7/00 , B01D15/00
CPC分类号： B01J19/0093 , B01F11/0042 , B01F13/0059 , B01F2215/0404 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01L3/5027 , B33Y80/00 , C07B59/00
摘要： New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.
摘要翻译：提供了用于进行化学反应的新型微流体装置。该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。

2. 发明申请

US20080281090A1 Microfluidic Chemical Reaction Circuits 有权
标题翻译：微流控化学反应电路
公开(公告)号：US20080281090A1
公开(公告)日：2008-11-13
申请号：US11792168
申请日：2005-12-05
申请人： Cheng-Chung Lee , Guodong Sui , Arkadij Elizarov , Hartmuth C. Kolb , Jiang Huang , James R. Heath , Michael E. Phelps , Stephen R. Quake , Hsian-rong Tseng , Paul Wyatt , Antoine Daridon
发明人： Cheng-Chung Lee , Guodong Sui , Arkadij Elizarov , Hartmuth C. Kolb , Jiang Huang , James R. Heath , Michael E. Phelps , Stephen R. Quake , Hsian-rong Tseng , Paul Wyatt , Antoine Daridon
IPC分类号： C07H5/02 , B01J19/00 , B01D15/04 , C07C211/43
CPC分类号： B01J19/0093 , B01F11/0042 , B01F13/0059 , B01F2215/0404 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01L3/5027 , B33Y80/00 , C07B59/00
摘要： New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.
摘要翻译：提供了用于进行化学反应的新型微流体装置。该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。

3. 发明申请

US20070138076A1 Devices and methods for microfluidic chromatography 审中-公开
标题翻译：微流体色谱的装置和方法
公开(公告)号：US20070138076A1
公开(公告)日：2007-06-21
申请号：US11305833
申请日：2005-12-16
申请人： Antoine Daridon , Jiang Huang , Oai Phi , Andy May
发明人： Antoine Daridon , Jiang Huang , Oai Phi , Andy May
IPC分类号： B01D15/08
CPC分类号： G01N30/6004 , B01D15/14 , B01D15/18 , G01N30/6026 , G01N30/603 , G01N30/6047 , G01N30/6095 , G01N30/72
摘要： Embodiments of the invention provide devices, methods and systems for performing microfluidic chromatography. Particular embodiments provide microfluidic chromatography column devices which can perform chemical separation using small sample volumes and low pressure differentials across the column. One embodiment provides a microfluidic chromatography column device comprising a first, second and third capillary tube. A chromatographic packing is disposed in the second tube with a first and second support layer disposed on opposite ends of the second tube. The support layers are disposed in a substantially flat orientation within the tube. An external coupling joins the tubes such that the tubes are fluidically sealed. The device is configured to have a fluidic resistance such that a pressure differential across the column of less than about 10 psi produces a flow rate through the device of at least about 0.5 ml/min for a liquid solution.
摘要翻译：本发明的实施方案提供用于进行微流体色谱的装置，方法和系统。具体实施方案提供了可以使用小样品体积和穿过该柱的低压差进行化学分离的微流体色谱柱装置。一个实施方案提供了包含第一，第二和第三毛细管的微流体色谱柱装置。色谱填料设置在第二管中，第一和第二支撑层设置在第二管的相对端上。支撑层在管内以基本平坦的方向设置。外部联接器连接管子，使得管子是流体密封的。该装置被配置为具有流体阻力，使得小于约10psi的柱上的压力差产生液体溶液通过装置的流速为至少约0.5ml / min。

4. 发明申请

US20060093836A1 Polymer surface modification 有权
公开(公告)号：US20060093836A1
公开(公告)日：2006-05-04
申请号：US11304316
申请日：2005-12-14
申请人： Jiang Huang , Shoujun Xiao , Marc Unger
发明人： Jiang Huang , Shoujun Xiao , Marc Unger
IPC分类号： B32B9/04 , B32B25/20
CPC分类号： B32B3/26 , B01J20/285 , B01J20/286 , B01J20/327 , B01J20/3272 , B01J2220/54 , B01L3/502707 , B01L2200/12 , B01L2300/16 , B01L2300/163 , C08F257/02 , C08F263/04 , C08F265/04 , C08F279/02 , C08F287/00 , C08F291/00 , C08J5/12 , C08J7/12 , F04B43/043 , Y10T428/139 , Y10T428/1393 , Y10T428/24661 , Y10T428/24744 , Y10T428/249953 , Y10T428/249958 , Y10T428/249978 , Y10T428/31663 , Y10T428/31667
摘要： The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

5. 发明申请

US20050000900A1 Microfluidic chromatography 有权
标题翻译：微流控色谱
公开(公告)号：US20050000900A1
公开(公告)日：2005-01-06
申请号：US10874103
申请日：2004-06-21
申请人： Jiang Huang , Hou-Pu Chou , Marc Unger
发明人： Jiang Huang , Hou-Pu Chou , Marc Unger
IPC分类号： G01N30/38 , G01N30/52 , G01N30/60 , B01D15/08
CPC分类号： B01D15/08 , G01N30/6065 , G01N30/6095 , G01N2030/387 , G01N2030/521 , Y10T137/86863 , Y10T436/2575
摘要： The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.
摘要翻译：本发明涉及包含微流体输送系统和与流体输送系统流体连通的色谱柱的微流体色谱装置及其制造和使用方法。优选地，色谱柱包括OTLC，PCLC或其组合。

6. 发明授权

US11253052B2 Electrical toothbrush head in secure contact engagement with vibration core 有权
公开(公告)号：US11253052B2
公开(公告)日：2022-02-22
申请号：US17478914
申请日：2021-09-18
申请人： Jiang Huang
发明人： Jiang Huang
IPC分类号： A61C17/22 , A46B5/00 , A46B9/04 , A46B13/02 , A61C17/34
摘要： An electrical toothbrush head includes a toothbrush body and an insertion piece that includes a core channel and a sideway slot in which an elastic bar is arranged. The core channel has a contact engagement surface. The elastic bar has a curved section. When the vibration core is inserted into the core channel, the contact engagement surface and the curved section respectively contact and engage with core side surfaces of the vibration core, and the elastic bar is pushed to elastically deform away from the contact engagement surface. When the electrical toothbrush head and the toothbrush handle are combined, the vibration core is clamped between the contact engagement surface and the curved section and the elastic bar deforms outward and the elastic filler block is compressed, such that the elastic filler block and the elastic bar cause the curved section to be in elastic engagement with the vibration core.

7. 发明申请

US20090142236A1 Microfluidic Devices and Methods of Using Same 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US20090142236A1
公开(公告)日：2009-06-04
申请号：US11929660
申请日：2007-10-30
申请人： Marc Unger , Jiang Huang , Emerson Quan
发明人： Marc Unger , Jiang Huang , Emerson Quan
IPC分类号： B01J19/00
CPC分类号： B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , C12Q1/686
摘要： An M.times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
摘要翻译：一种用于执行反应矩阵的M.times.N矩阵微流体装置，该装置具有多个反应池，其通过形成在装置的弹性体块内的通孔与样品入口或试剂入口之一连通。提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

8. 发明授权

US07476363B2 Microfluidic devices and methods of using same 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US07476363B2
公开(公告)日：2009-01-13
申请号：US10837885
申请日：2004-05-02
申请人： Marc Unger , Jiang Huang , Emerson Quan
发明人： Marc Unger , Jiang Huang , Emerson Quan
IPC分类号： B01L3/00
CPC分类号： B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , C12Q1/686
摘要： An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
摘要翻译：一种用于执行反应矩阵的MxN矩阵微流体装置，所述装置具有多个反应池，其通过形成在所述装置的弹性体块内的通孔与样品入口或试剂入口之一连通。提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

9. 发明授权

US07368163B2 Polymer surface modification 有权
标题翻译：聚合物表面改性
公开(公告)号：US07368163B2
公开(公告)日：2008-05-06
申请号：US11304316
申请日：2005-12-14
申请人： Jiang Huang , Shoujun Xiao , Marc A. Unger
发明人： Jiang Huang , Shoujun Xiao , Marc A. Unger
IPC分类号： B32B3/26 , B32B9/04
CPC分类号： B32B3/26 , B01J20/285 , B01J20/286 , B01J20/327 , B01J20/3272 , B01J2220/54 , B01L3/502707 , B01L2200/12 , B01L2300/16 , B01L2300/163 , C08F257/02 , C08F263/04 , C08F265/04 , C08F279/02 , C08F287/00 , C08F291/00 , C08J5/12 , C08J7/12 , F04B43/043 , Y10T428/139 , Y10T428/1393 , Y10T428/24661 , Y10T428/24744 , Y10T428/249953 , Y10T428/249958 , Y10T428/249978 , Y10T428/31663 , Y10T428/31667
摘要： The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.
摘要翻译：本发明涉及包含与表面改性化合物共价结合的表面的表面改性聚合物。通过聚合物中存在的固有官能团和表面改性化合物的官能团之间的反应可以实现聚合物与表面改性化合物之间的共价键的形成。通过使用具有固有官能团的聚合物，避免了单独的表面活化步骤。

10. 发明授权

US07251222B2 Procedures for merging the mediation device protocol with a network layer protocol 有权
标题翻译：将中介设备协议与网络层协议合并的过程
公开(公告)号：US07251222B2
公开(公告)日：2007-07-31
申请号：US10022935
申请日：2001-12-18
申请人： Priscilla Chen , Masahiro Maeda , Edgar H. Callaway, Jr. , Monique Bourgeois , Yan Huang , Jiang Huang , Qicai Shi
发明人： Priscilla Chen , Masahiro Maeda , Edgar H. Callaway, Jr. , Monique Bourgeois , Yan Huang , Jiang Huang , Qicai Shi
IPC分类号： H04L12/28 , H04J3/16 , G06F15/16
CPC分类号： H04L61/2038 , H04J3/0638 , H04L29/12254 , H04L45/02 , H04L45/026 , H04L45/26
摘要： A process for merging and using the Mediation Device Protocol with a network layer protocol. Under the merged protocol, each device joining a network enters into two stages: the Set-Up Stage and the Normal Operational Stage. During the Set-Up Stage, the device identifies its neighbors, builds a neighborhood list, obtains a Logical ID, and picks a parent node in the network. After the Set-Up Stage is complete, the device enters the Normal Operational Stage where it will send/receive control and data messages, invite and help new nodes to join the network, recover from broken links or topology changes, and other normal network operations.
摘要翻译：用于将中介设备协议与网络层协议合并和使用的过程。在合并协议下，加入网络的每个设备分为两个阶段：安装阶段和正常运行阶段。在设置阶段，设备识别其邻居，建立邻居列表，获取逻辑ID，并选择网络中的父节点。设置阶段完成后，设备进入正常操作阶段，发送/接收控制和数据消息，邀请和帮助新节点加入网络，从断链或拓扑变化恢复，以及其他正常的网络操作。

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