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1. 发明申请

US20110143949A1 ANALYSIS USING MICROFLUIDIC PARTITIONING DEVICES 审中-公开
标题翻译：使用微流化分离装置的分析
公开(公告)号：US20110143949A1
公开(公告)日：2011-06-16
申请号：US12945506
申请日：2010-11-12
申请人： Christian A. HEID , Antoine Daridon
发明人： Christian A. HEID , Antoine Daridon
IPC分类号： C40B30/00 , C12Q1/68 , C12Q1/02 , C12M1/34
CPC分类号： B01L3/5027 , B01L7/52 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0487 , B01L2400/0655 , C12Q1/686 , C12Q2525/155 , C12Q2525/301
摘要： The invention relates to methods, reagents and devices for detection and characterization of nucleic acids, cells, and other biological samples. Assay method are provided in which a sample is partitioned into sub-samples, and analysis of the contents of the sub-samples carried out. The invention also provides microfluidic devices for conducting the assay. The invention also provides an analysis method using a universal primers and probes for amplification and detection.
摘要翻译：本发明涉及核酸，细胞和其他生物样品的检测和表征的方法，试剂和装置。提供了将样品分割成子样品并进行子样品的内容的分析的测定方法。本发明还提供用于进行测定的微流体装置。本发明还提供了使用通用引物和探针进行扩增和检测的分析方法。

2. 发明授权

US09364829B2 Analysis using microfluidic partitioning devices 有权
标题翻译：使用微流体分配装置进行分析
公开(公告)号：US09364829B2
公开(公告)日：2016-06-14
申请号：US12945483
申请日：2010-11-12
申请人： Christian A. Heid , Antoine Daridon
发明人： Christian A. Heid , Antoine Daridon
IPC分类号： B01L3/00 , C12Q1/68 , B01L7/00
CPC分类号： B01L3/5027 , B01L7/52 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0487 , B01L2400/0655 , C12Q1/686 , C12Q2525/155 , C12Q2525/301
摘要： The invention relates to methods, reagents and devices for detection and characterization of nucleic acids, cells, and other biological samples. Assay method are provided in which a sample is partitioned into sub-samples, and analysis of the contents of the sub-samples carried out. The invention also provides microfluidic devices for conducting the assay. The invention also provides an analysis method using a universal primers and probes for amplification and detection.
摘要翻译：本发明涉及核酸，细胞和其他生物样品的检测和表征的方法，试剂和装置。提供了将样品分割成子样品并进行子样品的内容的分析的测定方法。本发明还提供用于进行测定的微流体装置。本发明还提供了使用通用引物和探针进行扩增和检测的分析方法。

3. 发明申请

US20090317798A1 ANALYSIS USING MICROFLUIDIC PARTITIONING DEVICES 审中-公开
标题翻译：使用微流化分离装置的分析
公开(公告)号：US20090317798A1
公开(公告)日：2009-12-24
申请号：US11916025
申请日：2006-06-02
申请人： Christian A. Heid , Antoine Daridon
发明人： Christian A. Heid , Antoine Daridon
IPC分类号： C12Q1/68
CPC分类号： B01L3/5027 , B01L7/52 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0487 , B01L2400/0655 , C12Q1/686 , C12Q2525/155 , C12Q2525/301
摘要： The invention relates to methods, reagents and devices for detection and characterization of nucleic acids, cells, and other biological samples. Assay method are provided in which a sample is partitioned into sub-samples, and analysis of the contents of the sub-samples carried out. The invention also provides microfluidic devices for conducting the assay. The invention also provides an analysis method using a universal primers and probes for amplification and detection.
摘要翻译：本发明涉及核酸，细胞和其他生物样品的检测和表征的方法，试剂和装置。提供了将样品分割成子样品并进行子样品的内容的分析的测定方法。本发明还提供用于进行测定的微流体装置。本发明还提供了使用通用引物和探针进行扩增和检测的分析方法。

4. 发明申请

US20110129841A1 ANALYSIS USING MICROFLUIDIC PARTITIONING DEVICES 审中-公开
公开(公告)号：US20110129841A1
公开(公告)日：2011-06-02
申请号：US12945483
申请日：2010-11-12
申请人： Christian A. Heid , Antoine Daridon
发明人： Christian A. Heid , Antoine Daridon
IPC分类号： C12Q1/68 , C12Q1/02 , B01L3/00
CPC分类号： B01L3/5027 , B01L7/52 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0487 , B01L2400/0655 , C12Q1/686 , C12Q2525/155 , C12Q2525/301
摘要： The invention relates to methods, reagents and devices for detection and characterization of nucleic acids, cells, and other biological samples. Assay method are provided in which a sample is partitioned into sub-samples, and analysis of the contents of the sub-samples carried out. The invention also provides microfluidic devices for conducting the assay. The invention also provides an analysis method using a universal primers and probes for amplification and detection.

5. 发明授权

US08658418B2 Microfluidic particle-analysis systems 有权
标题翻译：微流控粒子分析系统
公开(公告)号：US08658418B2
公开(公告)日：2014-02-25
申请号：US12501982
申请日：2009-07-13
申请人： Antoine Daridon
发明人： Antoine Daridon
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： C12M1/34 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/06 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/088 , B01L2300/0887 , B01L2300/0893 , B01L2300/123 , B01L2400/0409 , B01L2400/0415 , B01L2400/0481 , B01L2400/0622 , B01L2400/0655 , C12M21/06 , C12M23/16 , G01N15/1484 , G01N33/4833 , G01N2015/008 , G01N2015/0288 , G01N2015/149 , G01N2015/1493 , G02B21/32
摘要： The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analysis. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analysis, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
摘要翻译：本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置，方法和试剂盒的系统。本发明提供了用于微粒操作和/或分析颗粒例如细胞，病毒，细胞器，珠粒和/或囊泡的装置，方法和试剂盒的系统。本发明还提供了用于进行这些操作和分析的微流体机构。这些机制可以实现颗粒的控制输入，运动/定位，保留/定位，处理，测量，释放和/或输出。此外，这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。因此，这些组合可以允许将粒子分类，培养，混合，处理和/或测定为单粒子，粒子的混合组，粒子阵列，非均匀粒子组和/或均匀粒子组，其中其他，串联和/或并行。此外，这些组合可以使微流体系统能够重复使用。此外，这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。因此，本发明的系统可以允许广泛范围的细胞和颗粒测定，例如药物筛选，细胞特征化，研究研究和/或临床分析等等，以缩小至微流体大小。这种按比例缩小的测定可能使用较少的样品和试剂，可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。

6. 发明申请

US20100120077A1 MICROFLUIDIC PARTICLE-ANALYSIS SYSTEMS 有权
标题翻译：微流化粒子分析系统
公开(公告)号：US20100120077A1
公开(公告)日：2010-05-13
申请号：US12501982
申请日：2009-07-13
申请人： Antoine Daridon
发明人： Antoine Daridon
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： C12M1/34 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/06 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/088 , B01L2300/0887 , B01L2300/0893 , B01L2300/123 , B01L2400/0409 , B01L2400/0415 , B01L2400/0481 , B01L2400/0622 , B01L2400/0655 , C12M21/06 , C12M23/16 , G01N15/1484 , G01N33/4833 , G01N2015/008 , G01N2015/0288 , G01N2015/149 , G01N2015/1493 , G02B21/32
摘要： The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
摘要翻译：本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置，方法和试剂盒的系统。本发明提供了用于微粒操作和/或分析颗粒例如细胞，病毒，细胞器，珠粒和/或囊泡的装置，方法和试剂盒的系统。本发明还提供用于进行这些操作和分析的微流体机理。这些机制可以实现颗粒的控制输入，运动/定位，保留/定位，处理，测量，释放和/或输出。此外，这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。因此，这些组合可以允许将粒子分类，培养，混合，处理和/或测定为单粒子，粒子的混合组，粒子阵列，非均匀粒子组和/或均匀粒子组，其中其他，串联和/或并行。此外，这些组合可以使微流体系统能够重复使用。此外，这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。因此，本发明的系统可以允许广泛范围的细胞和颗粒测定，例如药物筛选，细胞特征化，研究研究和/或临床分析等，以缩小到微流体大小。这种按比例缩小的测定可能使用较少的样品和试剂，可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。

7. 发明申请

US20070138076A1 Devices and methods for microfluidic chromatography 审中-公开
标题翻译：微流体色谱的装置和方法
公开(公告)号：US20070138076A1
公开(公告)日：2007-06-21
申请号：US11305833
申请日：2005-12-16
申请人： Antoine Daridon , Jiang Huang , Oai Phi , Andy May
发明人： Antoine Daridon , Jiang Huang , Oai Phi , Andy May
IPC分类号： B01D15/08
CPC分类号： G01N30/6004 , B01D15/14 , B01D15/18 , G01N30/6026 , G01N30/603 , G01N30/6047 , G01N30/6095 , G01N30/72
摘要： Embodiments of the invention provide devices, methods and systems for performing microfluidic chromatography. Particular embodiments provide microfluidic chromatography column devices which can perform chemical separation using small sample volumes and low pressure differentials across the column. One embodiment provides a microfluidic chromatography column device comprising a first, second and third capillary tube. A chromatographic packing is disposed in the second tube with a first and second support layer disposed on opposite ends of the second tube. The support layers are disposed in a substantially flat orientation within the tube. An external coupling joins the tubes such that the tubes are fluidically sealed. The device is configured to have a fluidic resistance such that a pressure differential across the column of less than about 10 psi produces a flow rate through the device of at least about 0.5 ml/min for a liquid solution.
摘要翻译：本发明的实施方案提供用于进行微流体色谱的装置，方法和系统。具体实施方案提供了可以使用小样品体积和穿过该柱的低压差进行化学分离的微流体色谱柱装置。一个实施方案提供了包含第一，第二和第三毛细管的微流体色谱柱装置。色谱填料设置在第二管中，第一和第二支撑层设置在第二管的相对端上。支撑层在管内以基本平坦的方向设置。外部联接器连接管子，使得管子是流体密封的。该装置被配置为具有流体阻力，使得小于约10psi的柱上的压力差产生液体溶液通过装置的流速为至少约0.5ml / min。

8. 发明授权

US08105824B2 Integrated chip carriers with thermocycler interfaces and methods of using the same 有权
标题翻译：具有热循环器接口的集成芯片载体及其使用方法
公开(公告)号：US08105824B2
公开(公告)日：2012-01-31
申请号：US12987787
申请日：2011-01-10
申请人： Geoffrey Facer , Robert Grossman , Marc Unger , Phillip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
发明人： Geoffrey Facer , Robert Grossman , Marc Unger , Phillip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M1/00 , B01J2219/00317 , B01J2219/00495 , B01L3/0293 , B01L3/06 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/5635 , B01L3/565 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0816 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , C30B7/00 , C30B29/58 , Y10T29/49826 , Y10T436/25
摘要： Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
摘要翻译：提供方法和系统用于在选定的温度或时间范围内进行反应。提供阵列装置。阵列装置包含单独的反应室，并且由多层形成为弹性体块。至少一个层具有至少一个凹部，该凹部具有至少一个与该凹部一体的可偏转膜。阵列装置具有靠近至少一个反应室的热转印装置。热转印装置形成为接触热控制源。用于进行所需反应的试剂被引入阵列装置。阵列装置与热控制装置接触，使得热控制装置与热控制源热连通，使得至少一个反应室中的反应温度由于温度变化而改变的热控制源。

9. 发明申请

US20070196912A1 INTEGRATED CHIP CARRIERS WITH THERMOCYCLER INTERFACES AND METHODS OF USING THE SAME 有权
标题翻译：具有热交换器接口的集成芯片载体及其使用方法
公开(公告)号：US20070196912A1
公开(公告)日：2007-08-23
申请号：US11740735
申请日：2007-04-26
申请人： Geoffrey Facer , Robert Grossman , Marc Unger , Philip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
发明人： Geoffrey Facer , Robert Grossman , Marc Unger , Philip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
IPC分类号： C12M1/34
CPC分类号： C12M1/00 , B01J2219/00317 , B01J2219/00495 , B01L3/0293 , B01L3/06 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/5635 , B01L3/565 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0816 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , C30B7/00 , C30B29/58 , Y10T29/49826 , Y10T436/25
摘要： Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
摘要翻译：提供方法和系统用于在选定的温度或时间范围内进行反应。提供阵列装置。阵列装置包含单独的反应室，并且由多层形成为弹性体块。至少一个层具有至少一个凹部，该凹部具有至少一个与该凹部一体的可偏转膜。阵列装置具有靠近至少一个反应室的热转印装置。热转印装置形成为接触热控制源。用于进行所需反应的试剂被引入阵列装置。阵列装置与热控制装置接触，使得热控制装置与热控制源热连通，使得至少一个反应室中的反应温度由于温度变化而改变的热控制源。

10. 发明申请

US20050214173A1 Integrated chip carriers with thermocycler interfaces and methods of using the same 有权
标题翻译：具有热循环器接口的集成芯片载体及其使用方法
公开(公告)号：US20050214173A1
公开(公告)日：2005-09-29
申请号：US11058106
申请日：2005-02-14
申请人： Geoffrey Facer , Robert Grossman , Marc Unger , Phillip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
发明人： Geoffrey Facer , Robert Grossman , Marc Unger , Phillip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
IPC分类号： B01J19/00 , B01L3/00 , B01L3/06 , B01L9/00 , B01L99/00
CPC分类号： C12M1/00 , B01J2219/00317 , B01J2219/00495 , B01L3/0293 , B01L3/06 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/5635 , B01L3/565 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0816 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , C30B7/00 , C30B29/58 , Y10T29/49826 , Y10T436/25
摘要： Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
摘要翻译：提供方法和系统用于在选定的温度或时间范围内进行反应。提供阵列装置。阵列装置包含单独的反应室，并且由多层形成为弹性体块。至少一个层具有至少一个凹部，该凹部具有至少一个与该凹部一体的可偏转薄膜。阵列装置具有靠近至少一个反应室的热转印装置。热转印装置形成为接触热控制源。用于进行所需反应的试剂被引入阵列装置。阵列装置与热控制装置接触，使得热控制装置与热控制源热连通，使得至少一个反应室中的反应温度由于温度变化而改变的热控制源。

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