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1. 发明申请

US20190062502A1 FLOW REACTOR SYNTHESIS OF POLYMERS 审中-公开
公开(公告)号：US20190062502A1
公开(公告)日：2019-02-28
申请号：US16149867
申请日：2018-10-02
申请人： The Boeing Company
发明人： Patrick John Kinlen , Andrew M. Zweig
IPC分类号： C08G73/02 , B01J19/24 , B01J19/00 , C09D179/02
CPC分类号： C08G73/0266 , B01J19/0093 , B01J19/2415 , B01J19/242 , B01J19/2425 , B01J19/243 , B01J2219/00087 , B01J2219/00164 , B01J2219/00795 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00963 , B01J2219/24 , C09D179/02
摘要： A flow reactor system and methods having tubing useful as polymerization chamber. The flow reactor has at least one inlet and at least one mixing chamber, and an outlet. The method includes providing two phases, an aqueous phase and a non-aqueous phase and forming an emulsion for introduction into the flow reactor.

2. 发明授权

US10067249B2 Disposable radiochemistry device with radiation dose recordal 有权
公开(公告)号：US10067249B2
公开(公告)日：2018-09-04
申请号：US14653907
申请日：2013-12-20
申请人： GE Healthcare Limited
发明人： Alok M. Srivastava , Victor Samper , Stefan Riese
IPC分类号： B01J19/00 , B01J19/24 , G01T1/10 , G01T7/00
CPC分类号： G01T7/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00927 , B01J2219/00954 , B01J2219/00968 , G01T1/10
摘要： Radiation-sensitive material embedded in a disposable radiochemistry device gives the device the additional capability of recording radiation dose, for readout at a later time. There is provided a device comprising means for the introduction of a precursor compound, means for the introduction of a radionuclide, a reaction vessel for reacting said precursor compound and said suitable source of a radionuclide to obtain a radiolabelled compound, and one or more pieces of radiation-sensitive material embedded into said device wherein at least one of said pieces is positioned to be exposed to radioactivity associated with said radiolabelled compound.

3. 发明授权

US09802767B2 Multilayer hydrodynamic sheath flow structure 有权
公开(公告)号：US09802767B2
公开(公告)日：2017-10-31
申请号：US15269556
申请日：2016-09-19
申请人： CYTONOME/ST, LLC
发明人： John R. Gilbert , Manish Deshpande , Bernard Bunner
IPC分类号： B01F13/00 , B65G51/08 , B01L3/00 , G01N15/14 , B65G51/00
CPC分类号： B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

4. 发明授权

US09694339B2 Chemical synthesis device and method for manufacturing chemical synthesis device 有权
公开(公告)号：US09694339B2
公开(公告)日：2017-07-04
申请号：US14742865
申请日：2015-06-18
申请人： SEIKO EPSON CORPORATION
发明人： Takashi Miyata
IPC分类号： B01J19/00 , B01J19/24 , B32B37/00 , B32B37/12 , B32B37/14 , B32B37/24
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00804 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00842 , B01J2219/00873 , B01J2219/00894 , B32B37/12 , B32B2037/243 , B32B2037/246 , B32B2315/08 , B32B2535/00
摘要： A chemical synthesis device that can easily control the temperature of a fluid in a channel is provided. An embodiment of a chemical synthesis device according to the invention includes a substrate provided with a first channel in which a plurality of fluids are subjected to a chemical synthesis and a second channel for controlling a temperature of the fluids flowing through the first channel.

5. 发明授权

US09573803B2 Assembly of flat on structured glass layers 有权
标题翻译：平面结构化玻璃层的组装
公开(公告)号：US09573803B2
公开(公告)日：2017-02-21
申请号：US13522388
申请日：2011-01-28
申请人： Antoine Gaston Denis Bisson , Thierry Luc Alain Dannoux , Anne Paris
发明人： Antoine Gaston Denis Bisson , Thierry Luc Alain Dannoux , Anne Paris
IPC分类号： B01J19/00 , B81C1/00
CPC分类号： B81C1/00119 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/0086 , B01J2219/00873 , B81B2201/058 , B81C2201/019
摘要： A microfluidic device (100) made from glass, ceramic or vitroceramic, comprises an upper layer (122), a lower layer (124) and an intermediate layer (114), the intermediate layer (114) comprising an upper face (114b) and a lower face (114a), the lower face (114a) comprising a first open structured surface defining a first microfluidic channel (126) and the upper face (114b) comprising a second open structured surface defining a second microfluidic channel (112); the lower surface of the intermediate layer (114) cooperating with a first planar layer closing the first microchannel (126); the upper face (114b) of the intermediate layer (114) cooperating with a second planar layer (130), closing the second microfluidic channel (112) in a sealed manner, and the second planar layer constituting an intermediate layer (130) which cooperates, on its face opposite the intermediate layer (114), with another layer (122) comprising on its inner face (122a) a structured surface defining a third microfluidic channel (128).
摘要翻译：由玻璃，陶瓷或陶瓷制成的微流体装置（100）包括上层（122），下层（124）和中间层（114），中间层（114）包括上表面（114b）和下表面（114a），所述下表面（114a）包括限定第一微流体通道（126）的第一开放结构化表面，并且所述上表面（114b）包括限定第二微流体通道（112）的第二开放结构化表面; 中间层（114）的下表面与闭合第一微通道（126）的第一平面层协作; 所述中间层（114）的上表面（114b）与第二平面层（130）配合，密封地封闭所述第二微流体通道（112），所述第二平面层构成中间层（130），所述中间层在其与中间层（114）相对的表面上，另一层（122）在其内表面（122a）上包括限定第三微流体通道（128）的结构化表面。

6. 发明授权

US09566558B2 Device for manipulation of packets in micro-containers, in particular in microchannels 有权
标题翻译：用于操纵微型容器中的包装的装置，特别是在微通道中
公开(公告)号：US09566558B2
公开(公告)日：2017-02-14
申请号：US11662362
申请日：2005-09-09
申请人： Jean-Louis Viovy , Max Chabert , Kevin Dorfman
发明人： Jean-Louis Viovy , Max Chabert , Kevin Dorfman
IPC分类号： C12M1/00 , C12Q1/68 , C02F1/40 , G01N15/06 , G01N33/48 , G01N27/00 , B01F13/00 , B01J19/00 , B01L3/00 , F04B19/00 , G01N35/08 , B01L7/00 , G01N15/00 , G01N35/10
CPC分类号： B01L3/502784 , B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0097 , B01L3/5027 , B01L3/502723 , B01L7/525 , B01L2200/0605 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/0838 , B01L2300/1816 , B01L2300/1827 , B01L2300/1894 , B01L2400/0415 , B01L2400/0427 , B01L2400/0493 , C12Q1/686 , F04B19/006 , G01N35/08 , G01N2015/003 , G01N2015/0053 , G01N2035/1037
摘要： The present invention concerns a microfluidic device (1) for performing physical, chemical or biological treatment to at least one packet without contamination.
摘要翻译：本发明涉及用于对至少一个包进行物理，化学或生物处理而不被污染的微流体装置（1）。

7. 发明授权

US09486757B2 Scale-up of microfluidic devices 有权
标题翻译：微流体装置放大
公开(公告)号：US09486757B2
公开(公告)日：2016-11-08
申请号：US14710223
申请日：2015-05-12
申请人： President and Fellows of Harvard College
发明人： Mark Romanowsky , Adam R. Abate , David A. Weitz
IPC分类号： G01N1/10 , B01L3/00 , B01F13/00 , B01F3/08 , B01J19/00
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F2215/0037 , B01J19/0093 , B01J2219/00015 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00889 , B01J2219/00891 , B01J2219/0097 , B01J2219/00975 , B01L3/502784 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , Y10T137/0318 , Y10T137/8593
摘要： Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.
摘要翻译：描述了用于在流体中聚焦和/或形成相似或不同尺寸的不连续部分的微流体方法和装置的并行使用。在一些方面，本发明一般涉及流动聚焦型技术，还涉及微流体，更具体地说，并行使用布置成控制分散剂内的分散相的微流体系统，以及尺寸和尺寸分布分散相在多相流体系统中，以及用于将流体组分输送到多个这样的装置的系统。

8. 发明授权

US09464029B2 Method for producing nitroalkanes in a microstructured reactor 有权
标题翻译：在微结构反应器中生产硝基烷烃的方法
公开(公告)号：US09464029B2
公开(公告)日：2016-10-11
申请号：US14768391
申请日：2014-04-25
申请人： BASF SE
发明人： Ralf Boehling , Michael Hayer , Alwin Rehfinger , Michael Schelper , Johann-Peter Melder , Martin Ernst , Joaquim Henrique Teles
IPC分类号： C07C205/00 , C07C201/08 , B01J19/00
CPC分类号： C07C201/08 , B01J19/0093 , B01J2219/00792 , B01J2219/00795 , B01J2219/00824 , B01J2219/00826 , B01J2219/00831 , B01J2219/00835 , B01J2219/00842 , B01J2219/0086 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , Y02P20/582 , C07C205/02
摘要： The invention relates to a process for preparing nitroalkanes by reaction of at least one alkane with at least one nitrating agent in the gas phase, wherein the nitration is carried out in a microstructured reaction zone having parallel channels having hydraulic diameters of less than 2.5 mm and a total specific internal surface area of more than 1600 m2/m3 and the alkane and the nitrating agent are conveyed under a pressure of from 1 bar to 20 bar through the reaction zone and reacted at a temperature of from 150° C. to 650° C. and the reaction products are cooled downstream of the reaction zone and discharged and the at least one nitrating agent is introduced over from two to ten introduction points along the reaction zone.
摘要翻译：本发明涉及通过在气相中至少一种烷烃与至少一种硝化剂反应来制备硝基烷烃的方法，其中硝化在具有水力直径小于2.5mm的平行通道的微结构反应区中进行，以及超过1600m 2 / m 3的总比表面积和烷烃和硝化剂在1巴-20巴的压力下通过反应区输送，并在150℃至650℃的温度下反应并且反应产物在反应区的下游冷却并排出，并且将至少一种硝化剂沿着反应区引入二至十个引入点。

9. 发明授权

US09453165B2 Fischer-tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor 有权
标题翻译：使用微通道技术的费 - 托合成和新型催化剂和微通道反应器
公开(公告)号：US09453165B2
公开(公告)日：2016-09-27
申请号：US14700197
申请日：2015-04-30
申请人： Velocys, Inc.
发明人： Yong Wang , Anna Lee Tonkovich , Terry Mazanec , Francis P. Daly , Dave VanderWiel , Jianli Hu , Chunshe Cao , Charles Kibby , Xiaohong Li , Michael D. Briscoe , Nathan Gano , Ya-Huei Chin
IPC分类号： C10G2/00 , B01J23/75 , B01J19/00 , B01J37/03 , B01J38/48 , B01J35/04 , C10G45/58 , C10G47/00 , B01J23/94 , B01J37/02 , B01J23/755 , B01J23/83 , B01J23/889 , B01J23/89 , B01J35/00 , B01J35/10 , C10G21/00 , C10L1/08 , C10M105/04 , B01J38/58
CPC分类号： C10G2/332 , B01J19/0093 , B01J23/75 , B01J23/755 , B01J23/83 , B01J23/8896 , B01J23/8913 , B01J23/892 , B01J23/894 , B01J23/8986 , B01J23/94 , B01J35/0066 , B01J35/04 , B01J35/1019 , B01J35/1038 , B01J37/0201 , B01J37/0205 , B01J37/038 , B01J38/48 , B01J38/58 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00831 , B01J2219/00835 , B01J2219/00855 , B01J2219/0086 , B01J2219/00873 , C10G2/331 , C10G2/334 , C10G2/34 , C10G2/341 , C10G21/00 , C10G45/58 , C10G47/00 , C10G2300/1022 , C10G2400/04 , C10G2400/10 , C10L1/08 , C10L2200/0492 , C10L2270/026 , C10L2290/42 , C10L2290/544 , C10M105/04 , Y02P20/582
摘要： A process for converting a reactant composition comprising H2 and CO to a product comprising at least one aliphatic hydrocarbon having at least about 5 carbon atoms comprises: flowing the reactant composition through a microchannel reactor in contact with a Fischer-Tropsch catalyst to convert the reactant composition to the product, the microchannel reactor comprising a plurality of process microchannels containing the catalyst; transferring heat from the process microchannels to a heat exchanger; and removing the product from the microchannel reactor; the process producing at least about 0.5 gram of aliphatic hydrocarbon having at least about 5 carbon atoms per gram of catalyst per hour; the selectivity to methane in the product being less than about 25%. A supported catalyst comprises Co, and a microchannel reactor comprises at least one process microchannel and at least one adjacent heat exchange zone.
摘要翻译：将包含H 2和CO的反应物组合物转化为包含至少一种具有至少约5个碳原子的脂族烃的产物的方法包括：使反应物组合物流过与费 - 托催化剂接触的微通道反应器，以将反应物组合物所述微通道反应器包括含有所述催化剂的多个工艺微通道; 将热量从工艺微通道传递到热交换器; 并从微通道反应器中除去产物; 该方法每小时产生至少约0.5克具有至少约5个碳原子的每克催化剂的脂族烃; 产品中甲烷的选择性小于约25％。载体催化剂包括Co，微通道反应器包括至少一个工艺微通道和至少一个相邻的热交换区域。

10. 发明授权

US09421284B2 Biomolecule labeling reaction container, and reactor and reaction method using the same 有权
标题翻译：生物分子标记反应容器，反应器及反应方法使用
公开(公告)号：US09421284B2
公开(公告)日：2016-08-23
申请号：US14235005
申请日：2012-12-26
申请人： Hitachi, Ltd.
发明人： Nami Sugita , Naomi Manri , Wataru Takeuchi , Yuichi Morimoto , Hiroko Hanzawa
IPC分类号： B01J19/24 , A61K51/08 , B01J19/00 , B01L3/00 , B01F13/00 , C07B59/00
CPC分类号： A61K51/088 , B01F13/0062 , B01F13/0066 , B01J19/0006 , B01J19/0093 , B01J19/24 , B01J2219/00049 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00842 , B01J2219/00873 , B01J2219/0088 , B01J2219/00889 , B01J2219/00891 , B01J2219/00905 , B01J2219/00957 , B01J2219/00961 , B01J2219/00963 , B01J2219/00986 , B01J2219/24 , B01L3/5027 , B01L3/502715 , B01L2300/069 , B01L2300/0816 , B01L2300/0887 , C07B59/00 , Y10T436/12
摘要： A reaction container in which to mix a first chemical compound with a second chemical compound has a main body and a lid member formed oppositely on a top face side of the main body; a flow channel on the top face of the main body; and a labeling agent solidification section at an intermediate section of the flow channel to remove a solvent in a solution of the second chemical compound and solidify the second chemical compound. First and second chemical compound supply sections and a mixture discharge section are formed on the upstream and downstream sides of the labeling agent solidification section, respectively. The reactor is provided with a liquid sending unit to supply the first and second chemical compounds and reciprocally send a solution of the first chemical compound to an upper part of the second chemical compound solidified at the solidification section.
摘要翻译：将第一化合物与第二化合物混合的反应容器具有主体和在主体的顶面相对地形成的盖部件; 主体顶面上的流路; 以及在流路的中间部分处的标记剂固化部分，以除去第二化合物的溶液中的溶剂并固化第二化合物。分别在标签试剂凝固部的上游侧和下游侧形成第一和第二化合物供给部和混合物排出部。反应器设有一个送液单元，用于供应第一和第二化合物，并将第一化合物的溶液往凝固段固化的第二化合物的上部相互转移。

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