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1. 发明授权

US06017496A Matrices with memories and uses thereof 失效
公开(公告)号：US06017496A
公开(公告)日：2000-01-25
申请号：US709435
申请日：1996-09-06
申请人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
发明人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07H21/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , G01N15/06 , G01N33/48 , G01N35/02 , G01N35/04
CPC分类号： G11C13/0019 , B01J19/0046 , B01L3/50825 , B01L3/5453 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/04 , C07K1/047 , G01N35/00732 , G01N35/00871 , G11C13/0014 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/022 , B01L2300/0609 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

2. 发明授权

US5961923A Matrices with memories and uses thereof 失效
公开(公告)号：US5961923A
公开(公告)日：1999-10-05
申请号：US723423
申请日：1996-09-30
申请人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
发明人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07H21/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , G01N33/48 , G01N21/01 , G01N33/544 , G06G7/58
CPC分类号： G01N35/00732 , B01J19/0046 , B01L3/50825 , B01L3/5453 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/047 , G01N35/00871 , G11C13/0014 , G11C13/0019 , G11C13/02 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0609 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

3. 发明授权

US06329139B1 Automated sorting system for matrices with memory 失效
标题翻译：具有存储器的矩阵的自动排序系统
公开(公告)号：US06329139B1
公开(公告)日：2001-12-11
申请号：US08912998
申请日：1997-08-11
申请人： Michael P. Nova , John E. Lillig , Kanchana Sanjaya Gunesekera Karunaratne , William Ewing , Yozo Satoda , Hanan Potash
发明人： Michael P. Nova , John E. Lillig , Kanchana Sanjaya Gunesekera Karunaratne , William Ewing , Yozo Satoda , Hanan Potash
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00319 , B01J2219/00333 , B01J2219/00344 , B01J2219/00454 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/50255 , B01L3/50825 , B01L3/5453 , B01L2300/022 , B01L2300/0609 , B01L2400/0655 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/04 , C07K1/047 , C08J7/16 , C08J2327/12 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/542 , G01N33/54353 , G01N33/54393 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/0014 , G11C13/025 , G11C2213/81
摘要： Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide a means for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microvessels, which contain memories, an automated or semi-automated synthesizer, a microvessel washer/dryer, a manual or automated cleaver for removing compounds from the matrix with memory microvessels, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodabie during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.
摘要翻译：自动药物发现协议或部分自动化协议，其中具有记忆的矩阵作为执行所有操作的平台，或者当作为合成化合物被处理和筛选时被传送到其他存储器的信息库。还提供了用于协议的自动化药物发现单元。这些单元为无缝数据跟踪提供了一种手段，其中包括仪器和样品瓶，用于将信息传输到单元中的其他存储器。这里提供的单元包括以下部分或全部：自动或手动分拣机，包含记忆的微血管，自动或半自动合成器，微血清洗涤器/干燥器，用于去除化合物的手动或自动切割器从具有记忆微血管的矩阵和相关联的软件。存储器可以是任何类型的存储器，包括电磁编码存储器和光存储器，或其组合。存储器可以被预编码，或者可以在处理期间，之后或之前编码。还提供了用于使用存储器排序矩阵的手动和自动化方法。

4. 发明授权

US6136274A Matrices with memories in automated drug discovery and units therefor 失效
标题翻译：具有自动化药物发现和单位记忆的矩阵
公开(公告)号：US6136274A
公开(公告)日：2000-10-24
申请号：US958254
申请日：1997-10-07
申请人： Michael P. Nova , John E. Lillig , Kanchana Sanjaya Gunesekera Karunaratne , Donald O'Neil , William Ewing , Yozo Satoda
发明人： Michael P. Nova , John E. Lillig , Kanchana Sanjaya Gunesekera Karunaratne , Donald O'Neil , William Ewing , Yozo Satoda
IPC分类号： B01J19/00 , C07K1/04 , C08J7/16 , C40B50/14 , C40B60/14 , C40B70/00 , G01N15/14 , G01N33/542 , G01N33/543 , G11C13/02 , B01L3/00
CPC分类号： G01N33/54393 , B01J19/0046 , B82Y10/00 , C07K1/047 , C08J7/16 , G01N33/542 , G01N33/54353 , G11C13/0014 , G11C13/0019 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00319 , B01J2219/00344 , B01J2219/00454 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00542 , B01J2219/00547 , B01J2219/00567 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01L2300/0609 , C08J2327/12 , C40B50/14 , C40B60/14 , C40B70/00 , G01N2015/149 , G11C13/025 , G11C2213/81
摘要： Automated drug discovery protocols, or partially automated protocols, in which matrices-with-memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microreactors and microvessels, which contain memories, an automated or semi-automated synthesizer, a microreactor washer/dryer, a manual or automated cleaver with a valved U-tube outlet for removing compounds from the matrix-with-memory microreactors, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodable during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.
摘要翻译：自动药物发现协议或部分自动化协议，其中矩阵与存储器作为执行所有操作的平台，或者当作为合成化合物被处理和筛选时被传送到其他存储器的信息库。还提供了用于协议的自动化药物发现单元。这些单元提供无缝数据跟踪，并包括仪器和样品瓶，具有将信息传输到单元中其他存储器的存储器。这里提供的单元包括以下部分或全部：自动或手动分拣机，微反应器和微血管，其包含记忆，自动或半自动合成器，微反应器洗涤器/干燥器，手动或自动切割器，具有用于从具有存储器的基质微反应器中除去化合物的带有阀的U形管出口以及相关的软件。存储器可以是任何类型的存储器，包括电磁编码存储器和光存储器，或其组合。存储器可以是预编码的，或者可以在处理期间，之后或之前编码。还提供了用于使用存储器排序矩阵的手动和自动化方法。

5. 发明申请

US20150377374A1 CRYOGENIC VALVE 有权
标题翻译：低温阀
公开(公告)号：US20150377374A1
公开(公告)日：2015-12-31
申请号：US14766709
申请日：2014-01-23
申请人： Yozo SATODA
发明人： Yozo Satoda
IPC分类号： F16K27/10 , F16K27/02 , F16K31/06 , F16K1/14
CPC分类号： F16K27/102 , F16K1/14 , F16K27/029 , F16K31/0651 , F16K31/0665 , Y10T137/7036 , Y10T137/86759
摘要： A cryogenic valve includes a first port and a second port, a valve body, a valve stem, a sealing member, a valve element and a housing. The valve body includes a valve seat defining a fluid orifice in fluid communication with the first port. The valve stem is configured to engage with the valve body, wherein at least one of the valve stem and valve body form an inner valve cavity. The valve element is positioned within the inner valve cavity. The valve element is also configured to bias the sealing member against the orifice to substantially block flow through the orifice and the first port. The bias is controlled in response to control of the valve element by a valve actuator. A channel is configured to allow fluid flow through at least one of the valve stem and valve element along a longitudinal axis. A housing is configured to substantially seal and enclose at least a portion of the valve body and valve stem. The housing forms an inner housing cavity configured to thermally isolate the exterior of the valve body and valve stem from the housing.
摘要翻译：低温阀包括第一端口和第二端口，阀体，阀杆，密封构件，阀元件和壳体。阀体包括限定与第一端口流体连通的流体孔口的阀座。阀杆构造成与阀体接合，其中阀杆和阀体中的至少一个形成内阀腔。阀元件位于内阀腔内。阀元件还构造成将密封构件偏置抵靠孔口，以基本上阻挡通过孔口和第一端口的流动。响应于通过阀致动器对阀元件的控制来控制偏压。通道构造成允许流体沿着纵向轴线流过阀杆和阀元件中的至少一个。壳体构造成基本上密封和封闭阀体和阀杆的至少一部分。壳体形成内壳体空腔，其构造成将阀体的外部和阀杆与壳体隔离。

6. 发明授权

US06441697B1 Ultra-low-loss feedthrough for microwave circuit package 有权
标题翻译：微波电路封装的超低损耗馈通
公开(公告)号：US06441697B1
公开(公告)日：2002-08-27
申请号：US09238273
申请日：1999-01-27
申请人： Paul Garland , James Kyo Long , Yozo Satoda , Chong-Il Park
发明人： Paul Garland , James Kyo Long , Yozo Satoda , Chong-Il Park
IPC分类号： H01P104
CPC分类号： H01P1/047 , H01L23/66 , H01L2223/6627 , H01L2223/6683 , H01L2924/0002 , H01L2924/00
摘要： RF feedthroughs for use with monolithic microwave integrated circuits (MMIC) are installed in environmentally protective or hermetically sealed packages that provide electromagnetic shielding. A feedthrough for an MMIC package has a dielectric substrate, a microstrip or transmission line formed on the substrate for transmitting high frequency electronic signals and a wall disposed above the transmission line and the substrate. The wall of the feedthrough has a varying thickness so that the narrowest portion of the wall is disposed on the transmission line substantially perpendicular to the substrate. The transmission line also has a varying width so that the narrowest width portion of the transmission line crosses the narrowest portion of the wall. The narrowest portion of the wall may be created by placing two oppositely facing concaved surfaces on each side of the wall. To reduce parasitic capacitance, the substrate and the wall may each have an air cavity embedded in respective bodies.
摘要翻译：用于单片微波集成电路（MMIC）的RF馈通装置安装在提供电磁屏蔽的环境保护或密封封装中。用于MMIC封装的馈通装置具有电介质基板，形成在用于传输高频电子信号的基板上的微带或传输线，以及设置在传输线和基板之上的壁。馈通的壁具有变化的厚度，使得壁的最窄部分设置在基本上垂直于衬底的传输线上。传输线还具有变化的宽度，使得传输线的最窄宽度部分与壁的最窄部分交叉。壁的最窄部分可以通过在壁的每一侧上放置两个相对的凹面来产生。为了减少寄生电容，衬底和壁可以各自具有嵌入相应体内的空气腔。

7. 发明授权

US09803768B2 Cryogenic valve 有权
公开(公告)号：US09803768B2
公开(公告)日：2017-10-31
申请号：US14766709
申请日：2014-01-23
申请人： Yozo Satoda
发明人： Yozo Satoda
IPC分类号： F16K27/10 , F16K27/02 , F16K1/14 , F16K31/06
CPC分类号： F16K27/102 , F16K1/14 , F16K27/029 , F16K31/0651 , F16K31/0665 , Y10T137/7036 , Y10T137/86759
摘要： A cryogenic valve includes a first port and a second port, a valve body, a valve stem, a sealing member, a valve element and a housing. The valve body includes a valve seat defining a fluid orifice in fluid communication with the first port. The valve stem is configured to engage with the valve body, wherein at least one of the valve stem and valve body form an inner valve cavity. The valve element is positioned within the inner valve cavity. The valve element is also configured to bias the sealing member against the orifice to substantially block flow through the orifice and the first port. The bias is controlled in response to control of the valve element by a valve actuator. A channel is configured to allow fluid flow through at least one of the valve stem and valve element along a longitudinal axis. A housing is configured to substantially seal and enclose at least a portion of the valve body and valve stem. The housing forms an inner housing cavity configured to thermally isolate the exterior of the valve body and valve stem from the housing.

8. 发明授权

US06204448B1 High frequency microwave packaging having a dielectric gap 失效
标题翻译：具有电介质间隙的高频微波封装
公开(公告)号：US06204448B1
公开(公告)日：2001-03-20
申请号：US09205903
申请日：1998-12-04
申请人： Paul Garland , James Kyo Long , Yozo Satoda , Chong-il Park
发明人： Paul Garland , James Kyo Long , Yozo Satoda , Chong-il Park
IPC分类号： H05K506
CPC分类号： H01L23/66 , H01L2223/6616 , H01L2223/6627 , H01L2924/0002 , H01L2924/09701 , H01L2924/1903 , H01L2924/3011 , H05K1/024 , H05K1/0243 , H05K9/0039 , H05K2201/0792 , H05K2201/09063 , H05K2201/10371 , H05K2201/10689 , H01L2924/00
摘要： A hermetically sealed package assembly for microwave circuits in the high microwave frequencies having a dielectric gap defined in the substrate. The package assembly comprises a substrate for carrying the circuit on a top surface, a seal ring wall carried on the top surface, a via structure provided through the substrate for transmitting high-frequency signals into and out of the package, and a conducive lead carried on the bottom surface of the substrate and passes under the seal ring wall. A dielectric gap is provided in the substrate between the seal ring wall and the lead to reduce the capacitive coupling between the lead and the wall. The gap may be a sealed cavity provided inside the substrate, or a cutout area in the substrate so that the lead is suspended in air at the location where it passes under the seal ring wall.
摘要翻译：用于在高微波频率中的微波电路的密封封装组件，其具有限定在衬底中的电介质间隙。封装组件包括用于在顶表面上承载电路的基板，承载在顶表面上的密封环壁，通过基板提供的通孔结构，用于将高频信号传输到和流出封装，以及一个有利的引线在基底的底面上，通过密封环壁。在密封环壁和引线之间的衬底中提供电介质间隙以减小引线与壁之间的电容耦合。间隙可以是设置在基板内部的密封空腔或基板中的切口区域，使得引线悬浮在其在密封环壁下方通过的位置处的空气中。

9. 发明授权

US08684036B1 Cryogenic valve 有权
标题翻译：低温阀
公开(公告)号：US08684036B1
公开(公告)日：2014-04-01
申请号：US13788240
申请日：2013-03-07
申请人： Yozo Satoda
发明人： Yozo Satoda
IPC分类号： F16K1/14 , F16K27/10 , F16K27/02
CPC分类号： F16K27/102 , F16K1/14 , F16K27/029 , F16K31/0651 , F16K31/0665 , Y10T137/7036 , Y10T137/86759
摘要： A cryogenic valve includes a first port and a second port, a valve body, a valve stem, a sealing member, a valve element and a housing. The valve body includes a valve seat defining a fluid orifice in fluid communication with the first port. The valve stem is configured to engage with the valve body, wherein at least one of the valve stem and valve body form an inner valve cavity. The valve element is positioned within the inner valve cavity. The valve element is also configured to bias the sealing member against the orifice to substantially block flow through the orifice and the first port. The bias is controlled in response to control of the valve element by a valve actuator. A channel is configured to allow fluid flow through at least one of the valve stem and valve element along a longitudinal axis. A housing is configured to substantially seal and enclose at least a portion of the valve body and valve stem. The housing forms an inner housing cavity configured to thermally isolate the exterior of the valve body and valve stem from the housing.
摘要翻译：低温阀包括第一端口和第二端口，阀体，阀杆，密封构件，阀元件和壳体。阀体包括限定与第一端口流体连通的流体孔口的阀座。阀杆构造成与阀体接合，其中阀杆和阀体中的至少一个形成内阀腔。阀元件位于内阀腔内。阀元件还构造成将密封构件偏置抵靠孔口，以基本上阻挡通过孔口和第一端口的流动。响应于通过阀致动器对阀元件的控制来控制偏压。通道构造成允许流体沿着纵向轴线流过阀杆和阀元件中的至少一个。壳体构造成基本上密封和封闭阀体和阀杆的至少一部分。壳体形成内壳体空腔，其构造成将阀体的外部和阀杆与壳体隔离。

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