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1. 发明授权

US07208172B2 Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices 失效
标题翻译：金属复合涂层，用于从可植入装置的表面输送治疗剂
公开(公告)号：US07208172B2
公开(公告)日：2007-04-24
申请号：US10701262
申请日：2003-11-03
申请人： Matthew J. Birdsall , Richard L. Klein , Nathan Maier
发明人： Matthew J. Birdsall , Richard L. Klein , Nathan Maier
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/088 , A61L2300/102 , A61L2300/104 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.
摘要翻译：公开了一种用于可植入医疗装置的金属复合涂层及其形成方法。该复合涂层包括形成在该装置的表面上的至少一个金属或金属粘结层，随后是连接层上的一个或多个附加层的化学电化学包层。一种或多种治疗或生物活性剂与至少一种无电化学电化学包层共沉积。

2. 发明申请

US20130158471A1 Dual Cannula System for Enteric Feeding 审中-公开
标题翻译：双管插管系统肠内喂养
公开(公告)号：US20130158471A1
公开(公告)日：2013-06-20
申请号：US13328971
申请日：2011-12-16
申请人： James V. Neel , Matthew J. Birdsall , Richard L. Klein
发明人： James V. Neel , Matthew J. Birdsall , Richard L. Klein
IPC分类号： A61M25/14 , A61M1/00
CPC分类号： A61J15/0003 , A61J15/0015 , A61J15/0023 , A61J15/0061 , A61J15/0069 , A61J15/0073 , A61J15/0088 , A61J15/0096 , A61M1/0084 , A61M25/0023 , A61M25/005 , A61M25/0097 , A61M25/0108 , A61M2025/0047 , A61M2025/0059 , A61M2025/0681 , A61M2210/106
摘要： A dual cannula apparatus is provided for insertion into the gastrointestinal tract. One end of a first outer cannula is placed within the small intestine providing a guide for advancement of a second inner cannula. The second inner cannula extends beyond the first outer cannula and provides a source of nutritional support and pharmacological therapy. The first outer cannula has a radiopaque tip to facilitate placement thereof under x-ray or fluoroscopic guidance. The first outer cannula can also be provided with a flared end for maintenance with the naris. The second inner cannula includes one or more openings for flow of the nutritional support or pharmacological therapy into the small intestine.
摘要翻译：提供双插管装置用于插入胃肠道。第一外套管的一端放置在小肠内，提供用于推进第二内插管的引导件。第二内插管延伸超出第一外插管，并提供营养支持和药物治疗的来源。第一外套管具有不透射线的尖端，以便于在x射线或荧光镜引导下放置它。第一外套管还可以设置有用于与鼻孔维持的喇叭口端。第二内套管包括用于将营养支持物或药理学治疗流入小肠的一个或多个开口。

3. 发明申请

US20100125323A1 Coil Stent Delivery System and Method of Use 审中-公开
标题翻译：线圈支架输送系统及使用方法
公开(公告)号：US20100125323A1
公开(公告)日：2010-05-20
申请号：US12271465
申请日：2008-11-14
申请人： Joseph Berglund , Matthew J. Birdsall , Lesley Crookall
发明人： Joseph Berglund , Matthew J. Birdsall , Lesley Crookall
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61F2/88 , A61F2/95 , A61F2002/9517 , A61F2002/9665 , A61F2220/0016
摘要： The coil stent delivery system and method of use includes a stent delivery system including a coil stent; a housing, the housing having a receiver defining a receiver chamber and a sheath defining a sheath lumen, the receiver chamber being in communication with the sheath lumen; and a screw assembly, the screw assembly having a shaft, a helical screw disposed about a distal portion of the shaft, and a drive operably coupled to the shaft. The shaft is disposed in the receiver chamber and the sheath lumen, the helical screw is disposed in the sheath, and the coil stent is disposed about the shaft in the receiver chamber and engages the helical screw. Rotation of the drive moves the coil stent through the sheath lumen.
摘要翻译：线圈支架输送系统和使用方法包括支架输送系统，其包括线圈支架; 壳体，其具有限定了接收器室的接收器和限定护套管腔的护套，所述接收器腔室与鞘管腔连通; 和螺钉组件，所述螺钉组件具有轴，设置在所述轴的远侧部分周围的螺旋形螺钉以及可操作地联接到所述轴的驱动器。轴设置在接收器腔室和护套管腔中，螺旋形螺钉设置在护套中，线圈支架围绕接收器腔室中的轴设置并与螺旋形螺钉接合。驱动器的旋转将线圈支架移动通过鞘管。

4. 发明申请

US20110008405A1 Hollow Tubular Drug Eluting Medical Devices 有权
标题翻译：中空管状药物洗脱医疗器械
公开(公告)号：US20110008405A1
公开(公告)日：2011-01-13
申请号：US12500359
申请日：2009-07-09
申请人： Matthew J. Birdsall , Christopher Storment , D.H. Perkins , Dustin Thompson
发明人： Matthew J. Birdsall , Christopher Storment , D.H. Perkins , Dustin Thompson
IPC分类号： A61L27/54 , B44C1/22
CPC分类号： A61M25/0015 , A61B2017/00526 , A61L31/022 , A61L31/16 , A61M25/0012 , A61N1/0587
摘要： A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
摘要翻译：形成中空药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。复合构件成形为图案。通过复合构件的外部构件形成开口。处理复合构件以从外部构件的内腔移除芯构件而不损害外部构件，留下已经形成为期望图案的中空管状构件。外部构件的内腔填充有治疗物质。

5. 发明申请

US20090093871A1 Medical Implant With Internal Drug Delivery System 审中-公开
标题翻译：医疗植入物与内部药物输送系统
公开(公告)号：US20090093871A1
公开(公告)日：2009-04-09
申请号：US11868742
申请日：2007-10-08
申请人： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
发明人： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2250/0068
摘要： A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.
摘要翻译：用于治疗血管状态的系统包括导管和设置在导管上的支架。支架包括具有限定中心腔和多个孔的壁的管。该系统还包括设置在管的中心腔内的治疗剂。制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔，并从中空管形成支架框架。

6. 发明申请

US20080319534A1 Stent With Improved Mechanical Properties 审中-公开
标题翻译：具有改善机械性能的支架
公开(公告)号：US20080319534A1
公开(公告)日：2008-12-25
申请号：US11767308
申请日：2007-06-22
申请人： Matthew J. Birdsall , Gianfranco Pellegrini , Justin Goshgarian , Jeffrey Allen
发明人： Matthew J. Birdsall , Gianfranco Pellegrini , Justin Goshgarian , Jeffrey Allen
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/915 , A61F2002/91508 , A61F2002/91558 , A61F2220/0058 , A61F2250/0036
摘要： A stent includes a central portion having a first waveform. The first waveform is wrapped around a longitudinal axis of the stent at a pitch to define a plurality of helical turns. The stent also includes an end segment connected to one end of the central portion. The end segment has a second waveform that includes a plurality of struts and a plurality of crowns. Each of the plurality of struts has a different length so that peaks of the crowns that define an end of the stent lie within a plane that is substantially perpendicular to the longitudinal axis. Cross-sectional areas of the struts having different lengths vary so that the struts move substantially uniformly during radial contraction and/or radial expansion of the stent.
摘要翻译：支架包括具有第一波形的中心部分。第一波形以间距缠绕在支架的纵向轴线上以限定多个螺旋形匝。支架还包括连接到中心部分的一端的端部段。端部段具有包括多个支柱和多个冠部的第二波形。多个支柱中的每一个具有不同的长度，使得限定支架的端部的冠部的顶点位于基本上垂直于纵向轴线的平面内。具有不同长度的支柱的横截面积变化，使得支柱在支架的径向收缩和/或径向膨胀期间基本均匀地移动。

7. 发明授权

US06989028B2 Medical system and method for remodeling an extravascular tissue structure 有权
公开(公告)号：US06989028B2
公开(公告)日：2006-01-24
申请号：US10066302
申请日：2002-01-30
申请人： Randall T. Lashinski , Matthew J. Birdsall , Michael D. Lesh
发明人： Randall T. Lashinski , Matthew J. Birdsall , Michael D. Lesh
IPC分类号： A61F2/06
CPC分类号： A61F2/2451
摘要： A medical apparatus and method suitable for remodeling a mitral valve annulus adjacent to the coronary sinus. The apparatus comprises an elongate body having a proximal region and a distal region. Each of the proximal and distal regions is dimensioned to reside completely within the vascular system. The elongate body may be moved from a first configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mitral valve annulus proximate the coronary sinus. A forming element may be attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration. Further, the elongate body may comprise a tube having a plurality of transverse slots therein.

8. 发明授权

US06520988B1 Endolumenal prosthesis and method of use in bifurcation regions of body lumens 失效
标题翻译：腔内假体及其在体腔分叉区域的使用方法
公开(公告)号：US06520988B1
公开(公告)日：2003-02-18
申请号：US08937130
申请日：1997-09-24
申请人： Antonio Colombo , Robert D. Lashinski , Matthew J. Birdsall , Dennis L. Brooks , Philip J. Haarstad , James C. Peacock, III
发明人： Antonio Colombo , Robert D. Lashinski , Matthew J. Birdsall , Dennis L. Brooks , Philip J. Haarstad , James C. Peacock, III
IPC分类号： A61F206
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/91541 , A61F2002/91558 , A61F2250/0039
摘要： An endolumenal medical device assembly is provided for use in a bifurcation region of a body lumen. An expandable prosthesis, such as a stent, is included in the assembly and is adjustable from a radially collapsed condition to a radially expanded condition. The expandable prosthesis includes a prosthesis passageway and a side port. A dilator or an access device is engaged within the prosthesis passageway and also through the side port while the expandable prosthesis is in the radially collapsed condition. The expandable prosthesis may be positioned in the bifurcation region such that its distal end portion is in a first branch lumen extending from the bifurcation, its proximal end portion is in a common proximal lumen of the bifurcation region, and the side port is aligned with an entrance zone to a second branch lumen extending from the bifurcation. When the expandable prosthesis is so positioned the access device maintains percutaneous translumenal access to the second branch lumen through the prosthesis passageway and the side port while the expandable prosthesis is adjusted from the radially collapsed condition to the radially expanded condition. A dilator may also to expand the bore formed by the side port from an initial inner diameter to a larger expanded inner diameter. A second, lateral expandable prosthesis can also be coupled to the first expandable prosthesis at a location adjacent to the side port and engaged by the dilator or access device extending through the side port.
摘要翻译：提供了一种用于体腔分叉区域的腔内医疗装置组件。可扩张假体，例如支架，被包括在组件中，并且可以从径向塌陷状态调节到径向扩张状态。可扩张假体包括假体通道和侧端口。扩张器或进入装置接合在假体通道内并且还可以通过侧端口，而可扩张假体处于径向折叠状态。可扩张假体可以位于分叉区域中，使得其远端部分处于从分叉延伸的第一分支腔中，其近端部分位于分叉区域的共同的近侧内腔中，并且侧端口与入口区到从分叉延伸的第二分支腔。当可扩张假体如此定位时，进入装置通过假体通道和侧端口保持对第二分支腔的经皮腔内通路，同时将可扩张假体从径向折叠状态调节到径向扩张状态。扩张器还可以将由侧口形成的孔从初始内径扩大到较大的扩大内径。第二横向可膨胀假体还可以在与侧端口相邻的位置处联接到第一可扩张假体，并且通过延伸穿过侧端口的扩张器或进入装置接合。

9. 发明授权

US09283305B2 Hollow tubular drug eluting medical devices 有权
标题翻译：空心管状药物洗脱医疗器械
公开(公告)号：US09283305B2
公开(公告)日：2016-03-15
申请号：US12500359
申请日：2009-07-09
申请人： Matthew J. Birdsall , Christopher Storment , D. H. Perkins , Dustin Thompson
发明人： Matthew J. Birdsall , Christopher Storment , D. H. Perkins , Dustin Thompson
IPC分类号： A61L27/54 , A61L31/02 , A61L31/16
CPC分类号： A61M25/0015 , A61B2017/00526 , A61L31/022 , A61L31/16 , A61M25/0012 , A61N1/0587
摘要： A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
摘要翻译：形成中空药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。复合构件成形为图案。通过复合构件的外部构件形成开口。处理复合构件以从外部构件的内腔移除芯构件而不损害外部构件，留下已经形成为期望图案的中空管状构件。外部构件的内腔填充有治疗物质。

10. 发明申请

US20080249599A1 Stent With Therapeutic Agent Delivery Structures in Low Strain Regions 审中-公开
标题翻译：在低应变区域中具有治疗剂递送结构的支架
公开(公告)号：US20080249599A1
公开(公告)日：2008-10-09
申请号：US11696816
申请日：2007-04-05
申请人： Jeffrey Allen , Scott Doig , Matthew J. Birdsall , Darrel Untereker
发明人： Jeffrey Allen , Scott Doig , Matthew J. Birdsall , Darrel Untereker
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91558 , A61F2250/0023 , A61F2250/0067
摘要： A system for treating abnormalities of the cardiovascular system includes a stent having a plurality of therapeutic agent-carrying regions and non therapeutic agent-carrying regions. The therapeutic agent-carrying regions are located within low strain regions of the stent and the non therapeutic agent-carrying regions are located within high strain regions of the stent. Another embodiment of the invention includes a method of manufacturing a therapeutic agent-carrying stent comprising forming a stent framework and applying a formulation containing one or more therapeutic agents to the stent framework while preventing the therapeutic agents from contacting the high strain regions of the stent framework.
摘要翻译：用于治疗心血管系统异常的系统包括具有多个治疗剂携带区域和非治疗剂携带区域的支架。治疗剂携带区域位于支架的低应变区域内，并且非治疗剂携带区域位于支架的高应变区域内。本发明的另一个实施方案包括制备治疗剂携带支架的方法，包括形成支架框架并将含有一种或多种治疗剂的制剂施用于支架框架，同时防止治疗剂接触支架框架的高应变区域。

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