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1. 发明申请

US20110290330A1 FLUID FLOW CONTROL IN A MICROFLUIDIC DEVICE 审中-公开
标题翻译：微流控器件中的流体流量控制
公开(公告)号：US20110290330A1
公开(公告)日：2011-12-01
申请号：US12672653
申请日：2007-08-09
申请人： Marcus Gassmann , Fritz Bek
发明人： Marcus Gassmann , Fritz Bek
IPC分类号： F15D1/00
CPC分类号： B01L3/502761 , B01L3/502738 , B01L2200/0621 , B01L2200/0668 , B01L2200/0673 , B01L2200/146 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/043 , B01L2400/0487 , B01L2400/0688 , Y10T137/0396
摘要： A method for removing fluid in a microfluidic device, the microfluidic device having a fluid channel, a first well, and a second well, the first well and the second well being coupled to a first end of the fluid channel, the method including applying a pressure difference between the second well and the first well, and applying a pressure difference between the first end and a second end of the fluid channel being below a certain threshold, for at least partly removing a first fluid from a first supply line coupled between the first well and the first end of the fluid channel.
摘要翻译：一种用于去除微流体装置中的流体的方法，所述微流体装置具有流体通道，第一阱和第二阱，所述第一阱和所述第二阱耦合到所述流体通道的第一端，所述方法包括施加第二井和第一井之间的压力差，以及将流体通道的第一端和第二端之间的压差施加在一定阈值以下，以至少部分地从耦合在第二井和第二井之间的第一供应管线去除第一流体第一井和流体通道的第一端。

2. 发明申请

US20080311006A1 Droplet-based fluidic coupling 审中-公开
标题翻译：基于液滴的流体耦合
公开(公告)号：US20080311006A1
公开(公告)日：2008-12-18
申请号：US11897225
申请日：2007-08-29
申请人： Fritz Bek , Marcus Gassmann
发明人： Fritz Bek , Marcus Gassmann
IPC分类号： B01L3/00 , G01N1/10
CPC分类号： G01N35/1081 , B01L3/0262 , B01L3/0293 , B01L3/502715 , B01L2200/027 , B01L2300/0816 , B01L2400/0421 , B01L2400/0478 , G01N2035/1039 , Y10T436/2575
摘要： A fluid supply unit is described, with the fluid supply unit comprising a fluid dispenser with an orifice adapted for dispensing a fluid, and a microfluidic device comprising an inlet port located at one of the faces of the microfluidic device. The fluid supply unit is adapted for establishing a fluidic contact between a droplet formed at the fluid dispenser's orifice and an inlet port of the microfluidic device, and the fluid supply unit is adapted for electrophoretically moving charged compounds from the droplet towards the inlet port.
摘要翻译：描述了流体供应单元，其中流体供应单元包括具有适于分配流体的孔的流体分配器，以及包括位于微流体装置的一个面处的入口的微流体装置。流体供应单元适于在流体分配器的孔口处形成的液滴和微流体装置的入口之间建立流体接触，并且流体供应单元适于将带电荷的化合物从液滴电泳移动到入口端口。

3. 发明申请

US20070039823A1 Fluid injection system 审中-公开
标题翻译：流体注射系统
公开(公告)号：US20070039823A1
公开(公告)日：2007-02-22
申请号：US11443524
申请日：2006-05-30
申请人： Fritz Bek , Marcus Gassmann
发明人： Fritz Bek , Marcus Gassmann
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2400/0415 , G01N27/44743
摘要： A microfluidic system comprises a first reservoir, an injection channel fluidically coupled to the first reservoir and to an injection point adapted for injecting an amount of fluid, and a side channel fluidically coupled to the injection channel at an intersection point located between the first reservoir and the injection point, the side channel being fluidically coupled with a second reservoir. Both the injection channel and the side channel are at least partly filled with a first substance and the second reservoir is at least partly filled with a second substance. The first substance is a gel and the second substance is a buffer solution. The side channel's cross section is larger than the injection channel's cross section.
摘要翻译：微流体系统包括第一储存器，流体耦合到第一储存器的注入通道和适于注入一定量流体的注入点，以及在位于第一储存器和第一储存器之间的交叉点处与注入通道流体耦合的侧通道注射点，侧通道与第二储存器流体耦合。注入通道和侧通道都至少部分地填充有第一物质，并且第二储存器至少部分地填充有第二物质。第一物质是凝胶，第二物质是缓冲溶液。侧面通道的横截面大于喷射通道的横截面积。

4. 发明授权

US5645702A Low voltage miniaturized column analytical apparatus and method 失效
标题翻译：低压小型化柱分析仪和方法
公开(公告)号：US5645702A
公开(公告)日：1997-07-08
申请号：US483217
申请日：1995-06-07
申请人： Klaus E. Witt , Patrick Kaltenbach , Fritz Bek , Sally A. Swedberg , Laurie S. Mittelstadt
发明人： Klaus E. Witt , Patrick Kaltenbach , Fritz Bek , Sally A. Swedberg , Laurie S. Mittelstadt
IPC分类号： G01N27/447 , G01N30/02 , G01N30/60 , G01N27/26
CPC分类号： G01N27/44773 , G01N30/02 , G01N30/60
摘要： A miniaturized column analytical apparatus having a miniaturized column device containing a body with an elongate separation compartment is provided. Two or more sets of spaced apart antennas are positioned along the elongate separation compartment. The elongate separation compartment has first and second opposing sides along its elongate dimension. Each set of antenna contains a plurality of antennas. One antenna from each set is associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment on the opposing sides of the separation compartment. Each set of the antennas is associated with a different oscillating electrical potential to provide a plurality of oscillating electric fields along the elongate separation compartment to draw a target substance along the elongate separation compartment toward an exit end of the separation compartment. The detector can detect a target substance passing out of the elongate separation compartment.
摘要翻译：提供了一种小型化的柱分析装置，其具有包含具有细长隔离室的主体的小型化柱装置。两个或更多组间隔开的天线沿着细长分隔室定位。细长分离隔室具有沿其细长尺寸的第一和第二相对侧。每组天线包含多个天线。每组中的一个天线与至少一个其他组中的一个天线相关联，以在分隔室的相对侧上沿分隔室形成重复的天线序列。每组天线与不同的振荡电势相关联，以沿着细长分隔室提供多个振荡电场，以沿着细长隔离室将目标物质拉向分离室的出口端。检测器可以检测出从细长隔离室流出的目标物质。

5. 发明授权

US06660991B2 Method and apparatus for measuring a low power signal 有权
标题翻译：用于测量低功率信号的方法和装置
公开(公告)号：US06660991B2
公开(公告)日：2003-12-09
申请号：US10095235
申请日：2002-03-11
申请人： Volker Brombacher , Fritz Bek
发明人： Volker Brombacher , Fritz Bek
IPC分类号： H01J4014
CPC分类号： H03M3/00 , G01J1/46
摘要： Low intensity light is incident upon a photodiode whose output is coupled to an integrator. The output of the integrator is coupled to an input of an A/D converter, whose output is coupled to a microprocessor, whose output is coupled to a filter. A second output of the microprocessor is coupled to a gate electrode of a FET to provide a reset signal to the FET to reset the integrator. The microprocessor compares the digital samples of the integrated signal from the A/D converter and, firstly, generates the reset signal if a sample is beyond a set limit, and, secondly, calculates delta values between adjacent samples and interpolates the delta values for the reset periods so as to provide a continuous data stream which can be filtered by a filter matched to the form of the original signal.
摘要翻译：低强度光入射到其输出耦合到积分器的光电二极管上。积分器的输出耦合到A / D转换器的输入，其输出耦合到微处理器，其输出耦合到滤波器。微处理器的第二输出耦合到FET的栅电极，以向FET提供复位信号以复位积分器。微处理器将来自A / D转换器的积分信号的数字样本进行比较，首先如果样本超出设定极限，则产生复位信号，其次，计算相邻样本之间的增量值，并对复位周期，以便提供连续的数据流，该数据流可以由与原始信号的形式匹配的滤波器进行滤波。

6. 发明授权

US5785831A Mixing liquids using electroosmotic flow 失效
标题翻译：使用电渗流混合液体
公开(公告)号：US5785831A
公开(公告)日：1998-07-28
申请号：US598717
申请日：1996-02-08
申请人： Fritz Bek
发明人： Fritz Bek
IPC分类号： G01N1/36 , B01F3/08 , B01F5/00 , B01F5/04 , B01F13/00 , B01F15/04 , B01L3/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/34 , G01N37/00 , G05D11/03 , G01N27/26
CPC分类号： B01F13/0076 , B01F13/0001 , B01F15/0412 , B01F5/0403 , B01L3/50273 , G01N27/44704 , G01N30/34 , G05D11/03 , B01F2215/0037 , B01L2300/0867 , B01L2400/0418 , G01N2030/027 , G01N2030/285 , G01N2030/347
摘要： A method and apparatus for mixing liquids using electroosmotic flow. Multiple capillaries (100, 104, 106) or microchip channels meet at a common junction (102). One capillary (100) is used for mixed liquids and each of the remaining capillaries (104, 106) are used for supplying a liquid (112, 114) to be mixed. Each of the supply capillaries (104, 106) has a free end that is immersed into a vial (108, 110) of liquid (112, 114). A first power supply terminal (112) is attached to a free end of the mixed liquid capillary (100). The liquid in each vial has an electrode that is switchably connected to a second power supply terminal. Closing a switch (116, 118) causes liquid to flow from a vial through the common junction and through the mixed liquid capillary. Each switch is independent and each may be closed continuously, switched at a constant duty cycle, or switched at a variable duty cycle. As a result, continuous mixing or variable ratio mixing may be achieved.
摘要翻译：一种使用电渗流混合液体的方法和装置。多个毛细管（100,104,106）或微芯片通道在公共接点处相遇（102）。一个毛细管（100）用于混合液体，并且每个剩余的毛细管（104,106）用于供应要混合的液体（112,114）。每个供应毛细管（104,106）具有浸入液体（112,114）的小瓶（108,110）中的自由端。第一电源端子（112）附接到混合液体毛细管（100）的自由端。每个小瓶中的液体具有可切换地连接到第二电源端子的电极。关闭开关（116,118）使液体从小瓶流过公共接头并通过混合液体毛细管。每个开关是独立的，每个开关可以连续闭合，以恒定的占空比切换，或以可变的占空比进行切换。结果，可以实现连续混合或可变比混合。

7. 发明授权

US06264892B1 Miniaturized planar columns for use in a liquid phase separation apparatus 有权
标题翻译：用于液相分离装置的小型平面柱
公开(公告)号：US06264892B1
公开(公告)日：2001-07-24
申请号：US09480922
申请日：2000-01-11
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： G01N2726
CPC分类号： G01N30/6095 , B01L3/502707 , B01L3/502715 , B01L3/5055 , B01L7/54 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N27/44704 , G01N27/44708 , G01N27/44721 , G01N27/44773 , G01N27/44791 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , Y10T156/1064 , G01N2030/0035
摘要： Miniaturized planar column devices for use in a liquid phase separation apparatus are described. The devices include microstructures that have been fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the methods of the invention include associated laser-ablated features required for function, such as on-device reservoirs or makeup flow compartments, analyte detection means and sample injection means. The miniaturized columns can be used in an apparatus intended for analysis of either small and/or macromolecular solutes in the liquid phase which employs chromatographic, electrophoretic or electrochromatographic separation means. The apparatus can include a variety of optional injection means, manifolds, keeper means, post column collection means, and combinations thereof.
摘要翻译：描述了用于液相分离装置的微型平面柱装置。这些器件包括通过在各种新型支撑衬底中的激光烧蚀制造的微结构。根据本发明的方法形成的器件包括功能所需的相关的激光烧蚀特征，例如器件上储存器或补充流动隔室，分析物检测装置和样品注入装置。小型化柱可用于用于分析液相中的小分子和/或大分子溶质的装置，其使用色谱，电泳或电色谱分离装置。该装置可以包括各种可选的注射装置，歧管，保持装置，柱后收集装置及其组合。

8. 发明授权

US6033628A Miniaturized planar columns for use in a liquid phase separation apparatus 失效
标题翻译：用于液相分离装置的小型平面柱
公开(公告)号：US6033628A
公开(公告)日：2000-03-07
申请号：US656281
申请日：1998-04-27
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01D15/08 , B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , G01N37/00 , G01N27/26 , G01N30/00 , G01N33/50
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44704 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , Y10T156/1064
摘要： In a method of forming a microchannel and/or microcavity structure by bonding together two elements (1, 2) having opposed plane surfaces of the same or different material, one or both surfaces having open channels and/or cavities, bonding is effected by applying to one or both element surfaces (1, 2) a thin layer (3) of a solution of a material capable of fusing with and having a lower melting point than that of the material or materials of the two element surfaces (1, 2) in a solvent which substantially does not dissolve the element surface material or materials. The solvent is then removed, and the two elements (1, 2) are brought together and heated to a temperature where the dissolved material is caused to melt but not the element surface material or materials.
摘要翻译： PCT No.PCT / US95 / 13365 Sec。 371日期：1998年4月27日 102（e）日期1998年4月27日PCT提交1995年10月16日PCT公布。公开号WO96 / 12546 日期：1996年5月2日在通过将具有相同或不同材料的相对平面的两个元件（1,2）结合在一起形成微通道和/或微腔结构的方法中，一个或两个表面具有开放的通道和/或腔，通过向一个或两个元件表面（1,2）施加能够熔化并且具有比两个元件表面的材料或材料的熔点低的材料的溶液的薄层（1） 1,2）在基本上不溶解元件表面材料或材料的溶剂中。然后除去溶剂，将两个元件（1,2）放在一起并加热至使溶解的材料熔化而不是元件表面材料或材料的温度。

9. 发明授权

US5658413A Miniaturized planar columns in novel support media for liquid phase analysis 失效
标题翻译：用于液相分析的新颖载体介质中的小型平面柱
公开(公告)号：US5658413A
公开(公告)日：1997-08-19
申请号：US482245
申请日：1995-06-07
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01D15/08 , B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , G01N37/00 , B32B31/00
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44704 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , Y10T156/1064
摘要： Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.
摘要翻译：描述了用于液相分析的微型平面柱装置，该装置包括通过在各种新型支撑衬底中的激光烧蚀制造的微结构。根据本发明形成的装置包括功能所需的相关的激光烧蚀特征，例如分析物检测装置和流体连通装置。根据本发明构造的微型柱可用于在液相中的小分子和/或大分子溶质上进行的任何分析系统，并且可以使用色谱，电泳，电色谱分离装置或其任何组合。

10. 再颁专利

USRE39527E1 Method and apparatus for measuring a low power signal 有权
标题翻译：用于测量低功率信号的方法和装置
公开(公告)号：USRE39527E1
公开(公告)日：2007-03-27
申请号：US10956015
申请日：2004-09-30
申请人： Volker Brombacher , Fritz Bek
发明人： Volker Brombacher , Fritz Bek
IPC分类号： H01J40/14 , H03F3/08
CPC分类号： H03M3/00 , G01J1/46
摘要： Low intensity light is incident upon a photodiode whose output is coupled to an integrator. The output of the integrator is coupled to an input of an A/D converter, whose output is coupled to a microprocessor, whose output is coupled to a filter. A second output of the microprocessor is coupled to a gate electrode of a FET to provide a reset signal to the FET to reset the integrator. The microprocessor compares the digital samples of the integrated signal from the A/D converter and, firstly, generates the reset signal if a sample is beyond a set limit, and, secondly, calculates delta values between adjacent samples and interpolates the delta values for the reset periods so as to provide a continuous data stream which can be filtered by a filter matched to the form of the original signal.
摘要翻译：低强度光入射到其输出耦合到积分器的光电二极管上。积分器的输出耦合到A / D转换器的输入，其输出耦合到微处理器，其输出耦合到滤波器。微处理器的第二输出耦合到FET的栅电极，以向FET提供复位信号以复位积分器。微处理器将来自A / D转换器的积分信号的数字样本进行比较，首先如果样本超出设定极限，则产生复位信号，其次，计算相邻样本之间的增量值，并对复位周期，以便提供连续的数据流，该数据流可以由与原始信号的形式匹配的滤波器进行滤波。

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