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1. 发明申请

US20180078875A1 METHOD AND AN APPARATUS FOR CONTROLLING FLUID FLOWING THROUGH A CHROMATOGRAPHIC SYSTEM 审中-公开
公开(公告)号：US20180078875A1
公开(公告)日：2018-03-22
申请号：US15790946
申请日：2017-10-23
申请人： Waters Technologies Corporation
发明人： Kurt D. Joudrey , Paul Keenan , Richard W. Andrews , Peyton C. Beals , Joshua A. Shreve
IPC分类号： B01D15/10 , G01N30/32 , B01D15/40 , B01D15/16 , G01N30/30
CPC分类号： B01D15/10 , B01D15/163 , B01D15/40 , G01N30/32 , G01N2030/3007 , G01N2030/324
摘要： A method for controlling fluid flowing through a chromatographic system includes determining a fluidic parameter related to density at a first fluidic location in the chromatographic system; and in response to the determined fluidic parameter, modifying a volumetric flow rate or a pressure at a second fluidic location in the chromatographic system to produce a selected mass flow rate of the fluid.

2. 发明申请

US20170038346A1 CONVECTIVELY CONTROLLED ADIABATIC COLUMN CHAMBER FOR USE IN CHROMATOGRAPHIC SYSTEMS 审中-公开
标题翻译：用于色谱系统的连续控制的自动色谱柱
公开(公告)号：US20170038346A1
公开(公告)日：2017-02-09
申请号：US15303328
申请日：2015-04-10
申请人： Waters Technologies Corporation
发明人： Joshua A. Shreve , Kurt D. Joudrey
IPC分类号： G01N30/30 , F24H9/00 , F24H3/08 , B01D15/16 , B01D53/02
CPC分类号： G01N30/30 , B01D15/161 , B01D53/025 , F24H3/062 , F24H3/081 , F24H9/0073 , F24H9/1863 , F24H9/2071 , F24H2240/08 , F24H2250/06 , G01N2030/3007
摘要： A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path. An air mover disposed in the airflow path generates a flow of air within the duct system. A heat exchanger system disposed in the airflow path near the air to exchange heat with the air as the air flows past the heat exchanger system. The air circulates through the duct system around the column chamber, convectively exchanging heat with the column chamber to produce a thermally conditioned environment for the one or more chromatography separation columns held within the column chamber.
摘要翻译：柱调节外壳包括适于容纳一个或多个色谱分离柱的柱室。管道系统提供围绕柱室的气流路径，使得保持在柱室内的一个或多个色谱分离柱与气流路径隔离。设置在气流路径中的鼓风机在管道系统内产生空气流。一种热交换器系统，其布置在靠近空气的气流中，随着空气流过热交换器系统而与空气交换热量。空气循环通过柱室周围的管道系统，与塔室对流地进行热交换，以产生用于保持在塔室内的一个或多个色谱分离柱的热调节环境。

3. 发明授权

US09488624B2 Chromatographic sample for determining equivalent thermal conditions between liquid chromatography systems 有权
标题翻译：用于确定液相色谱系统之间的等温热条件的色谱样品
公开(公告)号：US09488624B2
公开(公告)日：2016-11-08
申请号：US14737812
申请日：2015-06-12
申请人： Waters Technologies Corporation
发明人： Richard W. Andrews , Peyton C. Beals
IPC分类号： G01N30/04 , G01N30/86 , B01D15/42 , G01N30/30
CPC分类号： G01N30/04 , B01D15/424 , G01N30/8672 , G01N2030/047 , G01N2030/3007
摘要： Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems and a sample for performing the method. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.
摘要翻译：描述了在液相色谱（LC）系统和用于执行该方法的样品之间转移色谱方法的方法。该方法基于两个溶质共洗脱的等离子体停留温度的测定。该方法可以使用具有可重现性和等效结果的不同液相色谱系统进行分离。例如，该方法允许为HPLC开发的色谱方法容易转移到UPLC系统中，并且为UPLC系统开发的色谱方法更容易转移到HPLC系统。该方法解决了具有不同设计的列炉的LC系统，其中内部柱温度不相等，尽管柱式炉的操作温度可以被精确地控制为相等的值。导致不同LC系统的保持行为和分辨率基本相同，从而获得等效的分离结果。

4. 发明授权

US09453824B2 Column heater with active pre-heating 有权
标题翻译：带加热器的柱式加热器
公开(公告)号：US09453824B2
公开(公告)日：2016-09-27
申请号：US13519818
申请日：2011-01-11
申请人： Peter Kirby , Tony A. Lin , Steven D. Trudeau
发明人： Peter Kirby , Tony A. Lin , Steven D. Trudeau
IPC分类号： G01N30/30 , G01N30/54 , F24H1/14 , H05B3/42
CPC分类号： G01N30/30 , F24H1/142 , G01N30/54 , G01N2030/3007 , G01N2030/3061 , H05B3/42 , H05B2203/021
摘要： To heat a flowing liquid, an apparatus includes a heater block assembly having a heater block made of thermally conductive material. The heater block assembly has a tube inlet, a tube outlet, and a tube path between the tube inlet and tube outlet. Tubing extends through the tube path from the tube inlet to the tube outlet. The tubing is in thermal communication with the heater block. A heater cartridge, in thermal communication with the heater block, is configured to provide heat to the heater block for transfer to liquid flowing through the tubing between the tube inlet and the tube outlet of the heater block assembly. Circuitry is in electrical communication with the heater cartridge to control a temperature of the heater block by controlling operation of the heater cartridge.
摘要翻译：为了加热流动的液体，装置包括具有由导热材料制成的加热器块的加热器块组件。加热器组件具有管入口，管出口和管入口和管出口之间的管路。管道从管入口延伸穿过管路径到管出口。管道与加热器块热连通。与加热器块热连通的加热器盒构造成向加热器块提供热量，以传递到流过加热器组件的管入口和管出口之间的管道的液体。电路与加热器盒电连通，通过控制加热器盒的操作来控制加热器块的温度。

5. 发明授权

US09194849B2 Column unit and gas chromatography device provided with the same 有权
标题翻译：柱单元和气相色谱装置提供
公开(公告)号：US09194849B2
公开(公告)日：2015-11-24
申请号：US14226018
申请日：2014-03-26
申请人： SHIMADZU CORPORATION
发明人： Masaki Kanai , Takahiro Nishimoto , Masanori Nishino , Satoshi Matsuoka
IPC分类号： G01N30/30 , G01N30/60 , G01N30/02
CPC分类号： G01N30/30 , G01N30/6052 , G01N30/6095 , G01N2030/025 , G01N2030/3007 , G01N2030/303 , G01N2030/3061 , G01N2030/3084
摘要： A housing of a column unit is tubular-shaped, and includes a first opening and a second opening, and an inner space separated from outside air by an insulating material. An air cooling section including a cooling device is arranged on a side of the first opening of the housing. At the time of cooling the inside of the inner space of the housing, air is caused, by a fan, to flow through the air cooling section and from the side of the first opening to a side of the second opening. A column section including a separation column and a heater is arranged inside the housing. A gap through which air flows from the first opening to the second opening is formed between the column section and an inner wall of the inner space of the housing.
摘要翻译：柱单元的壳体是管状的，并且包括第一开口和第二开口，以及通过绝缘材料与外部空气隔开的内部空间。包括冷却装置的空气冷却部分布置在壳体的第一开口的一侧。在冷却壳体的内部空间的内部时，通过风扇使空气流过空气冷却部分并从第一开口的一侧流到第二开口的一侧。包括分离柱和加热器的柱部分布置在壳体内。在柱部和壳体的内部空间的内壁之间形成有从第一开口到第二开口的空气流过的间隙。

6. 发明申请

US20150129494A1 METHOD AND AN APPARATUS FOR CONTROLLING FLUID FLOWING THROUGH A CHROMATOGRAPHIC SYSTEM 审中-公开
标题翻译：用于通过色谱系统控制流体流动的方法和装置
公开(公告)号：US20150129494A1
公开(公告)日：2015-05-14
申请号：US14539336
申请日：2014-11-12
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： Kurt D. Joudrey , Paul Keenan , Richard W. Andrews , Peyton C. Beals , Joshua A. Shreve
IPC分类号： B01D15/10 , B01D15/40
CPC分类号： B01D15/10 , B01D15/163 , B01D15/40 , G01N30/32 , G01N2030/3007 , G01N2030/324
摘要： A method for controlling fluid flowing through a chromatographic system includes determining a fluidic parameter related to density at a first fluidic location in the chromatographic system; and in response to the determined fluidic parameter, modifying a volumetric flow rate or a pressure at a second fluidic location in the chromatographic system to produce a selected mass flow rate of the fluid.
摘要翻译：用于控制流过色谱系统的流体的方法包括确定与色谱系统中第一流体位置处的密度有关的流体参数; 并且响应于所确定的流体参数，修改色谱系统中的第二流体位置的体积流量或压力以产生所选流体的质量流量。

7. 发明授权

US08906692B2 Instrument and method for analysis of mannose 6-phosphate 有权
标题翻译：用于甘露糖6-磷酸的分析仪器和方法
公开(公告)号：US08906692B2
公开(公告)日：2014-12-09
申请号：US14007977
申请日：2012-03-26
申请人： Tetsuo Yokoyama
发明人： Tetsuo Yokoyama
IPC分类号： G01N30/02 , G01N21/64 , G01N30/30 , G01N30/74 , G01N30/84 , G01N30/88
CPC分类号： G01N21/6486 , G01N30/30 , G01N30/74 , G01N30/84 , G01N30/88 , G01N2030/3007 , G01N2030/8435 , G01N2030/8836 , Y10T436/143333
摘要： Disclosed are an apparatus and method for separation analysis of mannose-6-phosphate (M6P) by post-column fluorescence detection method. The apparatus is based on chromatography, and includes a column with a solid phase having affinity for phosphate, a flow path for the eluate, a heater installed on the flow path for M6P and a basic amino acid to react by heating the eluate in the flow path, and a fluorescence detector installed downstream of the heater for continuously irradiating the eluate with excitation light and measuring the intensity of the emission, and may include in the flow path a supply channel for addition of a basic amino acid between the column and the heater. The method is characterized in that it uses the apparatus and a second mobile phase consisting of a second buffer containing phosphate of predetermined concentration and adjusted to a predetermined pH.
摘要翻译：公开了通过柱后荧光检测方法分离甘露糖-6-磷酸（M6P）的装置和方法。该装置基于色谱法，并且包括具有对磷酸盐具有亲和力的固相的柱，洗脱液的流动路径，安装在用于M6P的流动路径上的加热器和通过加热流体中的洗脱液进行反应的碱性氨基酸路径和安装在加热器下游的荧光检测器，用于用激发光连续照射洗脱液并测量发射强度，并且可以在流路中包括在柱和加热器之间添加碱性氨基酸的供应通道。该方法的特征在于其使用该装置和由含有预定浓度的磷酸盐并调节至预定pH的第二缓冲液组成的第二流动相。

8. 发明申请

US20140051175A1 INSTRUMENT AND METHOD FOR ANALYSIS OF MANNOSE 6-PHOSPHATE 有权
标题翻译：用于分析6-PHOSPHOSE的仪器和方法
公开(公告)号：US20140051175A1
公开(公告)日：2014-02-20
申请号：US14007977
申请日：2012-03-26
申请人： Tetsuo Yokoyama
发明人： Tetsuo Yokoyama
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N30/30 , G01N30/74 , G01N30/84 , G01N30/88 , G01N2030/3007 , G01N2030/8435 , G01N2030/8836 , Y10T436/143333
摘要： Disclosed are an apparatus and method for separation analysis of mannose-6-phosphate (M6P) by post-column fluorescence detection method. The apparatus is based on chromatography, and includes a column with a solid phase having affinity for phosphate, a flow path for the eluate, a heater installed on the flow path for M6P and a basic amino acid to react by heating the eluate in the flow path, and a fluorescence detector installed downstream of the heater for continuously irradiating the eluate with excitation light and measuring the intensity of the emission, and may include in the flow path a supply channel for addition of a basic amino acid between the column and the heater. The method is characterized in that it uses the apparatus and a second mobile phase consisting of a second buffer containing phosphate of predetermined concentration and adjusted to a predetermined pH.
摘要翻译：公开了通过柱后荧光检测方法分离甘露糖-6-磷酸（M6P）的装置和方法。该装置基于色谱法，并且包括具有对磷酸盐具有亲和力的固相的柱，洗脱液的流动路径，安装在用于M6P的流动路径上的加热器和通过加热流体中的洗脱液进行反应的碱性氨基酸路径和安装在加热器下游的荧光检测器，用于用激发光连续照射洗脱液并测量发射强度，并且可以在流路中包括在柱和加热器之间添加碱性氨基酸的供应通道。该方法的特征在于其使用该装置和由含有预定浓度的磷酸盐并调节至预定pH的第二缓冲液组成的第二流动相。

9. 发明申请

US20130061662A1 APPARATUS AND METHOD FOR POLYMER CHARACTERIZATION 审中-公开
标题翻译：聚合物表征的装置和方法
公开(公告)号：US20130061662A1
公开(公告)日：2013-03-14
申请号：US13672363
申请日：2012-11-08
申请人： Dow Global Technologies LLC
发明人： David T. Gillespie , Colin LiPiShan , Lonnie G. Hazlitt , Alexander W. Degroot , Peter B. Arnoudse , Charles A. Williams
IPC分类号： G01N30/84
CPC分类号： G01N30/468 , G01N25/147 , G01N30/463 , G01N30/54 , G01N33/442 , G01N2030/008 , G01N2030/3007 , G01N33/44
摘要： Apparatus for GPC/TREF and TREF/GPC characterization of a polymer sample. The apparatus provides for the automated and integrated use of multiple TREF columns and a GPC system employing a multiple flow through detectors. In addition, a method for TREF/GPC characterization of a polymer sample by GPC analysis of TREF fractions at increasing TREF elution temperatures from multiple TREF columns operated in a coordinated and synchronized temperature cycle for increased sample throughput. Also, a method for GPC/TREF characterization of a polymer sample by GPC fractionation followed by TREF fractionation of the GPC fractionations.
摘要翻译：用于GPC / TREF和TREF / GPC表征聚合物样品的装置。该装置提供了多个TREF柱的自动化和集成使用以及采用多个流过检测器的GPC系统。此外，通过在增加TREF洗脱温度的TREF洗脱温度下，通过GPC分析TREF级分，通过在协同和同步的温度循环中操作以提高样品通量的多个TREF柱来对聚合物样品进行TREF / GPC表征的方法。此外，通过GPC分级随后进行GPC分馏的TREF分馏，GPC / TREF表征聚合物样品的方法。

10. 发明授权

US08187539B2 Device and method for determining material properties by means of HPLC 有权
标题翻译：通过HPLC测定材料性质的装置和方法
公开(公告)号：US08187539B2
公开(公告)日：2012-05-29
申请号：US11667992
申请日：2005-11-11
申请人： Joachim Gerstel , Jörg Radtke
发明人： Joachim Gerstel , Jörg Radtke
IPC分类号： G01N30/02 , B01L3/00
CPC分类号： G01N30/7253 , G01N30/30 , G01N30/34 , G01N2030/3007 , G01N2030/3076 , G01N2030/342
摘要： An assembly for determining material properties and/or material concentrations of components of a sample, containing: a chromatographic separating column with a liquid mobile solvent; means for controlling the temperature inside the separating column between room temperature and 250° C.; means for creating a pressure level which is greater than ambient pressure inside the separating column; and a detector with a sample volume adapted to insert the components of the sample, is characterized in that the mobile solvent contains water to a large extent; means are provided for expanding the mobile solvent from the increased pressure level inside the separating column to the ambient pressure and for producing a phase change of the mobile solvent from the liquid to gaseous state; and means are provided for transferring the gaseous mobile solvent containing the components of the sample into the sample volume of the detector.
摘要翻译：用于确定样品组分的材料性质和/或材料浓度的组件，其包含：具有液体移动溶剂的色谱分离柱; 用于在室温至250℃之间控制分离塔内的温度的装置; 用于在分离塔内产生大于环境压力的压力水平的装置; 并且具有适于插入样品组分的样品体积的检测器，其特征在于所述移动溶剂在很大程度上含有水; 提供了用于将流动溶剂从分离塔内的增加的压力水平扩展到环境压力并且用于产生流动溶剂从液体到气态的相变的装置; 并且提供用于将含有样品组分的气态流动性溶剂转移到检测器的样品体积中的装置。

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