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1. 发明申请

US20080272313A1 Luminescence Sensor Operating in Reflection Mode 有权
标题翻译：发光传感器在反射模式下工作
公开(公告)号：US20080272313A1
公开(公告)日：2008-11-06
申请号：US12158451
申请日：2006-12-19
申请人： Maarten Marinus Johannes Wilhemus Van Herpen , Derk Jan Wilfred Klunder , Hendrik Roelof Stapert
发明人： Maarten Marinus Johannes Wilhemus Van Herpen , Derk Jan Wilfred Klunder , Hendrik Roelof Stapert
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/6428
摘要： The present invention relates to a luminescence sensor (10), such as a luminescence biosensor or a luminescence chemical sensor, comprising at least one aperture (1) having a first lateral dimension larger than the diffraction limit of excitation radiation (3) in a medium the at least one aperture (1) is filled with and a second lateral dimension below the diffraction limit of excitation radiation (3) in a medium the at least one aperture (1) is filled with. The invention furthermore relates to a method for the detection of luminescence radiation (5), e.g. fluorescence radiation, generated by at least one optically variable molecule (2), e.g. fluorophore, in the at least one aperture (1). The excitation radiation (3) is preferably polarised to suppress the excitation radiation (3) in the apertures (1). The luminescence sensor (10) according to the present invention is able to detect relatively low concentrations of optically variable molecules (2), e.g. fluorophores.
摘要翻译：本发明涉及一种发光传感器（10），例如发光生物传感器或发光化学传感器，其包括至少一个孔（1），其具有比介质中的激发辐射（3）的衍射极限大的第一横向尺寸所述至少一个孔（1）在所述至少一个孔（1）填充的介质中填充有低于激发辐射（3）的衍射极限的第二横向尺寸。本发明还涉及用于检测发光辐射（5）的方法，例如，由至少一个光学可变分子（2）产生的荧光辐射，例如。在所述至少一个孔（1）中的荧光团。激发辐射（3）优选地被极化以抑制孔（1）中的激发辐射（3）。根据本发明的发光传感器（10）能够检测相对低浓度的光学可变分子（2），例如，荧光团

2. 发明申请

US20120040853A1 REAL TIME MULTIPLEX PCR DETECTION ON SOLID SURFACES USING DOUBLE STRANDED NUCLEIC ACID SPECIFIC DYES 审中-公开
标题翻译：使用双重棒状核酸特异性染料对固体表面进行实时多重PCR检测
公开(公告)号：US20120040853A1
公开(公告)日：2012-02-16
申请号：US13131333
申请日：2009-11-17
申请人： Anke Pierik , Derk Jan Wilfred Klunder , Marius Losif Boamfa , Richard Joseph Marinus Schroedes , Hendrik Roelof Stapert , Danielle Elisa Willemine Clout
发明人： Anke Pierik , Derk Jan Wilfred Klunder , Marius Losif Boamfa , Richard Joseph Marinus Schroedes , Hendrik Roelof Stapert , Danielle Elisa Willemine Clout
IPC分类号： C40B30/04
CPC分类号： C12Q1/6851 , C12Q2565/519 , C12Q2565/101 , C12Q2561/113
摘要： The present invention provides method allowing for real time detection of a multitude of target nucleic acids of interest in one reaction (multiplexing) using dyes that are specific for double stranded nucleic acids.
摘要翻译：本发明提供允许使用对双链核酸特异性的染料的一次反应（多重）中实时检测大量目标核酸的方法。

3. 发明授权

US08039814B2 Luminescence sensor operating in reflection mode 有权
标题翻译：发光传感器以反射模式工作
公开(公告)号：US08039814B2
公开(公告)日：2011-10-18
申请号：US12158451
申请日：2006-12-19
申请人： Maarten Marinus Johannes Wilhelm Van Herpen , Derk Jan Wilfred Klunder , Hendrik Roelof Stapert
发明人： Maarten Marinus Johannes Wilhelm Van Herpen , Derk Jan Wilfred Klunder , Hendrik Roelof Stapert
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/6428
摘要： A luminescence sensor, such as a luminescence biosensor or a luminescence chemical sensor, includes a substrate having at least one aperture filled with a medium. The aperture has a first lateral dimension larger than the diffraction limit of excitation radiation in the medium, and a second lateral dimension smaller than the diffraction limit of the excitation radiation in the medium. A method is also provided for the detection of luminescence radiation, e.g. fluorescence radiation, generated by at least one optically variable molecule, e.g. fluorophore, in the at least one aperture. Beneficially, the excitation radiation is polarized to suppress the excitation radiation in the apertures. The luminescence sensor and the method are able to detect relatively low concentrations of optically variable molecules, e.g. fluorophores.
摘要翻译：诸如发光生物传感器或发光化学传感器的发光传感器包括具有填充有介质的至少一个孔的基板。该孔具有比介质中的激发辐射的衍射极限大的第一横向尺寸，以及小于介质中的激发辐射的衍射极限的第二横向尺寸。还提供了一种用于检测发光辐射的方法，例如，由至少一个光学可变分子产生的荧光辐射，例如。荧光团，在至少一个孔中。有利地，激发辐射被极化以抑制孔中的激发辐射。发光传感器和方法能够检测相对低浓度的光学可变分子，例如，荧光团

4. 发明申请

US20100019155A1 LUMINESCENCE SENSORS USING SUB-WAVELENGTH APERTURES OR SLITS 审中-公开
标题翻译：使用子波长波形或者倾斜的发光体传感器
公开(公告)号：US20100019155A1
公开(公告)日：2010-01-28
申请号：US11917947
申请日：2006-06-16
申请人： Derk Jan Wilfred Klunder , Maarten Marinus Johannes Wilhelm Van Herpen , Hendrik Roelof Stapert
发明人： Derk Jan Wilfred Klunder , Maarten Marinus Johannes Wilhelm Van Herpen , Hendrik Roelof Stapert
IPC分类号： G01N21/64 , G01N21/63
CPC分类号： G01N21/6428 , B82Y15/00 , G01N21/648 , G01N33/54373
摘要： The present invention provide a qualitative or quantitative luminescence sensor, for example a bio sensor or chemical sensor, using sub-wavelength aperture or slit structures, i.e. using apertures or slit structures having a smallest dimension smaller than the wavelength of the excitation radiation in the medium that fills the aperture or slit structure. The invention furthermore provides a method for the detection of luminescence radiation generated by one or more luminophores present in aperture or slit structure in such a luminescence sensor.
摘要翻译：本发明提供定性或定量发光传感器，例如使用亚波长孔径或狭缝结构的生物传感器或化学传感器，即使用具有小于介质中的激发辐射的波长的最小尺寸的孔或狭缝结构其填充孔或狭缝结构。本发明还提供了一种用于检测在这种发光传感器中存在于孔或狭缝结构中的一个或多个发光体产生的发光辐射的方法。

5. 发明授权

US10101321B2 Detecting target molecules in a sample 有权
公开(公告)号：US10101321B2
公开(公告)日：2018-10-16
申请号：US12446461
申请日：2007-10-19
申请人： Maarten Marinus Johannes Wilhelm Van Herpen , Derk Jan Wilfred Klunder , Hendrik Roelof Stapert
发明人： Maarten Marinus Johannes Wilhelm Van Herpen , Derk Jan Wilfred Klunder , Hendrik Roelof Stapert
IPC分类号： C40B30/10 , G01N33/53 , G01N21/64
摘要： The invention relates to detection the presence of a target molecule in a sample, wherein the sample is contacted with a substrate, the substrate subsequently being washed in a wash step. In particular, the invention relates to a method of detecting the presence of a target molecule in a sample, the method comprising: (a) contacting the sample (37) with a substrate having immobilized thereon probe molecules that specifically binds to the target molecule; (b) washing the substrate (38) in a wash step by a wash fluid in order to remove or dilute unbound target molecules; (c) detect the presence of resultant binding complexes (39) on the substrate to determine whether the target molecule is present in the sample. The wash fluid being substantially refractive index matched to the substrate.

6. 发明申请

US20100197515A1 DETECTING TARGET MOLECULES IN A SAMPLE 审中-公开
标题翻译：在样品中检测目标分子
公开(公告)号：US20100197515A1
公开(公告)日：2010-08-05
申请号：US12446461
申请日：2007-10-19
申请人： Maarten Marinus Johannes Wilhelm Van Herpen , Derk Jan Wilfred Klunder , Hendrik Roelof Stapert
发明人： Maarten Marinus Johannes Wilhelm Van Herpen , Derk Jan Wilfred Klunder , Hendrik Roelof Stapert
IPC分类号： C40B30/04 , C40B40/04
CPC分类号： G01N33/5306 , C40B30/10 , G01N21/6428
摘要： The invention relates to detection the presence of a target molecule in a sample, wherein the sample is contacted with a substrate, the substrate subsequently being washed in a wash step. In particular, the invention relates to a method of detecting the presence of a target molecule in a sample, the method comprising: (a) contacting the sample (37) with a substrate having immobilized thereon probe molecules that specifically binds to the target molecule; (b) washing the substrate (38) in a wash step by a wash fluid in order to remove or dilute unbound target molecules; (c) detect the presence of resultant binding complexes (39) on the substrate to determine whether the target molecule is present in the sample. The wash fluid being substantially refractive index matched to the substrate.
摘要翻译：本发明涉及检测样品中靶分子的存在，其中样品与底物接触，随后在洗涤步骤中洗涤底物。特别地，本发明涉及检测样品中目标分子的存在的方法，该方法包括：（a）使样品（37）与其上固定有特异性结合靶分子的探针分子的底物接触; （b）通过洗涤液在洗涤步骤中洗涤基质（38）以去除或稀释未结合的靶分子; （c）检测所得结合复合物（39）在底物上的存在，以确定靶分子是否存在于样品中。洗涤液体基本上与基材的折射率匹配。

7. 发明授权

US09612239B2 Substance determining apparatus 有权
公开(公告)号：US09612239B2
公开(公告)日：2017-04-04
申请号：US14001566
申请日：2012-02-27
申请人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout , Wilhelmina Maria Hardeman , Derk Jan Wilfred Klunder
发明人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout , Wilhelmina Maria Hardeman , Derk Jan Wilfred Klunder
IPC分类号： G01N21/17 , G01N33/543 , G01N21/552 , G01N21/64 , G01N21/77 , G01N27/74
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N21/7703 , G01N27/745
摘要： The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.

8. 发明授权

US09075052B2 Biosensor system for single particle detection 有权
标题翻译：用于单粒子检测的生物传感器系统
公开(公告)号：US09075052B2
公开(公告)日：2015-07-07
申请号：US13498482
申请日：2010-09-23
申请人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
发明人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
IPC分类号： G01N21/00 , G01N33/543 , G01N21/47 , G01N21/552 , G01N21/64 , G01R33/12 , G01N21/51 , G01N21/49 , G01N27/72 , G01N15/10 , G01N15/00
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： A biosensor system for the detection of particles includes a biosensor cartridge having a sensor surface. A biosensor magnet assembly is disposed on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface. The biosensor magnet assembly includes at least two magnetic sub-units separated by a gap. A first optical detection system detects the particles arranged at the same side of the cartridge as the magnet assembly. The magnet assembly and the first optical sensor are disposed such that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：用于检测颗粒的生物传感器系统包括具有传感器表面的生物传感器盒。生物传感器磁体组件设置在盒的一侧，用于在盒和传感器表面产生有效的磁场。生物传感器磁体组件包括由间隙分开的至少两个磁性子单元。第一光学检测系统检测与磁体组件布置在盒的同一侧的颗粒。磁体组件和第一光学传感器被布置成使得通过磁体组件的间隙实现光学检测。

9. 发明申请

US20130114076A1 CARTRIDGE WITH LARGE-SCALE MANUFACTURING DESIGN 审中-公开
标题翻译：具有大规模制造设计的盒子
公开(公告)号：US20130114076A1
公开(公告)日：2013-05-09
申请号：US13809304
申请日：2011-07-05
申请人： Johannes Joseph Hubertina Barbara Schleipen , Albert Hendrik Jan Immink , Menno William Jose Prins , Derk Jan Wilfred Klunder
发明人： Johannes Joseph Hubertina Barbara Schleipen , Albert Hendrik Jan Immink , Menno William Jose Prins , Derk Jan Wilfred Klunder
IPC分类号： G01N21/01
CPC分类号： G01N21/01 , A61B5/0059 , B01L3/508 , B01L2300/044 , B01L2300/0654 , B01L2300/0822 , B01L2300/0887 , B01L2400/043 , G01N21/552 , G01N21/648 , G01N21/7703
摘要： The invention relates to a cartridge (110) and an examination apparatus (100) for optical examinations of a sample. The cartridge (110) comprises a transparent bottom layer (113) that is of substantially uniform thickness and a top layer (111, 112) comprising a sample chamber (SC). The bottom layer and the top layer are preferably laminated onto each other, for example in a C roll-to-roll process. The bottom layer (113) is provided with structures like gratings (115) that allow the incoupling or outcoupling of light.
摘要翻译：本发明涉及用于样品光学检查的盒（110）和检查装置（100）。盒（110）包括具有基本均匀厚度的透明底层（113）和包括样品室（SC）的顶层（111,112）。底层和顶层优选层压在彼此上，例如以C卷对卷方法。底层（113）设置有允许光耦合或耦合的光栅（115）的结构。

10. 发明申请

US20100320397A1 MOLECULAR DIAGNOSTIC SYSTEM BASED ON EVANESCENT ILLUMINATION AND FLUORESCENCE 有权
标题翻译：基于历史照明和荧光的分子诊断系统
公开(公告)号：US20100320397A1
公开(公告)日：2010-12-23
申请号：US12864910
申请日：2009-01-26
申请人： Marius Iosif Boamfa , Maarten Marinus Johannes Wilhelmus Van Herpen , Derk Jan Wilfred Klunder
发明人： Marius Iosif Boamfa , Maarten Marinus Johannes Wilhelmus Van Herpen , Derk Jan Wilfred Klunder
IPC分类号： G01N21/64 , G01N21/55
CPC分类号： G01N21/648
摘要： An illumination detection system comprises an excitation radiation source and associated radiation processing arrangement, and a focusing arrangement for focusing the excitation radiation from the radiation processing arrangement onto an analysis region of a sample. A radiation collection arrangement collects radiation from the analysis region of the sample resulting from the excitation, and a detector detects the collected radiation. The focused excitation radiation comprises an excitation line which is evanescent in the sample. This combines the advantages of line scanning (reduced analysis time) and evanescent excitation (reduced background signal) and therewith enables increased measurement speed and precision for point of care application.
摘要翻译：照明检测系统包括激发辐射源和相关联的辐射处理装置，以及用于将来自辐射处理装置的激发辐射聚焦到样品的分析区域上的聚焦装置。辐射收集装置从由激发产生的样品的分析区域收集辐射，并且检测器检测收集的辐射。聚焦的激发辐射包括在样品中消逝的激发线。这结合了线扫描的优点（减少的分析时间）和ev逝激发（降低的背景信号），并且因此可以提高点护理应用的测量速度和精度。

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