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1. 发明申请

US20100320397A1 MOLECULAR DIAGNOSTIC SYSTEM BASED ON EVANESCENT ILLUMINATION AND FLUORESCENCE 有权
标题翻译：基于历史照明和荧光的分子诊断系统
公开(公告)号：US20100320397A1
公开(公告)日：2010-12-23
申请号：US12864910
申请日：2009-01-26
申请人： Marius Iosif Boamfa , Maarten Marinus Johannes Wilhelmus Van Herpen , Derk Jan Wilfred Klunder
发明人： Marius Iosif Boamfa , Maarten Marinus Johannes Wilhelmus Van Herpen , Derk Jan Wilfred Klunder
IPC分类号： G01N21/64 , G01N21/55
CPC分类号： G01N21/648
摘要： An illumination detection system comprises an excitation radiation source and associated radiation processing arrangement, and a focusing arrangement for focusing the excitation radiation from the radiation processing arrangement onto an analysis region of a sample. A radiation collection arrangement collects radiation from the analysis region of the sample resulting from the excitation, and a detector detects the collected radiation. The focused excitation radiation comprises an excitation line which is evanescent in the sample. This combines the advantages of line scanning (reduced analysis time) and evanescent excitation (reduced background signal) and therewith enables increased measurement speed and precision for point of care application.
摘要翻译：照明检测系统包括激发辐射源和相关联的辐射处理装置，以及用于将来自辐射处理装置的激发辐射聚焦到样品的分析区域上的聚焦装置。辐射收集装置从由激发产生的样品的分析区域收集辐射，并且检测器检测收集的辐射。聚焦的激发辐射包括在样品中消逝的激发线。这结合了线扫描的优点（减少的分析时间）和ev逝激发（降低的背景信号），并且因此可以提高点护理应用的测量速度和精度。

2. 发明授权

US08502166B2 Molecular diagnostic system based on evanescent illumination and fluorescence 有权
标题翻译：基于ev逝照明和荧光的分子诊断系统
公开(公告)号：US08502166B2
公开(公告)日：2013-08-06
申请号：US12864910
申请日：2009-01-26
申请人： Marius Iosif Boamfa , Maarten Marinus Johannes Wilhelmus Van Herpen , Derk Jan Wilfred Klunder
发明人： Marius Iosif Boamfa , Maarten Marinus Johannes Wilhelmus Van Herpen , Derk Jan Wilfred Klunder
IPC分类号： G01N21/64
CPC分类号： G01N21/648
摘要： An illumination detection system includes an excitation radiation source and associated radiation processing arrangement for focusing the excitation radiation from the radiation processing arrangement onto an analysis region of a sample. A radiation collection arrangement collects radiation from the analysis region of the sample resulting from the excitation, and a detector detects the collected radiation. The focused excitation radiation includes an excitation line which is evanescent in the sample. This combines the advantages of line scanning (reduced analysis time) and evanescent excitation (reduced background signal) and therewith enables increase measurement speed and precision for point of care application.
摘要翻译：照明检测系统包括激发辐射源和相关联的辐射处理装置，用于将来自辐射处理装置的激发辐射聚焦到样品的分析区域上。辐射收集装置从由激发产生的样品的分析区域收集辐射，并且检测器检测收集的辐射。聚焦的激发辐射包括在样品中消逝的激发线。这结合了线扫描的优点（减少的分析时间）和渐逝激励（降低的背景信号），并且因此可以提高护理点应用的测量速度和精度。

3. 发明授权

US09114395B2 Cartridge for an amplification process 有权
标题翻译：用于放大过程的墨盒
公开(公告)号：US09114395B2
公开(公告)日：2015-08-25
申请号：US13264187
申请日：2010-04-13
申请人： Derk Jan Wilfred Klunder , Anke Pierik , Richard Joseph Marinus Schroeders , Marius Iosif Boamfa
发明人： Derk Jan Wilfred Klunder , Anke Pierik , Richard Joseph Marinus Schroeders , Marius Iosif Boamfa
IPC分类号： B01L3/00 , B23P11/00 , B01L7/00 , C40B60/12 , G01N35/00 , B01L9/00
CPC分类号： B01L3/5027 , B01J2219/00608 , B01L7/52 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/141 , B01L2300/0609 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0887 , G01N2035/00158 , Y10T29/49826
摘要： The invention relates to real-time array PCR cartridges. The cartridge (100) has a fluid chamber (101) for a fluid bath (102) and a first support element (200) for fixing a microarray (103) in the fluid chamber (101). Thereby the first support element (200) fixes the microarray (103) in such a way that a change of a size of the microarray (103) due to thermal expansion of the microarray (103) is possible without inducing substantial mechanical stress to the cartridge (100). Thereby the cartridge materials chosen independently from thermal expansion coefficients of different microarrays that are to be inserted and fixed into the cartridge (100).
摘要翻译：本发明涉及实时阵列PCR盒。药筒（100）具有用于流体浴（102）的流体室（101）和用于将微阵列（103）固定在流体室（101）中的第一支撑元件（200）。因此，第一支撑元件（200）以这样的方式固定微阵列（103），使得由于微阵列（103）的热膨胀而导致的微阵列（103）的尺寸变化是可能的，而不会对盒子造成实质的机械应力（100）。由此，盒材料独立于不同微阵列的热膨胀系数而被选择，其将被插入和固定到盒（100）中。

4. 发明申请

US20120035075A1 CARTRIDGE FOR AN AMPLIFICATION PROCESS 有权
标题翻译：用于放大过程的盒
公开(公告)号：US20120035075A1
公开(公告)日：2012-02-09
申请号：US13264187
申请日：2010-04-13
申请人： Derk Jan Wilfred Klunder , Anke Pierik , Richard Joseph Marinus Schroeders , Marius Iosif Boamfa
发明人： Derk Jan Wilfred Klunder , Anke Pierik , Richard Joseph Marinus Schroeders , Marius Iosif Boamfa
IPC分类号： C40B30/04 , B23P11/00 , B01L3/00 , C40B60/14 , C40B60/12
CPC分类号： B01L3/5027 , B01J2219/00608 , B01L7/52 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/141 , B01L2300/0609 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0887 , G01N2035/00158 , Y10T29/49826
摘要： The invention relates to real-time array PCR cartridges. The cartridge (100) has a fluid chamber (101) for a fluid bath (102) and a first support element (200) for fixing a microarray (103) in the fluid chamber (101). Thereby the first support element (200) fixes the microarray (103) in such a way that a change of a size of the microarray (103) due to thermal expansion of the microarray (103) is possible without inducing substantial mechanical stress to the cartridge (100). Thereby the cartridge materials chosen independently from thermal expansion coefficients of different microarrays that are to be inserted and fixed into the cartridge (100).
摘要翻译：本发明涉及实时阵列PCR盒。盒（100）具有用于流体槽（102）的流体室（101）和用于将微阵列（103）固定在流体室（101）中的第一支撑元件（200）。因此，第一支撑元件（200）以这样的方式固定微阵列（103），使得由于微阵列（103）的热膨胀而导致的微阵列（103）的尺寸变化是可能的，而不会对盒子造成实质的机械应力（100）。由此，盒材料独立于不同微阵列的热膨胀系数而被选择，其将被插入和固定到盒（100）中。

5. 发明申请

US20110086361A1 AMPLIFICATION OF NUCEIC ACIDS USING TEMPERATURE ZONES 审中-公开
标题翻译：使用温度区的核酸增殖
公开(公告)号：US20110086361A1
公开(公告)日：2011-04-14
申请号：US12999641
申请日：2009-06-16
申请人： Derk Jan Wilfred Klunder , Anke Pierik , Aleksey Kolesnychenko , Marius Iosif Boamfa , Richard Joseph Marinus Schroeders
发明人： Derk Jan Wilfred Klunder , Anke Pierik , Aleksey Kolesnychenko , Marius Iosif Boamfa , Richard Joseph Marinus Schroeders
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6834 , B01L7/525 , B01L7/54 , B01L2300/088 , B01L2300/0883 , C12Q1/686 , C12Q2565/519 , C12Q2561/113 , C12Q2527/101
摘要： The present invention relates to the amplification and detection of amplified nucleic acid sequences employing methods and devices with distinct temperature zones. The methods and devices of the present invention may be used for quantitative analysis of target nucleic acid sequences, for simultaneous quantitative analysis of multiple target nucleic acid sequences or for analyzing a sample for the presence of a target nucleic acid.
摘要翻译：本发明涉及使用具有不同温度区的方法和装置扩增和检测扩增的核酸序列。本发明的方法和装置可用于靶核酸序列的定量分析，用于同时定量分析多个靶核酸序列或用于分析样品中靶核酸的存在。

6. 发明授权

US08686376B2 Microarray characterization system and method 有权
标题翻译：微阵列表征系统及方法
公开(公告)号：US08686376B2
公开(公告)日：2014-04-01
申请号：US12999639
申请日：2009-06-23
申请人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
发明人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
IPC分类号： F21V9/16
CPC分类号： G01N21/6452 , B01L3/5027 , G02B21/0028
摘要： A system for detecting a plurality of analytes in a sample includes an aperture array and a lens array for generating and focusing a plurality of excitation sub-beams on different sub-regions of a substrate. These sub-regions can be provided with different binding sites for binding different analytes in the sample. By detecting the different luminescent responses in a detector, the presence or amount of different analytes can be determined simultaneously. Alternatively or in addition, collection of the luminescence radiation can be performed using the lens array for directly collecting the luminescence response and for guiding the collected luminescence response to corresponding apertures. The excitation sub-beams may be focused at the side of the substrate opposite of the lens array, and an immersion fluid is provided between the lens array and the substrate to increase the collection efficiency of the luminescence radiation.
摘要翻译：用于检测样品中多个分析物的系统包括孔径阵列和用于在衬底的不同子区域上产生和聚焦多个激发子束的透镜阵列。这些子区域可以具有不同的结合位点，用于结合样品中的不同分析物。通过检测检测器中的不同发光响应，可以同时测定不同分析物的存在或量。或者或另外，可以使用透镜阵列来执行发光辐射的收集，用于直接收集发光响应并且用于将所收集的发光响应引导到相应的孔。激发子光束可以聚焦在与透镜阵列相对的一侧的基板处，并且在透镜阵列和基板之间提供浸没流体以增加发光辐射的收集效率。

7. 发明授权

US08987684B2 Detection system and method 有权
标题翻译：检测系统及方法
公开(公告)号：US08987684B2
公开(公告)日：2015-03-24
申请号：US12747522
申请日：2008-12-10
申请人： Reinhold Wimberger-Friedl , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
发明人： Reinhold Wimberger-Friedl , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
IPC分类号： F21V9/16 , G01N21/64
CPC分类号： G01N21/6456
摘要： A detection system, comprising: a radiation source (24) for providing input radiation; a radiation focusing arrangement (26) for providing the input radiation to an analysis region of a sample (20);—a radiation collection (26) arrangement for collecting output radiation from the analysis region of the sample resulting from interaction of the input radiation with the sample; a radiation detector (28) for detecting the collected output radiation; operating means (40,50,60) for operating the detection device in a first detection mode and a second detection mode, wherein in the first detection mode the analysis has a first size and/or shape and wherein in the second detection mode the analysis region has a second size and/or shape that is different from the first size and/or shape.
摘要翻译：一种检测系统，包括：用于提供输入辐射的辐射源（24）; 用于将输入辐射提供给样品（20）的分析区域的辐射聚焦装置（26）; - 辐射收集（26）装置，用于收集来自所述样品的分析区域的输出辐射，所述分析区域由所述输入辐射与例子; 用于检测所收集的输出辐射的辐射检测器（28）; 用于在第一检测模式和第二检测模式下操作所述检测装置的操作装置（40,50,60），其中在所述第一检测模式中，所述分析具有第一尺寸和/或形状，并且其中在所述第二检测模式中，所述分析区域具有与第一尺寸和/或形状不同的第二尺寸和/或形状。

8. 发明授权

US08421000B2 Beam shaping without introducing divergence within a light beam 有权
标题翻译：光束成形，而不会在光束内引入发散
公开(公告)号：US08421000B2
公开(公告)日：2013-04-16
申请号：US12743024
申请日：2008-11-20
申请人： Erik Martinus Hubertus Petrus Van Dijk , Sjoerd Stallinga , Dirk Leo Joep Vossen , Marius Iosif Boamfa
发明人： Erik Martinus Hubertus Petrus Van Dijk , Sjoerd Stallinga , Dirk Leo Joep Vossen , Marius Iosif Boamfa
IPC分类号： G02F1/01 , G02B5/30
CPC分类号： G01N21/6458 , G02B5/1833
摘要： An optical beam shaper comprises a polarization-dependent phase adjustment member which applies a phase pattern of equal magnitude and opposite sign to two orthogonal polarization states. In a preferred embodiment the beamer shaper is a dif tractive element made of a birefringent material, such as a photo-polymerizable liquid crystal polymer frozen in a uniaxial alignment, said dif tractive element comprising a plurality of zones, each zone having a stepped thickness defining a plurality of steps. The beam shaper can be used to introduce astigmatism to a polarized light beam or to undo the astigmatism to a beam with an orthogonal polarization state. The beam shaper is advantageously used within a detection device, such as a fluorescence scanner.
摘要翻译：光束整形器包括偏振相关相位调整构件，其对两个正交偏振状态施加相等幅度和相反符号的相位图案。在优选实施例中，光束整形器是由双折射材料制成的吸引元件，例如以单轴取向冷冻的光可聚合液晶聚合物，所述吸引元件包括多个区域，每个区域具有限定多个步骤。光束整形器可用于对偏振光束引入像散或者使具有正交偏振状态的光束的散光消除。光束整形器有利地用在诸如荧光扫描仪的检测装置内。

9. 发明申请

US20090309049A1 MULTI-COLOR BIOSENSOR 失效
标题翻译：多色生物传感器
公开(公告)号：US20090309049A1
公开(公告)日：2009-12-17
申请号：US12374006
申请日：2007-07-05
申请人： Erik Martinus Hubertus Petrus Van Dijk , Marius Iosif Boamfa , Reinhold Wimberger-Friedl
发明人： Erik Martinus Hubertus Petrus Van Dijk , Marius Iosif Boamfa , Reinhold Wimberger-Friedl
IPC分类号： G01J1/58 , G02B27/16
CPC分类号： G01N21/6428 , G01J3/02 , G01J3/021 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6463
摘要： A detection system is described (100) for detecting luminescence sites on a substrate (6). The detection system (100) typically comprises an irradiation unit (102) for generating at least one excitation irradiation beam for exciting luminescence sites on the substrate (6). The at least one excitation irradiation beam may be a plurality of excitation irradiation beams. The detection system (100) also comprises a first optical element, e.g. refractive element (25), adapted for receiving at least two irradiation beams of different wavelengths or wavelength ranges, the at least two irradiation beams being excitation irradiation beam(s) to be focused on a substrate and/or luminescence irradiation beam(s) to be collected from the excited luminescence sites on the substrate (6). The detection system (100) also comprises an optical compensator for adjusting at least one of the at least two irradiation beams of different wavelengths or wavelength ranges so as to reduce or compensate for optical aberrations. The present invention also relates to a corresponding method for detecting, a phase plate and a method for designing such a phase plate.
摘要翻译：描述了用于检测衬底（6）上的发光部位的检测系统（100）。检测系统（100）通常包括用于产生用于激发衬底（6）上的发光位点的至少一个激发照射束的照射单元（102）。所述至少一个激发照射光束可以是多个激发照射光束。检测系统（100）还包括第一光学元件，例如，折射元件（25），适于接收不同波长或波长范围的至少两个照射光束，所述至少两个照射光束是被聚焦在基底和/或发光照射光束上的激发照射光束从基底（6）上的激发的发光部位收集。检测系统（100）还包括用于调整不同波长或波长范围的至少两个照射束中的至少一个的光学补偿器，以便减少或补偿光学像差。本发明还涉及用于检测相位板和相位板的设计方法的相应方法。

10. 发明申请

US20110201942A1 DEVICE AND METHOD FOR OPTICALLY EXAMINING THE INTERIOR OF A BODY PART 审中-公开
标题翻译：用于光学检查身体部分的内部的装置和方法
公开(公告)号：US20110201942A1
公开(公告)日：2011-08-18
申请号：US13125677
申请日：2009-10-21
申请人： Marius Iosif Boamfa , Wouter Harry Jacinth Rensen
发明人： Marius Iosif Boamfa , Wouter Harry Jacinth Rensen
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/4528 , A61B5/6825
摘要： A device for optically examining the interior of a body part by transillumination is provided. The device comprises: an illumination unit (2) adapted for emitting polarized light (8) towards a body part (5) to be examined; and a detector unit (6) adapted for detecting light in transmission. A polarizer (10) is arranged in front of the detector unit (6).
摘要翻译：提供了通过透照光学检查身体部分的内部的装置。该装置包括：照明单元（2），适于向待检查的身体部分（5）发射偏振光（8）; 以及适于检测透射光的检测器单元（6）。偏振器（10）布置在检测器单元（6）的前面。

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