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1. 发明授权

US06756782B2 Magnetic field measuring sensor having a shunt resistor and method of regulating the sensor 失效
标题翻译：具有分流电阻的磁场测量传感器和调节传感器的方法
公开(公告)号：US06756782B2
公开(公告)日：2004-06-29
申请号：US10118878
申请日：2002-04-09
申请人： Joannes Baptist Adrianus Dionisius Van Zon
发明人： Joannes Baptist Adrianus Dionisius Van Zon
IPC分类号： G01R3302
CPC分类号： G01R33/09
摘要： A sensor for measuring a magnetic field includes a substrate, four magnetic elements arranged in a bridge configuration on the substrate, a first bridge portion. A first element and a second element are connected in series, a second bridge portion, and a third element and a fourth element are connected in series, being situated between a first contact and a second contact. The first bridge portion includes an electrical shunt resistor, which is arranged parallel to the first magnetic element of the bridge. In order to compensate for offset voltage and offset voltage drift in the output voltage of the bridge configuration, the temperature coefficient of the shunt resistor compensates for the variation of the temperature coefficients of the magnetic elements in the bridge.
摘要翻译：用于测量磁场的传感器包括基板，以基板上的桥结构布置的四个磁性元件，第一桥接部分。第一元件和第二元件串联连接，第二桥接部分以及第三元件和第四元件串联连接，位于第一触点和第二触点之间。第一桥接部分包括与桥的第一磁性元件平行布置的分流电阻器。为了补偿桥式结构的输出电压中的失调电压和失调电压漂移，分流电阻的温度系数补偿了桥中磁性元件温度系数的变化。

2. 发明授权

US06501678B1 Magnetic systems with irreversible characteristics and a method of manufacturing and repairing and operating such systems 有权
标题翻译：具有不可逆特性的磁性系统以及制造和修理和操作这种系统的方法
公开(公告)号：US06501678B1
公开(公告)日：2002-12-31
申请号：US09763206
申请日：2001-02-16
申请人： Kars-Michiel Hubert Lenssen , Derk Jan Adelerhof , Gerardus Henricus Johannes Somers , Joannes Baptist Adrianus Dionisius Van Zon , Antonius Emilius Theodorus Kuiper
发明人： Kars-Michiel Hubert Lenssen , Derk Jan Adelerhof , Gerardus Henricus Johannes Somers , Joannes Baptist Adrianus Dionisius Van Zon , Antonius Emilius Theodorus Kuiper
IPC分类号： G11C1100
CPC分类号： B82Y25/00 , G01R33/093 , G01R33/096 , G11C11/16 , G11C11/161 , G11C11/1673 , G11C17/02 , H01L27/22 , H01L27/222
摘要： A novel magnetic data storage system and a sensing system of magnetic characteristics are disclosed; the systems have a magnetization direction that is irreversible in an external magnetic field. A method of manufacturing, a method of resetting or changing or repairing and a method of operating such systems are also disclosed. The systems can include a set of magnetic devices in a balancing configuration; essentially each of said devices comprises a structure of layers including at least a first ferromagnetic layer and a second ferromagnetic layer with at least a separation layer of a non-magnetic material there between, said structure having at least a magneto resistance effect. The magnetization direction of the first ferromagnetic layer of at least one of said devices is irreversible in an external magnetic field higher than about 35 kA/m.
摘要翻译：公开了一种新型磁数据存储系统和磁特性检测系统; 系统具有在外部磁场中不可逆的磁化方向。还公开了一种制造方法，复位或更换或修理方法以及操作这种系统的方法。该系统可以包括一组平衡配置的磁性装置; 基本上每个所述装置包括至少包括第一铁磁层和第二铁磁层的层的结构，其中至少具有非磁性材料的分离层，所述结构至少具有磁阻效应。至少一个所述装置的第一铁磁层的磁化方向在高于约35kA / m的外部磁场中是不可逆的。

3. 发明授权

US10466163B2 Concurrently evaluating assays with optical inhomogeneities 有权
公开(公告)号：US10466163B2
公开(公告)日：2019-11-05
申请号：US14113964
申请日：2012-04-23
申请人： Toon Hendrik Evers , Derk Jan Wilfred Klunder , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus Dionisius Van Zon
发明人： Toon Hendrik Evers , Derk Jan Wilfred Klunder , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus Dionisius Van Zon
IPC分类号： G01N33/53 , G01N21/00 , G01N21/552 , G01N21/88 , G01N21/94 , G06T7/00 , G01N33/52 , G01N21/15
摘要： During an assay, optical measurements are made at a sensing surface (112), and at least one “homogeneity-image” of the sensing surface (112) is generated. From this image, an “homogeneity-indicator” is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest (ROI) may be rejected.

4. 发明授权

US09841421B2 Sensor device for magnetically actuated particles 有权
公开(公告)号：US09841421B2
公开(公告)日：2017-12-12
申请号：US13988833
申请日：2011-11-28
申请人： Wendy Uyen Dittmer , Mikhail Mikhaylovich Ovsyanko , Toon Hendrik Evers , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus Dionisius Van Zon
发明人： Wendy Uyen Dittmer , Mikhail Mikhaylovich Ovsyanko , Toon Hendrik Evers , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus Dionisius Van Zon
IPC分类号： G01N33/543 , G01N27/82 , G01N27/72 , G01N27/74 , G01N35/00 , G01N21/27 , G01N21/552
CPC分类号： G01N33/54373 , G01N21/274 , G01N21/552 , G01N27/72 , G01N27/745 , G01N27/825 , G01N33/54326 , G01N35/0098
摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).

5. 发明授权

US09772272B2 Substance determining apparatus 有权
公开(公告)号：US09772272B2
公开(公告)日：2017-09-26
申请号：US13498615
申请日：2010-09-24
申请人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
发明人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
IPC分类号： G01N15/06 , G01N15/14 , G01N21/47 , G01N21/552 , G01N21/64 , G01N27/74 , G01N33/543 , G01N15/02 , G01N35/00
CPC分类号： G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要： A substance determining apparatus determines a substance within a fluid where particles, which have attached the substance, are bound to a binding surface. A sensing unit is configured to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface and the binding surface, and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit is configured to discriminate between different kinds of binding of the particles bound on the binding surface depending on the generated sensing signal. The binding discrimination unit may be a unit for determining the part of the sensing signal being caused by specifically bound particles and for determining the substance based on this determined part of the sensing signal.

6. 发明授权

US09339813B2 Substance determining apparatus 有权
标题翻译：物质确定装置
公开(公告)号：US09339813B2
公开(公告)日：2016-05-17
申请号：US13516060
申请日：2010-12-10
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
IPC分类号： G01N21/17 , B01L3/00 , G01N21/552 , G01N21/84 , G01N33/543
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

7. 发明授权

US09250181B2 Sensor device with imaging optics 有权
标题翻译：具有成像光学元件的传感器装置
公开(公告)号：US09250181B2
公开(公告)日：2016-02-02
申请号：US13498347
申请日：2010-09-27
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon
IPC分类号： H04N13/00 , G01N21/55 , G01N27/00 , G01N21/00 , G01J1/58 , G01N21/552 , G01N21/64 , G02B21/36
CPC分类号： G01N21/552 , G01N21/648 , G02B21/367
摘要： The invention relates to a method and a sensor device (100) for detecting particles (MP) that are bound to the binding surface (12) of a carrier (11). The sensor device (100) comprises a microscope (50) for imaging bound particles (MP) onto an image sensor (53). In order to increase the spatial resolution of the microscope (50), a displacement unit (60,70,80) is provided that can displace the carrier (11) relative to the image sensor (53). The distance of a bound particle (MP) from the binding surface (12) and/or its lateral displacement in reaction to forces can thus be determine with high accuracy. This allows to discriminate specific bindings of large magnetic particles (MP) that are bound to the binding surface (12) via smaller target particles from nonspecific direct bindings.
摘要翻译：本发明涉及一种用于检测与载体（11）的结合表面（12）结合的颗粒（MP）的方法和传感器装置（100）。传感器装置（100）包括用于将结合颗粒（MP）成像到图像传感器（53）上的显微镜（50）。为了增加显微镜（50）的空间分辨率，提供了可相对于图像传感器（53）移动载体（11）的位移单元（60,70,80）。因此，可以高精度地确定结合粒子（MP）与结合面（12）的距离和/或其与力的反应的横向位移。这允许通过来自非特异性直接结合的较小靶颗粒来区分与结合表面（12）结合的大磁性颗粒（MP）的特异性结合。

8. 发明申请

US20120329039A1 SUBSTANCE DETERMINING APPARATUS 有权
标题翻译：物质确定装置
公开(公告)号：US20120329039A1
公开(公告)日：2012-12-27
申请号：US13516060
申请日：2010-12-10
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
IPC分类号： G01N33/566 , C12M1/34 , C12Q1/70 , G01N30/00 , G01N33/53
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

9. 发明申请

US20120202194A1 SUBSTANCE DETERMINING APPARATUS 有权
标题翻译：物质确定装置
公开(公告)号：US20120202194A1
公开(公告)日：2012-08-09
申请号：US13498615
申请日：2010-09-24
申请人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
发明人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
IPC分类号： G01N21/63 , C12M1/34 , C12Q1/02 , C12Q1/70 , G01N33/53 , G01N21/64
CPC分类号： G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles, which have attached the substance, are bound to a binding surface (30). A sensing unit (33) is adapted to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface (30) and the binding surface (30) and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit (34) is adapted to discriminate between different kinds of binding of the particles bound on the binding surface (30) depending on the generated sensing signal. The binding discrimination unit (34) is preferentially a unit for determining the part of the sensing signal being caused by specifically bound particles and to determine the substance based on this determined part of the sensing signal.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。具有附着物质的颗粒结合至结合表面（30）。感测单元（33）适于产生感测信号，该感测信号指示i）结合在装订表面（30）和装订表面（30）上的颗粒之间的距离和ii）平面内位置的结合表面上的颗粒。绑定识别单元（34）适于根据产生的感测信号来区分绑定在绑定表面（30）上的粒子的不同种类的绑定。装订识别单元（34）优选地是用于确定由特定结合的粒子引起的感测信号的部分的单元，并且基于该确定的感测信号的部分来确定物质。

10. 发明授权

US10876964B2 System, apparatus and method for determining a substance within a fluid 有权
公开(公告)号：US10876964B2
公开(公告)日：2020-12-29
申请号：US13515853
申请日：2010-12-10
申请人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Maatje Koets
发明人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Maatje Koets
IPC分类号： G01N33/543 , G01N21/552
CPC分类号： G01N21/552 , G01N33/54373
摘要： The invention relates to a substance determining apparatus and method for determining a substance within a fluid. Particles attach to the substance and bind to a binding surface (30), wherein a particle release curve being indicative of a release of bound particles from the binding surface (30) is determined, and a part of the particle release curve caused by particles bound to the binding surface via a predefined kind of binding is determined based on the temporal behaviour of the particle release curve. The substance within the fluid is determined based on the part of the particle release curve. The substance can therefore be determined based on particles which are bound to the binding surface via a certain kind of binding, i.e. other kinds of binding substantially do not affect the determination of the substance, thereby improving the accuracy of determining the substance.

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