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1. 发明申请

US20060134016A1 Drug to be introduced tooth or periodontal tissue and apparatus for introducing drug to tooth or periodontal tissue 审中-公开
标题翻译：用于引入牙齿或牙周组织的药物和用于将药物引入牙齿或牙周组织的装置
公开(公告)号：US20060134016A1
公开(公告)日：2006-06-22
申请号：US10535696
申请日：2003-11-21
申请人： Katsuro Tachibana , Misako Nakashima
发明人： Katsuro Tachibana , Misako Nakashima
IPC分类号： A61K8/96 , A61K8/66
CPC分类号： A61K9/0063 , A61K9/0009
摘要： Disclosed are a medical material for use in therapeutic agent delivery to a tooth or periodontal tissue, and an agent delivery apparatus for delivering a therapeutic agent to a tooth or periodontal tissue, by means of ultrasonic energy with less damage to the tooth or periodontal tissue. The medical material comprises a mixture of microbubbles and a therapeutic agent consisting of at least one of a plasmid DNA and a drug with a therapeutic effect on a tooth or periodontal disease. The agent delivery apparatus comprises an ultrasonic transducer having a tip provided with a detachable ultrasonic emitter for emitting an ultrasonic wave to a target site of a tooth or periodontal tissue, and a medical-material ejecting device for supplying the medical material to the target site.
摘要翻译：公开了用于治疗剂递送到牙齿或牙周组织的医疗材料，以及用于通过对牙齿或牙周组织具有较小损伤的超声能量将治疗剂递送至牙齿或牙周组织的药剂输送装置。该医疗材料包括由对牙齿或牙周病具有治疗作用的质粒DNA和药物中的至少一种组成的微泡和治疗剂的混合物。药剂输送装置包括超声波换能器，其具有设置有用于向牙齿或牙周组织的靶部位发射超声波的可拆卸超声波发射器的末端，以及用于将医疗材料供给到靶位置的医疗材料喷射装置。

2. 发明授权

US09452036B2 Dental ultrasonic drug delivery system and dental ultrasonic drug delivery method 有权
标题翻译：牙科超声药物输送系统和牙科超声药物递送方法
公开(公告)号：US09452036B2
公开(公告)日：2016-09-27
申请号：US13516678
申请日：2010-12-16
申请人： Misako Nakashima , Katsuro Tachibana
发明人： Misako Nakashima , Katsuro Tachibana
IPC分类号： A61C1/07 , A61C17/02 , A61C17/20 , A61C5/02
CPC分类号： A61C17/0202 , A61C5/40 , A61C17/20
摘要： A dental ultrasonic drug delivery system capable of accurately cleaning the inside of root canals and killing bacteria in dentin tubules is provided. The dental ultrasonic drug delivery system delivers a drug to a target using an ultrasonic delivery device 800 . The drug is delivered in a mixed state with nanobubbles. A dental therapeutic probe for applying ultrasound is attached to the ultrasonic delivery device 800 . The dental therapeutic probe is selected from: (1) a root canal insertion probe 100 which is configured to be inserted into a root canal and causes ultrasound to propagate in the root canal; (2) a dental caries therapeutic probe which causes ultrasound to propagate in a dental caries portion; (3) a periodontal disease therapeutic probe which applies ultrasound to a periodontal disease portion; and (4) a hyperesthesia therapeutic probe which applies ultrasound to hyperesthesia portion.
摘要翻译：提供了能够精确地清洁牙根内部的牙科超声药物递送系统和杀死牙本质细管的细菌。牙科超声药物递送系统使用超声波输送装置800向药物递送药物。药物以纳米气泡的混合状态递送。用于施加超声波的牙科治疗探针附接到超声输送装置800。牙科治疗探针选自：（1）根管插入探针100，其构造成插入根管中并使超声在根管中传播; （2）使龋齿治疗探针引起超声波在龋齿部分中传播; （3）牙周病治疗探针，将超声波应用于牙周病部位; 和（4）将超声波应用于感觉过敏部位的感叹治疗探针。

3. 发明申请

US20120270177A1 DENTAL ULTRASONIC DRUG DELIVERY SYSTEM AND DENTAL ULTRASONIC DRUG DELIVERY METHOD 有权
标题翻译：牙科超声波药物输送系统和牙科超声波药物递送方法
公开(公告)号：US20120270177A1
公开(公告)日：2012-10-25
申请号：US13516678
申请日：2010-12-16
申请人： Misako Nakashima , Katsuro Tachibana
发明人： Misako Nakashima , Katsuro Tachibana
IPC分类号： A61C1/07
CPC分类号： A61C17/0202 , A61C5/40 , A61C17/20
摘要： A dental ultrasonic drug delivery system capable of accurately cleaning the inside of root canals and killing bacteria in dentin tubules is provided. The dental ultrasonic drug delivery system delivers a drug to a target using an ultrasonic delivery device 800. The drug is delivered in a mixed state with nanobubbles. A dental therapeutic probe for applying ultrasound is attached to the ultrasonic delivery device 800. The dental therapeutic probe is selected from: (1) a root canal insertion probe 100 which is configured to be inserted into a root canal and causes ultrasound to propagate in the root canal; (2) a dental caries therapeutic probe which causes ultrasound to propagate in a dental caries portion; (3) a periodontal disease therapeutic probe which applies ultrasound to a periodontal disease portion; and (4) a hyperesthesia therapeutic probe which applies ultrasound to hyperesthesia portion.
摘要翻译：提供了能够精确地清洁牙根内部的牙科超声药物递送系统和杀死牙本质细管的细菌。牙科超声药物递送系统使用超声波输送装置800向药物递送药物。药物以纳米气泡以混合状态递送。用于施加超声波的牙科治疗探针被附接到超声输送装置800.牙科治疗探针选自：（1）根管插入探针100，其构造成插入根管中并使超声波在牙根; （2）使龋齿治疗探针引起超声波在龋齿部分中传播; （3）牙周病治疗探针，将超声波应用于牙周病部位; 和（4）将超声波应用于感觉过敏部位的感叹治疗探针。

4. 发明授权

US06585678B1 Booster for therapy of disease with ultrasound and pharmaceutical IDLIQU composition containing the same 失效
标题翻译：用超声治疗疾病的助推器和含有它的药物液体组合物
公开(公告)号：US06585678B1
公开(公告)日：2003-07-01
申请号：US09375339
申请日：1999-08-16
申请人： Katsuro Tachibana , Shunro Tachibana
发明人： Katsuro Tachibana , Shunro Tachibana
IPC分类号： A61B1720
CPC分类号： A61K41/0028 , A61K9/0009 , A61K9/5052 , A61K41/0004 , A61K41/0047 , A61K49/223
摘要： A booster comprising a plurality of microbubbles of a gas in a liquid, e.g. about 4×107 cells/ml of microbubbles of a gas having a diameter of 0.1. to 100 &mgr;m in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.
摘要翻译：助力器，其包括液体中的气体的多个微泡，例如。约4×10 7个细胞/ ml的直径为0.1的气体的微泡。在3至5％的人血清白蛋白溶液中至100微克，以及包含如上所述的助推器的药物液体组合物和药物，其可用于与超声波暴露一起治疗各种疾病，其中治疗效果通过在助力器的存在下应用超声波来增强药物。

5. 发明授权

US06582392B1 Ultrasound assembly for use with a catheter 有权
标题翻译：用于导管的超声组件
公开(公告)号：US06582392B1
公开(公告)日：2003-06-24
申请号：US09375162
申请日：1999-08-16
申请人： Frederick J. Bennett , John Zhang , Gary Lichttenegger , James E. Rodriguey , Katsuro Tachibana
发明人： Frederick J. Bennett , John Zhang , Gary Lichttenegger , James E. Rodriguey , Katsuro Tachibana
IPC分类号： A61B1720
CPC分类号： A61M37/0092 , A61B17/22012 , A61B17/2202 , A61B2017/00526 , A61B2017/22021 , A61B2017/22042 , A61B2017/22062 , A61B2017/22082 , A61B2017/22084 , A61B2017/22088 , A61B2017/320084 , A61B2018/00011 , A61K41/0047 , A61M25/0009 , A61M25/007 , A61M2025/0057 , A61M2205/058 , B06B1/0674 , B06B1/0677 , B06B2201/76 , G10K11/004 , G10K11/02 , G10K11/162
摘要： The invention relates to a catheter system. The system comprises a catheter body having a chamber containing a low acoustic impedance medium. The catheter body includes an elongated body with an external surface and an ultrasound transducer having an external side between a first end and a second end. The ultrasound transducer is positioned over the external surface of the elongated body such that the first end is adjacent to the chamber.
摘要翻译：本发明涉及一种导管系统。该系统包括具有包含低声阻抗介质的室的导管主体。导管主体包括具有外表面的细长主体和具有在第一端和第二端之间的外侧的超声换能器。超声换能器定位在细长体的外表面上，使得第一端与腔室相邻。

6. 发明授权

US5401237A Blood processing for treating blood disease 失效
标题翻译：血液处理用于治疗血液病
公开(公告)号：US5401237A
公开(公告)日：1995-03-28
申请号：US905245
申请日：1992-06-26
申请人： Shunro Tachibana , Ichiro Sogawa , Katsuro Tachibana
发明人： Shunro Tachibana , Ichiro Sogawa , Katsuro Tachibana
IPC分类号： H04R17/00 , A61M1/36 , H04R17/08 , A61M37/00
CPC分类号： A61M1/3687 , A61M1/36 , H04R17/08
摘要： A method and an apparatus for an effective chemical treatment of a blood disease apply a drug of a wider range with a smaller dose or lower concentration to the blood outside the patient's body. Blood which is collected from a patient is fed through a tube (2a) into a chamber (4) by a pump (3). A drug is injected into the chamber (4) from a container (5), while ultrasonic waves are applied to the blood contained in the chamber (4) from an actuator (7). The blood treated with the drug and by the ultrasonic waves, is returned into the body of the patient through a tube (2c), while the same is monitored by sensors (10) and (11).
摘要翻译：用于血液病的有效化学处理的方法和装置将较小剂量或较低浓度的较宽范围的药物应用于患者体外外的血液。从患者收集的血液通过泵（3）通过管（2a）进入腔室（4）。将药物从容器（5）注入到腔室（4）中，同时从致动器（7）将超声波施加到容纳在腔室（4）中的血液。用药物和超声波处理的血液通过管（2c）返回到患者的身体，同时由传感器（10）和（11）监测。

7. 发明授权

US07413556B2 Sheath for use with an ultrasound element 有权
标题翻译：护套用于超声波元件
公开(公告)号：US07413556B2
公开(公告)日：2008-08-19
申请号：US10369270
申请日：2003-02-18
申请人： John Zhang , Gary Lichttenegger , James E. Rodriguey , Katsuro Tachibana
发明人： John Zhang , Gary Lichttenegger , James E. Rodriguey , Katsuro Tachibana
IPC分类号： A61B17/20
CPC分类号： A61M5/14 , A61B1/00135 , A61B8/12 , A61B17/22 , A61B17/2202 , A61B17/320068 , A61B2017/22082 , A61B2017/22084 , A61B2017/320072 , A61B2017/320084 , A61B2018/00011 , A61M25/007 , A61M37/0092 , A61M2025/0057 , A61M2025/105
摘要： A system for delivering ultrasound energy to a treatment section in a vessel is disclosed. The system includes a sheath with a utility lumen and an energy delivery section at least partially constructed from a material which transmits ultrasound energy. The system also includes a drug delivery member having a plurality of drug delivery ports which are positioned adjacent the energy delivery section. The system further includes an elongated body including at least one ultrasound element and configured to be movably positioned within the utility lumen to transmit the ultrasound energy from the ultrasound element through the energy delivery section.
摘要翻译：公开了一种用于将超声波能量输送到容器中的处理部分的系统。该系统包括具有效用管腔的护套和至少部分由发射超声能量的材料构成的能量传递部分。该系统还包括具有多个药物输送端口的药物递送部件，该药物输送端口邻近能量输送部分定位。该系统还包括细长主体，其包括至少一个超声元件，并被配置为可移动地定位在公用管腔内，以将来自超声元件的超声波能量透过能量传递部分。

8. 发明授权

US07186246B2 Ultrasound catheter with utility lumen 有权
标题翻译：超声导管与实用管腔
公开(公告)号：US07186246B2
公开(公告)日：2007-03-06
申请号：US10383295
申请日：2003-03-06
申请人： Frederick J. Bennett , John Zhang , Gary Lichttenegger , James E. Rodriguey , Katsuro Tachibana
发明人： Frederick J. Bennett , John Zhang , Gary Lichttenegger , James E. Rodriguey , Katsuro Tachibana
IPC分类号： A61M31/00
CPC分类号： A61M37/0092 , A61B17/22012 , A61B17/2202 , A61B2017/00526 , A61B2017/22021 , A61B2017/22042 , A61B2017/22062 , A61B2017/22082 , A61B2017/22084 , A61B2017/22088 , A61B2017/320084 , A61B2018/00011 , A61K41/0047 , A61M25/0009 , A61M25/007 , A61M2025/0057 , A61M2205/058 , B06B1/0674 , B06B1/0677 , B06B2201/76 , G10K11/004 , G10K11/02 , G10K11/162
摘要： The invention relates to a catheter system. The system comprises a catheter body having a chamber containing a low acoustic impedance medium. The catheter body includes an elongated body with an external surface and an ultrasound transducer having an external side between a first end and a second end. The ultrasound transducer is positioned over the external surface of the elongated body such that the first end is adjacent to the chamber.
摘要翻译：本发明涉及一种导管系统。该系统包括具有包含低声阻抗介质的室的导管主体。导管主体包括具有外表面的细长主体和具有在第一端和第二端之间的外侧的超声换能器。超声换能器定位在细长体的外表面上，使得第一端与腔室相邻。

9. 发明授权

US5660909A Sheet for measuring ultrasonic waves 失效
标题翻译：用于测量超声波的纸张
公开(公告)号：US5660909A
公开(公告)日：1997-08-26
申请号：US530671
申请日：1995-09-19
申请人： Katsuro Tachibana , Shunro Tachibana
发明人： Katsuro Tachibana , Shunro Tachibana
IPC分类号： G01H3/00 , A61B8/00 , G01H9/00 , G01N29/032 , G01N29/30 , B32B3/02 , G01N29/00
CPC分类号： G01N29/032 , G01N29/30 , G01N2291/0231 , G01N2291/02433 , Y10T428/23 , Y10T428/231 , Y10T428/239 , Y10T428/249994 , Y10T428/249995 , Y10T428/25
摘要： A sheet for measuring ultrasonic waves with which it is possible to easily measure a 2-dimensional ultrasonic wave distribution comprises a fluid in which multiple bubbles, each consisting of a minute quantity of gas covered by an extremely thin covering, are dispersed and sealed in a transparent baglike sheet.
摘要翻译：用于测量可以容易地测量二维超声波分布的超声波的片材包括其中分散并密封在由极薄覆盖物覆盖的微量气体组成的多个气泡的流体透明袋状片。

10. 发明授权

US5628728A Medicine applying tool 失效
标题翻译：医药应用工具
公开(公告)号：US5628728A
公开(公告)日：1997-05-13
申请号：US455444
申请日：1995-05-31
申请人： Katsuro Tachibana , Shunro Tachibana
发明人： Katsuro Tachibana , Shunro Tachibana
IPC分类号： A61N1/30 , A61M25/00
CPC分类号： A61N1/30
摘要： A medicine applying tool is provided at the tip of a catheter that is used to inject the medicine. An electrode portion has first and second electrodes that are provided so that they interpose a piezoelectric element therebetween. An opening is provided in the vicinity of the electrode portion, and serves to inject a medicine supplied through the catheter into a patient. A third electrode is electrically connected to the patient. An electric signal of an ultrasonic frequency is applied to the first and second electrodes therebetween. A DC voltage is applied to the third electrode and the outside one of the first and second electrodes therebetween.
摘要翻译：在用于注射药物的导管的尖端处设置药剂施加工具。电极部分具有第一和第二电极，其设置成使得它们之间插入压电元件。在电极部附近设置开口，用于将通过导管供给的药剂注入患者体内。第三电极与患者电连接。超声频率的电信号被施加到它们之间的第一和第二电极。直流电压被施加到第三电极和其间的第一和第二电极之间。

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