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1. 发明申请

US20060134016A1 Drug to be introduced tooth or periodontal tissue and apparatus for introducing drug to tooth or periodontal tissue 审中-公开
标题翻译：用于引入牙齿或牙周组织的药物和用于将药物引入牙齿或牙周组织的装置
公开(公告)号：US20060134016A1
公开(公告)日：2006-06-22
申请号：US10535696
申请日：2003-11-21
申请人： Katsuro Tachibana , Misako Nakashima
发明人： Katsuro Tachibana , Misako Nakashima
IPC分类号： A61K8/96 , A61K8/66
CPC分类号： A61K9/0063 , A61K9/0009
摘要： Disclosed are a medical material for use in therapeutic agent delivery to a tooth or periodontal tissue, and an agent delivery apparatus for delivering a therapeutic agent to a tooth or periodontal tissue, by means of ultrasonic energy with less damage to the tooth or periodontal tissue. The medical material comprises a mixture of microbubbles and a therapeutic agent consisting of at least one of a plasmid DNA and a drug with a therapeutic effect on a tooth or periodontal disease. The agent delivery apparatus comprises an ultrasonic transducer having a tip provided with a detachable ultrasonic emitter for emitting an ultrasonic wave to a target site of a tooth or periodontal tissue, and a medical-material ejecting device for supplying the medical material to the target site.
摘要翻译：公开了用于治疗剂递送到牙齿或牙周组织的医疗材料，以及用于通过对牙齿或牙周组织具有较小损伤的超声能量将治疗剂递送至牙齿或牙周组织的药剂输送装置。该医疗材料包括由对牙齿或牙周病具有治疗作用的质粒DNA和药物中的至少一种组成的微泡和治疗剂的混合物。药剂输送装置包括超声波换能器，其具有设置有用于向牙齿或牙周组织的靶部位发射超声波的可拆卸超声波发射器的末端，以及用于将医疗材料供给到靶位置的医疗材料喷射装置。

2. 发明申请

US20120164604A1 UNEXTRACTED TOOTH ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD FOR UNEXTRACTED TOOTH 审中-公开
标题翻译：独立牙根牙根填充物和牙科组织再生方法
公开(公告)号：US20120164604A1
公开(公告)日：2012-06-28
申请号：US13395374
申请日：2010-09-10
申请人： Misako Nakashima , Koichiro Iohara
发明人： Misako Nakashima , Koichiro Iohara
IPC分类号： A61C5/04 , A61K35/32
CPC分类号： A61K35/28 , A61C5/50 , A61K35/32 , A61K38/193 , A61L27/3633 , A61L27/3834 , A61L27/3865 , A61L2430/12 , C12N5/0664 , A61K2300/00
摘要： Disclosed is a root canal filler for non-extracted tooth which causes no internal resorption or external resorption in a tooth with complete root formation, shows no odontoclast, and contributes to the regeneration of a dental tissue in which odontoblasts are smoothly aligned on the dentin wall. After pulpectomy or enlargement/cleaning of an infected root canal, a root canal filler for non-extracted tooth, which comprises tooth pulp stem cells and an extracellular matrix, is inserted into the apical side of the root canal of the non-extracted tooth. The tooth pulp stem cells may be, for example, dental pulp CXCR4-positive cells. It is preferred to attach, to the crown side of the root canal, migration factor(s) including at least one factor selected from among a cell migration factor, a cell proliferation factor, a neurotrophic factor and an angiogenic factor.
摘要翻译：公开了一种用于非提取牙齿的根管填料，其在完全根部形成的牙齿中不引起内部吸收或外部吸收，不显示牙齿清除物，并且有助于牙齿组织的再生，其中成牙本质细胞在牙本质壁上平滑地排列。在对受感染的根管进行切割或扩大/清洁之后，将包含牙髓干细胞和细胞外基质的未提取牙齿的根管填充物插入非提取牙齿根管的顶端。牙髓干细胞可以是例如牙髓CXCR4阳性细胞。优选在根管的冠侧附着包括选自细胞迁移因子，细胞增殖因子，神经营养因子和血管生成因子中的至少一种因子的迁移因子。

3. 发明申请

US20110020310A1 ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD 有权
标题翻译： ROOT CANAL FILLER和牙齿组织再生方法
公开(公告)号：US20110020310A1
公开(公告)日：2011-01-27
申请号：US12922097
申请日：2009-03-12
申请人： Misako Nakashima , Koichiro Iohara
发明人： Misako Nakashima , Koichiro Iohara
IPC分类号： A61K35/12 , A61P1/02
CPC分类号： A61L27/3834 , A61K6/0032 , A61L27/3633 , A61L27/3865 , A61L2400/06 , A61L2430/12
摘要： Provided is a novel and creative dental tissue regeneration method for regenerating dental tissue after pulpectomy or the enlargement and cleaning of an infected root canal. After pulpectomy or the enlargement and cleaning of an infected root canal, a root canal filler (200) having an extracellular matrix (210) containing the cells (220) enriched for dental pulp stem cells, is inserted into the apical side of the root canal of a target tooth (100). The cells including dental pulp stem cells include at least one of the following: dental pulp SP cells, CD31-negative and CD146-negative cells, CD24-positive cells, CD105-positive cells, and CD150-positive cells. For instance, dental pulp SP cells are CD31− and CD146− negative. Even if pulpitis due to deep caries occurs, appropriate dental pulp regeneration and recovery of dental pulp function are possible.
摘要翻译：提供了一种新颖创新的牙科组织再生方法，用于在切除术后进行牙齿组织再生或扩大和清洁受感染的根管。在进行切割或扩大和清洁感染的根管之后，将含有富含牙髓干细胞的细胞（220）的细胞外基质（210）的根管填料（200）插入到根管的顶端的目标牙齿（100）。包括牙髓干细胞的细胞包括以下至少一种：牙髓SP细胞，CD31阴性和CD146阴性细胞，CD24阳性细胞，CD105阳性细胞和CD150阳性细胞。例如，牙髓SP细胞是CD31-和CD146-阴性的。即使发生由于深度龋齿引起的牙髓炎，也可以适当地进行牙髓再生和恢复牙髓功能。

4. 发明授权

US09962237B2 Root canal filling material containing mesenchymal stem cells and method for regenerating dental tissue using the same 有权
公开(公告)号：US09962237B2
公开(公告)日：2018-05-08
申请号：US13985111
申请日：2012-01-31
申请人： Misako Nakashima , Koichiro Iohara
发明人： Misako Nakashima , Koichiro Iohara
IPC分类号： A01N63/00 , A61C5/04 , A61K6/00 , A61L27/36 , A61L27/38 , A61L27/54 , A61C5/40 , A61C5/50
CPC分类号： A61C5/40 , A61C5/50 , A61K6/0035 , A61K6/0041 , A61L27/3633 , A61L27/3834 , A61L27/54 , A61L2300/412 , A61L2430/12
摘要： A root canal filling material for a tooth extraction or tooth non-extraction process can be used clinically because of its easy availability and can efficiently enhance dental tissue regeneration; a method for regenerating dental tissue using the filling material is also provided. A root canal filling material 200 including mesenchymal stem cells 220 excluding dental pulp stem cells, which are inserted into the apical side of a root canal subjected to pulp extirpation or to root canal enlargement and cleaning of an infected root canal and including an extracellular matrix 210 is provided, and a method for regenerating dental tissue, through a tooth extracting or tooth non-extracting process, including a step of injecting the root canal filling material into the apical side of a root canal of a non-extracted tooth subjected to pulp extirpation or to root canal enlargement and cleaning of an infected root canal is provided.

5. 发明申请

US20140178992A1 MEMBRANE-SEPARATION-TYPE CULTURE DEVICE, MEMBRANE-SEPARATION-TYPE CULTURE KIT, STEM CELL SEPARATION METHOD USING SAME, AND SEPARATION MEMBRANE 审中-公开
标题翻译：膜分离型培养装置，膜分离型培养试剂盒，使用其的干细胞分离方法和分离膜
公开(公告)号：US20140178992A1
公开(公告)日：2014-06-26
申请号：US14008760
申请日：2012-03-30
申请人： Misako Nakashima , Koichiro Iohara , Kazumasa Yamada , Masaaki Shimagaki , Masahiro Osabe
发明人： Misako Nakashima , Koichiro Iohara , Kazumasa Yamada , Masaaki Shimagaki , Masahiro Osabe
IPC分类号： C12M1/00 , B05D1/18 , B05D3/06 , C12N5/0775
CPC分类号： C12M47/04 , B01D63/087 , B01D67/0093 , B01D71/50 , B01D2315/06 , B05D1/18 , B05D3/068 , C12M23/12 , C12M25/04 , C12M29/04 , C12N5/0663 , C12N5/0664 , C12N5/0667
摘要： A membrane separation culture device includes an upper structure including a vessel in which at least a portion of the bottom thereof is formed with a separation membrane having pores that allow stem cells to permeate therethrough, and a lower structure including a vessel that retains a fluid in which the membrane of the upper structure is immersed.
摘要翻译：膜分离培养装置包括上部结构，其包括其中底部的至少一部分形成有具有允许干细胞渗透通过的孔的分离膜的容器，以及包括保持流体的容器的下部结构其上部结构的膜被浸没。

6. 发明申请

US20110044960A1 MEDICAMENT, DENTAL MATERIAL, AND METHOD OF SCREENING 审中-公开
标题翻译：药物，牙科材料和筛选方法
公开(公告)号：US20110044960A1
公开(公告)日：2011-02-24
申请号：US12936474
申请日：2009-04-06
申请人： Misako Nakashima , Hiroshi Nakamura
发明人： Misako Nakashima , Hiroshi Nakamura
IPC分类号： A61K35/12 , A61K38/46 , A61K38/16 , C12Q1/68 , A61P1/02
CPC分类号： A61K35/32 , A61K6/0017 , A61K6/0067 , A61K6/02 , A61K35/36 , A61K35/44 , A61K38/4886 , G01N33/5023 , G01N33/5064 , G01N33/5073 , G01N2333/96494 , G01N2800/18
摘要： The present invention provides a novel and creative dental materials for treatment of pulpitis and/or enhancement of dentinogenesis. The dental materials of the present invention contain at least one of a protein having matrix metalloprotease 3 activities or matrix metalloprotease 3 precursor protein as an active ingredient. The dental materials of the present invention contain a carrier having biocompatibility. The dental materials of the present invention can contain at least one cell type among pulp cells, pulp stem cells, pulp progenitor cells, odontoblasts or cells that can differentiate into odontoblasts.
摘要翻译：本发明提供了一种用于治疗牙髓炎和/或增强牙本质发生的新颖且创造性的牙科材料。本发明的牙科材料含有具有基质金属蛋白酶3活性的蛋白质或基质金属蛋白酶3前体蛋白质中的至少一种作为活性成分。本发明的牙科材料含有具有生物相容性的载体。本发明的牙科材料可以在牙髓细胞，牙髓干细胞，牙髓祖细胞，成牙质细胞或可分化成成牙质细胞的细胞中含有至少一种细胞类型。

7. 发明授权

US08920791B2 Root canal filler and dental tissue regeneration method 有权
标题翻译：根管填充和牙组织再生方法
公开(公告)号：US08920791B2
公开(公告)日：2014-12-30
申请号：US12922097
申请日：2009-03-12
申请人： Misako Nakashima , Koichiro Iohara
发明人： Misako Nakashima , Koichiro Iohara
IPC分类号： A61K6/02 , A61K35/12 , A61L27/38 , A61K6/00 , A61L27/36
CPC分类号： A61L27/3834 , A61K6/0032 , A61L27/3633 , A61L27/3865 , A61L2400/06 , A61L2430/12
摘要： Provided is a novel and creative dental tissue regeneration method for regenerating dental tissue after pulpectomy or the enlargement and cleaning of an infected root canal. After pulpectomy or the enlargement and cleaning of an infected root canal, a root canal filler (200) having an extracellular matrix (210) containing the cells (220) enriched for dental pulp stem cells, is inserted into the apical side of the root canal of a target tooth (100). The cells including dental pulp stem cells include at least one of the following: dental pulp SP cells, CD31-negative and CD146-negative cells, CD24-positive cells, CD105-positive cells, and CD150-positive cells. For instance, dental pulp SP cells are CD31− and CD146− negative. Even if pulpitis due to deep caries occurs, appropriate dental pulp regeneration and recovery of dental pulp function are possible.
摘要翻译：提供了一种新颖创新的牙科组织再生方法，用于在切除术后进行牙齿组织再生或扩大和清洁受感染的根管。在进行切割或扩大和清洁感染的根管之后，将含有富含牙髓干细胞的细胞（220）的细胞外基质（210）的根管填料（200）插入到根管的顶端的目标牙齿（100）。包括牙髓干细胞的细胞包括以下至少一种：牙髓SP细胞，CD31阴性和CD146阴性细胞，CD24阳性细胞，CD105阳性细胞和CD150阳性细胞。例如，牙髓SP细胞是CD31-和CD146-阴性的。即使发生由于深度龋齿引起的牙髓炎，也可以适当地进行牙髓再生和恢复牙髓功能。

8. 发明申请

US20140322672A1 ROOT CANAL FILLING MATERIAL CONTAINING MESENCHYMAL STEM CELLS AND METHOD FOR REGENERATING DENTAL TISSUE USING THE SAME 有权
标题翻译：含有中枢神经干细胞的根冠填充材料及其再生牙周组织的方法
公开(公告)号：US20140322672A1
公开(公告)日：2014-10-30
申请号：US13985111
申请日：2012-01-31
申请人： Misako Nakashima , Koichiro Iohara
发明人： Misako Nakashima , Koichiro Iohara
IPC分类号： A61L27/38 , A61C5/04 , A61C5/02 , A61L27/54
CPC分类号： A61C5/40 , A61C5/50 , A61K6/0035 , A61K6/0041 , A61L27/3633 , A61L27/3834 , A61L27/54 , A61L2300/412 , A61L2430/12
摘要： A root canal filling material for a tooth extraction or tooth non-extraction process can be used clinically because of its easy availability and can efficiently enhance dental tissue regeneration; a method for regenerating dental tissue using the filling material is also provided. A root canal filling material 200 including mesenchymal stem cells 220 excluding dental pulp stem cells, which are inserted into the apical side of a root canal subjected to pulp extirpation or to root canal enlargement and cleaning of an infected root canal and including an extracellular matrix 210 is provided, and a method for regenerating dental tissue, through a tooth extracting or tooth non-extracting process, including a step of injecting the root canal filling material into the apical side of a root canal of a non-extracted tooth subjected to pulp extirpation or to root canal enlargement and cleaning of an infected root canal is provided.
摘要翻译：用于拔牙或牙齿非提取过程的根管填充材料可以临床使用，因为其容易获得并且可以有效地增强牙齿组织再生; 还提供了使用填充材料再生牙组织的方法。一根根管填充材料200，其包括不包括牙髓干细胞的间充质干细胞220，其被插入经根髓脱髓鞘根管扩大和清洁感染根管并包括细胞外基质210的根管顶端以及用于通过拔牙或拔牙过程再生牙科组织的方法，包括将根管填充材料注入经脱髓鞘的非提取牙齿的根管的顶端侧的步骤或根管扩大和清洁受感染的根管。

9. 发明申请

US20110177041A1 MATERIAL FOR TREATMENT OF CEREBRAL INFARCTION AND BRAIN TISSUE REGENERATION METHOD 审中-公开
标题翻译：治疗脑膜炎和脑组织再生方法的材料
公开(公告)号：US20110177041A1
公开(公告)日：2011-07-21
申请号：US13059710
申请日：2009-08-21
申请人： Misako Nakashima , Masahiko Sugiyama
发明人： Misako Nakashima , Masahiko Sugiyama
IPC分类号： A61K35/12 , A61P25/00
CPC分类号： A61K35/32 , A61L27/3834 , A61L27/3878
摘要： Disclosed is a therapeutic material for cerebral infarction, which can recover a vascular disorder in an area affected by cerebral infarction to improve the brain function. The therapeutic material for cerebral infarction includes a dental pulp stem cell comprising at least one member selected from a CD105-positive cell, an SP cell, a CD24-positive cell, a CD133-positive cell, a CD271-positive cell and a CD150-positive cell. The therapeutic material may additionally include a protein secreted from a dental pulp cell. A transplanted dental pulp stem cell cannot be differentiated directly into a neural progenitor cell or a neurocyte, but is involved indirectly in the promotion of differentiation to eliminate an area affected by cerebral infarction, thereby recovering the affected area into a normal area.
摘要翻译：本发明公开了脑梗死治疗材料，其可以恢复受脑梗死影响的区域的血管疾病，以改善脑功能。脑梗死治疗材料包括：牙髓干细胞，其包含选自CD105阳性细胞，SP细胞，CD24阳性细胞，CD133阳性细胞，CD271阳性细胞和CD150细胞中的至少一种，阳性细胞。治疗材料还可以包括从牙髓细胞分泌的蛋白质。移植的牙髓干细胞不能直接分化成神经祖细胞或神经细胞，而是间接地涉及促进分化以消除受脑梗死影响的区域，从而将受影响的区域恢复到正常区域。

10. 发明授权

US09452036B2 Dental ultrasonic drug delivery system and dental ultrasonic drug delivery method 有权
标题翻译：牙科超声药物输送系统和牙科超声药物递送方法
公开(公告)号：US09452036B2
公开(公告)日：2016-09-27
申请号：US13516678
申请日：2010-12-16
申请人： Misako Nakashima , Katsuro Tachibana
发明人： Misako Nakashima , Katsuro Tachibana
IPC分类号： A61C1/07 , A61C17/02 , A61C17/20 , A61C5/02
CPC分类号： A61C17/0202 , A61C5/40 , A61C17/20
摘要： A dental ultrasonic drug delivery system capable of accurately cleaning the inside of root canals and killing bacteria in dentin tubules is provided. The dental ultrasonic drug delivery system delivers a drug to a target using an ultrasonic delivery device 800 . The drug is delivered in a mixed state with nanobubbles. A dental therapeutic probe for applying ultrasound is attached to the ultrasonic delivery device 800 . The dental therapeutic probe is selected from: (1) a root canal insertion probe 100 which is configured to be inserted into a root canal and causes ultrasound to propagate in the root canal; (2) a dental caries therapeutic probe which causes ultrasound to propagate in a dental caries portion; (3) a periodontal disease therapeutic probe which applies ultrasound to a periodontal disease portion; and (4) a hyperesthesia therapeutic probe which applies ultrasound to hyperesthesia portion.
摘要翻译：提供了能够精确地清洁牙根内部的牙科超声药物递送系统和杀死牙本质细管的细菌。牙科超声药物递送系统使用超声波输送装置800向药物递送药物。药物以纳米气泡的混合状态递送。用于施加超声波的牙科治疗探针附接到超声输送装置800。牙科治疗探针选自：（1）根管插入探针100，其构造成插入根管中并使超声在根管中传播; （2）使龋齿治疗探针引起超声波在龋齿部分中传播; （3）牙周病治疗探针，将超声波应用于牙周病部位; 和（4）将超声波应用于感觉过敏部位的感叹治疗探针。

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