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1. 发明授权

US06987164B2 Electrically conductive polymer, sensor using the same, and method for detecting target molecule using the sensor 有权
标题翻译：导电聚合物，使用其的传感器以及使用传感器检测靶分子的方法
公开(公告)号：US06987164B2
公开(公告)日：2006-01-17
申请号：US10383809
申请日：2003-03-06
申请人： Jun-hoe Cha , Young Choi , Jung-im Han , Geun-bae Lim
发明人： Jun-hoe Cha , Young Choi , Jung-im Han , Geun-bae Lim
IPC分类号： E08G75/00
CPC分类号： G01N33/545 , C08G61/126 , G01N33/5438 , H01B1/127
摘要： A novel electrically conductive polymer, a sensor using the electrically conductive polymer, and a method for detecting a target molecule that hybridizes to a probe, using the sensor, are provided. The electrically conductive polymer has the following formula: where m is 1, 2, or 3; R is a hydroxysuccinimidyl group, a hydroxyphthalimidyl group, or a pentafluorophenolyl group; and n is zero or an integer.
摘要翻译：提供了一种新型导电聚合物，使用导电聚合物的传感器，以及使用传感器检测与探针杂交的靶分子的方法。导电聚合物具有下式：其中m为1,2或3; R是羟基琥珀酰亚胺基，羟基邻苯二甲酰亚氨基或五氟苯基; 并且n为零或整数。

2. 发明授权

US07341759B2 Electrically conductive polymer, sensor using the same, and method for detecting target molecule using the sensor 失效
标题翻译：导电聚合物，使用其的传感器以及使用传感器检测靶分子的方法
公开(公告)号：US07341759B2
公开(公告)日：2008-03-11
申请号：US11134984
申请日：2005-05-23
申请人： Jun-hoe Cha , Young Choi , Jung-im Han , Geun-bae Lim
发明人： Jun-hoe Cha , Young Choi , Jung-im Han , Geun-bae Lim
IPC分类号： B05D5/12 , C08G15/00
CPC分类号： G01N33/545 , C08G61/126 , G01N33/5438 , H01B1/127
摘要： A novel electrically conductive polymer, a sensor using the electrically conductive polymer, and a method for detecting a target molecule that hybridizes to a probe, using the sensor, are provided. The electrically conductive polymer has the following formula: where m is 1, 2, or 3; R is a hydroxysuccinimidyl group, a hydroxyphthalimidyl group, or a pentafluorophenolyl group; and n is zero or an integer.
摘要翻译：提供了一种新型导电聚合物，使用导电聚合物的传感器，以及使用传感器检测与探针杂交的靶分子的方法。导电聚合物具有下式：其中m为1,2或3; R是羟基琥珀酰亚胺基，羟基邻苯二甲酰亚氨基或五氟苯基; 并且n为零或整数。

3. 发明申请

US20050208579A1 Novel electrically conductive polymer, sensor using the same, and method for detecting target molecule using the sensor 失效
标题翻译：新型导电聚合物，使用该传感器的传感器，以及使用传感器检测靶分子的方法
公开(公告)号：US20050208579A1
公开(公告)日：2005-09-22
申请号：US11134984
申请日：2005-05-23
申请人： Jun-hoe Cha , Young Choi , Jung-im Han , Geun-bae Lim
发明人： Jun-hoe Cha , Young Choi , Jung-im Han , Geun-bae Lim
IPC分类号： G01N33/53 , C07D409/12 , C07D409/14 , C08G61/12 , C25D9/02 , G01N27/12 , G01N27/30 , G01N27/327 , G01N27/333 , G01N27/416 , G01N27/48 , G01N33/543 , G01N33/545 , G01N33/566 , H01B1/12 , C12Q1/68 , B05D5/12 , C08G69/08 , C08G73/10 , C08G75/00 , C08G75/04 , G03G15/00
CPC分类号： G01N33/545 , C08G61/126 , G01N33/5438 , H01B1/127
摘要： A novel electrically conductive polymer, a sensor using the electrically conductive polymer, and a method for detecting a target molecule that hybridizes to a probe, using the sensor, are provided. The electrically conductive polymer has the following formula: where m is 1, 2, or 3; R is a hydroxysuccinimidyl group, a hydroxyphthalimidyl group, or a pentafluorophenolyl group; and n is zero or an integer.
摘要翻译：提供了一种新型导电聚合物，使用导电聚合物的传感器，以及使用传感器检测与探针杂交的靶分子的方法。导电聚合物具有下式：其中m为1,2或3; R是羟基琥珀酰亚胺基，羟基邻苯二甲酰亚氨基或五氟苯基; 并且n为零或整数。

4. 发明授权

US07129363B2 Conductive compound, electrode and sensor containing the same, and target molecule detection method using the sensor 有权
标题翻译：导电性化合物，含有它们的电极和传感器，以及使用传感器的靶分子检测方法
公开(公告)号：US07129363B2
公开(公告)日：2006-10-31
申请号：US10791524
申请日：2004-03-01
申请人： Jung-im Han , Jun-hoe Cha , Geun-bae Lim
发明人： Jung-im Han , Jun-hoe Cha , Geun-bae Lim
IPC分类号： C07D333/38 , C08F26/06 , C12M3/00 , G01N1/00
CPC分类号： C07D409/14 , B82Y15/00 , B82Y30/00 , C07D333/24 , G01N33/54373 , H01B1/127 , H01M4/60 , H01M4/608
摘要： A conductive compound of formula (I) below, an electrode coated with the conductive compound, a sensor including the electrode, and a target molecule detection method using the sensor are provided: wherein Y is a carbonyl or —NH—; R is one of H, OH, a leaving group, and a probe group; l is an integer from 3 to 6; m is an integer from 1 to 4; and n is an integer from 0 to 3.
摘要翻译：提供下述式（I）的导电化合物，涂覆有导电化合物的电极，包含该电极的传感器和使用该传感器的靶分子检测方法：其中Y为羰基或-NH-; R是H，OH，离去基团和探针基团之一; l为3〜6的整数; m是1至4的整数; n为0〜3的整数。

5. 发明授权

US07329535B2 Apparatus for circulating carrier fluid 失效
标题翻译：载体流体循环装置
公开(公告)号：US07329535B2
公开(公告)日：2008-02-12
申请号：US10292012
申请日：2002-11-11
申请人： Kwang-wook Oh , Geun-bae Lim , Young-sun Lee , Yoon-kyoung Cho
发明人： Kwang-wook Oh , Geun-bae Lim , Young-sun Lee , Yoon-kyoung Cho
IPC分类号： C12M1/34 , C12M3/00 , F16K13/00 , B01L11/00 , B32B5/02
CPC分类号： B01L7/525 , B01L3/502738 , B01L2200/0673 , B01L2300/0816 , B01L2300/087 , B01L2300/1822 , B01L2300/185 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , Y10T137/4643 , Y10T137/4651
摘要： Provided are an apparatus for circulating a carrier fluid having two or more chambers or sections, an apparatus for amplifying a nucleic acid using the same, and a chip containing the same. The apparatus for circulating a carrier fluid includes two or more chambers maintained at different temperatures, each chamber having an inlet valve containing a pneumatic air pressure port for controlling inflow of the carrier fluid to the chamber (inlet pneumatic air pressure port), and an outlet valve containing a pneumatic air pressure for controlling outflow of the carrier fluid from the chamber (outlet pneumatic air pressure port), wherein the chambers are sequentially connected such that the outlet valve of one chamber is connected to the inlet valve of an adjacent chamber in a direction the fluid flows.
摘要翻译：提供一种用于循环具有两个或更多个室或部分的载体流体的装置，用于使用其的核酸的放大装置和含有该核酸的芯片的装置。用于循环载体流体的装置包括保持在不同温度的两个或更多个室，每个室具有入口阀，该入口阀包含用于控制载体流体流入室（进气气压端口）的气动空气压力端口，以及出口阀包含用于控制从腔室（出口气动空气压力端口）流出的载气的气动空气压力，其中腔室顺序地连接，使得一个室的出口阀连接到相邻室的入口阀方向流体流动。

6. 发明申请

US20050202489A1 Method and apparatus for amplifying nucleic acids 有权
标题翻译：扩增核酸的方法和装置
公开(公告)号：US20050202489A1
公开(公告)日：2005-09-15
申请号：US11071383
申请日：2005-03-03
申请人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
发明人： Yoon-kyoung Cho , Joon-ho Kim , Kak Namkoong , Geun-bae Lim , Jun-hong Min
IPC分类号： C12N15/09 , B01F5/06 , B01F13/00 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/38 , C12N15/00 , C12Q1/68 , G01N35/00 , G01N35/08 , C12P19/34
CPC分类号： G01N35/08 , B01F5/0646 , B01F5/0647 , B01F5/0654 , B01F13/0071 , B01F2015/0221 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00873 , B01J2219/00891 , B01L3/5027 , B01L3/502715 , B01L2300/0809 , B01L2300/0861 , B01L2300/0883 , G01N2035/00366 , G01N2035/00514
摘要： Provided are a method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate.
摘要翻译：提供了用于扩增核酸的方法和装置。该方法包括通过不同的入口通道将含有用于核酸扩增的反应物的反应物水溶液和与反应物水溶液相分离并且不参与扩增反应的流体引入反应容器，形成多个反应物水溶液通过使反应物水溶液与反应容器中的流体接触，并且扩增反应物水溶液液滴中的核酸，由流体包围的液滴。该装置包括基板，形成在基板内部的反应容器，形成在基板内部的至少一个第一入口通道，与反应容器的端部连接，并且允许将含有用于核酸扩增的反应物的反应物水溶液引入到反应容器，形成在基板内部的第二入口通道，连接到反应容器的端部，并且允许引入与反应物水溶液相分离并且不参与扩增反应的流体进入反应容器，以及加热单元，其以与基板热接触并加热基板的方式安装在基板上。

7. 发明授权

US07442503B2 Method of treating surface of substrate used in biological reaction system 有权
标题翻译：生物反应体系中使用的底物表面处理方法
公开(公告)号：US07442503B2
公开(公告)日：2008-10-28
申请号：US10765366
申请日：2004-01-27
申请人： Sun-hee Kim , Soo-suk Lee , Geun-bae Lim , Young-sun Lee
发明人： Sun-hee Kim , Soo-suk Lee , Geun-bae Lim , Young-sun Lee
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： B01L3/508 , B01L7/52 , B01L2300/163 , B05D1/62 , B05D2203/35 , C03C17/30
摘要： Provided is a method of treating a surface of a substrate used in a biochemical reaction system, the method including forming a polymer film on the surface by vapor deposition of a compound of formula (1) below and a compound of formula (2) below: (RO)3—Si—(CH2)n1—X (1) (RO)3—Si—(CH2)n2—(CF2)m—X (2) wherein R is one of a methyl group and an ethyl group, X is one of a methyl group and a trifluoromethyl group, n1 is an integer from 1 to 3, n2 is an integer from 1 to 10, and m is an integer from 1 to 10.
摘要翻译：本发明提供一种处理生物化学反应体系中使用的基板的表面的方法，该方法包括通过以下式（1）的化合物和下述式（2）的化合物的气相沉积在表面上形成聚合物膜：（？）（？）（？）？（？）？（？）？（？）？ n1 -X（1）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“ （RO）3 - （CH 2）2 - （CF 2）2 - （CH 2）其中R是甲基和乙基之一，X是一个，其中R是甲基和乙基之一，的甲基和三氟甲基，n1为1〜3的整数，n2为1〜10的整数，m为1〜10的整数。

8. 发明授权

US07338808B2 Method and apparatus for determining zeta potential using alternating current electric field and T channel 失效
标题翻译：使用交流电场和T通道确定ζ电位的方法和装置
公开(公告)号：US07338808B2
公开(公告)日：2008-03-04
申请号：US10698507
申请日：2003-10-31
申请人： Yoon-kyoung Cho , Sang-min Shin , In-seok Kang , Geun-bae Lim
发明人： Yoon-kyoung Cho , Sang-min Shin , In-seok Kang , Geun-bae Lim
IPC分类号： G01N25/18 , G01N27/00 , B01L3/02 , B32B5/02 , B32B27/04
CPC分类号： B01F13/0076 , B01L3/50273 , B01L3/502769 , B01L2400/0418 , G01N27/44752 , Y10T436/11
摘要： Provided is a method for determining a zeta potential generated between a solid wall and a solution. The method includes (a) injecting an electrolyte solution into a first inlet of a T channel, which is provided with first and second inlet electrodes and a grounded outlet electrode, and a mixed solution of the electrolyte solution and a fluorescent dye into a second channel of the T channel and maintaining a steady-state of the two solutions; (b) applying a direct current electric field from the first and second electrodes to the outlet electrode to form an interface between the electrolyte solution and the mixed solution; (c) applying an alternating current electric field from one of the two inlet electrodes to the outlet electrode to oscillate the interface; and (d) measuring an amplitude of oscillation of the interface and determining the zeta potential from the standard relationship between the zeta potential and the amplitude.
摘要翻译：提供了一种确定固体壁和溶液之间产生的ζ电位的方法。该方法包括：（a）将电解质溶液注入T沟道的第一入口，T通道的第一入口设置有第一入口电极和第二入口电极和接地的出口电极，以及电解质溶液和荧光染料的混合溶液到第二通道的T通道，并保持两种解决方案的稳定状态; （b）将直流电场从第一和第二电极施加到出口电极以形成电解质溶液和混合溶液之间的界面; （c）将两个入口电极之一的交流电场施加到出口电极以使界面振荡; 和（d）测量界面的振荡幅度，并根据ζ电位和幅度之间的标准关系确定ζ电位。

9. 发明授权

US07060948B2 Temperature control method and apparatus for driving polymerase chain reaction (PCR) chip 有权
标题翻译：用于驱动聚合酶链反应（PCR）芯片的温度控制方法和装置
公开(公告)号：US07060948B2
公开(公告)日：2006-06-13
申请号：US10307694
申请日：2002-12-02
申请人： Dong-il Cho , Dae-sung Yoon , Young-sun Lee , Dong-hoon Yi , Geun-bae Lim
发明人： Dong-il Cho , Dae-sung Yoon , Young-sun Lee , Dong-hoon Yi , Geun-bae Lim
IPC分类号： H05B1/02
CPC分类号： B01L7/525 , B01L2200/147 , G05D23/1934 , Y10T307/469
摘要： Provided are a temperature control method and apparatus for driving a polymerize chain reaction (PCR) chip. In the temperature control apparatus, which is for a polymerize chain reaction chip, PCR chips receive electric power from the outside and generating heat to maintain a predetermined temperature and for outputting actual temperature information to the outside. electric power supply units supply electric power to the PCR chips according to input control signals, and a controller generates the control signals based on control information including pre-established control temperature and control time information and the actual temperature information supplied from the PCR chips in order to supply the control signals to the electric power supply units. In the present invention, it is possible to examine various kinds of DNA at the same time because the temperature control apparatus controls the temperatures of DNA samples at the same time.
摘要翻译：提供了用于驱动聚合链式反应（PCR）芯片的温度控制方法和装置。在用于聚合链式反应芯片的温度控制装置中，PCR芯片从外部接收电力并产生热量以保持预定温度并将实际温度信息输出到外部。电源单元根据输入控制信号向PCR芯片提供电力，并且控制器基于包括预先建立的控制温度和控制时间信息的控制信息以及从PCR芯片提供的实际温度信息按顺序产生控制信号以将控制信号提供给电力供应单元。在本发明中，可以同时检测各种DNA，因为温度控制装置同时控制DNA样品的温度。

10. 发明申请

US20050199917A1 Sensitivity enhanced biomolecule field effect transistor 有权
标题翻译：灵敏度增强的生物分子场效应晶体管
公开(公告)号：US20050199917A1
公开(公告)日：2005-09-15
申请号：US11057642
申请日：2005-02-14
申请人： Kyu-tae Yoo , Geun-bae Lim , Joon-ho Kim , Kak Namkoong
发明人： Kyu-tae Yoo , Geun-bae Lim , Joon-ho Kim , Kak Namkoong
IPC分类号： G01N27/327 , C12Q1/68 , G01N27/414 , G01N33/487 , H01L29/08
CPC分类号： G01N27/4145
摘要： There is provided a biomolecule FET enhancing a sensitivity. The biomolecule FET includes a substrate, first and second impurity regions formed on both sides of the substrate, and doped with impurities of a polarity opposite to that of the substrate, a gate formed on the substrate and being in contact with the first and second impurity regions, and a probe biomolecule attached to the gate. A region of the gate adjacent to the first impurity region is wider than a region thereof adjacent to the second impurity region. A density of the probe biomolecule attached to the surface of the gate is increased, and when detecting a level of hybridization of the probe biomolecule and the target biomolecule, its sensitivity is improved.
摘要翻译：提供了提高灵敏度的生物分子FET。生物分子FET包括基板，形成在基板两侧的第一和第二杂质区，并且掺杂极性与基板极性相反的杂质;形成在基板上并与第一和第二杂质接触的栅极区域，以及连接到门的探针生物分子。与第一杂质区相邻的栅极的区域比与第二杂质区相邻的区域宽。附着在栅极表面的探针生物分子的密度增加，并且当检测到探针生物分子和靶生物分子的杂交水平时，其灵敏度得到改善。

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