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1. 发明申请

US20050285060A1 Liquid level measurement 有权
标题翻译：液位测量
公开(公告)号：US20050285060A1
公开(公告)日：2005-12-29
申请号：US11130606
申请日：2005-05-16
申请人： Douwe Haga , Michael Flatbush , Michael Mosseau , Tony Yan , Willy Wiyatno , Mark Reed
发明人： Douwe Haga , Michael Flatbush , Michael Mosseau , Tony Yan , Willy Wiyatno , Mark Reed
IPC分类号： G01F23/00 , G01F23/292 , G01N9/04 , G01N15/06 , G01N21/49 , G01N35/02 , G01N35/10
CPC分类号： G01F23/292 , G01F23/0061 , G01F23/2928 , G01N9/04 , G01N35/028 , G01N2035/1025
摘要： The present application relates to an apparatus and method for measuring liquid levels in small-volume wells.
摘要翻译：本申请涉及用于测量小容量井中的液面的装置和方法。

2. 发明申请

US20080077582A1 System and method of ad-hoc analysis of data 有权
标题翻译：数据临时分析的系统和方法
公开(公告)号：US20080077582A1
公开(公告)日：2008-03-27
申请号：US11897984
申请日：2007-08-31
申请人： Mark Reed
发明人： Mark Reed
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30613
摘要： It is a first aspect of the present invention to provide a computer implemented method of performing ad-hoc analysis including the steps of: generating a text index of the textual information items, generating a metadata lookup structure based, at least in part, on the text index, searching the text index using a search query, compiling results of the text index search into aggregate information related to characteristics of the search results from the metadata items associated with the textual information items in the search results from the metadata lookup structure, and reporting the aggregate information.
摘要翻译：本发明的第一方面是提供一种执行临时分析的计算机实现方法，包括以下步骤：生成文本信息项的文本索引，至少部分地基于文本信息项生成元数据查找结构文本索引，使用搜索查询搜索文本索引，将来自与来自元数据查找结构的搜索结果中的文本信息项相关联的元数据项的搜索结果的特征相关的文本索引搜索的结果编译成聚合信息;以及报告汇总信息。

3. 发明申请

US20070014694A1 High density plate filler 审中-公开
标题翻译：高密度板填料
公开(公告)号：US20070014694A1
公开(公告)日：2007-01-18
申请号：US11086800
申请日：2005-03-22
申请人： Nigel Beard , Albert Carrillo , Ian Harding , Mark Reed
发明人： Nigel Beard , Albert Carrillo , Ian Harding , Mark Reed
IPC分类号： B01L3/02
CPC分类号： B01L3/50853 , B01L3/0293 , B01L3/5025 , B01L3/50851 , B01L3/563 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2300/0829 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N35/1074
摘要： A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an assay input layer having a first surface and an opposing second surface. The assay input layer can comprise an assay input port extending from the first surface to the second surface and at least one pressure nodule extending from the second surface. An output layer can comprise a plurality of staging capillaries each having an inlet and an outlet. A intermediate layer can be disposed between the assay input layer and the output layer. The intermediate layer can be flexible and comprise a plurality of microfluidic channels and a flow aperture being in fluid communication with the assay input port and the plurality of microfluidic channels. The assay input layer can be moveable relative to the intermediate layer such that the at least one pressure nodule engages the intermediate layer to apply a clamping force on at least a portion of one of the plurality of microfluidic channels to reduce flow of the assay therethrough.
摘要翻译：一种用于填充微板的填充装置。微量培养板具有多个孔，每个孔的大小用于接受测定。填充装置可以包括具有第一表面和相对的第二表面的测定输入层。测定输入层可以包括从第一表面延伸到第二表面的测定输入端口和从第二表面延伸的至少一个压力结节。输出层可以包括多个具有入口和出口的分段毛细管。中间层可以设置在测定输入层和输出层之间。中间层可以是柔性的并且包括多个微流体通道，并且流动孔与测定输入端口和多个微流体通道流体连通。测定输入层可以相对于中间层移动，使得至少一个压力结节接合中间层，以在多个微流体通道之一的至少一部分上施加夹紧力，以减少测定的流动。

4. 发明申请

US20060233673A1 High density plate filler 审中-公开
标题翻译：高密度板填料
公开(公告)号：US20060233673A1
公开(公告)日：2006-10-19
申请号：US11393083
申请日：2006-03-30
申请人： Nigel Beard , Mark Reed
发明人： Nigel Beard , Mark Reed
IPC分类号： B01L3/00 , G01N35/00
CPC分类号： G01N35/1074 , B01L3/0293 , B01L3/5025 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2300/0829 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487
摘要： A filling apparatus for filling a microplate. The microplate can comprise a plurality of wells each sized to receive an assay. A substrate can comprise a first surface and an opposing second surface, a first assay input port for receiving the assay disposed on the first surface, a plurality of staging capillaries extending through the substrate, a fluid interconnect system fluidly coupling the first assay input port with at least one of the plurality of staging capillaries, and an overflow retention system receiving and retaining excess assay from said fluid interconnect system. Each of the plurality of staging capillaries can comprise an inlet and an outlet and be sized to receive the assay.
摘要翻译：一种用于填充微板的填充装置。微量培养板可以包括多个孔，每个孔的尺寸适于接受测定。基底可以包括第一表面和相对的第二表面，用于接收设置在第一表面上的测定的第一测定输入端口，延伸穿过基底的多个分期毛细血管，将第一测定输入端口与所述多个分级毛细管中的至少一个，以及从所述流体互连系统接收和保留多余测定的溢流保持系统。多个分级毛细管中的每一个可以包括入口和出口，并且其大小适于接收测定。

5. 发明申请

US20050226782A1 High density plate filler 审中-公开
标题翻译：高密度板填料
公开(公告)号：US20050226782A1
公开(公告)日：2005-10-13
申请号：US11086683
申请日：2005-03-22
申请人： Mark Reed , Albert Carrillo , Ian Harding
发明人： Mark Reed , Albert Carrillo , Ian Harding
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , B01L99/00 , G01N21/27 , G01N21/64 , G01N33/00 , G01N35/02
CPC分类号： G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L7/52 , B01L9/523 , B01L9/56 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0689 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N21/274 , G01N21/6452
摘要： A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an output layer having a plurality of capillaries. Each of the plurality of capillaries can comprise an inlet and an outlet. A funnel member can comprise a first assay chamber and a first outlet in fluid communication with the first assay chamber. The first outlet can deliver a first fluid bead of the assay along a top surface of the output layer and in fluid communication with at least some of the plurality of capillaries such that a portion of the fluid bead is drawn within at least some of the plurality of capillaries in response to capillary force. The funnel member and the output layer can be moveable relative to each other between a first position and a second position to draw the first fluid bead across the top surface.
摘要翻译：一种用于填充微板的填充装置。微量培养板具有多个孔，每个孔的大小用于接受测定。填充装置可以包括具有多个毛细管的输出层。多个毛细管中的每一个可以包括入口和出口。漏斗构件可以包括第一测定室和与第一测定室流体连通的第一出口。第一出口可以沿着输出层的顶表面递送测定的第一流体珠，并且与多个毛细管中的至少一些毛细管流体连通，使得流体珠的一部分在至少一些多个毛细管内被拉伸的毛细血管弹力。漏斗构件和输出层可以在第一位置和第二位置之间相对于彼此移动，以便通过顶表面拉动第一流体珠。

6. 发明申请

US20050208539A1 Quantitative amplification and detection of small numbers of target polynucleotides 审中-公开
标题翻译：定量扩增和检测少量目标多核苷酸
公开(公告)号：US20050208539A1
公开(公告)日：2005-09-22
申请号：US11026924
申请日：2004-12-30
申请人： Charles Vann , Kai Lao , Mark Reed , Seth Stern , Dennis Lehto
发明人： Charles Vann , Kai Lao , Mark Reed , Seth Stern , Dennis Lehto
IPC分类号： B01L3/00 , B01L7/00 , C12M1/34 , C12Q1/68
CPC分类号： B01L7/52 , B01L3/502707 , B01L3/502715 , B01L2300/0861 , B01L2300/18 , B01L2400/06 , C12Q1/686 , C12Q2527/125
摘要： Devices, assemblies, systems and methods described herein enable detection of as few as a single copy of a target nucleic acid molecule. Polynucleotides copied from a single or a small number of target nucleotide(s) within regions near to an initial copying site may be detected by optical or other methods as disclosed herein. Devices, assemblies and systems may comprise probes and/or primer molecules. Systems comprising optical assemblies, thermal assemblies and reaction assemblies (having reaction chambers for amplification of target nucleic acid molecules) are provided in which used reaction assemblies may be replaced to provide reusable devices. Systems comprising analytical assemblies and detection assemblies are provided in which an assay cartridge having assay chambers may engage a thermal assembly for amplification of target nucleic acid molecules. These devices, systems and methods offer the advantages of detection of as few as a single copy of a target nucleic acid molecule.
摘要翻译：本文描述的装置，组件，系统和方法能够检测目标核酸分子的单拷贝数。从初始复制部位附近的区域内单个或少数目标核苷酸复制的多核苷酸可以通过本文公开的光学或其它方法检测。装置，组件和系统可以包括探针和/或引物分子。提供了包括光学组件，热组件和反应组件（具有用于扩增靶核酸分子的反应室）的系统，其中可以更换所使用的反应组件以提供可重复使用的装置。提供了包括分析组件和检测组件的系统，其中具有测定室的测定盒可以接合热组件以扩增靶核酸分子。这些装置，系统和方法提供了检测目标核酸分子的单拷贝的优点。

7. 发明授权

US5170361A Fluid temperature, flow rate, and volume control system 失效
标题翻译：流体温度，流量和体积控制系统
公开(公告)号：US5170361A
公开(公告)日：1992-12-08
申请号：US465369
申请日：1990-01-16
申请人： Mark Reed
发明人： Mark Reed
IPC分类号： G05D23/13
CPC分类号： G05D23/1393
摘要： A system is disclosed for independently attaining, monitoring, and dispensing a fluid mix or a plurality of fluid mixes of a desired temperature, flow rate, and volume, the fluid mixes each comprising two separate mixable fluids usually at different temperatures as they enter the system. The system comprises one microprocessor configuration connected with any number of fluid mixing apparatuses including their drive means, sensors, and an appropriate number of user command and system status feedback means. In one embodiment, as disclosed herein, a plurality of system users can independently and even simultaneously instruct, using a variety of means, a single microprocessor configuration to provide their desired fluid mixes. The microprocessor configuration compares the instructions with the system status data provided by the sensors and its own calculations. Whenever the data differs from the instructions, it causes the fluid mixing apparatuses' drive means to operate in such a way as to provide mixes which match the users' commands. Users are provided with system status information all the while.
摘要翻译：公开了一种系统，用于独立地实现，监测和分配具有期望温度，流速和体积的流体混合物或多个流体混合物，每个流体混合物包含两个单独的可混合流体，通常在进入系统时处于不同的温度。该系统包括与任何数量的流体混合装置连接的一个微处理器配置，其包括其驱动装置，传感器以及适当数量的用户命令和系统状态反馈装置。在一个实施例中，如本文所公开的，多个系统用户可以独立地甚至同时地以各种方式同时指示单个微处理器配置来提供它们所需的流体混合物。微处理器配置将指令与传感器提供的系统状态数据及其自身的计算进行比较。无论何时数据与指令不同，它使得流体混合装置的驱动装置以提供符合用户命令的混合的方式操作。用户随时都可以获得系统状态信息。

8. 发明授权

US08252250B2 Electroosmotic pump with improved gas management 有权
标题翻译：电渗泵具有改进的气体管理
公开(公告)号：US08252250B2
公开(公告)日：2012-08-28
申请号：US12626353
申请日：2009-11-25
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： B01L3/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.
摘要翻译：提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。

9. 发明申请

US20100167293A1 Digital Assay 审中-公开
标题翻译：数字测定
公开(公告)号：US20100167293A1
公开(公告)日：2010-07-01
申请号：US12562108
申请日：2009-09-17
申请人： Charles S. Vann , Kai Qin Lao , Mark Reed
发明人： Charles S. Vann , Kai Qin Lao , Mark Reed
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , B82Y5/00 , B82Y10/00 , C12Q1/6827 , C12Q2563/155 , C12Q2561/125 , C12Q2545/114 , C12Q2565/102 , C12Q2563/143
摘要： The invention relates to methods and compositions for the detection of targets in a sample.
摘要翻译：本发明涉及用于检测样品中靶标的方法和组合物。

10. 发明申请

US20090103666A1 CHANNEL ESTIMATION FOR RAPID DISPERSIVE FADING CHANNELS 审中-公开
标题翻译：用于快速分散衰减信道的信道估计
公开(公告)号：US20090103666A1
公开(公告)日：2009-04-23
申请号：US12295713
申请日：2007-03-30
申请人： Ming Zhao , Zhenning Shi , Mark Reed
发明人： Ming Zhao , Zhenning Shi , Mark Reed
IPC分类号： H04L27/06
CPC分类号： H04L25/022 , H04L25/023 , H04L27/2647
摘要： This invention addresses the problem of channel estimation in fast fading communications channels, particularly for OFDM systems. It finds wide application in existing and future systems such as WLAN and WiMax. In particular, the invention involves a method of channel estimation and data detection for rapid dispersive fading channels due to high mobility. The invention involves decoding a symbol of the received transmission by retrieving pilot tones from it and using these to estimate variations in the channel frequency response using an iterative maximum likelihood channel estimation process, in which the estimation process comprises the following steps: In a first iteration, deriving soft decoded data information, that is information having a confidence value or reliability associated with it, from the estimates of the channel frequency response for the symbol obtained from pilot tones. And, in at least a second iteration using the soft decoded data information as virtual pilot tones together with the pilot tones to re-estimate the channel frequency response for the symbol. In other aspects the invention concerns a receiver and software designed to perform the method.
摘要翻译：本发明解决了在快速衰落通信信道中的信道估计问题，特别是用于OFDM系统。它在现有和未来的系统中广泛应用，如WLAN和WiMax。特别地，本发明涉及由于高移动性而对快速色散衰落信道进行信道估计和数据检测的方法。本发明涉及通过从其中检索导频音来解码所接收的传输的符号，并使用它们来估计信道频率响应的变化，其中估计过程包括以下步骤：在第一次迭代中根据从导频音获得的符号的信道频率响应的估计，导出软解码数据信息，即具有与其相关联的置信度值或可靠度的信息的软解码数据信息。并且在至少第二次迭代中，使用软解码数据信息作为虚拟导频音与导频音一起重新估计符号的信道频率响应。在其它方面，本发明涉及被设计用于执行该方法的接收器和软件。

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