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1. 发明申请

US20050020786A1 Polymer microspheres containing latent colorants and method of preparation 有权
标题翻译：含有潜着色剂的聚合物微球及其制备方法
公开(公告)号：US20050020786A1
公开(公告)日：2005-01-27
申请号：US10876871
申请日：2004-06-25
申请人： Jeffrey Leon , Tiecheng Qiao , Robert McCovick
发明人： Jeffrey Leon , Tiecheng Qiao , Robert McCovick
IPC分类号： C08J3/00 , C08L89/00 , C09B67/02 , C09B67/28 , C09D157/00 , G03C7/327
CPC分类号： G03C7/3275 , C09B67/0077 , C09B67/0078 , C09B67/0097
摘要： The present invention relates to a polymer microsphere comprising at least one polymer and at least one bound latent colorant, wherein the microsphere is stabilized by at least one stabilizing polymer. The invention also includes a method of preparing polymer microspheres comprising combining latent colorant, ethylenically unsaturated monomer, stabilizing polymer, and an initiator in solvent and initiating polymerization to form a polymeric microsphere stabilized by a stabilizing polymer bound to the surface of the polymeric microsphere.
摘要翻译：本发明涉及包含至少一种聚合物和至少一种结合的潜在着色剂的聚合物微球，其中所述微球由至少一种稳定聚合物稳定。本发明还包括制备聚合物微球的方法，其包括将潜着色剂，烯键式不饱和单体，稳定聚合物和引发剂在溶剂中组合并引发聚合以形成通过与聚合物微球表面结合的稳定化聚合物稳定的聚合物微球。

2. 发明申请

US20050027045A1 POLYMER MICROSPHERES CONTAINING LATENT COLORANTS AND METHOD OF PREPARATION 失效
标题翻译：含聚合物的聚合物微球和制备方法
公开(公告)号：US20050027045A1
公开(公告)日：2005-02-03
申请号：US10625684
申请日：2003-07-23
申请人： Jeffrey Leon , Tiecheng Qiao , Robert McCovick
发明人： Jeffrey Leon , Tiecheng Qiao , Robert McCovick
IPC分类号： C08J3/00 , C08L89/00 , C09B67/02 , C09B67/28 , C09D157/00 , G03C7/327
CPC分类号： G03C7/3275 , C09B67/0077 , C09B67/0078 , C09B67/0097
摘要： The present invention relates to a polymer microsphere comprising at least one polymer and at least one bound latent colorant, wherein the microsphere is stabilized by at least one stabilizing polymer. The invention also includes a method of preparing polymer microspheres comprising combining latent colorant, ethylenically unsaturated monomer, stabilizing polymer, and an initiator in solvent and initiating polymerization to form a polymeric microsphere stabilized by a stabilizing polymer bound to the surface of the polymeric microsphere.
摘要翻译：本发明涉及包含至少一种聚合物和至少一种结合的潜在着色剂的聚合物微球，其中所述微球由至少一种稳定聚合物稳定。本发明还包括制备聚合物微球的方法，其包括将潜着色剂，烯键式不饱和单体，稳定聚合物和引发剂在溶剂中组合并引发聚合以形成通过与聚合物微球表面结合的稳定化聚合物稳定的聚合物微球。

3. 发明申请

US20070237821A1 Nanogel-based contrast agents for optical molecular imaging 审中-公开
标题翻译：基于Nanogel的光学分子成像造影剂
公开(公告)号：US20070237821A1
公开(公告)日：2007-10-11
申请号：US11401343
申请日：2006-04-10
申请人： Jeffrey Leon , James Bennett , Tiecheng Qiao , John Harder , Thomas Mourey , Gary Slater , Lijun Dai
发明人： Jeffrey Leon , James Bennett , Tiecheng Qiao , John Harder , Thomas Mourey , Gary Slater , Lijun Dai
IPC分类号： A61K9/14
CPC分类号： A61K49/0093 , A61K47/6903 , A61K47/6933 , A61K49/0032 , A61K49/0073 , B82Y5/00
摘要： The present invention relates to a nanogel comprising a polymer network of repetitive, crosslinked, ethylenically unsaturated monomers of Formula I: (X)m-(Y)n-(Z)o Formula I wherein X is a water-soluble monomer containing ionic or hydrogen bonding moieties; Y is a water-soluble macromonomer containing repetitive hydrophilic units bound to a polymerizeable ethylenically unsaturated group; Z is a multifunctional crosslinking monomer; m ranges from 50-90 mol %; n ranges from 2-30 mol %; and o range from 1-15 mol % and a method for preparing a nanogel comprising preparing a header composition of a mixture of monomers X, Y, and Z, and a first portion of initiators in water; preparing a reactor composition of a second portion initiators, surfactant, and water; bringing the reactor composition to the polymerization temperature; holding the reactor composition at the polymerization temperature, and adding the header composition to the reactor composition to form a nanogel of Formula I.
摘要翻译：本发明涉及纳米凝胶，其包含式I的重复，交联，烯键式不饱和单体的聚合物网络：<？在线公式描述=“在线式”末端=“铅”→（X）m- （Y）n-（Z）o式I <？in-line-formula description =“In-line Formulas”end =“tail”？>其中X是含有离子或氢键结构部分的水溶性单体; Y是含有与可聚合烯属不饱和基团结合的重复亲水单元的水溶性大分子单体; Z是多功能交联单体; m范围为50-90摩尔％; n范围为2-30mol％; 其范围为1-15mol％，制备纳米凝胶的方法包括制备单体X，Y和Z的混合物的头部组合物和在水中的第一部分引发剂; 制备第二部分引发剂，表面活性剂和水的反应器组合物; 使反应器组成达到聚合温度; 将反应器组合物保持在聚合温度，并将集管组合物加入到反应器组合物中以形成式I的纳米凝胶。

4. 发明申请

US20050079506A1 Filled, biological microarray and method for use 审中-公开
标题翻译：填充，生物微阵列和使用方法
公开(公告)号：US20050079506A1
公开(公告)日：2005-04-14
申请号：US10682271
申请日：2003-10-09
申请人： Jeffrey Leon , Tiecheng Qiao , Christine Landry-Coltrain
发明人： Jeffrey Leon , Tiecheng Qiao , Christine Landry-Coltrain
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/543 , G01N33/544
CPC分类号： G01N33/544 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , G01N33/54353 , G01N33/54393
摘要： The present invention relates to a biological microarray element comprising a support having disposed thereon at least one layer comprising filler and gelatin, and at least one functional compound, wherein the functional compound comprises a first functional group capable of interacting with gelatin and a second functional group capable of interacting with a biological capture agent, wherein the first functional group is the same as or different from the second functional group. Also provided is a method of making a biological microarray element comprising providing a support; and coating a layer comprising filler and gelatin and at least one functional compound, wherein the functional compound comprises a first functional group capable of interacting with the gelatin and a second functional group capable of interacting with a biological capture agent, wherein the first functional group is the same as or different from the second functional group.
摘要翻译：本发明涉及一种生物微阵列元件，其包括在其上设置有至少一层包含填充剂和明胶的载体和至少一种官能化合物的载体，其中所述官能化合物包含能够与明胶相互作用的第一官能团和第二官能团能够与生物捕获剂相互作用，其中第一官能团与第二官能团相同或不同。还提供了制备生物微阵列元件的方法，包括提供支撑体; 并涂覆包含填料和明胶和至少一种官能化合物的层，其中所述官能化合物包括能够与所述明胶相互作用的第一官能团和能够与生物捕获剂相互作用的第二官能团，其中所述第一官能团为与第二官能团相同或不同。

5. 发明申请

US20050054815A1 Stabilized polymer beads and method of preparation 有权
标题翻译：稳定聚合物珠粒及其制备方法
公开(公告)号：US20050054815A1
公开(公告)日：2005-03-10
申请号：US10658009
申请日：2003-09-09
申请人： Jeffrey Leon , Tiecheng Qiao
发明人： Jeffrey Leon , Tiecheng Qiao
IPC分类号： C08G75/00 , C08J7/04
CPC分类号： C08F265/04 , C08F257/02 , C08F2800/20 , C08F2810/30 , C08L51/003 , C08L2666/02
摘要： The present invention relates to a polymer particles comprising a polymer bead stabilized by vinylsulfonyl-functionalized polymers grafted to the surface of the bead, as well as a particle composition comprising monodisperse polymer beads stabilized by vinylsulfonyl-functionalized polymers, wherein the vinylsulfonyl-functionalized polymers are grafted to the surfaces of the beads. The invention also includes a method of preparing monodisperse polymer particles comprising preparing a homogeneous solution of an ethylenically unsaturated polymerizable monomer, an initiator, and a polymeric stabilizer, wherein the polymeric stabilizer consists of repetitive units, wherein the repetitive units comprise latent vinylsulfonyl moiety, polymerizing the homogeneous solution, and converting the latent vinylsulfonyl moiety to vinylsulfonyl moieties.
摘要翻译：本发明涉及包含由接枝到珠粒表面的乙烯基磺酰基官能化聚合物稳定的聚合物珠粒的聚合物颗粒，以及包含由乙烯基磺酰基官能化聚合物稳定的单分散聚合物珠粒的颗粒组合物，其中乙烯基磺酰基官能化聚合物是接枝到珠的表面。本发明还包括制备单分散聚合物颗粒的方法，其包括制备烯属不饱和可聚合单体，引发剂和聚合物稳定剂的均匀溶液，其中聚合物稳定剂由重复单元组成，其中重复单元包括潜在的乙烯基磺酰基部分，聚合均匀溶液，并将潜在的乙烯基磺酰基部分转化为乙烯基磺酰基部分。

6. 发明申请

US20050019944A1 Colorable microspheres for DNA and protein microarray 审中-公开
标题翻译：用于DNA和蛋白质微阵列的着色微球
公开(公告)号：US20050019944A1
公开(公告)日：2005-01-27
申请号：US10625424
申请日：2003-07-23
申请人： Tiecheng Qiao , Jeffrey Leon , Kurt Schroeder
发明人： Tiecheng Qiao , Jeffrey Leon , Kurt Schroeder
IPC分类号： B01J19/00 , G01N33/543 , G01N33/58 , G01N21/00
CPC分类号： G01N33/54386 , B01J19/0046 , B01J2219/00466 , B01J2219/00545 , B01J2219/00576 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , G01N33/54313 , G01N33/583
摘要： A microarray comprising: a support, on which is disposed a layer of microspheres bearing biological probes; wherein said microspheres comprise at least one material with a latent color that can be developed and used to identify said microsphere. A method of identifying biological analytes using the microarray is also disclosed.
摘要翻译：一种微阵列，包括：载体，其上设置有承载生物探针的微球体层; 其中所述微球包含至少一种具有潜在颜色的材料，其可显影并用于鉴定所述微球。还公开了使用微阵列识别生物分析物的方法。

7. 发明申请

US20050064431A1 Biological microarray comprising polymer particles and method of use 审中-公开
标题翻译：包含聚合物颗粒的生物微阵列和使用方法
公开(公告)号：US20050064431A1
公开(公告)日：2005-03-24
申请号：US10658438
申请日：2003-09-09
申请人： Jeffrey Leon , Tiecheng Qiao , Christine Landry-Coltrain
发明人： Jeffrey Leon , Tiecheng Qiao , Christine Landry-Coltrain
IPC分类号： C07H21/04 , C12Q1/68 , C12M1/34
CPC分类号： C07H21/04
摘要： The present invention relates to a microarray comprising a support having attached to a surface thereof at least one porous layer, wherein the porous layer comprises a hydrophilic binder and polymer particles. The present invention also relates to a method of using a microarray comprising providing a microarray comprising a support having attached to a surface thereof at least one porous layer, wherein the porous layer comprises a hydrophilic binder and polymer particles; contacting the microarray with biological targets labeled with optical emission tag; and measuring the signals from the optical emission tag.
摘要翻译：本发明涉及一种微阵列，其包括具有附着在至少一个多孔层的表面上的载体，其中所述多孔层包含亲水性粘合剂和聚合物颗粒。本发明还涉及一种使用微阵列的方法，其包括提供微阵列，所述微阵列包括附着在至少一个多孔层的表面上的载体，其中所述多孔层包括亲水性粘合剂和聚合物颗粒; 使微阵列与标记有光发射标签的生物靶接触; 并测量来自光发射标签的信号。

8. 发明授权

US08753959B2 Coating adhesives onto dicing before grinding and micro-fabricated wafers 有权
标题翻译：在研磨和微晶片之前将涂料粘合剂切割
公开(公告)号：US08753959B2
公开(公告)日：2014-06-17
申请号：US13613142
申请日：2012-09-13
申请人： Hwang Kyu Yun , Jeffrey Leon , Raj Peddi , YounSang Kim
发明人： Hwang Kyu Yun , Jeffrey Leon , Raj Peddi , YounSang Kim
IPC分类号： H01L21/78 , H01L21/784 , H01L21/822 , H01L21/67
CPC分类号： H01L21/78 , H01L21/67132 , H01L21/6836 , H01L21/784 , H01L21/822
摘要： A method for preparing a semiconductor wafer into individual semiconductor dies uses both a dicing before grinding step and/or via hole micro-fabrication step, and an adhesive coating step.
摘要翻译：将半导体晶片制备成单个半导体管芯的方法使用在研磨步骤和/或通孔微加工步骤之间的切割和粘合剂涂布步骤。

9. 发明申请

US20060051712A1 THERMALLY DEVELOPABLE MATERIALS CONTAINING IONIC POLYMER INTERLAYER 失效
标题翻译：含有离子聚合物中间层的热发生材料
公开(公告)号：US20060051712A1
公开(公告)日：2006-03-09
申请号：US10935641
申请日：2004-09-07
申请人： Jon Hammerschmidt , Jeffrey Leon
发明人： Jon Hammerschmidt , Jeffrey Leon
IPC分类号： G03C1/00
CPC分类号： G03C1/49872 , G03C1/0051 , G03C1/04 , G03C1/498 , G03C1/49809 , G03C1/49818 , G03C1/49845 , G03C1/49863 , G03C1/4989 , G03C5/17 , G03C2001/7425 , G03C2200/35 , G03C2200/36 , G03C2200/40 , Y10S430/162 , Y10S430/165
摘要： Thermally developable imaging materials have an outermost protective layer that is composed of one or more hydrophilic film-forming components. Between the outermost protective layer and the underlying thermally developable imaging layers is an interlayer containing a film-forming ionic latex polymer other than a carboxy-containing latex polymer. This ionic polymer can be negatively-charged or positively-charged. The ionic latex polymer is present as latex particles that have been prepared in the presence of a stabilizer in an amount of at least 0.5% (by weight) that has an HLB value of 7 to 20. The stabilizer becomes associated with the latex polymer particles. Both thermographic and photothermographic materials can be prepared with such protective layers.
摘要翻译：可热显影成像材料具有由一种或多种亲水成膜组分组成的最外层保护层。在最外面的保护层和下面的可热显影成像层之间是含有除了含羧基的胶乳聚合物之外的成膜离子胶乳聚合物的中间层。该离子聚合物可以带负电荷或带正电荷。离子胶乳聚合物作为在稳定剂存在下制备的胶乳颗粒以至少0.5％（重量）的HLB值为7至20的量存在。稳定剂与胶乳聚合物颗粒相关联。热成像和光热成像材料都可以用这样的保护层制备。

10. 发明申请

US20070238656A1 Functionalized poly(ethylene glycol) 审中-公开
标题翻译：官能化聚（乙二醇）
公开(公告)号：US20070238656A1
公开(公告)日：2007-10-11
申请号：US11400935
申请日：2006-04-10
申请人： John Harder , Jeffrey Leon
发明人： John Harder , Jeffrey Leon
IPC分类号： A61K38/00
CPC分类号： C08G65/329 , C08G65/334 , C08G65/3344 , C08G65/3348
摘要： The present invention relates to a bi-functional compound containing a linking material, and a particle comprising a linking material, and a linking material comprising a polyethylene glycol macromonomer backbone with a radical polymerizable group at one end of the macromonomer backbone and a different reactive chemical functionality at the other end of the macromonomer backbone, according to Formula I: wherein X is CH3, CN or H; Y is O, NR1, or S; L is a linking group or spacer; FG is a functional group; n is greater than 4 and less than 1000; and wherein R1 and R2 are independently selected from substituted or unsubstituted alkyl, aryl, or heteroyl.
摘要翻译：本发明涉及包含连接材料的双功能化合物和包含连接材料的颗粒，以及包含在大分子单体骨架的一端具有自由基聚合性基团的聚乙二醇大分子单体骨架和不同的反应性化学物质的连接材料在大分子单体骨架的另一端的官能团，根据式I：其中X是CH 3，CN或H; Y是O，NR 1或S; L是连接基团或间隔基; FG是功能组; n大于4且小于1000; 并且其中R 1和R 2独立地选自取代或未取代的烷基，芳基或杂基。

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