专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070237821A1 Nanogel-based contrast agents for optical molecular imaging 审中-公开
标题翻译：基于Nanogel的光学分子成像造影剂
公开(公告)号：US20070237821A1
公开(公告)日：2007-10-11
申请号：US11401343
申请日：2006-04-10
申请人： Jeffrey Leon , James Bennett , Tiecheng Qiao , John Harder , Thomas Mourey , Gary Slater , Lijun Dai
发明人： Jeffrey Leon , James Bennett , Tiecheng Qiao , John Harder , Thomas Mourey , Gary Slater , Lijun Dai
IPC分类号： A61K9/14
CPC分类号： A61K49/0093 , A61K47/6903 , A61K47/6933 , A61K49/0032 , A61K49/0073 , B82Y5/00
摘要： The present invention relates to a nanogel comprising a polymer network of repetitive, crosslinked, ethylenically unsaturated monomers of Formula I: (X)m-(Y)n-(Z)o Formula I wherein X is a water-soluble monomer containing ionic or hydrogen bonding moieties; Y is a water-soluble macromonomer containing repetitive hydrophilic units bound to a polymerizeable ethylenically unsaturated group; Z is a multifunctional crosslinking monomer; m ranges from 50-90 mol %; n ranges from 2-30 mol %; and o range from 1-15 mol % and a method for preparing a nanogel comprising preparing a header composition of a mixture of monomers X, Y, and Z, and a first portion of initiators in water; preparing a reactor composition of a second portion initiators, surfactant, and water; bringing the reactor composition to the polymerization temperature; holding the reactor composition at the polymerization temperature, and adding the header composition to the reactor composition to form a nanogel of Formula I.
摘要翻译：本发明涉及纳米凝胶，其包含式I的重复，交联，烯键式不饱和单体的聚合物网络：<？在线公式描述=“在线式”末端=“铅”→（X）m- （Y）n-（Z）o式I <？in-line-formula description =“In-line Formulas”end =“tail”？>其中X是含有离子或氢键结构部分的水溶性单体; Y是含有与可聚合烯属不饱和基团结合的重复亲水单元的水溶性大分子单体; Z是多功能交联单体; m范围为50-90摩尔％; n范围为2-30mol％; 其范围为1-15mol％，制备纳米凝胶的方法包括制备单体X，Y和Z的混合物的头部组合物和在水中的第一部分引发剂; 制备第二部分引发剂，表面活性剂和水的反应器组合物; 使反应器组成达到聚合温度; 将反应器组合物保持在聚合温度，并将集管组合物加入到反应器组合物中以形成式I的纳米凝胶。

IPRDB

热门服务

关于我们

友情链接

联系方式