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1. 发明公开

US20240319183A1 METHODS FOR MEASURING AN AMOUNT OF AN ANALYTE IN A COMPLEX SAMPLE 审中-公开
公开(公告)号：US20240319183A1
公开(公告)日：2024-09-26
申请号：US18678144
申请日：2024-05-30
申请人： Robert Bosch GmbH
发明人： Nadezda FOMINA , Christopher JOHNSON , Young Shik SHIN , Christoph LANG
IPC分类号： G01N33/544 , G01N27/327 , G01N33/84
CPC分类号： G01N33/544 , G01N27/3277 , G01N33/84
摘要： A method for detecting an amount of an analyte in a solution includes providing an assay chamber including an electrode positioned at a first end of the assay chamber and a capture molecule attached to the electrode via a linker. A solution including an analyte, a binding partner of the analyte, at least one electrochemically active agent, and a detecting probe having a signaling tag attached thereto may be provided to the assay chamber. An electrical signal may be applied to the electrode to change the pH of the solution in the area near the electrode. The analyte may bind to the capture molecule and to the detecting probe at the first end of the assay chamber at the new pH. A signal produced by the signaling tag at the first end of the assay chamber may be measured to calculate the amount of the analyte in the solution.

2. 发明公开

US20240133878A1 METHOD FOR IMMUNOSENSING ON A LIPID LAYER 审中-公开
公开(公告)号：US20240133878A1
公开(公告)日：2024-04-25
申请号：US18541476
申请日：2023-12-15
申请人： Roche Diagnostics Operations, Inc.
发明人： Nikolaus-Peter Stengele
IPC分类号： G01N33/544 , G01N33/543
CPC分类号： G01N33/544 , G01N33/54386
摘要： The present invention relates to diagnostic test and technology. In particular, the present invention relates to a method for determining an analyte suspected to be present in a sample comprising contacting said sample with a sensor element comprising i) an anchor layer which is present on a solid support, ii) a first binding agent which is capable of specifically binding to the analyte, which is anchored in the anchor layer and which comprises at least one detectable label, and iii) a second binding agent which is capable of specifically binding to the analyte when bound to the first binding agent and which is immobilized on the solid support, for a time and under conditions which allow for specific binding of the analyte suspected to be present in the sample to the first binding agent and specific binding of the second binding agent to the analyte bound to the first binding agent and detecting the formation of the complex of first binding agent, analyte and second binding agent whereby the analyte is determined. Moreover, provided is a device for determining an analyte suspected to be present in a sample and the use thereof for determining an analyte suspected to be present in a sample in said sample. Moreover, the present invention contemplates a kit for determining an analyte suspected to be present in a sample.

3. 发明公开

US20230324379A1 Functional Porous Substrates for Attaching Biomolecules 审中-公开
公开(公告)号：US20230324379A1
公开(公告)日：2023-10-12
申请号：US18118844
申请日：2023-03-08
申请人： W. L. Gore & Associates, Inc.
发明人： Anit Dutta , Heidi Flannery , William P. Mortimer, JR.
IPC分类号： G01N33/552 , G01N33/544
CPC分类号： G01N33/552 , G01N33/544 , C12Q1/6837
摘要： An expanded polytetrafluoroethylene substrate comprising a microporous microstructure, an interlayer over at least a portion of the microstructure, the interlayer containing a reactive functionality, and a functional layer attached to the interlayer, the interlayer comprising a sol-gel coating or a polyvinylalcohol. The functional layer of the substrate having functional sites with a density of at least 50 nanomoles/cm2.

4. 发明申请

US20180217035A1 LIGAND-FUNCTIONALIZED SUBSTRATES WITH ENHANCED BINDING CAPACITY 审中-公开
公开(公告)号：US20180217035A1
公开(公告)日：2018-08-02
申请号：US15936767
申请日：2018-03-27
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, JR.
IPC分类号： G01N1/40 , B01J20/32 , B01D71/44 , B01D71/52 , B01D71/56 , B01J20/26 , B01J20/28 , G01N33/544 , C08J7/18 , C07K1/34 , C07K1/18 , C07F9/38 , B01D67/00
CPC分类号： G01N1/405 , B01D67/0093 , B01D71/44 , B01D71/52 , B01D71/56 , B01D2323/345 , B01D2323/38 , B01D2325/14 , B01D2325/16 , B01J20/261 , B01J20/28038 , B01J20/321 , B01J20/3242 , B01J20/3251 , B01J20/3253 , B01J20/327 , C07F9/3808 , C07K1/18 , C07K1/34 , C08J7/18 , C08J2377/00 , G01N1/4077 , G01N33/544 , G01N2001/4088 , G01N2333/924
摘要： An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.

5. 发明申请

US20170261432A1 FABRICATION OF A FLUORESCENT MATERIAL FOR SENSING AN ANALYTE 审中-公开
公开(公告)号：US20170261432A1
公开(公告)日：2017-09-14
申请号：US15606260
申请日：2017-05-26
申请人： Senseonics, Incorporated
发明人： Philip Huffstetler , Jeremy Emken , Todd Whitehurst
IPC分类号： G01N21/64 , G01N33/544 , G01N33/58 , G01N21/77
CPC分类号： G01N21/6428 , G01N21/77 , G01N31/22 , G01N33/544 , G01N33/582 , G01N2021/773 , G01N2021/7786
摘要： An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.

6. 发明授权

US09562898B1 Method and assay for detection of residues 有权
标题翻译：检测残留物的方法和测定
公开(公告)号：US09562898B1
公开(公告)日：2017-02-07
申请号：US14461742
申请日：2014-08-18
申请人： Charm Sciences, Inc.
发明人： Steven J. Saul , Robert J. Markovsky , David W. Douglas
IPC分类号： G01N33/558 , G01N33/544
CPC分类号： G01N33/544 , G01N33/543 , G01N33/558 , G01N33/94 , G01N33/9446 , G01N2333/37
摘要： Embodiments described herein include methods and assays for detecting beta-lactam analytes and mycotoxin analytes in a sample. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
摘要翻译：本文描述的实施方案包括用于检测样品中β-内酰胺分析物和霉菌毒素分析物的方法和测定。一些实施方案包括利用多个分析物结合物检测样品中的多种分析物和含有多个控制区捕获剂的对照区。在一些实施例中，多个控制区捕获剂在一个控制区内捕获多个粘合剂。通过将控制区信号与测试区信号进行比较来确定测试结果。

7. 发明申请

US20160320403A1 SIMULTANEOUS CHARACTERIZATION OF IgG AND IgA ANTIBODIES TO MULTIPLE FOOD ANTIGENS AND C1Q-FOOD PROTEIN IMMUNE COMPLEXES 有权
标题翻译： IgG和IgA抗体同时表达多种食物抗体和C1Q-蛋白质蛋白质免疫复合物
公开(公告)号：US20160320403A1
公开(公告)日：2016-11-03
申请号：US14609865
申请日：2015-01-30
申请人： Aristo Vojdani
发明人： Aristo Vojdani
IPC分类号： G01N33/68 , G01N33/544
CPC分类号： G01N33/6854 , G01N33/543 , G01N33/544 , G01N33/564 , G01N2800/24
摘要： Compositions and methods for accurately characterizing immune reactivity to food allergens have been developed, in which test surfaces that incorporate different food antigen preparations derived from the same food into individual test sites are provided. Such coated surfaces can be produced using raw and cooked foods. The use of a panel of such test surfaces to characterize specific IgG, IgA, and/or C1q binding provides improved sensitivity and accuracy in determining immune reactivity and response to specific foods.
摘要翻译：已经开发了用于准确表征对食物过敏原的免疫反应性的组合物和方法，其中将从相同食物衍生的不同食品抗原制剂的试验表面提供到各个测试部位。这样的涂覆表面可以使用生的和熟的食物来生产。使用一组这样的测试表面来表征特异性IgG，IgA和/或C1q结合提供了确定免疫反应性和对特定食物的反应的改进的灵敏度和准确性。

8. 发明申请

US20160097764A1 DEVICE AND METHOD FOR CHEMICAL ANALYSIS 有权
标题翻译：用于化学分析的装置和方法
公开(公告)号：US20160097764A1
公开(公告)日：2016-04-07
申请号：US14874228
申请日：2015-10-02
申请人： Rite Taste, LLC
发明人： Mohammad E. Taslim , Mohammed Fotouhi , Mehdi Abedi , Reza Mollaaghababa , Bahram Fotouhi , Kashayar Javaherian , Edward Alvin Greenfield
IPC分类号： G01N33/53 , G01N1/28 , G01N33/544
CPC分类号： G01N33/5302 , B01L3/5027 , B01L2200/04 , B01L2300/023 , B01L2300/0663 , G01N1/286 , G01N1/4044 , G01N1/4077 , G01N27/045 , G01N33/02 , G01N33/025 , G01N33/5308 , G01N33/54366 , G01N33/5438 , G01N33/544 , G01N33/551 , G01N33/552 , G01N33/68 , G01N2001/2866 , G01N2001/4088 , G01N2333/415
摘要： A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.
摘要翻译：一种用于检测食品样品中至少一种面筋蛋白的存在的加工和检测系统包括食品加工机，其包括：储存器，其包含用于处理所述食品样品的处理液体; 包括构造成容纳食物样品的腔室的主体; 以及按压表面，其构造成在所述储存器上按压以使所述处理液体离开所述储存器并与所述食品样品混合，从而产生加工食品液体; 以及出口端口，被配置为将处理过的食品液体从食物处理器中导出; 以及盒，包括：至少一个传感器，被配置为接收所处理的食物液体并且响应于与所述加工食品液体中的所述至少一个麸质蛋白的相互作用产生电信号;以及分析器，其与所述至少一个传感器，用于检测电信号，并基于检测到的电信号确定食物样品中至少一种面筋蛋白的存在。

9. 发明申请

US20150377865A1 Method for using nanodiamonds to detect nearby magnetic nanoparticles 有权
标题翻译：使用纳米金刚石检测附近磁性纳米粒子的方法
公开(公告)号：US20150377865A1
公开(公告)日：2015-12-31
申请号：US14318220
申请日：2014-06-27
申请人： Google Inc.
发明人： Victor Marcel Acosta , Vikram Singh Bajaj , Jason Donald Thompson , Eric Peeters
IPC分类号： G01N33/50 , A61B5/1455
CPC分类号： A61K49/005 , A61B5/0035 , A61B5/0059 , A61B5/0071 , A61B5/0507 , A61B5/055 , A61B5/14507 , A61B5/14546 , A61B5/1455 , A61B2576/00 , A61K49/0002 , A61K49/001 , A61M5/007 , G01N33/5091 , G01N33/54333 , G01N33/54346 , G01N33/544 , G01N33/551
摘要： An imaging agent for detecting analytes in an environment includes functionalized nanodiamonds and functionalized magnetic particles that can selectively interact with an analyte. Each functionalized nanodiamond contains at least one color center configured emit light in response to illumination. At least one property of the light emitted by the color centers is related to the proximity of the functionalized magnetic particles to the color centers. This property can be detected to determine that the functionalized nanodiamonds are proximate to the functionalized magnetic particles, to determine that the functionalized nanodiamonds and the functionalized magnetic particles are interacting with the analyte, or other applications. Devices and methods for detecting properties of the analyte by interacting with the functionalized nanodiamonds and functionalized magnetic particles are also provided.
摘要翻译：用于检测环境中的分析物的成像剂包括可以选择性地与分析物相互作用的官能化纳米金刚石和官能化磁性颗粒。每个功能化纳米金刚石包含至少一个配置为响应照明而发光的色心。由色心发出的光的至少一个性质与功能化磁性颗粒与着色中心的接近度有关。可以检测该性质以确定官能化纳米金刚石接近官能化磁性颗粒，以确定官能化纳米金刚石和官能化磁性颗粒与分析物或其它应用相互作用。还提供了通过与官能化纳米金刚石和官能化磁性颗粒相互作用来检测分析物的性质的装置和方法。

10. 发明申请

US20150369802A1 Biomolecule Binding Composite Surfaces, Methods Of Making Such Surfaces, Devices Incorporating Such Surfaces, And Methods Of Using Such Surfaces In Biomolecule Binding Assays, And Devices Therefor 审中-公开
标题翻译：生物分子结合复合表面，制造这种表面的方法，结合这种表面的装置以及在生物分子结合分析中使用这些表面的方法及其装置
公开(公告)号：US20150369802A1
公开(公告)日：2015-12-24
申请号：US14545782
申请日：2015-06-18
申请人： GVS North America, Inc.
发明人： Michael A Harvey , Debra W English , Yuander A Ju , Emma R Smith , Weibing Teng , Janet Yancey-Wrona
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N33/544 , Y02A50/57 , Y10T156/10 , Y10T156/1052
摘要： The present invention relates to novel microporous, biomolecule binding composite surfaces. It also relates to processes for making such surfaces. It also relates to processes for incorporating such surfaces into assay devices, and the resulting assay devices. It also relates to readable biomolecule binding assay devices and methods of using such devices in protein microarrays or immunoassays.
摘要翻译：本发明涉及新型微孔，生物分子结合复合物表面。它还涉及制造这种表面的方法。它还涉及将这些表面并入测定装置的方法，以及所得的测定装置。它还涉及可读生物分子结合测定装置和在蛋白质微阵列或免疫测定中使用这些装置的方法。

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