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    • 3. 发明授权
    • Exercise apparatus
    • 运动器材
    • US4655448A
    • 1987-04-07
    • US740729
    • 1985-06-03
    • John Harder
    • John Harder
    • A63B21/068A63B21/00
    • A63B21/068
    • An exercise device of the body supporting type includes a generally H-shaped frame with collapsible legs at each end thereof, so that the frame can be elevated at the foot or head end; a board or backrest pivotally connected to the head end of the frame and extending towards the foot end of the frame; handles extending outwardly from the free end of the backrest for grasping by the user when in the prone position; and footrests for anchoring the feet of a user to the foot end of the frame. By grasping the handles and pressing against the footrests, the user can rotate the backrest around the head end of the frame to an inclined position in which the user is standing on the footrests.
    • 身体支撑型的运动装置包括在其每个端部具有可折叠的腿的大致H形的框架,使得框架可以在脚部或头部端部被升高; 枢转地连接到框架的头端并朝向框架的脚端延伸的板或靠背; 手柄从靠背的自由端向外延伸,用于当处于俯卧位时由使用者握住; 以及用于将使用者的脚固定到框架的脚端的搁脚板。 通过握住把手并按压脚踏板,用户可以将围绕框架的头端的靠背旋转到使用者站在搁脚板上的倾斜位置。
    • 6. 发明申请
    • Functionalized poly(ethylene glycol)
    • 官能化聚(乙二醇)
    • US20070238656A1
    • 2007-10-11
    • US11400935
    • 2006-04-10
    • John HarderJeffrey Leon
    • John HarderJeffrey Leon
    • A61K38/00
    • C08G65/329C08G65/334C08G65/3344C08G65/3348
    • The present invention relates to a bi-functional compound containing a linking material, and a particle comprising a linking material, and a linking material comprising a polyethylene glycol macromonomer backbone with a radical polymerizable group at one end of the macromonomer backbone and a different reactive chemical functionality at the other end of the macromonomer backbone, according to Formula I: wherein X is CH3, CN or H; Y is O, NR1, or S; L is a linking group or spacer; FG is a functional group; n is greater than 4 and less than 1000; and wherein R1 and R2 are independently selected from substituted or unsubstituted alkyl, aryl, or heteroyl.
    • 本发明涉及包含连接材料的双功能化合物和包含连接材料的颗粒,以及包含在大分子单体骨架的一端具有自由基聚合性基团的聚乙二醇大分子单体骨架和不同的反应性化学物质的连接材料 在大分子单体骨架的另一端的官能团,根据式I:其中X是CH 3,CN或H; Y是O,NR 1或S; L是连接基团或间隔基; FG是功能组; n大于4且小于1000; 并且其中R 1和R 2独立地选自取代或未取代的烷基,芳基或杂基。
    • 7. 发明申请
    • Nanogel-based contrast agents for optical molecular imaging
    • 基于Nanogel的光学分子成像造影剂
    • US20070237821A1
    • 2007-10-11
    • US11401343
    • 2006-04-10
    • Jeffrey LeonJames BennettTiecheng QiaoJohn HarderThomas MoureyGary SlaterLijun Dai
    • Jeffrey LeonJames BennettTiecheng QiaoJohn HarderThomas MoureyGary SlaterLijun Dai
    • A61K9/14
    • A61K49/0093A61K47/6903A61K47/6933A61K49/0032A61K49/0073B82Y5/00
    • The present invention relates to a nanogel comprising a polymer network of repetitive, crosslinked, ethylenically unsaturated monomers of Formula I: (X)m-(Y)n-(Z)o  Formula I wherein X is a water-soluble monomer containing ionic or hydrogen bonding moieties; Y is a water-soluble macromonomer containing repetitive hydrophilic units bound to a polymerizeable ethylenically unsaturated group; Z is a multifunctional crosslinking monomer; m ranges from 50-90 mol %; n ranges from 2-30 mol %; and o range from 1-15 mol % and a method for preparing a nanogel comprising preparing a header composition of a mixture of monomers X, Y, and Z, and a first portion of initiators in water; preparing a reactor composition of a second portion initiators, surfactant, and water; bringing the reactor composition to the polymerization temperature; holding the reactor composition at the polymerization temperature, and adding the header composition to the reactor composition to form a nanogel of Formula I.
    • 本发明涉及纳米凝胶,其包含式I的重复,交联,烯键式不饱和单体的聚合物网络:<?在线公式描述=“在线式”末端=“铅”→(X)m- (Y)n-(Z)o式I <?in-line-formula description =“In-line Formulas”end =“tail”?>其中X是含有离子或氢键结构部分的水溶性单体; Y是含有与可聚合烯属不饱和基团结合的重复亲水单元的水溶性大分子单体; Z是多功能交联单体; m范围为50-90摩尔%; n范围为2-30mol%; 其范围为1-15mol%,制备纳米凝胶的方法包括制备单体X,Y和Z的混合物的头部组合物和在水中的第一部分引发剂; 制备第二部分引发剂,表面活性剂和水的反应器组合物; 使反应器组成达到聚合温度; 将反应器组合物保持在聚合温度,并将集管组合物加入到反应器组合物中以形成式I的纳米凝胶。