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1. 发明授权

US06597438B1 Portable flow cytometry 有权
标题翻译：便携式流式细胞仪
公开(公告)号：US06597438B1
公开(公告)日：2003-07-22
申请号：US09630924
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3349
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150343 , A61B5/150351 , A61B5/150809 , A61B5/150824 , A61B5/157 , B01L3/5027 , G01N2015/1486 , Y10T436/101666
摘要： A portable or wearable cytometer that can be used at remote locations, such as in the field or at home. The flow cytometer of the present invention may help improve the healthcare of many weak, sick or elderly people by providing early detection of infection. By detecting the infection early, the infection may be more readily treatable. In military applications, the portable cytometer of the present invention may help save lives by providing early detection of infection due to biological agents.
摘要翻译：便携式或可穿戴式的血细胞计数仪，可在远程位置使用，如在野外或家中使用。本发明的流式细胞仪可以通过提供早期检测感染来帮助改善许多弱者，病人或老年人的医疗保健。通过早期检测感染，感染可能更容易治疗。在军事应用中，本发明的便携式血细胞计数器可以通过提供由于生物制剂引起的感染的早期检测来帮助挽救生命。

2. 发明授权

US06549275B1 Optical detection system for flow cytometry 有权
标题翻译：流式细胞仪光学检测系统
公开(公告)号：US06549275B1
公开(公告)日：2003-04-15
申请号：US09630927
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3348
CPC分类号： G01N15/1456 , G01N15/1434 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075
摘要： An optical detection system for flow cytometry that uses two or more light sources positioned laterally at different distances from the central axis of the flow stream for providing light through different parts of the flow stream. By using two or more light sources, the particle position can be detected, and the alignment and width of the core stream can be monitored and controlled. In addition, the velocity and size of the particles can be more accurately determined than when only a single light source is used.
摘要翻译：一种用于流式细胞术的光学检测系统，其使用两个或更多个光源，其位于与流动流的中心轴线不同的距离处横向，用于通过流动流的不同部分提供光。通过使用两个或更多个光源，可以检测颗粒位置，并且可以监测和控制核心流的对准和宽度。此外，与仅使用单个光源相比，可以更准确地确定颗粒的速度和尺寸。

3. 发明授权

US09267844B2 Method and apparatus for correcting bias error in ring-down spectroscopy 有权
标题翻译：振铃光谱校正偏差误差的方法和装置
公开(公告)号：US09267844B2
公开(公告)日：2016-02-23
申请号：US13478156
申请日：2012-05-23
申请人： James Allen Cox , Teresa M. Marta
发明人： James Allen Cox , Teresa M. Marta
IPC分类号： G01N21/00 , G01B9/02 , G01J3/28 , G01J3/30 , G02B5/08 , H01S3/00 , H01S3/11 , H01S3/10 , G01J3/42 , G01N21/3504 , G01N21/31
CPC分类号： G01J3/42 , G01N21/31 , G01N21/3504
摘要： An apparatus is provided. The apparatus includes a laser source and a ring-down optical resonator that performs cavity ring-down spectroscopy, the optical resonator receives coherent optical energy from the laser, wherein an extinction rate of optical resonance within the optical resonator is at least 100 times longer than an extinction rate of optical energy emitted from the laser source first following deactivation of the laser source.
摘要翻译：提供了一种装置。该装置包括激光源和执行空腔衰减光谱的环形光学谐振器，光学谐振器从激光器接收相干光能，其中光学谐振器内的光学谐振的消光速率比在激光源失活之后，首先从激光源发射的光能的消光速率。

4. 发明授权

US08437000B2 Multiple wavelength cavity ring down gas sensor 有权
标题翻译：多波长腔环形气体传感器
公开(公告)号：US08437000B2
公开(公告)日：2013-05-07
申请号：US12825985
申请日：2010-06-29
申请人： Barrett E. Cole , Terry Marta , James Allen Cox , Fouad Nusseibeh
发明人： Barrett E. Cole , Terry Marta , James Allen Cox , Fouad Nusseibeh
IPC分类号： G01N21/00
CPC分类号： G01N21/031 , G01N21/3151 , G01N21/3504 , G01N21/39
摘要： An illustrative cavity ring down gas sensor includes an optical cavity for receiving a gas to be detected and at least two electromagnetic radiation sources. The first electromagnetic radiation source may emit a first beam of light having a wavelength corresponding to an absorption wavelength of the gas to be detected, and the second electromagnetic radiation source may emit a second beam of light having a second wavelength that is off of an absorption wavelength of the gas to be detected. The first beam of light may detect a cavity ring down time decay, which is related to the concentration of the gas to be detected. The second beam of light may be used to detect a baseline cavity ring down time decay, which may be used to help increase the accuracy of the sensor by, for example, helping to compensate the concentration of the gas detected by the first beam of light for sensor variations caused by, for example, sensor age, temperature or pressure changes, and/or other conditions.
摘要翻译：示例性的空腔环形气体传感器包括用于接收要检测的气体和至少两个电磁辐射源的光学腔。第一电磁辐射源可以发射具有对应于待检测气体的吸收波长的波长的第一光束，并且第二电磁辐射源可以发射具有不同于吸收的第二波长的第二光束待检测气体的波长。第一束光束可以检测到空腔环时间衰减，这与待检测气体的浓度有关。第二光束可用于检测基线空腔衰减时间衰减，其可以用于通过例如有助于补偿由第一光束检测到的气体的浓度来增加传感器的精度用于例如由传感器年龄，温度或压力变化引起的传感器变化和/或其他条件。

5. 发明授权

US07612885B2 Spectroscopy method and apparatus for detecting low concentration gases 有权
标题翻译：用于检测低浓度气体的光谱法和设备
公开(公告)号：US07612885B2
公开(公告)日：2009-11-03
申请号：US11615617
申请日：2006-12-22
申请人： Barrett E. Cole , James Allen Cox , Yuandong Gu , Rodney H. Thorland
发明人： Barrett E. Cole , James Allen Cox , Yuandong Gu , Rodney H. Thorland
IPC分类号： G01N21/00
CPC分类号： G01J3/02 , G01J3/021 , G01J3/027 , G01J3/0286 , G01J3/42 , G01N21/15 , G01N21/39 , G01N2021/151 , G01N2021/391
摘要： The invention is a method and apparatus capable of detecting constituents of a gas at extremely low concentrations comprising providing a medium that is absorbent of at least a first particular gas under a first environmental condition and desorbent of the particular gas under a second environmental condition, exposing the medium to a sample gas for a first period of time under the first environmental condition, during a second period of time after the first period of time, exposing the medium to the second environmental condition to cause the medium to desorb gas into an optical cavity of a cavity ring down spectrometer and introducing electromagnetic radiation into the cavity, during a third period of time after the second period of time, ceasing introduction of the electromagnetic radiation into the cavity and detecting the decay of the electromagnetic radiation in the cavity, and analyzing the decay of the light in the cavity to obtain a spectral analysis of the sample gas.
摘要翻译：本发明是能够以非常低的浓度检测气体的成分的方法和装置，其包括在第一环境条件下提供至少第一特定气体的吸收剂的介质和在第二环境条件下特定气体的解吸附剂在第一环境条件下在第一时间段内的样品气体的介质，在第一时间段之后的第二时间段内，将介质暴露于第二环境条件，以使介质将气体解吸到光腔中的腔环下光谱仪，并在第二时间段内的第三个时间段内将电磁辐射引入空腔，停止将电磁辐射引入空腔中，并检测腔内电磁辐射的衰减，并分析在空腔中的光的衰减以获得样品气体的光谱分析。

6. 发明授权

US06782027B2 Resonant reflector for use with optoelectronic devices 有权
标题翻译：用于光电器件的谐振反射器
公开(公告)号：US06782027B2
公开(公告)日：2004-08-24
申请号：US09751422
申请日：2000-12-29
申请人： James Allen Cox , Robert A. Morgan
发明人： James Allen Cox , Robert A. Morgan
IPC分类号： H01S500
CPC分类号： H01S5/18355 , H01S5/105 , H01S5/18308 , H01S5/18319 , H01S5/18358 , H01S5/18369 , H01S5/18377 , H01S5/18388 , H01S5/18397 , H01S5/4087 , H01S5/423
摘要： An optoelectronic device that provides isolation between a resonant reflector and an adjacent conducting layer of the optoelectronic device. Isolation may be accomplished by providing a buffer or cladding layer between the resonant reflector and the adjacent conducting layer of the optoelectronic device. The cladding or buffer layer is preferably sufficiently thick, or has a sufficiently low refractive index relative to the refractive index of the waveguide of the resonant reflector, to substantially prevent energy in the evanescent tail of the guided mode in the waveguide from entering the adjacent conductive layer of the optoelectronic device.
摘要翻译：提供谐振反射器与光电器件的相邻导电层之间的隔离的光电子器件。可以通过在谐振反射器和光电器件的相邻导电层之间设置缓冲层或覆层来实现隔离。包层或缓冲层优选足够厚，或相对于谐振反射器的波导的折射率具有足够低的折射率，以基本上防止波导中的引导模式的ev逝尾部的能量进入相邻的导电层的光电器件。

7. 发明申请

US20110317164A1 MULTIPLE WAVELENGTH CAVITY RING DOWN GAS SENSOR 有权
标题翻译：多波长环形环形气体传感器
公开(公告)号：US20110317164A1
公开(公告)日：2011-12-29
申请号：US12825985
申请日：2010-06-29
申请人： Barrett E. Cole , Terry Marta , James Allen Cox , Fouad Nusseibeh
发明人： Barrett E. Cole , Terry Marta , James Allen Cox , Fouad Nusseibeh
IPC分类号： G01N21/31 , G01N21/00
CPC分类号： G01N21/031 , G01N21/3151 , G01N21/3504 , G01N21/39
摘要： An illustrative cavity ring down gas sensor includes an optical cavity for receiving a gas to be detected and at least two electromagnetic radiation sources. The first electromagnetic radiation source may emit a first beam of light having a wavelength corresponding to an absorption wavelength of the gas to be detected, and the second electromagnetic radiation source may emit a second beam of light having a second wavelength that is off of an absorption wavelength of the gas to be detected. The first beam of light may detect a cavity ring down time decay, which is related to the concentration of the gas to be detected. The second beam of light may be used to detect a baseline cavity ring down time decay, which may be used to help increase the accuracy of the sensor by, for example, helping to compensate the concentration of the gas detected by the first beam of light for sensor variations caused by, for example, sensor age, temperature or pressure changes, and/or other conditions.
摘要翻译：示例性的空腔环形气体传感器包括用于接收要检测的气体和至少两个电磁辐射源的光学腔。第一电磁辐射源可以发射具有对应于待检测气体的吸收波长的波长的第一光束，并且第二电磁辐射源可以发射具有不同于吸收的第二波长的第二光束待检测气体的波长。第一束光束可以检测到空腔环时间衰减，这与待检测气体的浓度有关。第二光束可用于检测基线空腔衰减时间衰减，其可以用于通过例如有助于补偿由第一光束检测到的气体的浓度来增加传感器的精度用于例如由传感器年龄，温度或压力变化引起的传感器变化和/或其他条件。

8. 发明申请

US20100108891A1 HIGH REFLECTANCE TERAHERTZ MIRROR AND RELATED METHOD 有权
标题翻译：高反射TERAHERTZ镜和相关方法
公开(公告)号：US20100108891A1
公开(公告)日：2010-05-06
申请号：US12261911
申请日：2008-10-30
申请人： James Allen Cox , Robert Higashi
发明人： James Allen Cox , Robert Higashi
IPC分类号： H01L31/0352 , H01L21/02 , G01J5/20
CPC分类号： G01N21/3581 , G01N21/3504 , G02B5/0816 , H01S3/08059
摘要： A method includes forming a plurality of mirror periods, stacking the mirror periods, and bonding the mirror periods together to form a high reflectance mirror. At least one of the mirror periods is formed by bonding a first semiconductor layer to a first side of a film layer (where the film layer is formed on a second semiconductor layer), forming an opening through the second semiconductor layer to expose the film layer, and cutting through the first semiconductor layer, the film layer, and the second semiconductor layer. The first semiconductor layer could include a high resistivity silicon wafer, the film layer could include an oxide film, and the second semiconductor layer could include a silicon wafer. The high resistivity silicon wafer could be approximately 110 μm thick, and the silicon wafer could be approximately 125 μm thick. The opening through the second semiconductor layer could be 1.25 cm to 1.75 cm in width.
摘要翻译：一种方法包括形成多个反射镜周期，堆叠反射镜周期，以及将反射镜周期结合在一起以形成高反射镜。通过将第一半导体层接合到膜层的第一侧（其中膜层形成在第二半导体层上）形成反射镜周期中的至少一个，通过第二半导体层形成开口以暴露膜层并切割穿过第一半导体层，膜层和第二半导体层。第一半导体层可以包括高电阻率硅晶片，膜层可以包括氧化物膜，并且第二半导体层可以包括硅晶片。高电阻率硅晶片可以是大约110μm厚，并且硅晶片可以是大约125μm厚。通过第二半导体层的开口的宽度可以为1.25cm至1.75cm。

9. 发明申请

US20090185175A1 CAVITY RING DOWN SYSTEM HAVING A COMMON INPUT/OUTPUT PORT 有权
标题翻译：具有通用输入/输出端口的CAVITY环形下降系统
公开(公告)号：US20090185175A1
公开(公告)日：2009-07-23
申请号：US12233396
申请日：2008-09-18
申请人： Barrett E. Cole , James Allen Cox , Terry Marta , Carl Anderson , Rodney Thorland
发明人： Barrett E. Cole , James Allen Cox , Terry Marta , Carl Anderson , Rodney Thorland
IPC分类号： G01J1/00 , G02B5/08
CPC分类号： G01J3/42 , G01J1/44 , G01N21/03 , G01N21/0303 , G01N21/031 , G01N21/39 , G01N2021/0378 , G01N2021/399
摘要： A system having a multiple-mirror ring-down cavity with one mirror where light may be input into the cavity and light from the cavity may be detected. A valve may permit light to enter or not to enter the cavity. An amplifier may be connected to a detector for detecting light from the cavity. The amplifier may be off or set at a low gain when light is entering the cavity and be on at a medium or high gain at a time when light is not entering the cavity.
摘要翻译：可以检测具有多个镜面倒环腔的系统，其具有一个反射镜，其中光可以被输入到空腔中并且可以检测到来自空腔的光。阀可以允许光进入或不进入腔。放大器可以连接到用于检测来自空腔的光的检测器。当光进入空腔时，放大器可能会关闭或设置在低增益，并且在光不进入空腔时以中等或高增益接通。

10. 发明授权

US07288421B2 Method for forming an optoelectronic device having an isolation layer 有权
标题翻译：用于形成具有隔离层的光电子器件的方法
公开(公告)号：US07288421B2
公开(公告)日：2007-10-30
申请号：US10884895
申请日：2004-07-06
申请人： James Allen Cox , Robert A. Morgan
发明人： James Allen Cox , Robert A. Morgan
IPC分类号： H01L21/00
CPC分类号： H01S5/18355 , H01S5/105 , H01S5/18308 , H01S5/18319 , H01S5/18358 , H01S5/18369 , H01S5/18377 , H01S5/18388 , H01S5/18397 , H01S5/4087 , H01S5/423
摘要： Methods are disclosed for forming optoelectronic devices. In one example of such a method, a substrate is provided and a partially conductive bottom mirror formed thereon. An active region is then formed on the bottom mirror, and a top mirror formed on the active region. A gain guide is then formed in the top mirror. Finally, a substantially dielectric isolation layer, as well as a resonant reflector, are formed on the top mirror. The isolation layer is interposed between the resonant reflector and the top mirror, and the isolation layer is formed so as to substantially prevent energy in an evanescent tail of a guided mode associated with the resonant reflector from entering the top mirror.
摘要翻译：公开了用于形成光电器件的方法。在这种方法的一个实例中，提供了衬底并且形成在其上的部分导电的底部反射镜。然后在底部反射镜上形成有源区域，以及形成在有源区域上的顶部反射镜。然后在顶部镜子中形成增益指南。最后，在上反射镜上形成基本介电隔离层以及谐振反射器。隔离层插入在谐振反射器和顶部反射镜之间，隔离层被形成为基本上防止与谐振反射器相关联的引导模式的渐逝尾部的能量进入顶部反射镜。

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