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1. 发明授权

US07057067B2 Process for the preparation of 2-halobenzoic acids 有权
标题翻译： 2-卤代苯甲酸的制备方法
公开(公告)号：US07057067B2
公开(公告)日：2006-06-06
申请号：US10258478
申请日：2001-04-27
申请人： Hiroki Kodama , Takeshi Katsuhira , Tateki Nishida , Tomokazu Hino , Kenji Tsubata
发明人： Hiroki Kodama , Takeshi Katsuhira , Tateki Nishida , Tomokazu Hino , Kenji Tsubata
IPC分类号： C07C63/04 , C07D239/00 , C07D213/40
CPC分类号： C07D213/643 , B01J27/13 , B01J31/28 , C07B39/00 , C07C51/363 , C07C231/12 , C07C315/04 , C07C319/20 , C07D213/75 , C07D239/34 , C07D239/60 , C07C63/70 , C07C65/34 , C07C317/28 , C07C317/40 , C07C317/44 , C07C323/41 , C07C323/42 , C07C323/62 , C07C233/65
摘要： The present invention provides a process for producing 2-halobenzoic acids of the general formula (I), characterized by reacting a benzoic acid of formula (II) with a halogenating agent in the presence of Pd catalyst: (wherein A is —OH, —OM (M is alkali metal), —N(R6)R7 (R6 and R7 are each H, C1–C6 alkyl, optionally substituted phenyl, or the like); R is H, C1–C6 alkyl, C1–C6 alkylcarbonyl, carboxyl, C1–C12 alkoxycarbonyl, optionally substituted phenylcarbonyl, or the like; n is 0 to 4; X is Cl, Br or I, or alternatively (R)n may be present on benzene-constituting carbon atoms adjacent to each other and form a C3–C4 alkylene- or C3–C4 alkenylene-fused ring).
摘要翻译：本发明提供一种制备通式（I）的2-卤代苯甲酸的方法，其特征在于在Pd催化剂存在下使式（Ⅱ）的苯甲酸与卤化剂反应：（其中A是-OH， - OM（M是碱金属），-N（R 6）R 7（R 6和R 7）各自为H，C 1 -C 6烷基，任选取代的苯基等）; R为H，C 1 -C 6烷基， C 1 -C 6烷基，C 1 -C 6烷基羰基，羧基，C 1 -C 12烷基，C 1 -C 6烷基，C 1 -C 6烷基，烷氧基羰基，任选取代的苯基羰基等; n为0至4; X为Cl，Br或I，或者（R）n可以存在于彼此相邻的构成苯的碳原子上并形成C _{3个亚烷基亚烷基或C 3 -C 4亚链烯基稠环）。}

2. 发明授权

US5456234A Fuel pump control system for internal combustion engine 失效
标题翻译：内燃机燃油泵控制系统
公开(公告)号：US5456234A
公开(公告)日：1995-10-10
申请号：US223821
申请日：1994-04-06
申请人： Hiroki Kodama , Shinichi Kitajima
发明人： Hiroki Kodama , Shinichi Kitajima
IPC分类号： F02D19/08 , F02D41/00 , F02D41/02 , F02D41/30 , F02D45/00 , F02M37/00 , F02M37/08 , F02M37/04
CPC分类号： F02D19/087 , F02D19/0605 , F02D19/084 , F02D41/3082 , F02M37/08 , F02D19/0621 , F02D41/0025 , F02M2037/085 , Y02T10/36
摘要： A system for controlling an electric fuel pump housing a DC motor therein for an internal combustion engine using a gasoline-alcohol blend fuel. A switchover line is preestablished with respect to alcohol concentration in the fuel and operating condition of the engine such as an engine load, an engine speed or both the engine load and engine speed. If the detected condition exceeds the switchover line in a high engine load, a relay is energized so that battery voltage is supplied to the motor through a line bypassing a resistor provided at an initial power supply line. Voltage and hence current applied to the motor is thus increased to raise pump speed higher. Although the system construction is simple and low-cost, sufficient fuel can be supplied at the high engine load.
摘要翻译：一种用于控制使用汽油 - 醇混合燃料的用于内燃机的DC电动机的电动燃料泵的控制系统。相对于燃料中的酒精浓度和发动机的操作状态（例如发动机负荷，发动机转速或发动机负荷和发动机转速）都预先建立了切换线。如果检测到的条件在高发动机负荷下超过切换线，则继电器通电，以便通过绕过初始电源线上提供的电阻器的电源将电池电压提供给电动机。因此，施加到电动机的电压和因此的电流增加以提高泵速度。虽然系统结构简单，成本低，但在高发动机负荷下可以提供足够的燃料。

3. 发明授权

US5230309A Spark plug heater control system for internal combustion engine 失效
标题翻译：内燃机火花塞加热器控制系统
公开(公告)号：US5230309A
公开(公告)日：1993-07-27
申请号：US974024
申请日：1992-11-10
申请人： Toshiyuki Suga , Hiroki Kodama , Shinichi Kitajima , Yoshihiko Kobayashi
发明人： Toshiyuki Suga , Hiroki Kodama , Shinichi Kitajima , Yoshihiko Kobayashi
IPC分类号： F02B1/04 , F02N19/08 , F02P13/00 , H01T13/18
CPC分类号： F02N19/08 , F02P13/00 , H01T13/18 , F02B1/04
摘要： A system for controlling heater mounted on a spark plug which ignites the air-fuel mixture in the combustion chamber of an internal combustion chamber. The heater-on time is determined such that it decreases with increasing engine temperature and increasing alcohol concentration. Current supplied to the heater is also determined such that it increases with increasing alcohol concentration and decreases with increasing engine temperature. Therefore, droplets at the spark plug caused by high alcohol concentration fuel can be removed while eliminating carbon fouling. The engine startablity can thus been improved without shorting the service life of the spark plug. Moreover, fuel injection amount is reduced so as not another fuel be deposited on a droplet fuel which is still being present. The heater is furthermore kept off when a starter motor is turning to supply sufficient power to the motor.
摘要翻译：一种用于控制安装在火花塞上的加热器的系统，该火花塞点燃内燃室的燃烧室中的空气燃料混合物。加热器开启时间被确定为随着发动机温度的升高和酒精浓度的增加而减小。供应给加热器的电流也被确定为随着酒精浓度的增加而增加，并随着发动机温度的升高而降低。因此，可以除去高酒精浓度燃料引起的火花塞处的液滴，同时消除碳污染。因此可以改善发动机的起动性，而不会使火花塞的使用寿命短暂。此外，燃料喷射量减少，从而不会将另外的燃料沉积在仍然存在的液滴燃料上。此外，当起动电动机转动以向电动机提供足够的动力时，加热器进一步保持关闭。

4. 发明授权

US08034931B2 Process for producing substituted aminoquinazolinone derivative, intermediate therefor, and pest control agent 有权
标题翻译：制备取代氨基喹唑啉酮衍生物，其中间体和害虫防治剂的方法
公开(公告)号：US08034931B2
公开(公告)日：2011-10-11
申请号：US10556218
申请日：2004-05-11
申请人： Osamu Sanpei , Masahiro Uehara , Nobuyuki Niino , Hiroki Kodama , Kazuyuki Sakata
发明人： Osamu Sanpei , Masahiro Uehara , Nobuyuki Niino , Hiroki Kodama , Kazuyuki Sakata
IPC分类号： C07D239/80
CPC分类号： A01N43/54 , A01N47/16 , C07D401/12
摘要： A process for producing a substituted aminoquinazolinone derivative of formula (I), characterized by reducing a substituted iminoquinazolinone derivative of formula (II) with hydrogen in the presence of a catalyst and either of a halogen compound and a sulfur compound; a substituted iminoquinazolinone derivative of formula (II′); and a pest control agent containing the derivative of formula (II′) or a salt thereof as an active ingredient and a method of using the same (in the formulae, R represents hydrogen, formyl, (C1-C6) alkyl, (C1-C6)alkoxy(C1-C3)alkyl, (C1-C6) alkylsulfonyl, optionally substituted phenylcarbonyl, etc.; R1 represents an optionally substituted, 5- or 6-membered heterocycle having one to three heteroatoms selected among oxygen, sulfur, and nitrogen; R2 represents hydrogen or (C1-C3) alkyl; X and X′ may be the same or different and each represents (C1-C6) haloalkyl, (C1-C6) haloalkoxy, etc.; n is an integer of 0; and n′ is an integer of 1-4).
摘要翻译：一种制备式（I）的取代氨基喹唑啉酮衍生物的方法，其特征在于在催化剂和卤素化合物和硫化合物中的任一种存在下，用氢还原式（II）的取代亚氨基喹唑啉酮衍生物; 式（II'）的取代亚氨基喹唑啉酮衍生物; 和含有式（II'）的衍生物或其盐作为有效成分的害虫控制剂及其使用方法（式中，R表示氢，甲酰基，（C1-C6）烷基，（C1- C6烷氧基（C1-C3）烷基，（C1-C6）烷基磺酰基，任选取代的苯基羰基等; R 1表示具有一至三个选自氧，硫和氮的杂原子的任选取代的五元或六元杂环 ; R 2表示氢或（C 1 -C 3）烷基; X和X'可以相同或不同，表示（C1-C6）卤代烷基，（C1-C6）卤代烷氧基等; n为0的整数; n'是1-4的整数）。

5. 发明申请

US20070293701A1 Process for Producing 2-Halogenobenzamide Compound 有权
标题翻译：生产2-卤代苯甲酰胺化合物的方法
公开(公告)号：US20070293701A1
公开(公告)日：2007-12-20
申请号：US10584221
申请日：2004-12-22
申请人： Noboru Abe , Hiroki Kodama , Akihiko Yoshiura
发明人： Noboru Abe , Hiroki Kodama , Akihiko Yoshiura
IPC分类号： C07C231/12
CPC分类号： C07C315/04 , C07C317/28
摘要： A novel process for producing a 2-halogenobenzamide compound useful as a raw material or active ingredient for medicines and agricultural chemicals. The process, which is for producing a 2-halogenobenzamide compound represented by the general formula (I): (wherein R1, R2, R3, R4, and R6 may be the same or different and each represents hydrogen or C1-6 alkyl; R5 represents C1-6 alkyl; k is 1 or 2; Y1, Y2, Y3, and Y4 may be the same or different and each represents hydrogen, halogeno, etc.; and X represents chlorine, bromine, or iodine), is characterized by reacting an benzamide compound with a halogenating agent in the presence of a palladium catalyst to obtain a substituted benzamide compound and then reacting the resultant substituted benzamide compound with an oxidizing agent after or without isolating the substituted benzamide compound.
摘要翻译：一种生产用作药物和农药的原料或活性成分的2-卤代苯甲酰胺化合物的新方法。用于制备由通式（I）表示的2-卤代苯甲酰胺化合物的方法：（其中R 1，R 2，R 2，R 3， R 4，R 4和R 6可以相同或不同，各自表示氢或C 1-6烷基; R 0-4 > 5表示C 1-6烷基; k是1或2; Y 1，Y 2，Y 2， 3和Y 4可以相同或不同，各自表示氢，卤素等; X表示氯，溴或碘），其特征在于使苯甲酰胺化合物在钯催化剂的存在下用卤化剂得到取代的苯甲酰胺化合物，然后在得到的取代的苯甲酰胺化合物分离后，使得到的取代的苯甲酰胺化合物与氧化剂反应。

6. 发明申请

US20070185142A1 Process for producing substituted aminoquinazolinone derivative, intermediate therefor, and pest control agent 有权
标题翻译：制备取代氨基喹唑啉酮衍生物，其中间体和害虫防治剂的方法
公开(公告)号：US20070185142A1
公开(公告)日：2007-08-09
申请号：US10556218
申请日：2004-05-11
申请人： Osamu Sanpei , Masahiro Uehara , Nobuyuki Niino , Hiroki Kodama , Kazuyuki Sakata
发明人： Osamu Sanpei , Masahiro Uehara , Nobuyuki Niino , Hiroki Kodama , Kazuyuki Sakata
IPC分类号： A61K31/517 , C07D239/92
CPC分类号： A01N43/54 , A01N47/16 , C07D401/12
摘要： A process for producing a substituted aminoquinazolinone derivative represented by the formula (I), characterized by reducing a substituted iminoquinazolinone derivative represented by the formula (II) with hydrogen in the presence of a catalyst and either of a halogen compound and a sulfur compound; a substituted iminoquinazolinone derivative represented by the formula (II′), which is an intermediate in the production process; and a pest control agent containing the derivative of the formula (II′) or a salt thereof as an active ingredient and a method of using the same (in the formulae, R represents hydrogen, formyl, (C1-C6) alkyl, (C1-C6)alkoxy(C1-C3)alkyl, (C1-C6) alkylsulfonyl, optionally substituted phenylcarbonyl, etc.; R1 represents an optionally substituted, 5- or 6-membered heterocycle having one to three heteroatoms selected among oxygen, sulfur, and nitrogen; R2 represents hydrogen or (C1-C3) alkyl; X and X′ may be the same or different and each represents (C1-C6) haloalkyl, (C1-C6) haloalkoxy, etc.; n is an integer of 0 to 4; and n′ is an integer of 1 to 4).
摘要翻译：一种制备由式（I）表示的取代氨基喹唑啉酮衍生物的方法，其特征在于在催化剂和卤素化合物和硫化合物之一中，用氢还原式（II）表示的取代亚氨基喹唑啉酮衍生物; 由式（II'）表示的取代亚氨基喹唑啉酮衍生物，其为生产过程中的中间体; 和含有式（II'）的衍生物或其盐作为有效成分的害虫防除剂及其使用方法（式中，R表示氢，甲酰基，（C 1〜 C 1 -C 6烷基，（C 1 -C 6 -C 6）烷氧基（C 1 -C 6亚烷基）烷基，（C 1 -C 6 -C 6）烷基磺酰基，任选取代的苯基羰基等; R 1表示任选取代的具有一至三个选自氧，硫和氮的杂原子的5-或6-元杂环; R 2表示氢或（C 1 -C 3 -C （C 1 -C 6）烷基; X和X'可以相同或不同，并且各自表示（C 1 -C 6 -C 6）卤代烷基，（C 1 -C 6烷基） C 1 -C 6卤代烷氧基等; n为0〜4的整数，n'为1〜4的整数。

7. 发明授权

US07763750B2 Process for producing 2-halogenobenzamide compound 有权
标题翻译： 2-卤代苯甲酰胺化合物的制备方法
公开(公告)号：US07763750B2
公开(公告)日：2010-07-27
申请号：US10584221
申请日：2004-12-22
申请人： Noboru Abe , Hiroki Kodama , Akihiko Yoshiura
发明人： Noboru Abe , Hiroki Kodama , Akihiko Yoshiura
IPC分类号： C07C315/02 , C07C315/04 , C07C317/28 , C07B61/00
CPC分类号： C07C315/04 , C07C317/28
摘要： A novel process for producing a 2-halogenobenzamide compound useful as a raw material or active ingredient for medicines and agricultural chemicals. The process, which is for producing a 2-halogenobenzamide compound represented by the general formula (I): (wherein R1, R2, R3, R4, and R6 may be the same or different and each represents hydrogen or C1-6 alkyl; R5 represents C1-6 alkyl; k is 1 or 2; Y1, Y2, Y3, and Y4 may be the same or different and each represents hydrogen, halogeno, etc.; and X represents chlorine, bromine, or iodine), is characterized by reacting an benzamide compound with a halogenating agent in the presence of a palladium catalyst to obtain a substituted benzamide compound and then reacting the resultant substituted benzamide compound with an oxidizing agent after or without isolating the substituted benzamide compound.
摘要翻译：一种生产用作药物和农药的原料或活性成分的2-卤代苯甲酰胺化合物的新方法。用于制备由通式（I）表示的2-卤代苯甲酰胺化合物的方法：其中R 1，R 2，R 3，R 4和R 6可以相同或不同，各自表示氢或C 1-6烷基; R 5 表示C 1-6烷基; k为1或2; Y 1，Y 2，Y 3和Y 4可以相同或不同，各自表示氢，卤素等; X表示氯，溴或碘）在钯催化剂的存在下使苯甲酰胺化合物与卤化剂反应，得到取代的苯甲酰胺化合物，然后在得到的取代苯甲酰胺化合物分离后，使得到的取代苯甲酰胺化合物与氧化剂反应。

8. 发明授权

US06390215B1 Electric vehicle 失效
标题翻译：电动车
公开(公告)号：US06390215B1
公开(公告)日：2002-05-21
申请号：US09322898
申请日：1999-05-29
申请人： Hiroki Kodama , Ryoji Ei , Yukihisa Ishii
发明人： Hiroki Kodama , Ryoji Ei , Yukihisa Ishii
IPC分类号： B60L908
CPC分类号： B60K1/04 , B60L11/126 , B60L11/1861 , B60L11/1868 , B60L11/1877 , B60L2200/28 , Y02T10/6217 , Y02T10/7005 , Y02T10/7044 , Y02T10/7066 , Y02T10/7077
摘要： An electric vehicle includes a main battery mounted on a vehicle body and a sub-battery detachably connected to the vehicle body. The electric vehicle travels with the electric power of the main battery in the case where the traveling distance is not long. In the case where the traveling distance is long, a trailer with the sub-battery is coupled to the rear of the electric vehicle, so that both the electric powers of the two batteries are used to drive an electric motor to allow the electric vehicle to travel. At the time of driving of the motor, the electric power of the sub-battery is preferentially used. When the sub-battery becomes completely discharged, the trailer is disconnected from the electric vehicle. In this case, with the vehicle body weight reduced, the traveling of the electric vehicle with the electric power of the main battery can be continued, and therefore the total traveling distance is further increased. At the time of regeneration of electrical energy by the motor during braking operations, the main battery is preferentially charged with the regenerative power, so that the electric power of the main battery is maintained as long as possible.
摘要翻译：电动车辆包括安装在车身上的主电池和可拆卸地连接到车体的子电池。在行驶距离不长的情况下，电动车辆与主电池的电力一起行驶。在行驶距离长的情况下，具有副电池的拖车联接到电动车辆的后部，使得两个电池的电力都用于驱动电动机以允许电动车辆旅行。在电动机驱动时，优先使用副蓄电池的电力。当副电池完全放电时，拖车与电动车辆断开。在这种情况下，随着车体重量的降低，电动车辆与主电池的电力的行驶可以继续，因此总行驶距离进一步增加。在制动操作期间，由电动机再生电能时，主电池优选用再生电力充电，使得主电池的电力尽可能长。

9. 发明授权

US5981807A Production of optically active 2-halo-1-(substituted phenyl)ethanol and substituted styrene oxide 失效
标题翻译：制备光学活性2-卤代-1-（取代苯基）乙醇和取代的氧化苯乙烯
公开(公告)号：US5981807A
公开(公告)日：1999-11-09
申请号：US958333
申请日：1997-10-27
申请人： Hiroki Kodama , Takuya Motokawa , Hiroshi Yamaguchi , Masanori Yoshida
发明人： Hiroki Kodama , Takuya Motokawa , Hiroshi Yamaguchi , Masanori Yoshida
IPC分类号： C07B57/00 , C07C29/09 , C07D303/08 , C07C29/74 , C07C33/46
CPC分类号： C07D303/08 , C07B57/00 , C07C29/095 , C07B2200/07
摘要： A process for producing optically active 2-halo-1-(substituted phenyl)ethanol of a formula (Ia) or optically active styrene oxide of a formula (Ib). The process comprises the steps of reacting a compound of a formula (II) with phthalic anhydride to give a compound of a formula (III), performing optical resolution on the resulting compound using an optically active organic amine as a resolving agent, and finally performing hydrolysis or alcoholysis on the optically resolved compound (Ia) or (Ib). The scheme of the above process is: wherein X represents a halogen atom, Y represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a C.sub.1 -C.sub.6 haloalkyl group or a C.sub.1 -C.sub.6 haloalkoxy group, Z represents a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.6 alkyl group, n is 0 or an integer of 1 to 3 and m is 0 or an integer of 1 to 2. The resulting optically active compounds are useful as an intermediate for medicines.
摘要翻译：制备式（Ia）的光学活性2-卤代-1-（取代苯基）乙醇或式（Ib）的光学活性氧化苯乙烯的方法。该方法包括以下步骤：使式（II）的化合物与邻苯二甲酸酐反应，得到式（III）的化合物，使用光学活性的有机胺作为拆分剂对所得的化合物进行光学拆分，最后进行在光学拆分的化合物（Ia）或（Ib）上进行水解或醇解。上述方法的方案是：其中X表示卤素原子，Y表示氢原子，卤素原子，C1-C6烷基，C1-C6烷氧基，C1-C6卤代烷基或C1-C6 卤代烷氧基，Z表示氢原子，卤素原子或C1-C6烷基，n为0或1〜3的整数，m为0或1〜2的整数。所得光学活性化合物可用作药物中间体。

10. 发明授权

US5900488A Method for treating mycosis using imidazolylacetonitrile derivatives 失效
标题翻译：使用咪唑基乙腈衍生物治疗真菌病的方法
公开(公告)号：US5900488A
公开(公告)日：1999-05-04
申请号：US981420
申请日：1997-12-31
申请人： Hiroki Kodama , Yoshimi Niwano , Kazuo Kanai , Masanori Yoshida
发明人： Hiroki Kodama , Yoshimi Niwano , Kazuo Kanai , Masanori Yoshida
IPC分类号： A61K31/4178 , A61P31/10 , C07D521/00 , A61K31/415 , C07D233/00 , C07D239/00 , C07D409/06
CPC分类号： C07D231/12 , A61K31/4178 , C07D233/56 , C07D249/08
摘要： R-(+)-(E)-�4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene!-1-imidazolylacetonitrile, R-(-)-(E)-�4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene!-1-imidazolylacetonitrile, and pharmaceutically acceptable salts thereof which can be used as a pharmaceutical agent are disclosed. A process for producing them and a method for treating mycoses using them are also disclosed.
摘要翻译： PCT No.PCT / JP96 / 01872 Sec。 371日期1997年12月31日 102（e）1997年12月31日PCT PCT 1996年7月5日PCT公布。第WO97 / 02821号公报日期1997年1月30日R - （+） - （E） - [4-（2-氯苯基）-1,3-二硫戊环-2-亚基] -1-咪唑基乙腈R - （ - ） - （E）公开了可用作药剂的4-（2,4-二氯苯基）-1,3-二硫戊环-2-亚基] -1-咪唑基乙腈及其药学上可接受的盐。还公开了其制备方法和使用它们治疗霉菌病的方法。

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