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    • 1. 发明授权
    • Production of optically active 2-halo-1-(substituted phenyl)ethanol and
substituted styrene oxide
    • 制备光学活性2-卤代-1-(取代苯基)乙醇和取代的氧化苯乙烯
    • US5981807A
    • 1999-11-09
    • US958333
    • 1997-10-27
    • Hiroki KodamaTakuya MotokawaHiroshi YamaguchiMasanori Yoshida
    • Hiroki KodamaTakuya MotokawaHiroshi YamaguchiMasanori Yoshida
    • C07B57/00C07C29/09C07D303/08C07C29/74C07C33/46
    • C07D303/08C07B57/00C07C29/095C07B2200/07
    • A process for producing optically active 2-halo-1-(substituted phenyl)ethanol of a formula (Ia) or optically active styrene oxide of a formula (Ib). The process comprises the steps of reacting a compound of a formula (II) with phthalic anhydride to give a compound of a formula (III), performing optical resolution on the resulting compound using an optically active organic amine as a resolving agent, and finally performing hydrolysis or alcoholysis on the optically resolved compound (Ia) or (Ib). The scheme of the above process is: wherein X represents a halogen atom, Y represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a C.sub.1 -C.sub.6 haloalkyl group or a C.sub.1 -C.sub.6 haloalkoxy group, Z represents a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.6 alkyl group, n is 0 or an integer of 1 to 3 and m is 0 or an integer of 1 to 2. The resulting optically active compounds are useful as an intermediate for medicines.
    • 制备式(Ia)的光学活性2-卤代-1-(取代苯基)乙醇或式(Ib)的光学活性氧化苯乙烯的方法。 该方法包括以下步骤:使式(II)的化合物与邻苯二甲酸酐反应,得到式(III)的化合物,使用光学活性的有机胺作为拆分剂对所得的化合物进行光学拆分,最后进行 在光学拆分的化合物(Ia)或(Ib)上进行水解或醇解。 上述方法的方案是:其中X表示卤素原子,Y表示氢原子,卤素原子,C1-C6烷基,C1-C6烷氧基,C1-C6卤代烷基或C1-C6 卤代烷氧基,Z表示氢原子,卤素原子或C1-C6烷基,n为0或1〜3的整数,m为0或1〜2的整数。所得光学活性化合物可用作 药物中间体。
    • 2. 发明授权
    • Production of optically active 2-halo-1-(substituted phenyl)ethanol and
substituted styrene oxide
    • 制备光学活性2-卤代-1-(取代苯基)乙醇和取代的氧化苯乙烯
    • US5756862A
    • 1998-05-26
    • US699457
    • 1996-08-19
    • Hiroki KodamaTakuya MotokawaHiroshi YamaguchiMasanori Yoshida
    • Hiroki KodamaTakuya MotokawaHiroshi YamaguchiMasanori Yoshida
    • C07B57/00C07C29/09C07D303/08C07C29/74
    • C07D303/08C07B57/00C07C29/095C07B2200/07
    • A process for producing optically active 2-halo-1-(substituted phenyl)ethanol of a formula (Ia) or optically active styrene oxide of a formula (Ib). The process comprises the steps of reacting a compound of a formula (II) with phthalic anhydride to give a compound of a formula (III), performing optical resolution on the resulting compound using an optically active organic amine as a resolving agent, and finally performing hydrolysis or alcoholysis on the optically resolved compound (Ia) or (Ib). The scheme of the above process is: ##STR1## wherein X represents a halogen atom, Y represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a C.sub.1 -C.sub.6 haloalkyl group or a C.sub.1 -C.sub.6 haloalkoxy group, Z represents a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.6 alkyl group, n is 0 or an integer of 1 to 3 and m is 0 or an integer of 1 to 2. The resulting optically active compounds are useful as an intermediate for medicines.
    • 制备式(Ia)的光学活性2-卤代-1-(取代苯基)乙醇或式(Ib)的光学活性氧化苯乙烯的方法。 该方法包括以下步骤:使式(II)的化合物与邻苯二甲酸酐反应,得到式(III)的化合物,使用光学活性的有机胺作为拆分剂对所得的化合物进行光学拆分,最后进行 在光学拆分的化合物(Ia)或(Ib)上进行水解或醇解。 上述方法的方案是:其中X表示卤原子,Y表示氢原子,卤素原子,C1-C6烷基,C1-C6烷基, 烷氧基,C1-C6卤代烷基或C1-C6卤代烷氧基,Z表示氢原子,卤素原子或C1-C6烷基,n为0或1〜3的整数,m为0或 所得光学活性化合物可用作药物的中间体。
    • 8. 发明授权
    • Endoscope apparatus
    • 内窥镜装置
    • US09044163B2
    • 2015-06-02
    • US13306135
    • 2011-11-29
    • Hiroshi YamaguchiTakaaki Saito
    • Hiroshi YamaguchiTakaaki Saito
    • H04N7/18A61B5/1455A61B5/1459A61B1/00A61B1/06
    • A61B1/0653A61B1/00009A61B1/063A61B1/0638A61B5/14551A61B5/1459
    • The endoscope apparatus includes an illumination unit for irradiating at least three kinds of illumination light having different wavelengths including standard light, first and second reference light onto a biological object, a switching unit for periodically switching the illumination light, an imaging unit for capturing image data by the illumination light in each imaging frame, and an acquisition unit for acquiring biological function information from the captured image data. The irradiation order of illumination light is switched at least in order of the first reference light, the standard light and the second reference light, a standard image by the standard light and reference images by the reference light are acquired, and the biological function information is calculated based on the standard image and the reference images.
    • 所述内窥镜装置包括照射单元,用于将具有标准光,第一和第二参考光的不同波长的至少三种照明光照射到生物体上,用于周期性地切换照明光的切换单元,用于捕获图像数据的成像单元 通过每个成像帧中的照明光,以及用于从捕获的图像数据获取生物功能信息的获取单元。 照射光的照射次序至少按照第一参考光,标准光和第二参照光的顺序切换,通过标准光进行标准图像,并且获取参考光的参考图像,生物学功能信息是 基于标准图像和参考图像计算。