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1. 发明申请

US20190127397A1 Complexes for Nucleophilic, Radical, and Electrophilic Polyfluoroalkylation 审中-公开
公开(公告)号：US20190127397A1
公开(公告)日：2019-05-02
申请号：US16308304
申请日：2017-06-23
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Nathaniel Szymczak , Jacob Geri
IPC分类号： C07F5/05 , C07B37/02 , C07B47/00
CPC分类号： C07F5/05 , C07B37/02 , C07B39/00 , C07B47/00 , C07C17/278 , C07C29/64 , C07C209/52 , Y02P20/582
摘要： Disclosed herein are borazine complexes and use of the same in perfluoroalkylation reactions.

2. 发明申请

US20180318797A1 CATALYST AND PROCESS USING THE CATALYST 审中-公开
公开(公告)号：US20180318797A1
公开(公告)日：2018-11-08
申请号：US16032605
申请日：2018-07-11
申请人： MEXICHEM AMANCO HOLDING S.A. DE C.V.
发明人： Andrew P. Sharratt
IPC分类号： B01J23/26 , B01J35/10 , B01J37/03 , B01J37/00 , B01J37/02 , B01J35/02 , B01J37/04 , B01J37/08 , C07B39/00 , B01J27/138 , C07C17/21 , C07C17/20 , B01J35/00
CPC分类号： B01J23/26 , B01J27/138 , B01J35/002 , B01J35/0073 , B01J35/023 , B01J35/1014 , B01J35/1019 , B01J37/0009 , B01J37/0027 , B01J37/0236 , B01J37/031 , B01J37/04 , B01J37/08 , B01J37/26 , C07B39/00 , C07C17/206 , C07C17/21 , C07C19/08 , C07C19/12
摘要： A new chromium-containing fluorination catalyst is described. The catalyst comprises an amount of zinc that promotes activity. The zinc is contained in aggregates which have a size across their largest dimension of up to 1 micron. The aggregates are distributed throughout at least the surface region of the catalyst and greater than 40 weight % of the aggregates contain a concentration of zinc that is within ±1 weight % of the modal concentration of zinc in those aggregates.

3. 发明申请

US20180162892A1 CHLORINATION OF SUCROSE-6-ESTERS 审中-公开
公开(公告)号：US20180162892A1
公开(公告)日：2018-06-14
申请号：US15104620
申请日：2014-12-15
申请人： Tate & Lyle Technology Limited
发明人： Thomas EILERS , Halil AKTAS
IPC分类号： C07H1/06 , C07H5/02 , C07H13/04 , C07B39/00 , C07C19/08 , C07D333/48
CPC分类号： C07H1/06 , C07B39/00 , C07C19/08 , C07D333/48 , C07H1/00 , C07H5/02 , C07H13/04
摘要： There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford a mixture; (iv) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1′ and 6′ positions thereof; (v) quenching said mixture to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate; wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; and wherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises perfluorooctane.

4. 发明申请

US20180162814A1 METHOD OF PREPARING BENZYL 4-AMINO-3-CHLORO-5-FLUORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PICOLINATE 审中-公开
公开(公告)号：US20180162814A1
公开(公告)日：2018-06-14
申请号：US15833111
申请日：2017-12-06
申请人： Dow AgroSciences LLC
发明人： Jason S. Fisk , David J. Couling , Abraham D. Schuitman , Megan E. Donaldson , Brian Murdoch , Ronald B. Leng
IPC分类号： C07D213/127 , C07D213/61 , C07D213/72 , C07D213/803 , C07B39/00 , C07B43/04 , B01D9/00
CPC分类号： C07D213/127 , B01D9/00 , B01D9/005 , C07B39/00 , C07B43/04 , C07D213/61 , C07D213/72 , C07D213/803
摘要： A method of preparing benzyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate (I) from benzyl 4,5-difluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate (II) is described. The method includes the use of amination and chlorination process steps to provide the compound of Formula I.

5. 发明申请

US20180037526A1 TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION 审中-公开
公开(公告)号：US20180037526A1
公开(公告)日：2018-02-08
申请号：US15549040
申请日：2016-02-09
申请人： The Trustees of Princeton University
发明人： John T. Groves , Xiongyi Huang
IPC分类号： C07C17/363 , B01J31/32 , C07B39/00 , B01J31/22 , C07C22/08 , C07C23/46
CPC分类号： C07C17/363 , B01J31/22 , B01J31/32 , C07B39/00 , C07B2200/05 , C07C22/08 , C07C23/46 , C07C41/22 , C07C45/676 , C07C67/297 , C07C253/30 , C07C255/35 , C07C2601/14 , C07C2603/74 , C07D209/46 , C07D209/48 , C07D319/20 , C07D333/12 , C07D493/18 , C07J1/0059 , C07C22/00 , C07C43/225 , C07C49/813 , C07C69/65
摘要： Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.

6. 发明授权

US09809596B1 Method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous catalysis 有权
公开(公告)号：US09809596B1
公开(公告)日：2017-11-07
申请号：US15522336
申请日：2015-11-05
申请人： Lonza Ltd
发明人： Christoph Taeschler , Florencio Zaragoza Doerwald , Stefan Ellinger , Matthias Beller , Helfried Neumann , Lin He , Kishore Natte
IPC分类号： C07D473/10 , C07C41/30 , C07C17/272 , C07C45/68 , C07D209/10 , C07D207/33 , C07D333/12 , C07D207/333
CPC分类号： C07D473/10 , C07B39/00 , C07C17/272 , C07C17/275 , C07C22/08 , C07C41/30 , C07C43/225 , C07C45/68 , C07C45/69 , C07C49/80 , C07D207/325 , C07D207/33 , C07D207/333 , C07D209/10 , C07D333/12 , C07D473/08 , C07C49/84
摘要： The invention discloses a method for preparations of fluoro, chloro and fluorochloro alkylated compounds by homogeneous Pd catalyzed fluoro, chloro and fluorochloro alkylation with fluoro, chloro and fluorochloroalkyl halides in the presence of di(1-adamantyl)-adamantyl-n-butylphosphine and in the presence of 2,2,6,6-tetramethylpiperdine 1-oxyl.

7. 发明授权

US09637462B2 Process for the preparation of N-iodoamides 有权
公开(公告)号：US09637462B2
公开(公告)日：2017-05-02
申请号：US15034751
申请日：2014-11-05
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
发明人： Gennady Nisnevich , Kseniya Kulbitski , Mark Gandelman , Alexander Artaryan
IPC分类号： C07D263/26 , C07D275/06 , C07D233/82 , C07C41/22 , C07D233/74 , C07D263/22 , C07D209/48 , C07C17/093 , C07C29/64 , C07C41/05 , C07C67/05 , C07C201/12 , C07D211/38 , C07C17/10 , C07C17/12 , C07C17/14 , C07C17/363 , C07B39/00 , C07D207/46
CPC分类号： C07D263/26 , C07B39/00 , C07C17/093 , C07C17/10 , C07C17/12 , C07C17/14 , C07C17/363 , C07C29/64 , C07C41/05 , C07C41/22 , C07C67/05 , C07C201/12 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07D207/46 , C07D209/48 , C07D211/38 , C07D233/74 , C07D233/82 , C07D263/22 , C07D275/06 , C07C43/225 , C07C35/48 , C07C43/192 , C07C33/46 , C07C43/174 , C07C69/63 , C07C22/04 , C07C25/02 , C07C205/12 , C07C25/13 , C07C205/11 , C07C23/10 , C07C23/28 , C07C23/08 , C07C23/14 , C07C23/16 , C07C19/07
摘要： The present invention provides new stable crystalline N-iodoamides-1-iodo-3,5,5-trimethylhydantoin (1-ITMH) and 3-iodo-4,4-dimethyl-2-oxazolidinone (IDMO). The present invention further provides a process for the preparation of organic iodides using N-iodoamides of this invention and recovery of the amide co-products from waste water.

8. 发明申请

US20160023971A1 Process for Preparing C3-6 (Hydro)Fluoroalkenes by Dehydrohalogenating C3-6 Halo(Hydro)Fluoroalkanes in the Presence of a Zinc/Chromia Catalyst 审中-公开
标题翻译：在铬/铬催化剂存在下通过脱氟化氢C 3-6卤代（氢）氟烷烃制备C3-6（氢）氟烯烃的方法
公开(公告)号：US20160023971A1
公开(公告)日：2016-01-28
申请号：US14876445
申请日：2015-10-06
申请人： MEXICHEM AMANCO HOLDING S.A. DE C.V.
发明人： Andrew P. Sharratt , LESLIE RICHARD SEDDON
IPC分类号： C07C17/25 , C09K5/04 , C07C17/358 , C07C21/18 , C07C17/20
CPC分类号： C07C17/25 , B01J23/06 , B01J23/26 , C07B39/00 , C07B2200/09 , C07C17/04 , C07C17/087 , C07C17/18 , C07C17/206 , C07C17/21 , C07C17/23 , C07C17/275 , C07C17/358 , C07C21/18 , C07C45/63 , C09K5/045 , C09K2205/126 , C07C19/10 , C07C19/01 , C07C19/08 , C07C49/16
摘要： The invention relates to a process for preparing a C3-6 (hydro)fluoroalkene comprising dehydrohalogenating a C3-6 hydro(halo)fluoroalkane in the presence of a zinc/chromia catalyst, wherein the C3-6 (hydro)fluoroalkene produced is isomerised in the presence of the zinc/chromia catalyst.
摘要翻译：本发明涉及一种制备C3-6（氢）氟代烯烃的方法，该方法包括在锌/氧化铬催化剂存在下将C3-6氢（卤代）氟代烷烃脱卤化氢，其中制备的C 3-6（氢）氟代烯烃异构化为存在锌/氧化铬催化剂。

9. 发明授权

US09193659B2 Process for the iodination of aromatic compounds 有权
标题翻译：芳香族化合物碘化方法
公开(公告)号：US09193659B2
公开(公告)日：2015-11-24
申请号：US12918001
申请日：2009-02-16
申请人： Giovanni Battista Giovenzana , Camilla Cavallotti , Luciano Lattuada , Fulvio Uggeri
发明人： Giovanni Battista Giovenzana , Camilla Cavallotti , Luciano Lattuada , Fulvio Uggeri
IPC分类号： C07C221/00 , C07C51/363 , C07B39/00 , C07C37/62 , C07C67/307 , C07C231/12 , C07C237/46 , C25B3/06
CPC分类号： C07C51/363 , C07B39/00 , C07C37/62 , C07C67/307 , C07C231/12 , C07C237/46 , C25B3/06 , C07C65/03 , C07C69/88 , C07C235/48 , C07C39/27
摘要： The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).
摘要翻译：本发明涉及一种制备碘化酚的方法，特别涉及一种方法，其包括将式（1）的3,5-二取代的酚电化学碘化为相应的3,5-二取代的-2，式（2）的4,6-三碘苯酚，其是用于合成x射线造影剂的有用的中间体，以及造影剂本身的制备。此外，本发明包括将式（6）的3,5-二取代的苯胺电化学碘化为相应的式（7）的3,5-二取代-2,4,6-三碘苯胺。

10. 发明申请

US20150283273A1 Catalytic Radiofluorination 审中-公开
标题翻译：催化放电氟化
公开(公告)号：US20150283273A1
公开(公告)日：2015-10-08
申请号：US14695176
申请日：2015-04-24
申请人： The General Hospital Corporation
发明人： David R. Elmaleh , Alan J. Fischman , Timothy M. Shoup
IPC分类号： A61K51/04 , C07F9/54 , C07D295/073
CPC分类号： A61K51/0459 , A61B6/507 , A61K51/04 , A61K51/0489 , C07B39/00 , C07B2200/05 , C07D295/073 , C07F9/5442
摘要： One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a tetraaryl phosphonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.
摘要翻译：本发明的一个方面涉及制备放射氟化取代的烷基，环烷基，芳基和链烯基化合物的方法。在优选的实施方案中，使用氟化钾-18。本发明的另一方面涉及可用作成像剂的含有氟-18的哌嗪化合物。在某些实施方案中，哌嗪化合物含有季胺。本发明的另一方面涉及可用作成像剂的含有氟-18的芳基鏻化合物。在某些实施方案中，鏻化合物是四芳基鏻盐。本发明的另一方面涉及一种获得哺乳动物正电子发射图像的方法，包括以下步骤：向哺乳动物施用本发明的化合物，并获得哺乳动物的正电子发射光谱。

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