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1. 发明授权

US5469712A Device for dehydrating and/or embedding samples 失效
标题翻译：用于脱水和/或嵌入样品的装置
公开(公告)号：US5469712A
公开(公告)日：1995-11-28
申请号：US232152
申请日：1994-05-31
申请人： Hellmuth Sitte , Klaus Neumann , Ludwig Edelmann , Helmut Haessig , Anton Lang , Heinrich Kleber
发明人： Hellmuth Sitte , Klaus Neumann , Ludwig Edelmann , Helmut Haessig , Anton Lang , Heinrich Kleber
IPC分类号： F17C3/08 , F25D3/10 , G01N1/28 , G01N1/36 , G01N1/42 , F25B19/00
CPC分类号： F17C3/085 , F25D3/10 , G01N1/36 , G01N1/42 , F17C2203/03 , F17C2203/0636 , F17C2221/014 , F17C2223/0161
摘要： Device for dehydrating and/or embedding preferably frozen samples, comprising a Dewar vessel (1) filled with liquid nitrogen (2) and a metallic element (4), anchored to the floor (3), of material of good thermal conductivity, which exhibits at its upper end in the region of attachment of the Dewar neck a cover (5) with a metallic cooling surface (6, 7) which corresponds with the complementarily designed lower contact surfaces of the thermostatically heated (9, 10) substitution (PLT) containers (8) or respectively of the lower part of a freeze-drying chamber in a manner which ensures a good heat transfer between the corresponding surfaces.
摘要翻译： PCT No.PCT / EP93 / 02408 Sec。 371日期1994年5月31日（e）日期1994年5月31日PCT 1993年9月6日PCT。用于脱水和/或包埋优选冷冻样品的装置包括装有液氮（2）和金属元件（4）的杜瓦容器（1）锚定到地板（3）上，具有良好导热性的材料，其在其上端在杜瓦瓶颈附着的区域上展现出具有与补充对应的金属冷却表面（6,7）的盖（5）以确保相应表面之间的良好热传递的方式设计恒温加热（9,10）取代（PLT）容器（8）或冷冻干燥室下部的下部接触表面。

2. 发明授权

US5438838A Chamber for freeze-drying by cryosorption 失效
标题翻译：冷冻干燥冷冻室
公开(公告)号：US5438838A
公开(公告)日：1995-08-08
申请号：US232151
申请日：1994-06-01
申请人： Hellmuth Sitte , Klaus Neumann , Ludwig Edelmann , Helmut Haessig , Heinrich Kleber
发明人： Hellmuth Sitte , Klaus Neumann , Ludwig Edelmann , Helmut Haessig , Heinrich Kleber
IPC分类号： F17C3/08 , F25D3/10 , F26B5/06 , G01N1/28 , G01N1/42 , F04B37/08
CPC分类号： F17C3/085 , F25D3/10 , F26B5/06 , G01N1/42
摘要： A chamber system for cryosorption freeze-drying of biological specimens in a Dewar vessel, comprises a chamber having a cylindrical metal wall and fitted within the Dewar vessel, a lower outer edge of which chamber is connected in a vacuum-tight manner to a lower edge of a metallic rotational component, the metallic rotational component having a bottom contact surface, which bottom contact surface corresponds with a complementary top contact surface on top of a cylindrical body around which liquid nitrogen flows and cools the metallic rotational component, the rotational component having a chamber to receive a drying agent for conducting cryosorption, for example a molecular screen, as well as a connection to the drying chamber.The upper edge of the metal wall or a ring connected thereto in a vacuum-tight manner is situated outside the Dewar vessel and is therefore approximately at ambient temperature and has a vacuum connection for the connection of commercially available vacuum components. The opening at the top of the ring is preferably sealable in a vacuum-tight manner by a commercially available O-ring in conjunction with a cover.
摘要翻译： PCT No.PCT / EP93 / 02409 Sec。 371日期1994年6月1日 102（e）1994年6月1日PCT PCT 1993年9月6日PCT公布。出版物WO94 / 05996 日期：1994年3月17日。用于杜瓦容器中的生物样品冷冻干燥的室系统包括具有圆柱形金属壁并装配在杜瓦容器内的室，其下外边缘在真空中连接金属旋转部件具有底部接触表面，该底部接触表面对应于液体氮流动的圆筒体顶部的互补顶部接触表面，并且冷却金属旋转部件旋转部件具有用于接收用于进行低温吸附的干燥剂的室，例如分子筛，以及到干燥室的连接。金属壁或与真空密封连接的环的上边缘位于杜瓦容器的外部，因此大致处于环境温度并且具有用于连接市售真空部件的真空连接。环的顶部的开口优选地通过市售的O形环与盖结合而以真空密封的方式密封。

3. 发明授权

US06178757B2 Cooling chamber temperature control device 有权
标题翻译：冷却室温度控制装置
公开(公告)号：US06178757B2
公开(公告)日：2001-01-30
申请号：US09387559
申请日：1999-09-01
申请人： Hellmuth Sitte , Klaus Neumann , Helmut Haessig
发明人： Hellmuth Sitte , Klaus Neumann , Helmut Haessig
IPC分类号： G01N106
CPC分类号： G01N1/06 , F25D29/001 , G01N1/42 , G05D23/1931
摘要： A device for controlling the temperatures in a cooling chamber for a microtome, in particular an ultramicrotome, comprises at least two different temperature control circuits for controlling the temperatures of the specimen and of the cutter. The control circuit for the temperature of the specimen (8) and the control circuit for the temperature of the cutter (9), as well as, if appropriate, the control circuit for the temperature of the chamber gas, have a common setting element (17), such that the control circuit can be programmed to an identical temperature as the set value.
摘要翻译：用于控制切片机，特别是超薄切片机的冷却室中的温度的装置包括用于控制样品和切割器的温度的至少两个不同的温度控制回路。用于试样（8）的温度的控制电路和用于切割器（9）的温度的控制电路以及适当的情况下用于室内气体的温度的控制电路具有公共设定元件（ 17），使得控制电路可以被编程为与设定值相同的温度。

4. 发明授权

US4284894A Cold chamber for the working objects for microscopic and electron microscopic investigations 失效
标题翻译：用于微观和电子显微镜研究的工作对象的冷室
公开(公告)号：US4284894A
公开(公告)日：1981-08-18
申请号：US122215
申请日：1980-02-19
申请人： Hellmuth Sitte , Klaus Neumann , Heinrich Kleber , Helmut Hassig
发明人： Hellmuth Sitte , Klaus Neumann , Heinrich Kleber , Helmut Hassig
IPC分类号： A61B10/00 , F25D3/10 , G01N1/06 , G01N1/42 , G01N21/00
CPC分类号： A61B10/00 , F25D3/10 , G01N1/06 , G01N1/42 , G01N2001/068
摘要： A specimen working chamber having heat-conductive walls instead of insulative walls is disclosed.
摘要翻译：公开了一种具有导热壁而不是绝缘壁的试样工作室。

5. 发明授权

US5686313A Method for preparation of microscopic, especially electron-microscopic, slides for the preparation of sections 失效
标题翻译：用于制备显微镜，尤其是电子显微镜的幻灯片的制备方法
公开(公告)号：US5686313A
公开(公告)日：1997-11-11
申请号：US232080
申请日：1994-06-01
申请人： Hellmuth Sitte , Ludwig Edelmann
发明人： Hellmuth Sitte , Ludwig Edelmann
IPC分类号： G01N33/48 , F17C3/08 , F25D3/10 , G01N1/28 , G01N1/36
CPC分类号： G01N1/36 , Y10T436/25 , Y10T436/2525 , Y10T436/255
摘要： Method for the incubation of specimens (7) in fluids (5) for subsequent embedding in capsules by polymerization, the specimens (7) being put into hole capsules (2') which are open at the top and, in the lower third of their cylindrical wall, have at least a circle of passage orifices (6) which are smaller than the diameter of the specimens (7). These specimens (7) are incubated in a fluid (5) extending above these passage orifices (6). The hole capsules (2') are then introduced into enveloping capsules (3) of a larger diameter and with a likewise preferably cylindrical wall, a fluid (5) (a polymerizable monomer batch) present in the enveloping capsules (3) filling at least the gap (S) between the hole capsule (2') and the enveloping capsule (3), and this fluid (5) being finally polymerized under UV radiation or action of heat. The hole capsules (2') and the enveloping capsules (3) can be successively slipped over rams (4') which are located on a carrier (1).
摘要翻译： PCT No.PCT / EP93 / 02296 Sec。 371日期1994年6月1日 102（e）1994年6月1日PCT 1993年8月26日PCT公布。出版物WO94 / 05994 日期1994年3月17日为了将样品（7）在流体（5）中孵育以便随后通过聚合包埋在胶囊中，将样品（7）放入在顶部开口的孔胶囊（2'）中，其圆柱形壁的下三分之一具有至少一个小于试样（7）直径的通道孔（6）。这些样品（7）在这些通道孔（6）上延伸的流体（5）中孵育。然后将孔胶囊（2'）引入更大直径的包封胶囊（3）中并且同样优选为圆柱形壁，存在于包封胶囊（3）中的流体（5）（可聚合单体批次）至少填充孔胶囊（2'）和包封胶囊（3）之间的间隙（S），并且该流体（5）在UV辐射或热作用下最终聚合。孔胶囊（2'）和包封胶囊（3）可以连续地滑动在位于载体（1）上的喷嘴（4'）上。

6. 发明授权

US4551992A Apparatus for cooling a biological or medical specimen 失效
标题翻译：用于冷却生物或医学标本的装置
公开(公告)号：US4551992A
公开(公告)日：1985-11-12
申请号：US651400
申请日：1984-09-17
申请人： Hellmuth Sitte , Heinrich Kleber
发明人： Hellmuth Sitte , Heinrich Kleber
IPC分类号： B01L7/00 , F25D3/10 , G01N1/42 , F25B19/00
CPC分类号： F25D3/10 , G01N1/42
摘要： Apparatus for cooling a biological or medical specimen comprises a cooling bath, an injection device for injecting a specimen into cooling liquid in the bath at a velocity of between 5 and 15 m/sec, and a sleeve. The sleeve is movable between a lower position in the bath and an upper position for limiting the effects of splashing as a specimen enters the bath. The injection device comprises a closure plate for co-operating with the sleeve to further limit the effects of splashing. The sleeve is operatively associated with the injection device in a manner such that movement of a specimen carrier of the device towards the bath to immerse a specimen is initiated when the sleeve is moved from the lower position to the upper position.
摘要翻译：用于冷却生物或医学试样的装置包括冷却浴，用于以5至15m /秒的速度将样品注入浴中的冷却液中的注射装置和套筒。套筒可以在浴缸的下部位置和用于限制作为样品的飞溅的影响的上部位置之间移动进入浴室。注射装置包括用于与套管配合以进一步限制飞溅效果的封闭板。套筒与喷射装置可操作地相关联，使得当套筒从下部位置移动到上部位置时，开始将装置的样品载体朝向浴液移动以浸没试样。

7. 发明授权

US4306425A Device for the cryo-substitution of small biological objects for microscopic research, especially electron microscopic investigations 失效
标题翻译：用于微观研究的小生物物质的低温替代装置，特别是电子显微镜研究
公开(公告)号：US4306425A
公开(公告)日：1981-12-22
申请号：US185035
申请日：1980-09-08
申请人： Hellmuth Sitte , Ludwig Edelmann
发明人： Hellmuth Sitte , Ludwig Edelmann
IPC分类号： F25D3/10 , G01N1/42 , F25B19/00
CPC分类号： F25D3/10 , G01N1/42 , F17C2270/0509
摘要： The invention concerns a device for the cryo-substitution of small biological objects for microscopic, especially electron microscopic investigations, with a metal receptacle for the reception of at least one object, which is mounted in a dewar flask containing a liquid cryogen and which can be regulated to a desired temperature by means of the cryogen and a regulatable heating device joined to the receptacle.
摘要翻译：本发明涉及一种用于微观，特别是电子显微镜研究的小型生物物体的冷冻置换装置，其具有用于接收至少一个物体的金属容器，所述装置安装在含有液体冷冻剂的杜瓦瓶中，其可以是通过冷冻剂和连接到容器的可调节加热装置调节到所需温度。

8. 发明授权

US4221438A Bearing system for the pivot bar of microtomes particularly ultramicrotomes 失效
标题翻译：用于切片机枢轴杆的轴承系统，特别是超薄切片机
公开(公告)号：US4221438A
公开(公告)日：1980-09-09
申请号：US945371
申请日：1978-09-25
申请人： Hellmuth Sitte , Heinrich Kleber
发明人： Hellmuth Sitte , Heinrich Kleber
IPC分类号： F16C11/04 , G01N1/06 , F16C11/06 , F16C11/12
CPC分类号： F16C11/04 , G01N1/06 , G01N2001/065 , G01N2001/068
摘要： A joint having a plurality of spherical elements cemented to one member and the other member having adjustable sockets which cooperate with the spherical elements to permit rotation about a single axis. The joint is particularly useful in microtomes and ultramicrotomes.
摘要翻译：具有多个球形元件的接头，该多个球形元件胶合到一个构件，另一个构件具有可调节的插座，其与球形元件协作以允许围绕单个轴线旋转。关节在切片机和超薄切片机中特别有用。

9. 发明授权

US5181443A Device for controlling the drive and forward feed of microtomes, particularly ultramicrotomes 失效
标题翻译：用于控制切片机，特别是超薄切片机的驱动和正向进给的装置
公开(公告)号：US5181443A
公开(公告)日：1993-01-26
申请号：US682955
申请日：1991-04-10
申请人： Hellmuth Sitte , Helmut Hassig , Armin Kunz , Klaus Neumann
发明人： Hellmuth Sitte , Helmut Hassig , Armin Kunz , Klaus Neumann
IPC分类号： B26D5/20 , G01N1/06
CPC分类号： G01N1/06 , B26D5/20 , G01N2001/066 , G01N2001/068 , Y10T83/141 , Y10T83/6492 , Y10T83/6566
摘要： A device for controlling the drive and forward feed of a microtome, particularly an ultramicrotome, includes a driving motor for moving a specimen or knife and a servomotor for generating a forward feed of the specimen towards an edge of the knife or vice versa. A high travelling speed of the specimen needed for rapid initial cutting is coupled to a high rate of forward feed. One single switching operation is performed, for instance, by a snap-engaging step switch via relay switches. The driving motor and the servomotor can be simultaneously switched over to pairs of values which correspond to subsequent rough cutting and ultra-thin cutting. Individual values for cutting speed and forward feed are separately preselected, readjusted, and read from a display. Selected program stages are indicated by signals.
摘要翻译：用于控制切片机，特别是超薄切片机的驱动和向前进给的装置包括用于移动样本或刀的驱动马达和用于产生朝向刀的边缘的向前进给样品的伺服电机，反之亦然。快速初始切割所需的样品的高行进速度与高速率的正向进给相结合。通过例如通过继电器开关的卡扣式步进开关来执行单个切换操作。驱动电机和伺服电动机可以同时切换成对对应于随后的粗切割和超薄切割的值。切割速度和正向进给的各个值分别被预先选择，重新调整和从显示器读取。所选程序段由信号指示。

10. 发明授权

US4745764A Method and device for metal-mirror cryofixation of biomedical or similar technical specimens 失效
标题翻译：生物医学或类似技术标本金属镜冷冻法的方法和装置
公开(公告)号：US4745764A
公开(公告)日：1988-05-24
申请号：US78304
申请日：1987-07-27
申请人： Hellmuth Sitte , Helmut Hassig , Klaus Neumann
发明人： Hellmuth Sitte , Helmut Hassig , Klaus Neumann
IPC分类号： G01N1/42 , F24F3/16
CPC分类号： G01N1/42
摘要： A method for metal-mirror cryofixation of bio-medical or similar technical specimens in which a specimen is brought into contact with a highly polished, cooled metal mirror in order to cool at least a marginal zone of the specimen suddenly to a low temperature. In order to avoid deformation of the specimen caused by freezing, provision is made, immediately after the first contact between the specimen and the metal mirror, to press the latter against one another by an additional independent force until the specimen is completely frozen. A cryofixation device for this purpose comprises a force generating device, for example, a separate power storage device (135) which, under control, functions after contact between the specimen (106) and metal mirror (102), in other words exerts the additional force between the specimen and the metal mirror (FIG. 7).
摘要翻译：一种用于生物医学或类似技术试样的金属镜冷冻法的方法，其中使试样与高度抛光的冷却金属镜接触，以便将试样的至少边缘区域突然冷却至低温。为了避免试样和金属镜之间的第一次接触之后立即进行冻结引起的样品变形，通过额外的独立力将其压靠在另一个独立的力下，直到样品完全冷冻。用于此目的的冷冻固定装置包括力产生装置，例如，单独的蓄电装置（135），其在控制下在样本（106）和金属反射镜（102）之间接触之后起作用，换句话说，施加额外的试样和金属反射镜之间的力（图7）。

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