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1. 发明授权

US11933696B2 Microtome 有权
公开(公告)号：US11933696B2
公开(公告)日：2024-03-19
申请号：US17428186
申请日：2020-07-06
申请人： PFM MEDICAL AG
发明人： Steffen Kraus , Erwin Schneider
IPC分类号： G01N1/06
CPC分类号： G01N1/06 , G01N2001/065
摘要： The invention relates to a microtome, in particular a rotary microtome (1), comprising a micrometer mechanism (3) having a drive (2) for producing a relative movement between an object holder (4) and a blade and a positioning device acting on the micrometer mechanism (3) to influence the relative movement, the positioning device comprising an advancing device (6) and a trimming device (7) interacting with the advancing device (6), said microtome being designed and modified with regard to a simple and reliable adjustment of the trimming device (7) as well as activation/deactivation of a retraction by structurally simple means in such a way that the positioning device has a combined actuating device (8) for both an adjustment of the trimming device (7) and also an activation/deactivation of a retraction which can be carried out by means of the advancing device (6).

2. 发明授权

US10073011B2 Microtome having means for reversing a direction of rotation 有权
公开(公告)号：US10073011B2
公开(公告)日：2018-09-11
申请号：US14287002
申请日：2014-05-24
申请人： Leica Microsystems Ltd. Shanghai
发明人： Zheguang Fan , Xiao Zhou
IPC分类号： G01N1/06 , F16H3/40 , F16H1/20 , F16H3/34
CPC分类号： G01N1/06 , F16H1/20 , F16H3/34 , F16H3/40 , G01N2001/065 , Y10T74/19172
摘要： A microtome has first and second shafts at different fixed positions, wherein the first shaft may be rotated by a hand wheel. The shafts carry first and second gear wheels, respectively. A transmission unit couples the two gear wheels to each other so that the second shaft can be driven to rotate by the first shaft, and a shift unit for pivotably shifting the transmission unit between first and second positions. The two shafts rotate in the same direction when the transmission unit is in the first position, and in opposite directions when the transmission unit is in the second position. The transmission unit includes first and second idler gears meshing constantly with each other. The two shafts are coupled by only one of the idler gears when the transmission unit is in the first position, and by both idler gears when the transmission unit is in the second position.

3. 发明申请

US20170122844A1 OSCILLATING MICROTOME WITH FLEXURE DRIVE 审中-公开
公开(公告)号：US20170122844A1
公开(公告)日：2017-05-04
申请号：US15403924
申请日：2017-01-11
申请人： Tissuevision, Inc.
发明人： Shih-Chi Chen , Martin L. Culpepper
IPC分类号： G01N1/06 , G06T7/00 , H04N7/18
CPC分类号： G01N1/06 , G01N2001/065 , G06T7/0002 , G06T7/0004 , H04N7/18 , H04N7/183 , Y10S83/9155 , Y10T83/04 , Y10T83/0448 , Y10T83/0457 , Y10T83/0467 , Y10T83/8805 , Y10T83/8843 , Y10T83/8874 , Y10T83/8876
摘要： A microtome method and apparatus includes a microtome blade configured to oscillate in a direction transverse to a direction of advancing a cut, and a first flexure to support and guide the blade. The first flexure is compliant in the transverse direction while being stiff in the cut direction. A second flexure operatively engaged at one end portion with the first flexure, is stiff in the transverse direction while being compliant in the cut direction. The other end portion of the second flexure is rotatably engaged by an eccentric driven by a rotatable actuator, which oscillates the blade in the transverse direction while effectively isolating non-transverse motion from the blade. The second flexure is configured to move independently of any guides or other stationary objects during oscillation.

4. 发明授权

US09574973B2 Oscillating microtome with flexure drive 有权
标题翻译：振动切片机与弯曲驱动
公开(公告)号：US09574973B2
公开(公告)日：2017-02-21
申请号：US14459824
申请日：2014-08-14
申请人： Tissuevision, Inc.
发明人： Shih-Chi Chen , Martin L. Culpepper
IPC分类号： B23D7/06 , B26D7/00 , G01N1/06 , G06T7/00 , H04N7/18
CPC分类号： G01N1/06 , G01N2001/065 , G06T7/0002 , G06T7/0004 , H04N7/18 , H04N7/183 , Y10S83/9155 , Y10T83/04 , Y10T83/0448 , Y10T83/0457 , Y10T83/0467 , Y10T83/8805 , Y10T83/8843 , Y10T83/8874 , Y10T83/8876
摘要： A microtome method and apparatus includes a microtome blade configured to oscillate in a direction transverse to a direction of advancing a cut, and a first flexure to support and guide the blade. The first flexure is compliant in the transverse direction while being stiff in the cut direction. A second flexure operatively engaged at one end portion with the first flexure, is stiff in the transverse direction while being compliant in the cut direction. The other end portion of the second flexure is rotatably engaged by an eccentric driven by a rotatable actuator, which oscillates the blade in the transverse direction while effectively isolating non-transverse motion from the blade. The second flexure is configured to move independently of any guides or other stationary objects during oscillation.
摘要翻译：切片机方法和装置包括：切片机刀片，被配置为沿与切割方向相反的方向摆动;以及第一弯曲部，用于支撑和引导叶片。第一挠曲在横向方向上是顺从的，而在切割方向上是刚性的。在与第一弯曲部的一个端部处可操作地接合的第二挠曲件在横向上是刚性的，同时沿切割方向柔顺。第二挠曲件的另一端部由可旋转的致动器驱动的偏心体可旋转地接合，该偏心件在横向方向上使叶片振动，同时有效地隔离叶片的非横向运动。第二弯曲构造成在振荡期间独立于任何引导件或其它固定物体移动。

5. 发明授权

US08256332B2 Method for automatically feeding a specimen to be thinly cut to the knife of a microtome 有权
标题翻译：自动将切片薄片切片的样品送入切片机刀的方法
公开(公告)号：US08256332B2
公开(公告)日：2012-09-04
申请号：US12600362
申请日：2008-04-17
申请人： Roland Walter
发明人： Roland Walter
IPC分类号： B26D7/06
CPC分类号： G01N1/06 , G01N2001/065 , Y10T83/04 , Y10T83/178 , Y10T83/6492
摘要： A method for the automatic and contact-free relative approach between a specimen (6) and a knife (7) of a microtome (1). A first light beam bundle (9′) forms a detector-side zero point and a last light beam bundle (9″) forms a detector-side end point of a light band (8), the light band (8) being arranged perpendicular to the second spatial direction (Y) and in the direction thereof spaced from the knife, a zero point (X0) being assigned to a reference position of the knife blade (XBlade). The specimen (6) is guided through the light band (8) by way of a cutting movement. The position of the highest point of the specimen (XSpecimen) in the first spatial direction (X) is determined from the number of shaded light beam bundles (9).
摘要翻译：一种用于切片机（1）的样品（6）和刀（7）之间的自动和无接触相对接近的方法。第一光束束（9'）形成检测器侧零点，并且最后的光束束（9“）形成光带（8）的检测器侧端点，光带（8）垂直布置到第二空间方向（Y）并且在与刀分开的方向上，将零点（X0）分配给刀片的参考位置（XBlade）。样品（6）通过切割运动引导通过光带（8）。从阴影光束（9）的数量确定样品（XSpecimen）在第一空间方向（X）上的最高点的位置。

6. 发明授权

US08088330B1 Apparatus and method for preparing sliced specimen 有权
标题翻译：制备切片试样的装置和方法
公开(公告)号：US08088330B1
公开(公告)日：2012-01-03
申请号：US13214900
申请日：2011-08-22
申请人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
发明人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
IPC分类号： G01N21/00
CPC分类号： G01N1/06 , B26D3/28 , B26D5/02 , B26D7/32 , G01N1/312 , G01N35/00029 , G01N35/02 , G01N2001/065 , Y10T83/2074 , Y10T83/536 , Y10T83/6577 , Y10T436/2575
摘要： Sliced specimens can be automatically and continuously prepared and burdens of an operator can be reduced while accuracy required for the sliced specimen is maintained. The sliced specimen is prepared by relatively moving a specimen block transfer section and a cutter, and when a slicing operation to adjust the height position of the specimen block is continuously performed so that the cutting surface of the specimen block is located at a sliceable position, the cutter is moved so that a contacting area of a blade edge of the cutter that firstly contacts the specimen block after the height position adjustment is sequentially changed, every time previously set number of times of slicing operation is completed. Thereafter, the height position of the blade edge of the cutter after the change is measured by a detector, and based on the measurement information of the detector, the sliceable position is corrected and the slicing operation is resumed.
摘要翻译：切片样品可以自动连续地制备，并且可以减少操作者的负担，同时保持切片试样的精度。通过相对移动样品块转移部和切割器来制备切片样品，并且当连续进行调整样品块的高度位置的切片操作，使得样品块的切割面位于切割位置时，移动切割器，使得在每次预先设定的切片操作次数完成之后，在高度位置调整之后，切割器的叶片边缘的接触区域顺序地改变。此后，通过检测器测量切换器的刀刃的高度位置，并且基于检测器的测量信息，校正切片位置并恢复切片操作。

7. 发明授权

US07900545B2 Crank drive system of a shaft of a microtome 有权
标题翻译：切片机轴的曲柄驱动系统
公开(公告)号：US07900545B2
公开(公告)日：2011-03-08
申请号：US11764902
申请日：2007-06-19
申请人： Volker Schneider
发明人： Volker Schneider
IPC分类号： G01N1/04 , F16H3/08 , F16H3/14
CPC分类号： G01N1/06 , G01N2001/065 , Y10T74/18232 , Y10T74/1957 , Y10T74/19619 , Y10T83/222 , Y10T83/4795 , Y10T83/6492 , Y10T83/6563
摘要： A crank drive system (10) of a shaft (11) of a microtome (1) encompasses a first and a second shaft (11, 12). The first shaft (11) is rotatable with a crank (13) and comprises a first transfer gear (14). The second shaft (12) comprises a second transfer gear (15). A rotation of the first shaft (11) is transferable from the first transfer gear (14) to the second transfer gear (15) to cause the second shaft (12) to rotate. To make possible, with a microtome (1), an advance or a lowering of the specimen (2) in two respective oppositely directed rotation directions with the same crank drive system (10), the crank drive system (10) is characterized in that a third transfer gear (16) is provided. The first transfer gear (14) is selectably engageable with the second transfer gear (15) or with the third transfer gear (16) so that as a result, while the rotation direction of the second shaft (12) is maintained, the rotation direction of the first shaft (11) is reversible.
摘要翻译：切片机（1）的轴（11）的曲柄驱动系统（10）包围第一和第二轴（11,12）。第一轴（11）可旋转地具有曲柄（13）并且包括第一传动齿轮（14）。第二轴（12）包括第二传动齿轮（15）。第一轴（11）的旋转可以从第一传动齿轮（14）传递到第二传动齿轮（15），以使第二轴（12）旋转。为了使切片机（1）能够利用同一个曲柄驱动系统（10）在两个相反的相反方向上的样品（2）的进给或降低，曲柄驱动系统（10）的特征在于，提供了第三传动齿轮（16）。第一传动齿轮（14）可选择地与第二传动齿轮（15）或第三传动齿轮（16）接合，从而在第二轴（12）的旋转方向保持的同时，旋转方向的第一轴（11）是可逆的。

8. 发明申请

US20100180742A1 Device And Method For Braking A Shaft Of A Microtome 有权
标题翻译：用于制造切片机轴的装置和方法
公开(公告)号：US20100180742A1
公开(公告)日：2010-07-22
申请号：US12602183
申请日：2008-06-06
申请人： Roland Walter , Stefan Thiem , Andreas Laudat
发明人： Roland Walter , Stefan Thiem , Andreas Laudat
IPC分类号： G01N1/06 , B26D5/20
CPC分类号： G01N1/06 , G01N2001/065 , Y10T83/04 , Y10T83/141 , Y10T83/626 , Y10T83/6569
摘要： The present invention relates to a device for braking or locking a shaft (6) of a microtome (1). The microtome (1) comprises the shaft (6), an actuating element (2), a movement mechanism (37) and a housing (38). With the movement mechanism (37) an object to be cut can be moved relative to a knife blade. The actuating element (2) can be manually actuated by an operator. As a result thereof, the shaft (6) can be rotated. Via the shaft (6), the movement mechanism (37) for performing the relative motion between the object and the knife blade can be driven. Further, the present invention relates to a method for operating a device for braking a shaft (6) of a microtome (1). So that the device can be used in a mechanically formed movement mechanism (37), the inventive device is characterized by an actuator and a braking unit (25). The braking unit (25) is connected in a rotatably fixed manner to the shaft (6). With the actuator, the braking unit (25) can be automatically placed in a brake position in which the shaft (6) can be connected in a rotatably fixed manner to the housing (11).
摘要翻译：本发明涉及一种用于制动或锁定切片机（1）的轴（6）的装置。切片机（1）包括轴（6），致动元件（2），移动机构（37）和壳体（38）。利用移动机构（37），待切割的物体可以相对于刀片移动。致动元件（2）可由操作者手动致动。结果，轴（6）可以旋转。通过轴（6），可以驱动用于执行物体和刀片之间的相对运动的移动机构（37）。此外，本发明涉及一种操作用于制造切片机（1）的轴（6）的装置的方法。因此，该装置可以用于机械地形成的运动机构（37）中，本发明的装置的特征在于致动器和制动单元（25）。制动单元（25）以可旋转地固定的方式连接到轴（6）。通过致动器，制动单元（25）可以自动地放置在制动位置，在该制动位置中，轴（6）可以以可旋转地固定的方式连接到壳体（11）。

9. 发明授权

US07313993B2 Feeding mechanism for a microtome 有权
标题翻译：切片机的喂养机制
公开(公告)号：US07313993B2
公开(公告)日：2008-01-01
申请号：US10382287
申请日：2003-03-05
申请人： Klaus Foerderer
发明人： Klaus Foerderer
IPC分类号： B23D25/00
CPC分类号： G01N1/06 , G01N1/42 , G01N2001/065 , Y10T83/6521 , Y10T83/6664 , Y10T83/8805 , Y10T83/8821
摘要： A feed device (1) for a microtome, in particular for a cryostat microtome, for setting the cut thickness of the specimen (2) to be sectioned, is described. In order to set the cut thickness, either the cutting knife or the specimen holder (3) is mounted on a slide (8) in a slide guide (4) and is connected non-positively to a drive motor (5). The drive motor (5) is connected either to an eccentric cam (6) or to a helical cam (7), and the nonpositive connection between the motor (5) and the slide is accomplished via the eccentric cam (6) or the helical cam (7).
摘要翻译：描述了用于切片机（2）的切片厚度用于切片机的进给装置（1），特别是用于低温恒温切片机的进给装置（1）。为了设定切割厚度，切割刀或样品架（3）安装在滑动引导件（4）中的滑动件（8）上，并且与驱动马达（5）无关地连接。驱动马达（5）连接到偏心凸轮（6）或螺旋凸轮（7）上，马达（5）和滑块之间的非正向连接通过偏心凸轮（6）或螺旋凸轮（7）。

10. 发明申请

US20050115373A1 Antibacterial coating on microtome operating parts 审中-公开
标题翻译：切片机操作部件上的抗菌涂层
公开(公告)号：US20050115373A1
公开(公告)日：2005-06-02
申请号：US10983687
申请日：2004-11-09
申请人： Stefan Kunkel
发明人： Stefan Kunkel
IPC分类号： A61L2/16 , G01N1/06 , B26D7/00
CPC分类号： A61L2/16 , G01N1/06 , G01N2001/065 , Y10T83/242
摘要： A description is given of a microtome with functional areas to be manually operated, such as for example a sample holder (2), cutting device (3), cutting delivery (4) and cutting bin (5), which is distinguished by the fact that open and/or concealed surfaces of the structural elements for constructing the functional areas have a coating or doping with soluble silver ions.
摘要翻译：给出了具有手动操作的功能区域的切片机的描述，例如样品架（2），切割装置（3），切割输送（4）和切割仓（5），其由事实区分用于构建功能区域的结构元件的开放和/或隐藏表面具有涂层或掺杂可溶性银离子。

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