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1. 发明申请

US20100094006A1 NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型吡咯烷基胺化合物作为钙通道调节剂及其制备方法
公开(公告)号：US20100094006A1
公开(公告)日：2010-04-15
申请号：US12568243
申请日：2009-09-28
申请人： Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人： Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号： C07D403/12 , C07D241/04 , C07D231/12
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译：本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

2. 发明授权

US08299072B2 Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof 有权
标题翻译：吡唑基甲胺化合物作为钙通道调节剂及其制备方法
公开(公告)号：US08299072B2
公开(公告)日：2012-10-30
申请号：US12568243
申请日：2009-09-28
申请人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号： A61K31/496 , A61K31/506 , A61K31/5377 , C07D231/12 , C07D401/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/10
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译：本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

3. 发明申请

US20090325979A1 NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型咪唑啉酮衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US20090325979A1
公开(公告)日：2009-12-31
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/497 , C07D403/06 , C07D233/54
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

4. 发明授权

US08492384B2 Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof 有权
标题翻译：咪唑烷基羰基衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US08492384B2
公开(公告)日：2013-07-23
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/496 , C07D233/64
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

5. 发明授权

US07674596B2 Transfected cell line and a method using the same for the high throughput screening for inhibitors of the T-type calcium channel alpha-1H 失效
标题翻译：转染细胞系和使用该方法用于高通量筛选T型钙通道α-1H抑制剂的方法
公开(公告)号：US07674596B2
公开(公告)日：2010-03-09
申请号：US11162487
申请日：2005-09-12
申请人： Seong-Woo Jeong , Jung-Ha Lee , Byong-Gon Park , Edward Perez-Reyes , Dong Jin Kim , Hee Sup Shin , Taehyun Kim , Hyewhon Rhim
发明人： Seong-Woo Jeong , Jung-Ha Lee , Byong-Gon Park , Edward Perez-Reyes , Dong Jin Kim , Hee Sup Shin , Taehyun Kim , Hyewhon Rhim
IPC分类号： C12N5/10 , G01N33/53
CPC分类号： G01N33/5008 , G01N33/502 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type α1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is available for a high throughput screening of candidate T-type α1H calcium channel inhibitors, it may accelerate the development of therapeutic agents for diseases related to T-type α1H calcium channels.
摘要翻译：本发明涉及引入钾通道的细胞系。更具体地说，它是能够通过去极化激活T型α1H钙通道的细胞系，其中引入编码钾通道的载体。由于本发明的细胞系可用于候选T型α1H钙通道抑制剂的高通量筛选，因此可加速用于与T型α1H钙通道相关的疾病的治疗剂的开发。

6. 发明申请

US20130131485A1 TETRODE FOR MEASURING BIO-SIGNALS AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：用于测量生物信号的方法及其制造方法
公开(公告)号：US20130131485A1
公开(公告)日：2013-05-23
申请号：US13409862
申请日：2012-03-01
申请人： Se Jae OH , Jei Won Cho , Il Joo Cho , Soo Hyun Lee , Hee Sup Shin , Jin Seok Kim
发明人： Se Jae OH , Jei Won Cho , Il Joo Cho , Soo Hyun Lee , Hee Sup Shin , Jin Seok Kim
IPC分类号： A61B5/04 , H05K3/00 , A61N1/04
CPC分类号： A61N1/0529 , A61B5/04001 , A61B5/6849 , A61B5/6868 , A61B2562/0209 , A61B2562/046 , A61B2562/125 , A61N1/0531 , A61N1/0534 , H05K1/0274 , H05K1/0393
摘要： A tetrode for measuring bio-signals, the tetrode including four electrodes which extend in a lengthwise direction of the tetrode and are symmertrically arranged; and an insulation layer which surrounds the four electrodes to insulate the electrodes from each others. A method of manufacturing a tetrode for measuring bio-signals, the method including forming a first insulation layer; forming first and second electrodes on the first insulation layer and forming a second insulation layer on the first and second electrodes; and forming third and fourth electrodes on the second insulation layer and forming a third insulation layer on the third and fourth electrodes.
摘要翻译：用于测量生物信号的四极杆，四极管包括在四极管的长度方向上延伸并且以对称方式布置的四个电极; 以及围绕四个电极以使电极彼此绝缘的绝缘层。一种制造用于测量生物信号的四极杆的方法，所述方法包括形成第一绝缘层; 在第一绝缘层上形成第一和第二电极，并在第一和第二电极上形成第二绝缘层; 以及在所述第二绝缘层上形成第三和第四电极，并在所述第三和第四电极上形成第三绝缘层。

7. 发明授权

US08707809B2 Multi-selective micro manipulator 有权
标题翻译：多选微机械手
公开(公告)号：US08707809B2
公开(公告)日：2014-04-29
申请号：US12641083
申请日：2009-12-17
申请人： Eui Sung Yoon , Sung Wook Yang , Jinseok Kim , Duk moon Rho , JeiWon Cho , Hee Sup Shin
发明人： Eui Sung Yoon , Sung Wook Yang , Jinseok Kim , Duk moon Rho , JeiWon Cho , Hee Sup Shin
IPC分类号： A61B5/05
CPC分类号： A61B5/04001 , A61B5/6868 , A61B5/6879 , A61B34/70 , A61B34/72 , A61B2017/00402 , A61B2017/3409 , A61B2090/0811 , A61N1/0529 , Y10T74/1526 , Y10T74/18312 , Y10T74/20366
摘要： The multi-selective micromanipulator has a main mover which moves linearly or rotationally with respect to an axis, an actuator which moves the main mover, a projection which is formed on the main mover, and a plurality of submovers which the projection selectively contacts depending on the movement of the main mover, wherein a selected submover is linearly moved by the projection in a direction parallel to the axis direction.
摘要翻译：多选择性显微操纵器具有相对于轴线性地或旋转地移动的主移动体，移动主动臂的致动器，形成在主动臂上的突起，以及多个下降器，突出部根据所述主动臂的运动，其中所选择的底移动体通过所述突起在平行于所述轴线方向的方向上线性移动。

8. 发明申请

US20100217350A1 Wireless Electrical Stimulating Device for Living Body 有权
标题翻译：无线电动刺激装置
公开(公告)号：US20100217350A1
公开(公告)日：2010-08-26
申请号：US12710880
申请日：2010-02-23
申请人： Ilhwan Choe , Hee Sup Shin , Kyoobin Lee
发明人： Ilhwan Choe , Hee Sup Shin , Kyoobin Lee
IPC分类号： A61N1/08
CPC分类号： A61N1/37217 , A61N1/378 , A61N1/3787
摘要： A wireless electrical stimulating device for living body comprises a light source unit for irradiating an optical signal; a light source control unit for controlling the optical signal irradiated from the light source unit; and an electrical stimulating unit for converting the optical signal received from the light source unit into an electrical signal to generate electrical stimulation. In the wireless electrical stimulating device for living body, the electrical stimulating unit comprises a battery for supplying current; an optical switch for detecting the optical signal irradiated from the light source unit to switch current supplied from the battery; and a stimulating electrode for providing the current switched by the optical switch to a living body.
摘要翻译：一种用于生物体的无线电刺激装置包括用于照射光信号的光源单元; 光源控制单元，用于控制从光源单元照射的光信号; 以及电刺激单元，用于将从光源单元接收的光信号转换为电信号以产生电刺激。在用于生物体的无线电刺激装置中，电刺激单元包括用于提供电流的电池; 光开关，用于检测从光源单元照射的光信号，以切换从电池提供的电流; 以及用于将由光开关切换的电流提供给生物体的刺激电极。

9. 发明申请

US20100161017A1 APPARATUS FOR STIMULATING THE BRAIN AND MEASURING THE LIGHT INDUCED NEURONAL ACTIVITY AND METHOD FOR MANUFACTURING THE SAME 有权
标题翻译：用于刺激脑并测量光诱导的神经活性的装置及其制造方法
公开(公告)号：US20100161017A1
公开(公告)日：2010-06-24
申请号：US12551599
申请日：2009-09-01
申请人： Ji Hyun Choi , Guk Bae Kim , Hee Sup Shin
发明人： Ji Hyun Choi , Guk Bae Kim , Hee Sup Shin
IPC分类号： A61N1/05 , A61B6/00
CPC分类号： A61B5/04001 , A61B5/4041 , A61B5/4064 , A61N1/36082 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N2005/063
摘要： Disclosed is an apparatus for stimulating the brain and measuring the light induced neuronal activity including a signal application unit which applies a signal to a living tissue to stimulate the neuronal cells in the living tissue; an electrode unit which detects an electrophysiological signal of the neuronal cell in response to the signal; and an insulation unit which controls an impedance of the electrode unit. The signal application unit is formed integrally with the electrode unit, so that the site where the signal is applied to the living tissue is approximated to the site where the response to the stimulation is measured.
摘要翻译：公开了一种用于刺激大脑并测量光诱导的神经元活动的装置，包括向活组织施加信号以刺激生物体组织中的神经元细胞的信号施加单元; 电极单元，其响应于所述信号检测神经元细胞的电生理信号; 以及控制电极单元的阻抗的绝缘单元。信号施加单元与电极单元一体形成，使得向生物体组织施加信号的位置近似于测量对刺激的响应的位置。

10. 发明授权

US08798707B2 Flexible, multi-channel microelectrode for recording laboratory animal EEG and method for recording laboratory animal EEG using the same 有权
标题翻译：用于记录实验室动物脑电的灵活的多通道微电极和使用该实验室动物脑电图记录实验动物脑电图的方法
公开(公告)号：US08798707B2
公开(公告)日：2014-08-05
申请号：US13123217
申请日：2008-12-24
申请人： Ji Hyun Choi , Hee Sup Shin , Klaus Peter Koch
发明人： Ji Hyun Choi , Hee Sup Shin , Klaus Peter Koch
IPC分类号： A61B5/0478
CPC分类号： A61B5/0478 , A61B5/4094 , A61B2503/40 , A61B2562/0209 , A61B2562/046
摘要： Disclosed are a novel, elastic, biocompatible, micro-sized, polyimide-based multi-channel microelectrode for recording of electroencephalography (EEG) from a laboratory animal including mouse, and a method for recording of laboratory animal EEG using the microelectrode. The microelectrode may include 2 grounding electrodes and 32 recording electrodes. A connector for signal transmission easily connects the microelectrode to a signal acquiring apparatus. The total weight of the microelectrode, including the connector, does not exceed 150 mg. Laboratory animal EEG, including that of mouse, provides the advantage of monitoring the brain state of a freely moving animal following a genetic or pharmaceutical manipulation. The microelectrode can be implanted without surgery and may be detached from wires while EEG is not recorded from the laboratory animal. The microelectrode can successfully acquire broadband EEG signals from the skull of the laboratory animal and is effective in monitoring spatial and temporal pattern of brain activities of the laboratory animal.
摘要翻译：公开了一种用于从包括小鼠的实验室动物记录脑电图（EEG）的新型，弹性的，生物相容的，微尺寸的基于聚酰亚胺的多通道微电极，以及使用微电极记录实验动物脑电图的方法。微电极可以包括2个接地电极和32个记录电极。用于信号传输的连接器容易地将微电极连接到信号获取装置。包括连接器的微电极的总重量不超过150mg。包括小鼠在内的实验动物脑电图提供了在遗传或药物操作后监测自由移动的动物的脑状态的优点。微电极可以手术植入，并且可能从电线上脱离，而EEG未从实验室动物记录。微电极可以从实验室动物的头骨中成功获得宽带脑电信号，有效监测实验动物大脑活动的时空格局。

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