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1. 发明申请

US20100041744A1 OILY PACLITAXEL COMPOSITION AND FORMULATION FOR CHEMOEMBOLIZATION AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：油酰胺组合物及其制备方法及其制备方法
公开(公告)号：US20100041744A1
公开(公告)日：2010-02-18
申请号：US12540207
申请日：2009-08-12
申请人： Hesson Chung , Seo Young Jeong , Ick Chan Kwon , Yeong Taek Park , In Hyun Lee , Jae Hyung Park , Jin Wook Chung , Young Man Kim
发明人： Hesson Chung , Seo Young Jeong , Ick Chan Kwon , Yeong Taek Park , In Hyun Lee , Jae Hyung Park , Jin Wook Chung , Young Man Kim
IPC分类号： A61K31/337 , A61P35/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K47/44 , A61K49/0452
摘要： Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof solubilizing paclitaxel in an oily contrast medium. The composition of the present invention solubilizes paclitaxel and has an advantage of delivering anticancer drug to the target cells by chemoembolization since it is possible to visualize the blood vessel during the chemoembolization process. The present invention also relates to oily paclitaxel composition and formulation additionally comprising chemicals that prevent paclitaxel precipitation for prolonged preservation and the preparation method thereof. Since the composition of the present invention solubilize paclitaxel effectively and can be visualized during chemoembolization, it can be used for TACE to treat hepatoma and other solid tumors.
摘要翻译：油性紫杉醇组合物和化疗栓塞制剂及其在油性造影剂中增溶紫杉醇的制备方法。本发明的组合物溶解紫杉醇，并且具有通过化学栓塞将抗癌药物递送至靶细胞的优点，因为在化学栓塞过程中可以使血管可视化。本发明还涉及另外包含防止紫杉醇沉淀用于延长保存的化学物质的油性紫杉醇组合物和制剂及其制备方法。由于本发明的组合物有效地溶解紫杉醇并且可以在化学栓塞期间可视化，所以可用于TACE治疗肝癌和其他实体瘤。

2. 发明申请

US20090325979A1 NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型咪唑啉酮衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US20090325979A1
公开(公告)日：2009-12-31
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/497 , C07D403/06 , C07D233/54
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

3. 发明申请

US20080008755A1 PHARMACEUTICAL FORMULATION OF CHOLANIC ACID-CHITOSAN COMPLEX INCORPORATED WITH HYDROPHOBIC ANTICANCER DRUGS AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：用疏水性药物制剂混合制备丙酰胆碱复合物的药物制剂及其制备方法
公开(公告)号：US20080008755A1
公开(公告)日：2008-01-10
申请号：US11777705
申请日：2007-07-13
申请人： Ick Chan Kwon , Seo Young Jeong , In-san Kim , Hesson Chung , Sang Bong Seo , Jae Hyung Park , Seunglee Kwon , Kwangmyung Kim , Jong-ho Kim
发明人： Ick Chan Kwon , Seo Young Jeong , In-san Kim , Hesson Chung , Sang Bong Seo , Jae Hyung Park , Seunglee Kwon , Kwangmyung Kim , Jong-ho Kim
IPC分类号： A61K9/24 , A61K31/7072 , A61K31/704 , A61K31/407 , A61K31/337 , C08B37/08 , A61K33/24
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/5123 , A61K9/5161 , A61K47/61
摘要： Disclosed are a pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex and a preparation method thereof, and more particularly, the cholanic acid-chitosan complex composing of hydrophobic cholanic acid and hydrophilic chitosan forms self-aggregates in an aquatic environment. The pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex, wherein the cholanic acid-chitosan complex forms self-aggregates, prolongs the drug release period, enhances the selectivity of the complex for tumor tissue, and greatly increases drug loading content when a drug is incorporated into the self-aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the pharmaceutical formulation of the present invention is useful for anticancer chemotherapy.
摘要翻译：公开了一种药物制剂，其特征在于将疏水性抗癌药物并入胆酸 - 壳聚糖复合物及其制备方法中，更具体地说，由疏水性胆酸和亲水性壳聚糖组成的胆酸 - 壳聚糖复合物形成自聚集体水生环境。药物制剂的特征在于将疏水性抗癌药物掺入胆酸 - 壳聚糖复合物中，其中胆酸 - 壳聚糖复合物形成自聚集体，延长药物释放时间，提高复合物对肿瘤组织的选择性，并大大增加当药物掺入自聚集体中时，药物加载含量与化学键合相比，这限制了药物并入。因此，本发明的药物制剂可用于抗癌化疗。

4. 发明申请

US20060134144A1 Mucoadhesive composition and formulation for solubilization of insoluble drugs and preparation method thereof 审中-公开
标题翻译：用于溶解不溶性药物的粘膜组合物和制剂及其制备方法
公开(公告)号：US20060134144A1
公开(公告)日：2006-06-22
申请号：US10521989
申请日：2003-07-21
申请人： Hesson Chung , Seo-Young Jeong , Ick-Chan Kwon , Yeong-Taek Park , In-Hyun Lee
发明人： Hesson Chung , Seo-Young Jeong , Ick-Chan Kwon , Yeong-Taek Park , In-Hyun Lee
IPC分类号： A61K9/00 , A61K31/225
CPC分类号： A61K9/006 , A61K9/0019 , A61K9/1075 , A61K31/225 , A61K47/14 , A61K47/44
摘要： The present invention relates to a novel mucoadhesive composition for solubilization of insoluble drugs; its formulation including pharmaceutical compounds; and the preparation methods thereof wherein said solubilizing composition comprises 4˜90% by weight of at least one selected from the monoglycerides and 0.01˜90% by weight of at least one oil. The present invention relates to a novel mucoadhesive composition including pharmaceutical compounds; and the preparation methods thereof wherein said solubilizing composition including emulsifiers is composed of 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight, of at least one oil, and 0.01˜90% by weight of at least one selected from the emulsifiers. The compositions of the present invention is suitable as drug delivery systems since they exist as mucoadhesive liquid at physiological temperatures even though they exist as liquid or semi-solid at room temperature.
摘要翻译：本发明涉及一种用于溶解不溶性药物的新型粘膜粘附组合物，其制剂包括药物化合物; 及其制备方法，其中所述增溶组合物包含4〜90重量％的选自单酸甘油酯和0.01〜90重量％的至少一种油的至少一种。本发明涉及包含药物化合物的新型粘膜粘附组合物; 及其制备方法，其中所述包含乳化剂的增溶组合物由4〜90重量％的选自单酸甘油酯，0.01〜90重量％，至少1种油和0.01〜90重量％选自乳化剂中的至少一种。本发明的组合物适合作为药物递送系统，因为它们在生理温度下作为粘膜粘附液体存在，即使它们在室温下以液体或半固体形式存在。

5. 发明授权

US08299072B2 Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof 有权
标题翻译：吡唑基甲胺化合物作为钙通道调节剂及其制备方法
公开(公告)号：US08299072B2
公开(公告)日：2012-10-30
申请号：US12568243
申请日：2009-09-28
申请人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号： A61K31/496 , A61K31/506 , A61K31/5377 , C07D231/12 , C07D401/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/10
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译：本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

6. 发明申请

US20060141033A1 P-glycoprotein inhibitor comprising octilonium bromide as an effective ingredient 审中-公开
标题翻译： P-糖蛋白抑制剂包含溴化十八烷作为有效成分
公开(公告)号：US20060141033A1
公开(公告)日：2006-06-29
申请号：US10521678
申请日：2003-07-21
申请人： Hesson Chung , Seo-Young Jeong , Ick-Chan Kwon , Yeong-Taek Park , In-Hyun Lee , Soon-Hong Yuk
发明人： Hesson Chung , Seo-Young Jeong , Ick-Chan Kwon , Yeong-Taek Park , In-Hyun Lee , Soon-Hong Yuk
IPC分类号： A61K9/22 , A61K31/14
CPC分类号： A61K9/5078 , A61K9/0095 , A61K9/5026 , A61K9/5031 , A61K31/14 , A61K31/245 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a new use of octylonium bromide as p-glycoprotein inhibitor to increase cellular uptake of drugs. More particularly, the present invention provides octylonium bromide as a p-glycoprotein inhibitor to increase cellular uptake of drugs such as anticancer drugs by taking octylonium bromide simultaneously with or proceding drug administration.
摘要翻译：本发明涉及辛基溴化物作为P-糖蛋白抑制剂的新用途，以增加药物的细胞吸收。更具体地，本发明提供了作为P-糖蛋白抑制剂的辛基溴化铵，以通过同时服用辛基溴或同时给予药物来增加药物如抗癌药物的细胞摄取。

7. 发明授权

US08492384B2 Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof 有权
标题翻译：咪唑烷基羰基衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US08492384B2
公开(公告)日：2013-07-23
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/496 , C07D233/64
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

8. 发明授权

US08075917B2 Composition for solubilization of paclitaxel and preparation method thereof 有权
标题翻译：紫杉醇溶解组合物及其制备方法
公开(公告)号：US08075917B2
公开(公告)日：2011-12-13
申请号：US10521669
申请日：2003-07-18
申请人： Hesson Chung , Seo-Young Jeong , Ick-Chan Kwon , Yeong-Taek Park , In-Hyun Lee , Soon-Hong Yuk , Young-Wook Choi , Jae-Hyung Park , Jin-Wook Chung
发明人： Hesson Chung , Seo-Young Jeong , Ick-Chan Kwon , Yeong-Taek Park , In-Hyun Lee , Soon-Hong Yuk , Young-Wook Choi , Jae-Hyung Park , Jin-Wook Chung
IPC分类号： A61K7/00 , A61K8/02 , A61K9/14 , A61K47/00 , A61K31/04 , A61K31/15 , A01N25/00 , A01N33/18 , A01N33/24 , A01N27/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/0095 , A61K9/107 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/44 , A61K2300/00
摘要： The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one oil and 0.01 to 20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one emulsifier and 0.01 to 20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.
摘要翻译：本发明涉及紫杉醇组合物及其制备方法，其中所述组合物包含4-90重量％的选自单酸甘油酯，0.01至90重量％的至少一种油和0.01至20重量％的至少一种紫杉醇的重量％。本发明还涉及包含乳化剂的紫杉醇组合物及其制备方法来溶解紫杉醇，其中所述组合物包含4至90重量％的选自单酸甘油酯，0.01至90重量％的至少一种乳化剂和 0.01〜20重量％的紫杉醇。本发明的组合物是有效的紫杉醇递送系统，因为组合物溶解紫杉醇，在分散于水中后不形成聚集体，在肠壁上吸附良好，因此具有高的生物利用度。

9. 发明授权

US06994862B2 Formulation solubilizing water-insoluble agents and preparation method thereof 失效
标题翻译：制剂增溶水不溶性物质及其制备方法
公开(公告)号：US06994862B2
公开(公告)日：2006-02-07
申请号：US10221449
申请日：2001-03-13
申请人： Seo Young Jeong , Ick Chan Kwon , Hesson Chung
发明人： Seo Young Jeong , Ick Chan Kwon , Hesson Chung
IPC分类号： A61K7/00
CPC分类号： A61K9/1075 , A61K9/19
摘要： The present invention relates to an anhydrous liquid composition wherein monoglyceride is mixed with an emulsifier and a solvent, and the manufacturing method thereof, and more specifically, to an anhydrous liquid composition wherein monoglyceride is mixed with a water-insoluble material, an emulsifier and a solvent, and the manufacturing method thereof. Further, the present invention relates to a lyophilized powder and the manufacturing method thereof, wherein the lyophilized powder is prepared by dissolving the mixed liquid composition in water, adding with a cryoprotectant followed by the lyophilization. In the process of dispersion, the lyophilized liquid composition and the powder of the present invention can spontaneously generate particles of 200-500 nm by gently shaking with hands without a powerful mechanical force. Also the lyophilized liquid composition and the powder of the present invention are physicochemically stable since they neither contain water that causes oxidation or hydrolysis upon storage nor undergo phase separation. Considering all the raw materials of the present invention are biocompatible, the present invention will be useful in medical and pharmaceutical fields such as drug delivery.
摘要翻译：本发明涉及将单酸甘油酯与乳化剂和溶剂混合的无水液体组合物及其制造方法，更具体地，涉及将单酸甘油酯与水不溶性物质，乳化剂和溶剂及其制造方法。另外，本发明还涉及一种冻干粉末及其制造方法，其特征在于，所述冻干粉末是将所述混合液体组合物溶解在水中，加入冷冻保护剂后进行冻干。在分散过程中，本发明的冻干液体组合物和粉末可以通过用手轻轻晃动而自发产生200-500nm的颗粒，而没有强大的机械力。此外，冻干液体组合物和本发明的粉末在物理化学上是稳定的，因为它们既不含有在储存时引起氧化或水解的水也不经历相分离。考虑到本发明的所有原料都是生物相容的，本发明可用于医药领域如药物递送。

10. 发明申请

US20100094006A1 NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型吡咯烷基胺化合物作为钙通道调节剂及其制备方法
公开(公告)号：US20100094006A1
公开(公告)日：2010-04-15
申请号：US12568243
申请日：2009-09-28
申请人： Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人： Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号： C07D403/12 , C07D241/04 , C07D231/12
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译：本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

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