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1. 发明申请

US20100161017A1 APPARATUS FOR STIMULATING THE BRAIN AND MEASURING THE LIGHT INDUCED NEURONAL ACTIVITY AND METHOD FOR MANUFACTURING THE SAME 有权
标题翻译：用于刺激脑并测量光诱导的神经活性的装置及其制造方法
公开(公告)号：US20100161017A1
公开(公告)日：2010-06-24
申请号：US12551599
申请日：2009-09-01
申请人： Ji Hyun Choi , Guk Bae Kim , Hee Sup Shin
发明人： Ji Hyun Choi , Guk Bae Kim , Hee Sup Shin
IPC分类号： A61N1/05 , A61B6/00
CPC分类号： A61B5/04001 , A61B5/4041 , A61B5/4064 , A61N1/36082 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N2005/063
摘要： Disclosed is an apparatus for stimulating the brain and measuring the light induced neuronal activity including a signal application unit which applies a signal to a living tissue to stimulate the neuronal cells in the living tissue; an electrode unit which detects an electrophysiological signal of the neuronal cell in response to the signal; and an insulation unit which controls an impedance of the electrode unit. The signal application unit is formed integrally with the electrode unit, so that the site where the signal is applied to the living tissue is approximated to the site where the response to the stimulation is measured.
摘要翻译：公开了一种用于刺激大脑并测量光诱导的神经元活动的装置，包括向活组织施加信号以刺激生物体组织中的神经元细胞的信号施加单元; 电极单元，其响应于所述信号检测神经元细胞的电生理信号; 以及控制电极单元的阻抗的绝缘单元。信号施加单元与电极单元一体形成，使得向生物体组织施加信号的位置近似于测量对刺激的响应的位置。

2. 发明授权

US08652185B2 Apparatus for stimulating the brain and measuring the light induced neuronal activity and method for manufacturing the same 有权
标题翻译：用于刺激大脑并测量光诱导的神经元活性的装置及其制造方法
公开(公告)号：US08652185B2
公开(公告)日：2014-02-18
申请号：US12551599
申请日：2009-09-01
申请人： Ji Hyun Choi , Guk Bae Kim , Hee Sup Shin
发明人： Ji Hyun Choi , Guk Bae Kim , Hee Sup Shin
IPC分类号： A61N5/06
CPC分类号： A61B5/04001 , A61B5/4041 , A61B5/4064 , A61N1/36082 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N2005/063
摘要： Disclosed is an apparatus for stimulating the brain and measuring the light induced neuronal activity including a signal application unit which applies a signal to a living tissue to stimulate the neuronal cells in the living tissue; an electrode unit which detects an electrophysiological signal of the neuronal cell in response to the signal; and an insulation unit which controls an impedance of the electrode unit. The signal application unit is formed integrally with the electrode unit, so that the site where the signal is applied to the living tissue is approximated to the site where the response to the stimulation is measured.
摘要翻译：公开了一种用于刺激大脑并测量光诱导的神经元活动的装置，包括向活组织施加信号以刺激生物体组织中的神经元细胞的信号施加单元; 电极单元，其响应于所述信号检测神经元细胞的电生理信号; 以及控制电极单元的阻抗的绝缘单元。信号施加单元与电极单元一体形成，使得向生物体组织施加信号的位置近似于测量对刺激的响应的位置。

3. 发明授权

US08348986B2 Photostimulation apparatus 有权
标题翻译：光刺激装置
公开(公告)号：US08348986B2
公开(公告)日：2013-01-08
申请号：US12551613
申请日：2009-09-01
申请人： Jee Hyun Choi , Guk Bae Kim , Hee Sup Shin , Ho Kun Sung
发明人： Jee Hyun Choi , Guk Bae Kim , Hee Sup Shin , Ho Kun Sung
IPC分类号： A61N5/06
CPC分类号： A61N5/0613 , A61B5/04 , A61B5/04001 , A61N2005/0652
摘要： A photostimulation apparatus may include: a membrane for insertion into a living body; and at least one cell disposed on the membrane. Each cell may include a first light source for irradiating light to a photosensitive material in the living body. Further, a photostimulation apparatus may include: a membrane for insertion into a living body; and at least one first light source disposed on the membrane for irradiating light to a photosensitive material in the living body. Since the photostimulation apparatus is placed on the surface of cortex or dura, it may minimize damage of the brain tissue and may activate and/or inhibit a large area simultaneously using light.
摘要翻译：光刺激装置可以包括：用于插入生物体的膜; 和设置在膜上的至少一个细胞。每个单元可以包括用于将光照射到生物体中的感光材料的第一光源。此外，光刺激装置可以包括：用于插入生物体的膜; 以及设置在所述膜上的用于将光照射到所述生物体中的感光材料的至少一个第一光源。由于光刺激装置被放置在皮质或硬脑膜的表面上，所以可以使脑组织的损伤最小化，并且可以使用光来同时激活和/或抑制大面积的区域。

4. 发明申请

US20100241006A1 APPARATUS FOR DETECTING BRAIN CONDITIONS 审中-公开
标题翻译：检测脑条件的装置
公开(公告)号：US20100241006A1
公开(公告)日：2010-09-23
申请号：US12567193
申请日：2009-09-25
申请人： Jee Hyun Choi , Hee Sup Shin , Guk Bae Kim , Hokun Sung
发明人： Jee Hyun Choi , Hee Sup Shin , Guk Bae Kim , Hokun Sung
IPC分类号： A61B6/00 , A61B5/0478 , G01N21/47
CPC分类号： A61B5/6868 , A61B5/0031 , A61B5/0084 , A61B5/0086 , A61B5/14553 , A61B5/4064 , A61B5/6814
摘要： Disclosed embodiments relate to an apparatus for detecting brain conditions. The apparatus for detecting brain conditions may include: a layer which is located adjacent to the brain of a living body; a light source which is formed on the layer and irradiates light to the brain; and an optical sensor which is formed on the layer adjacent to the light source and detects the light scattered from the brain. Since detection is possible at a location relatively adjacent to the brain, the apparatus for detecting brain conditions may improve accuracy and reliability of detection. The apparatus for detecting brain conditions may be used to detect brain conditions such as cerebral oxygenation, cerebral blood volume, cerebral blood flow, etc. or to monitor brain activities, or to diagnose and/or localize the disease foci in case of neurovascular disease such as stroke including hemorrhage or bleeding, into or around the brain or brain tumors or epilepsy, etc. Since the apparatus for detecting brain conditions has a relatively flexible structure, damage to the brain tissue may be minimized.
摘要翻译：公开的实施例涉及用于检测脑部状况的装置。用于检测脑部状况的装置可以包括：位于生物体的脑附近的层; 形成在层上并将光照射到脑的光源; 以及形成在与光源相邻的层上的光学传感器，并检测从脑散射的光。由于可以在与脑相对相邻的位置进行检测，所以用于检测脑部状况的装置可提高检测的准确性和可靠性。用于检测脑部状况的装置可以用于检测脑部病症，例如脑氧合，脑血容量，脑血流量等，或者用于监测脑的活动，或者在神经血管疾病的情况下诊断和/或定位疾病灶作为包括出血或出血的中风，进入或周围的脑或脑肿瘤或癫痫等。由于用于检测脑部疾病的装置具有相对灵活的结构，所以可以使对脑组织的损伤最小化。

5. 发明申请

US20100249890A1 PHOTOSTIMULATION APPARATUS 有权
标题翻译：摄影装置
公开(公告)号：US20100249890A1
公开(公告)日：2010-09-30
申请号：US12551613
申请日：2009-09-01
申请人： Jee Hyun Choi , Guk Bae Kim , Hee Sup Shin , Ho Kun Sung
发明人： Jee Hyun Choi , Guk Bae Kim , Hee Sup Shin , Ho Kun Sung
IPC分类号： A61N5/06
CPC分类号： A61N5/0613 , A61B5/04 , A61B5/04001 , A61N2005/0652
摘要： A photostimulation apparatus may include: a membrane for insertion into a living body; and at least one cell disposed on the membrane. Each cell may include a first light source for irradiating light to a photosensitive material in the living body. Further, a photostimulation apparatus may include: a membrane for insertion into a living body; and at least one first light source disposed on the membrane for irradiating light to a photosensitive material in the living body. Since the photostimulation apparatus is placed on the surface of cortex or dura, it may minimize damage of the brain tissue and may activate and/or inhibit a large area simultaneously using light.
摘要翻译：光刺激装置可以包括：用于插入生物体的膜; 和设置在膜上的至少一个细胞。每个单元可以包括用于将光照射到生物体中的感光材料的第一光源。此外，光刺激装置可以包括：用于插入生物体的膜; 以及设置在所述膜上的用于将光照射到所述生物体中的感光材料的至少一个第一光源。由于光刺激装置被放置在皮质或硬脑膜的表面上，所以可以使脑组织的损伤最小化，并且可以使用光来同时激活和/或抑制大面积的区域。

6. 发明授权

US07227621B2 System for visualizing flow and measuring velocity field using X-ray particle image velocimetry 有权
标题翻译：使用X射线粒子图像测速法可视化流量和测量速度场的系统
公开(公告)号：US07227621B2
公开(公告)日：2007-06-05
申请号：US10928166
申请日：2004-08-30
申请人： Sang Joon Lee , Guk Bae Kim
发明人： Sang Joon Lee , Guk Bae Kim
IPC分类号： G01P3/36 , G01F25/00
CPC分类号： G01F1/00 , G01F1/661 , G01P5/001 , G01P5/20
摘要： A system for measuring flow information of a fluid, the system includes a light emission control unit for passing an X-ray through a specimen only at desired moments; a scintillator installed on an axis of a beam to convert an X-ray wavelength flow image, which is generated while the X-ray passes through the specimen, into a visible wavelength flow image; and a recording device for acquiring a flow image focused on the scintillator. The system may further include a synchronization unit for synchronizing the recording device with the light emission control unit to acquire two or more flow images at a predetermined interval using the recording device; and a PIV velocity field measurement unit for extracting quantitative flow information from the two or more flow images acquired by the recording device.
摘要翻译：一种用于测量流体的流动信息的系统，该系统包括仅在所需时刻使X射线通过样本的发光控制单元; 安装在光束轴上的闪烁体，以将在X射线通过样本时产生的X射线波长流图像转换成可见波长流图像; 以及用于获取聚焦在闪烁体上的流动图像的记录装置。该系统还可以包括同步单元，用于使记录装置与发光控制单元同步，以使用记录装置以预定间隔获取两个或更多个流图像; 以及PIV速度场测量单元，用于从由记录装置获取的两个或更多个流图像中提取定量流信息。

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