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1. 发明授权

US09012481B2 Benzoarylureido compounds, and composition for prevention or treatment of neurodegenerative brain disease containing the same 有权
标题翻译：苯并芳基脲基化合物，以及用于预防或治疗含有其的神经退行性脑病的组合物
公开(公告)号：US09012481B2
公开(公告)日：2015-04-21
申请号：US13142313
申请日：2009-12-29
申请人： Hoh-Gyu Hahn , Kee-Dal Nam , Dong-Yun Shin , Chan-Ho Park , Sung-Woo Cho , Eun-A Kim , Ghil-Soo Nam , Kyung-Il Chol , Seon-Hee Seo , Hee-Sup Shin , Dong-Jin Kim , Ae-Nim Pae , Hye-Jin Chung , Hyun-Ah Choo , Hye-Whon Rhim , Yong-Seo Cho , Eun-Joo Roh , Gyo-Chang Keum , Kee-Hyun Choi , Kye-Jung Shin , Chan-Seong Cheong , Jae-Kyun Lee , Yong-Koo Kang , Young-Soo Kim , Woong-Seo Park , Key-Sun Kim , He-Sson Chung , Chi-Man Song , Sun-Joon Min , Eunice Eun-Kyeong Kim , Cheol-Ju Lee , Soon-Bang Kang
发明人： Hoh-Gyu Hahn , Kee-Dal Nam , Dong-Yun Shin , Chan-Ho Park , Sung-Woo Cho , Eun-A Kim , Ghil-Soo Nam , Kyung-Il Chol , Seon-Hee Seo , Hee-Sup Shin , Dong-Jin Kim , Ae-Nim Pae , Hye-Jin Chung , Hyun-Ah Choo , Hye-Whon Rhim , Yong-Seo Cho , Eun-Joo Roh , Gyo-Chang Keum , Kee-Hyun Choi , Kye-Jung Shin , Chan-Seong Cheong , Jae-Kyun Lee , Yong-Koo Kang , Young-Soo Kim , Woong-Seo Park , Key-Sun Kim , He-Sson Chung , Chi-Man Song , Sun-Joon Min , Eunice Eun-Kyeong Kim , Cheol-Ju Lee , Soon-Bang Kang
IPC分类号： C07D235/22 , C07D263/58 , C07D333/06 , C07D327/04 , C07D277/82
CPC分类号： C07D277/82 , C07D235/22 , C07D263/58 , C07D327/04 , C07D333/06
摘要： Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.
摘要翻译：提供了新的苯甲酰脲基化合物及其用于预防和/或治疗神经退行性脑病的用途。神经变性脑疾病可包括阿尔茨海默病，痴呆，帕金森病，中风，淀粉样变性，皮克病，卢格里希氏病，亨廷顿舞蹈病，克雅氏病，雅各布病等。

2. 发明授权

US08492384B2 Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof 有权
标题翻译：咪唑烷基羰基衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US08492384B2
公开(公告)日：2013-07-23
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il Choi , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/496 , C07D233/64
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

3. 发明申请

US20100004286A1 NOVEL ISOINDOLINONE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST T-TYPE CALCIUM CHANNEL AND METHOD FOR PREPARATION THEREOF 有权
标题翻译：具有抗T型钙通道的抑制活性的新型茚二酮衍生物及其制备方法
公开(公告)号：US20100004286A1
公开(公告)日：2010-01-07
申请号：US12256701
申请日：2008-10-23
申请人： Yong Seo CHO , Ae Nim PAE , Hyunah CHOO , Jae Kyun LEE , You Na OH , Hee Sup SHIN , Dong Jin KIM , Hoh Gyu HAHN , Kyung Il CHOI , Ghilsoo NAM , Kye Jung SHIN , Soon Bang KANG , Eun Joo ROH , Dong Yun SHIN , Seon Hee SEO , Hyewhon RHIM , Gyo Chang KEUM , Key-Sun KIM , Chan Seong CHEONG , Eunice Eun-Kyeong KIM , Cheolju LEE , Youngsoo KIM , Kee Hyun CHOI , Kee Dal NAM , Woong Seo PARK , Yong Koo KANG , Hye Jin CHUNG
发明人： Yong Seo CHO , Ae Nim PAE , Hyunah CHOO , Jae Kyun LEE , You Na OH , Hee Sup SHIN , Dong Jin KIM , Hoh Gyu HAHN , Kyung Il CHOI , Ghilsoo NAM , Kye Jung SHIN , Soon Bang KANG , Eun Joo ROH , Dong Yun SHIN , Seon Hee SEO , Hyewhon RHIM , Gyo Chang KEUM , Key-Sun KIM , Chan Seong CHEONG , Eunice Eun-Kyeong KIM , Cheolju LEE , Youngsoo KIM , Kee Hyun CHOI , Kee Dal NAM , Woong Seo PARK , Yong Koo KANG , Hye Jin CHUNG
IPC分类号： A61K31/454 , C07D401/12 , A61P35/00 , A61P9/12 , A61P25/08
CPC分类号： C07D401/12 , A61K31/454
摘要： Disclosed are isoindolinone derivatives, represented by Chemical Formula 1, having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient. wherein R1˜R6 are as defined in the specification.
摘要翻译：公开了由化学式1表示的具有对T型钙通道的抑制活性的异吲哚啉酮衍生物，其药学上可接受的盐，其制备方法和包含其作为活性成分的药物组合物。其中R1〜R6如说明书中所定义。

4. 发明授权

US08299072B2 Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof 有权
标题翻译：吡唑基甲胺化合物作为钙通道调节剂及其制备方法
公开(公告)号：US08299072B2
公开(公告)日：2012-10-30
申请号：US12568243
申请日：2009-09-28
申请人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号： A61K31/496 , A61K31/506 , A61K31/5377 , C07D231/12 , C07D401/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/10
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译：本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

5. 发明授权

US07939672B2 Phenylacetate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for prevention or treatment of diseases induced by activation of T-type calcium ion channel containing the same as an active ingredient 有权
标题翻译：苯乙酸衍生物或其药学上可接受的盐，其制备方法和预防或治疗由含有其作为活性成分的T型钙离子通道激活引起的疾病的组合物
公开(公告)号：US07939672B2
公开(公告)日：2011-05-10
申请号：US12429004
申请日：2009-04-23
申请人： Kye Jung Shin , Hyung Kook Lee , Eun Joo Roh , Dong Jin Kim , Kyung Il Choi , Hyewhon Rhim , Hye Jin Chung , Seon Hee Seo
发明人： Kye Jung Shin , Hyung Kook Lee , Eun Joo Roh , Dong Jin Kim , Kyung Il Choi , Hyewhon Rhim , Hye Jin Chung , Seon Hee Seo
IPC分类号： C07D235/08
CPC分类号： C07D211/34 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/70 , C07D235/14 , C07D235/16 , C07D295/145 , C07D295/15
摘要： Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. wherein, X, R1, and R3 are as defined herein.
摘要翻译：本文公开了由化学式1表示的新的苯乙酸酯衍生物或其药学上可接受的盐，其制备方法，以及用于预防或治疗由含有其的T型钙离子通道活化引起的疾病的组合物。含有本发明的苯乙酸酯衍生物的组合物有效地抑制T型钙离子通道的活化，并且可用于预防或治疗诸如高血压，癌症，癫痫和T激活诱导的神经源性疼痛等疾病型钙离子通道。其中X，R 1和R 3如本文所定义。

6. 发明授权

US07799830B2 Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease 失效
标题翻译：肉桂酸二聚体，其制备及其用于治疗神经变性疾病的用途
公开(公告)号：US07799830B2
公开(公告)日：2010-09-21
申请号：US10515560
申请日：2002-06-25
申请人： Dong-Jin Kim , Kye-Jung Shin , Jaehoon Yu , Hee-Sul Lee
发明人： Dong-Jin Kim , Kye-Jung Shin , Jaehoon Yu , Hee-Sul Lee
IPC分类号： A61K31/235 , A61K31/19 , C07C69/00 , C07C229/00 , C07C62/00 , C07C55/28
CPC分类号： C07C229/44 , C07C45/71 , C07C47/575 , C07C59/68 , C07C67/343 , C07C69/734
摘要： The present invention relates to cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease, which have excellent effect on enhancing the learning and memory-retention ability in vivo and have fewer side-effects by showing no hormone properties, even when administered for a long period of time, and thus which can be used for neurodegenerative disease including dementia.
摘要翻译：本发明涉及肉桂酸二聚体及其制备方法及其用于治疗神经变性疾病的用途，其对于增强体内的学习和记忆保持能力具有优异的效果，并且即使在施用时也显示出不具有激素特性的副作用较少长时间，因此可用于包括痴呆的神经变性疾病。

7. 发明申请

US20050203180A1 Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease 失效
标题翻译：肉桂酸二聚体，其制备及其用于治疗神经变性疾病的用途
公开(公告)号：US20050203180A1
公开(公告)日：2005-09-15
申请号：US10515560
申请日：2002-06-25
申请人： Dong-Jin Kim , Kye-Jung Shin , Jaehoon Yu , Hee-Sul Lee
发明人： Dong-Jin Kim , Kye-Jung Shin , Jaehoon Yu , Hee-Sul Lee
IPC分类号： A61P25/28 , A61K31/194 , A61K31/195 , A61K31/216 , C07C45/70 , C07C45/71 , C07C47/575 , C07C51/38 , C07C59/68 , C07C67/32 , C07C67/343 , C07C69/734 , C07C69/736 , C07C227/02 , C07C229/44 , A61K31/235 , A61K31/192 , A61K31/205
CPC分类号： C07C229/44 , C07C45/71 , C07C47/575 , C07C59/68 , C07C67/343 , C07C69/734
摘要： The present invention relates to cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease, which have excellent effect on enhancing the learning and memory-retention ability in vivo and have fewer side-effects by showing no hormone properties, even when administered for a long period of time, and thus which can be used for neurodegenerative disease including dementia.
摘要翻译：本发明涉及肉桂酸二聚体及其制备方法及其用于治疗神经变性疾病的用途，其对于增强体内的学习和记忆保持能力具有优异的效果，并且即使在施用时也显示出不具有激素特性的副作用较少长时间，因此可用于包括痴呆的神经变性疾病。

8. 发明申请

US20050009765A1 Heterodimeric conjugates of neomycin-chloramphenicol having an enhanced specificity against rna targets and its preparation 失效
标题翻译：具有增强的rna靶标特异性的新霉素 - 氯霉素的异二聚体结合物及其制备
公开(公告)号：US20050009765A1
公开(公告)日：2005-01-13
申请号：US10496275
申请日：2001-12-05
申请人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Kye-Jung Shin
发明人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Kye-Jung Shin
IPC分类号： C07H5/10 , C07H15/232 , A61K31/704 , C07H15/20 , C07H15/22
CPC分类号： C07H5/10 , C07H15/232
摘要： The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol of formula 1, their preparation and their use. Because of their heterodimeric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, the can be effectively used as an antiviral agent, an antibacterial agent or an anti cancer drugs.
摘要翻译：本发明涉及式1的新霉素 - 氯霉素的异二聚体缀合物，其制备及其用途。由于它们的异二聚体结构，它们可以识别RNA基序的茎和环，并且显示出对某些RNA的结合能力，使得它们具有增强的药物功效并且可以由非特异性药物引起的副作用降低。由于这些原因，可以有效地用作抗病毒剂，抗菌剂或抗癌药物。

9. 发明授权

US5691278A Oxazolinone derivatives, process for preparing the same, and use of the same 失效
标题翻译：恶唑啉酮衍生物，其制备方法及其用途
公开(公告)号：US5691278A
公开(公告)日：1997-11-25
申请号：US515608
申请日：1995-08-16
申请人： Sang Woo Park , Kye Jung Shin , Dong Chan Kim
发明人： Sang Woo Park , Kye Jung Shin , Dong Chan Kim
IPC分类号： A01N43/76 , C07D213/82 , C07D263/42 , C07D413/04 , C07D263/22
CPC分类号： C07D413/04 , A01N43/76 , C07D263/42
摘要： An oxazolinone derivative compound, represented by the general formula I, shows superior herbicidal activity against, especially, dicotyledonous vegetables. It is effective upon applying both before and after the sprouting of vegetables. It is prepared by condensating an .alpha.-amino acid represented by the general formula II with an acid chloride represented by the general formula III, to give an acyl .alpha.-amino acid represented by the following formula IV: reacting the acyl .alpha.-amino acid with acetic anhydride; and dehydrating the resulting adduct: ##STR1## wherein, R represents a lower alkyl group or a phenyl group containing halogen, lower alkyl or trifluoromethyl group; X represents halogen atom, carbomethoxy group, nitro group, or halogen or trifluoromethyl-substituted phenoxy group, being the same or different from one another; A represents nitrogen or carbon atom; and n is an integer of 1 to 3.
摘要翻译：由通式I表示的恶唑啉酮衍生物化合物对于特别是双子叶蔬菜显示出优异的除草活性。在蔬菜发芽前后均适用。通过将由通式II表示的α-氨基酸与由通式III表示的酰氯缩合而制备，得到由下式IV表示的酰基α-氨基酸：使酰基α-氨基酸与醋酸酐; （II）其中R表示低级烷基或含有卤素的低级烷基或三氟甲基的基团， ; X表示卤原子，甲酯基，硝基或卤素或三氟甲基取代的苯氧基，彼此相同或不同; A表示氮或碳原子; n为1〜3的整数。

10. 发明申请

US20100094006A1 NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型吡咯烷基胺化合物作为钙通道调节剂及其制备方法
公开(公告)号：US20100094006A1
公开(公告)日：2010-04-15
申请号：US12568243
申请日：2009-09-28
申请人： Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人： Ghilsoo NAM , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号： C07D403/12 , C07D241/04 , C07D231/12
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译：本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

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