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1. 发明授权

US08980923B2 Compositions and methods for selective inhibition of nicotine acetylcholine receptors 有权
标题翻译：用于选择性抑制尼古丁乙酰胆碱受体的组合物和方法
公开(公告)号：US08980923B2
公开(公告)日：2015-03-17
申请号：US13526076
申请日：2012-06-18
申请人： Roger L. Papke , Nicole A. Horenstein , Michael M. Francis , Kyung Il Choi
发明人： Roger L. Papke , Nicole A. Horenstein , Michael M. Francis , Kyung Il Choi
IPC分类号： A61K31/4465 , C07D211/44
CPC分类号： C07D211/44
摘要： The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by administering 2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH), or a pharmaceutically acceptable salt thereof, to the patient. In another aspect, the present invention pertains to pharmaceutical compositions containing TMPH, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. In another aspect, the present invention pertains to methods for selectively inhibiting nicotinic acetylcholine receptors that lack an α5, α6, or β3 subunit by contacting an effective amount of TMPH, or a pharmaceutically acceptable salt thereof, to the receptor. The method for selectively inhibiting nicotinic acethylcholine receptors that lack an α5 subunit can be carried out in vivo or in vitro.
摘要翻译：本发明涉及通过向患者施用2,2,6,6-四甲基哌啶-4-基庚酸酯（TMPH）或其药学上可接受的盐来治疗或预防特征为烟碱乙酰胆碱受体功能障碍的神经障碍的方法。另一方面，本发明涉及含有TMPH或其药学上可接受的盐和药学上可接受的载体的药物组合物。另一方面，本发明涉及通过使有效量的TMPH或其药学上可接受的盐与受体接触来选择性地抑制缺乏α5，α6或αb亚基的烟碱乙酰胆碱受体的方法。选择性抑制缺乏α5亚基的烟碱型乙酰胆碱受体的方法可以在体内或体外进行。

2. 发明申请

US20100056545A1 NOVEL PHENYLACETATE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASES INDUCED BY ACTIVATION OF T-TYPE CALCIUM ION CHANNEL CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：新型苯乙酸衍生物或其药学上可接受的盐，其制备方法和组合物，用于预防或治疗通过激活含有其作为活性成分的T型钙通道引起的疾病
公开(公告)号：US20100056545A1
公开(公告)日：2010-03-04
申请号：US12429004
申请日：2009-04-23
申请人： Kye Jung SHIN , Hyung Kook LEE , Eun Joo ROH , Dong Jin KIM , Kyung Il CHOI , Hyewhon RHIM , Hye Jin CHUNG , Seon Hee SEO
发明人： Kye Jung SHIN , Hyung Kook LEE , Eun Joo ROH , Dong Jin KIM , Kyung Il CHOI , Hyewhon RHIM , Hye Jin CHUNG , Seon Hee SEO
IPC分类号： A61K31/4965 , C07D235/16 , C07D295/15 , C07D211/34 , A61K31/4184 , A61K31/445 , A61P35/00 , A61P9/12 , A61P25/00
CPC分类号： C07D211/34 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/70 , C07D235/14 , C07D235/16 , C07D295/145 , C07D295/15
摘要： Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. wherein, X, R1, and R3 are as defined herein.
摘要翻译：本文公开了由化学式1表示的新的苯乙酸酯衍生物或其药学上可接受的盐，其制备方法，以及用于预防或治疗由含有其的T型钙离子通道活化引起的疾病的组合物。含有本发明的苯乙酸酯衍生物的组合物有效地抑制T型钙离子通道的活化，并且可用于预防或治疗诸如高血压，癌症，癫痫和T激活诱导的神经源性疼痛等疾病型钙离子通道。其中X，R 1和R 3如本文所定义。

3. 发明申请

US20090325979A1 NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF 有权
标题翻译：新型咪唑啉酮衍生物作为钙通道调节剂及其制备方法
公开(公告)号：US20090325979A1
公开(公告)日：2009-12-31
申请号：US12492615
申请日：2009-06-26
申请人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
发明人： Kyung Il CHOI , Ghilsoo Nam , Hye Ran Kim , Hyewhon Rhim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Yong Seo Cho , Hyunah Choo , Eun Joo Roh , Soon Bang Kang , Kye Jung Shin , Hoh Gyu Hahn , Dong Yun Shin , Chan Seong Cheong , Kee Dal Nam , Yong Koo Kang , Jae Kyun Lee , Woong Seo Park , Youngsoo Kim , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Gyo Chang Keum , Cheolju Lee , Kee Hyun Choi
IPC分类号： A61K31/497 , C07D403/06 , C07D233/54
CPC分类号： C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.
摘要翻译：公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

4. 发明授权

US06673800B2 4,5,-dihydroisoxazolylakylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof 失效
标题翻译：在多巴胺D3或D4受体上具有选择性生物活性的4,5'-二氢异恶唑烷基哌嗪衍生物及其制备
公开(公告)号：US06673800B2
公开(公告)日：2004-01-06
申请号：US09838253
申请日：2001-04-20
申请人： Hun Yeong Koh , Kyung Il Choi , Yong Seo Cho , Ae Nim Pae , Jae Yang Kong , Dae Young Jeong , Sun Ho Jung , Ji Young Jung , Hee-Yoon Lee
发明人： Hun Yeong Koh , Kyung Il Choi , Yong Seo Cho , Ae Nim Pae , Jae Yang Kong , Dae Young Jeong , Sun Ho Jung , Ji Young Jung , Hee-Yoon Lee
IPC分类号： A61K31496
CPC分类号： C07D413/04 , C07D261/08
摘要： The present invention relates to 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors represented by the following Formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, wherein R1, R2, X and n are the same as defined in the specification.
摘要翻译：本发明涉及在下列通式（1）表示的多巴胺D3和D4受体中具有选择性生物活性的4,5-二氢异恶唑基烷基哌嗪衍生物及其还原胺还原胺化反应的制备方法，其中R1，R2， X和n与说明书中定义的相同。

5. 发明授权

US08299072B2 Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof 有权
标题翻译：吡唑基甲胺化合物作为钙通道调节剂及其制备方法
公开(公告)号：US08299072B2
公开(公告)日：2012-10-30
申请号：US12568243
申请日：2009-09-28
申请人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
发明人： Ghilsoo Nam , Kyung Il Choi , Hye Ran Kim , Seon Hee Seo , Yoon Jee Kim , Hee Sup Shin , Dong Jin Kim , Ae Nim Pae , Hye Jin Chung , Hyunah Choo , Hyewhon Rhim , Yong Seo Cho , Eun Joo Roh , Gyo Chang Keum , Kee Hyun Choi , Kye Jung Shin , Hoh Gyu Hahn , Chan Seong Cheong , Jae Kyun Lee , Kee Dal Nam , Yong Koo Kang , Youngsoo Kim , Woong Seo Park , Eunice Eun-Kyeong Kim , Key-Sun Kim , Hesson Chung , Dong Yun Shin , Chi man Song
IPC分类号： A61K31/496 , A61K31/506 , A61K31/5377 , C07D231/12 , C07D401/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/10
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.
摘要翻译：本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

6. 发明授权

US07939672B2 Phenylacetate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for prevention or treatment of diseases induced by activation of T-type calcium ion channel containing the same as an active ingredient 有权
标题翻译：苯乙酸衍生物或其药学上可接受的盐，其制备方法和预防或治疗由含有其作为活性成分的T型钙离子通道激活引起的疾病的组合物
公开(公告)号：US07939672B2
公开(公告)日：2011-05-10
申请号：US12429004
申请日：2009-04-23
申请人： Kye Jung Shin , Hyung Kook Lee , Eun Joo Roh , Dong Jin Kim , Kyung Il Choi , Hyewhon Rhim , Hye Jin Chung , Seon Hee Seo
发明人： Kye Jung Shin , Hyung Kook Lee , Eun Joo Roh , Dong Jin Kim , Kyung Il Choi , Hyewhon Rhim , Hye Jin Chung , Seon Hee Seo
IPC分类号： C07D235/08
CPC分类号： C07D211/34 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/70 , C07D235/14 , C07D235/16 , C07D295/145 , C07D295/15
摘要： Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. wherein, X, R1, and R3 are as defined herein.
摘要翻译：本文公开了由化学式1表示的新的苯乙酸酯衍生物或其药学上可接受的盐，其制备方法，以及用于预防或治疗由含有其的T型钙离子通道活化引起的疾病的组合物。含有本发明的苯乙酸酯衍生物的组合物有效地抑制T型钙离子通道的活化，并且可用于预防或治疗诸如高血压，癌症，癫痫和T激活诱导的神经源性疼痛等疾病型钙离子通道。其中X，R 1和R 3如本文所定义。

7. 发明授权

US06248230B1 Method for manufacturing cleaner fuels 有权
标题翻译：制造清洁燃料的方法
公开(公告)号：US06248230B1
公开(公告)日：2001-06-19
申请号：US09339639
申请日：1999-06-24
申请人： Wha-Sik Min , Kyung-Il Choi , Sin-Young Khang , Dong-Soon Min , Jae-Wook Ryu , Kwan-Sik Yoo , Jyu-Hwan Kim
发明人： Wha-Sik Min , Kyung-Il Choi , Sin-Young Khang , Dong-Soon Min , Jae-Wook Ryu , Kwan-Sik Yoo , Jyu-Hwan Kim
IPC分类号： C10G6704
CPC分类号： C10G67/06 , C10G67/04
摘要： A method is provided for manufacturing cleaner fuels, in which NPC (Natural Polar Compounds), naturally existing in small quantities within various petrolic hydrocarbon fractions, are removed from the petrolic hydrocarbon fractions ranging, in boiling point, from 110 to 560° C. and preferably from 200 to 400° C., in advance of catalytic hydroprocessing. The removal of NPC improves the efficiency of the catalytic process and produces environment-friendly products, such as diesel fuel with a sulfur content of 50 ppm (wt) or lower. Also, the NPC can be used to improve fuel lubricity.
摘要翻译：提供了一种用于制造清洁燃料的方法，其中在各种石油烃馏分中天然存在少量的NPC（天然极性化合物）从沸点为110-560℃的石油烃馏分中除去，优选为200-400℃，在催化加氢处理之前。 NPC的去除提高了催化过程的效率，并且生产了环境友好的产品，例如硫含量为50ppm（wt）或更低的柴油燃料。此外，NPC可用于提高燃油润滑性。

8. 发明授权

US08748422B2 Pharmaceutical compositions containing quinazoline derivatives for treating as serotonin receptor antagonist 有权
标题翻译：含有喹唑啉衍生物作为血清素受体拮抗剂治疗的药物组合物
公开(公告)号：US08748422B2
公开(公告)日：2014-06-10
申请号：US12195951
申请日：2008-08-21
申请人： Ghil Soo Nam , Hye Whon Rhim , Ae Nim Pae , Hyun Ah Choo , Kyung Il Choi , Seung Yeol Nah
发明人： Ghil Soo Nam , Hye Whon Rhim , Ae Nim Pae , Hyun Ah Choo , Kyung Il Choi , Seung Yeol Nah
IPC分类号： A61K31/5377 , A61K31/517 , A61P25/00
CPC分类号： A61K31/517 , A61K31/5377
摘要： The present invention relates to a pharmaceutical composition containing one or more quinazoline compounds as an active ingredient, which has antagonistic activity against serotonin 5-HT3A and is effective for the prevention and treatment of central nervous system (CNS) diseases, including emesis, nausea, alcoholism, drug abuse, depression, compulsive neurosis, anxiety, seizure, Alzheimer's disease, Parkinson's disease, Huntington's chorea, psychosis, schizophrenia, suicidal tendency, sleep disorder, appetite disorder and migraine.
摘要翻译：本发明涉及一种含有一种或多种喹唑啉化合物作为活性成分的药物组合物，其对5-羟色胺5-HT3A具有拮抗作用，对预防和治疗中枢神经系统（CNS）疾病有效，包括呕吐，恶心，酒精中毒，药物滥用，抑郁症，强迫性神经症，焦虑症，癫痫发作，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，精神病，精神分裂症，自杀倾向，睡眠障碍，食欲障碍和偏头痛。

9. 发明授权

US08507540B2 Oxazolidinone derivatives containing new bicyclic group, having antibacterial activity, and method for treating pathogenic bacterial infections using the same 有权
标题翻译：含有新的双环基团的恶唑烷酮衍生物，具有抗菌活性，以及使用其治疗致病性细菌感染的方法
公开(公告)号：US08507540B2
公开(公告)日：2013-08-13
申请号：US13314706
申请日：2011-12-08
申请人： Gyo-Chang Keum , Eunice Eun-Kyeong Kim , Ae-Nim Pae , Kyung-Il Choi , Soon-Bang Kang , Seon-Hee Seo , Deepak Bhattaral , Ju-Hyeon Lee
发明人： Gyo-Chang Keum , Eunice Eun-Kyeong Kim , Ae-Nim Pae , Kyung-Il Choi , Soon-Bang Kang , Seon-Hee Seo , Deepak Bhattaral , Ju-Hyeon Lee
IPC分类号： A61K31/422 , A61P31/04 , C07D413/14
CPC分类号： C07D413/10 , A61K31/422 , C07D413/14 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to oxazolidinone derivatives containing new bicyclic group, having antibacterial activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, an antibacterial composition comprising the oxazolidinone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a method for treating an infectious disease caused by pathogen using the same. The oxazolidinone derivative or a pharmaceutically acceptable salt thereof may exhibit excellent antibacterial activity against gram positive bacteria including various resistant strains.
摘要翻译：本发明涉及含有具有抗菌活性的新二环基的恶唑烷酮衍生物或其药学上可接受的盐，其制备方法，包含恶唑烷酮衍生物或其药学上可接受的盐作为活性成分的抗菌组合物，和用于治疗由使用其的病原体引起的感染性疾病的方法。恶唑烷酮衍生物或其药学上可接受的盐可以对包括各种抗性菌株的革兰氏阳性细菌表现出优异的抗菌活性。

10. 发明申请

US20110319619A1 NOVEL 1,6-DISUBSTITUTED-3-AMINO-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN-7-ONE COMPOUNDS AND PREPARATION THEREOF 有权
标题翻译：新的1,6-二异丙基氨基-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-7-酮化合物及其制备方法
公开(公告)号：US20110319619A1
公开(公告)日：2011-12-29
申请号：US12883987
申请日：2010-09-16
申请人： Ghilsoo NAM , Ae Nim Pae , Kyung Il Choi , Hyunah Choo , Vani Nelamane Devegowda , Seon Hee Seo
发明人： Ghilsoo NAM , Ae Nim Pae , Kyung Il Choi , Hyunah Choo , Vani Nelamane Devegowda , Seon Hee Seo
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Provided are a novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound, a pharmaceutically acceptable salt compound thereof, a method for preparing the compound, and an anticancer pharmaceutical composition including the compound as an effective ingredient.
摘要翻译：提供了新颖的1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮化合物，其药学上可接受的盐化合物，制备化合物的方法，以及包含该化合物作为有效成分的抗癌药物组合物。

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