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1. 发明授权

US5786458A Selective stabilization of protein during viral inactivation 失效
标题翻译：病毒灭活期间蛋白质的选择性稳定
公开(公告)号：US5786458A
公开(公告)日：1998-07-28
申请号：US672255
申请日：1996-06-28
申请人： George A. Baumbach , David J. Hammond , John M. Lang , Cynthia J. Galloway
发明人： George A. Baumbach , David J. Hammond , John M. Lang , Cynthia J. Galloway
IPC分类号： C12N7/06 , A61L2/00 , C07K1/22 , C07K7/06 , C07K7/23 , C07K3/00
CPC分类号： A61L2/0023 , C07K1/22
摘要： A process for viral inactivation of a solution containing a biologically active protein, wherein the process comprises the steps of 1) contacting the solution with an immobilized ligand under conditions which allow protein to bind to the ligand, 2) subjecting the bound protein to a viral inactivation method under conditions which would result in substantial denaturation of the protein if it were not bound to the ligand, and 3) recovering the protein by washing the immobilized protein under conditions which favor the release of the protein into the solution under conditions in which the recovered protein retains its biological activity.
摘要翻译：用于病毒灭活含有生物活性蛋白质的溶液的方法，其中所述方法包括以下步骤：1）使所述溶液与固定的配体在允许蛋白质结合所述配体的条件下接触，2）使结合的蛋白质与病毒灭活方法，如果不结合配体会导致蛋白质的显着变性，以及3）在有利于将蛋白质释放到溶液中的条件下洗涤固定的蛋白质来回收蛋白质，其条件是回收的蛋白质保留其生物活性。

2. 发明授权

US5723579A Fibrinogen binding peptides 失效
标题翻译：纤维蛋白原结合肽
公开(公告)号：US5723579A
公开(公告)日：1998-03-03
申请号：US595718
申请日：1996-02-02
申请人： Joseph A. Buettner , Christopher A. Dadd , George A. Baumbach , David J. Hammond
发明人： Joseph A. Buettner , Christopher A. Dadd , George A. Baumbach , David J. Hammond
IPC分类号： C07K1/22 , C07K5/103 , C07K5/107 , C07K7/06 , C07K14/75 , C07K17/00 , A61K38/08 , C07K7/04
CPC分类号： C07K7/06 , C07K5/101 , C07K5/1016
摘要： Peptides which bind to fibrinogen are disclosed. These peptides have available fibrinogen binding domains having a Phe-Leu-Leu-Val or Leu-Leu-Val-Pro sequence. The preferred peptide is a 6-mer having the sequence Phe-Leu-Leu-Val-Pro-Leu (SEQ ID NO:1). A method of using these peptides in an affinity chromatography process to purify fibrinogen is described.
摘要翻译：公开了结合纤维蛋白原的肽。这些肽具有可用的具有Phe-Leu-Leu-Val或Leu-Leu-Val-Pro序列的纤维蛋白原结合结构域。优选的肽是具有序列Phe-Leu-Leu-Val-Pro-Leu（SEQ ID NO：1）的6聚体。描述了在亲和层析方法中使用这些肽以净化纤维蛋白原的方法。

3. 发明授权

US5831003A Peptides which bind to prothrombin and thrombin 失效
标题翻译：结合凝血酶原和凝血酶的肽
公开(公告)号：US5831003A
公开(公告)日：1998-11-03
申请号：US672805
申请日：1996-06-28
申请人： George A. Baumbach , Christopher A. Dadd , Joseph A. Buettner , David J. Hammond
发明人： George A. Baumbach , Christopher A. Dadd , Joseph A. Buettner , David J. Hammond
IPC分类号： C07K1/22 , C07K7/06 , C07K14/745 , C12N9/74 , C07K7/00
CPC分类号： C07K7/06 , C07K14/745 , C12N9/6429 , C12Y304/21005
摘要： Peptide ligands which bind to thrombin and prothrombin are disclosed. The sequences of these peptides are Gln-Leu-Trp-Gly-Ser-His, Arg-Gln-Leu-Trp-Gly-Ser-His, His-Gln-Leu-Trp-Gly-Ser-His, and Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. The preferred peptides have the sequence Gln-Leu-Trp-Gly-Ser-His or Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. A method of using these peptides in an affinity chromatography process to purify thrombin is described.
摘要翻译：公开了结合凝血酶和凝血酶原的肽配体。这些肽的序列是Gln-Leu-Trp-Gly-Ser-His，Arg-Gln-Leu-Trp-Gly-Ser-His，His-Gln-Leu-Trp-Gly-Ser-His和Tyr-Phe -Pro-Gly-Pro-Tyr-Leu。优选的肽具有序列Gln-Leu-Trp-Gly-Ser-His或Tyr-Phe-Pro-Gly-Pro-Tyr-Leu。描述了在亲和层析方法中使用这些肽以净化凝血酶的方法。

4. 发明授权

US5688912A Peptide ligands which bind to von willebrand factor 失效
标题翻译：结合血管性血友病因子的肽配体
公开(公告)号：US5688912A
公开(公告)日：1997-11-18
申请号：US537069
申请日：1995-09-22
申请人： Christopher A. Dadd , George A. Baumbach , David J. Hammond
发明人： Christopher A. Dadd , George A. Baumbach , David J. Hammond
IPC分类号： G01N33/53 , B01J20/281 , C07K1/22 , C07K14/00 , C07K14/475 , C07K14/745 , C12N9/00 , G01N30/88 , G01N33/566 , C07K7/04 , A61K35/14 , C07K17/00
CPC分类号： C07K14/745 , C07K14/001
摘要： Peptide ligands which bind to von Willebrand Factor (vWF) are disclosed. These peptides are selected from the group consisting of RLHSFY, RLKSFY, RLNSFY, RLQSFY, RFRSFY, RIRSFY, RVRSFY, RYRSFY, RLRSFY, HLRSFY, and KLRSFY. The preferred peptide ligand has the sequence RVRSFY. A method of using the disclosed peptides to purify vWF comprises binding the peptides to a support, then passing a solution containing vWF over the supports under condition such that the vWF will selectively bind to the peptides, and then eluting the vWF.
摘要翻译：公开了结合血管性血友病因子（vWFF）的肽配体。这些肽选自RLHSFY，RLKSFY，RLNSFY，RLQSFY，RFRSFY，RIRSFY，RVRSFY，RYRSFY，RLRSFY，HLRSFY和KLRSFY。优选的肽配体具有序列RVRSFY。使用所公开的肽来纯化vWF的方法包括将肽结合到载体上，然后在含有vWF的溶液中使含有vWF的溶液在条件下通过，使得vWF将选择性地结合肽，然后洗脱vWF。

5. 发明申请

US20080160501A1 Plasma protein-binding ligands 审中-公开
标题翻译：血浆蛋白结合配体
公开(公告)号：US20080160501A1
公开(公告)日：2008-07-03
申请号：US11797318
申请日：2007-05-02
申请人： David J. Hammond , Serguei Soukharev
发明人： David J. Hammond , Serguei Soukharev
IPC分类号： C12Q1/00
CPC分类号： G01N33/54306 , C07K1/047 , C07K1/14 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C07K5/1008 , C07K7/06 , G01N33/54313 , G01N33/54386 , Y02P20/582
摘要： The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10 amino acids, and comprises an amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5, and amino acid sequence Gly-Xaa6-Arg-Xaa7, or an amino acid sequence selected from specific amino acid sequences provided herein. Alternatively, the isolated or purified protein binds to α1 proteinase inhibitor and/or a protein complex comprising Apo-A1 lipoprotein and paraoxonase. The peptide comprises no more than 10 amino acids and comprises an amino acid sequence Xaa8-Xaa1-His-Xaa1-Xaa3, and amino acid sequence His-Xaa8-Xaa9-Xaa1-Xaa10-Xaa2, or an amino acid sequence selected from specific amino acid sequence provided herein. In addition, the invention provides isolated or purified peptide that binds to von Willebrand Factor. The peptide comprises an amino acid sequence Xaa4-Xaa5-Xaa5, an amino acid sequence Tyr-Leu-Xaa11-Xaa4-Xaa12-Thr, or an amino acid sequence selected from specific amino acid sequences provided herein.
摘要翻译：本发明提供了结合至少一种血浆蛋白的分离或纯化的肽。在一个实施方案中，分离或纯化的肽结合纤维蛋白原，包含不超过10个氨基酸，并且包含氨基酸序列Xaa 1 -Xaa 2 -Xaa＆lt; SUB 3个-Xaa 4个-Xaa 5，和氨基酸序列Gly-Xaa 6 -Arg-Xaa 7 或选自本文提供的特定氨基酸序列的氨基酸序列。或者，分离或纯化的蛋白质结合α1蛋白酶抑制剂和/或包含Apo-A1脂蛋白和对氧磷酶的蛋白质复合物。肽包含不超过10个氨基酸，并且包含氨基酸序列Xaa 8 -Xaa 1-His-Xaa 1 -Xaa＆lt; SUB > 3个氨基酸序列和氨基酸序列His-Xaa 8 或者选自本文提供的特定氨基酸序列的氨基酸序列。此外，本发明提供了与血管性血友病因子结合的分离或纯化的肽。肽包含氨基酸序列Xaa 4 -Xaa 5 -Xaa 5 N，氨基酸序列Tyr-Leu-Xaa 11 或者选自本文提供的特定氨基酸序列的氨基酸序列。

6. 发明授权

US06750025B1 Method of detecting and isolating prion protein and variants thereof 失效
标题翻译：检测和分离朊病毒蛋白及其变体的方法
公开(公告)号：US06750025B1
公开(公告)日：2004-06-15
申请号：US09112956
申请日：1998-07-09
申请人： David J. Hammond , Emma L. Medina
发明人： David J. Hammond , Emma L. Medina
IPC分类号： A61K3514
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47 , G01N2800/2828
摘要： The present invention provides for a novel method of detecting the prion protein and variants thereof which utilizes specific amino acid binding sequences. Specifically, the present invention provides a method of detecting prion proteins, as well as isolating prion proteins, using an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Further provided by the present invention is a method of diagnosing prion diseases in a subject using an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Also provided are methods of treating and preventing prion diseases in a subject by administering an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Finally, a method of inhibiting the dissemination of prion diseases through ingestion or exposure to liquid or solid substances by treating of the liquid or solid substance with biotin is provided herein.
摘要翻译：本发明提供一种利用特异性氨基酸结合序列检测朊病毒蛋白及其变体的新方法。具体地，本发明提供了使用结合朊病毒蛋白质的氨基酸序列Gln-Pro-His的试剂检测朊病毒蛋白以及分离朊病毒蛋白的方法。本发明还提供了使用与朊病毒蛋白的氨基酸序列Gln-Pro-His结合的试剂来诊断受试者中的朊病毒疾病的方法。还提供了通过施用与朊病毒蛋白的氨基酸序列Gln-Pro-His结合的试剂来治疗和预防受试者中的朊病毒疾病的方法。最后，本文提供了通过用生物素处理液体或固体物质来摄取或暴露于液体或固体物质来抑制朊病毒疾病传播的方法。

7. 发明授权

US07510848B2 Prion protein binding materials and methods of use 有权
标题翻译：朊病毒蛋白结合材料及使用方法
公开(公告)号：US07510848B2
公开(公告)日：2009-03-31
申请号：US10962670
申请日：2004-10-13
申请人： David J. Hammond , Ruben G. Carbonell , Honglue Shen , Patrick V. Gurgel , Viterose Wiltshire-Lyerly , Steven J. Burton
发明人： David J. Hammond , Ruben G. Carbonell , Honglue Shen , Patrick V. Gurgel , Viterose Wiltshire-Lyerly , Steven J. Burton
IPC分类号： G01N33/53 , G01N33/68 , A61K39/00 , C12N15/00
CPC分类号： B01J20/286 , B01J20/265 , B01J20/285 , B01J20/321 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3257 , B01J20/3293 , B01J2220/54
摘要： Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.
摘要翻译：朊病毒蛋白结合材料和使用结合材料从样品如生物流体或环境样品中检测或除去朊病毒蛋白的方法。结合材料能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc），重组朊病毒蛋白（PrPr）和蛋白酶抗性朊病毒蛋白（PrPres）。来自各种物种的朊病毒，包括人类和仓鼠，都受到结合物质的束缚。

8. 发明授权

US07217507B2 Method for detecting ligands and targets in a mixture 失效
标题翻译：检测混合物中配体和靶标的方法
公开(公告)号：US07217507B2
公开(公告)日：2007-05-15
申请号：US10414523
申请日：2003-04-14
申请人： David J. Hammond , Julia Tait Lathrop
发明人： David J. Hammond , Julia Tait Lathrop
IPC分类号： C12Q1/70 , C12Q1/68 , C12Q1/46
CPC分类号： G01N33/54306 , C07K1/047 , C07K1/14 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C07K5/1008 , C07K7/06 , G01N33/54313 , G01N33/54386 , Y02P20/582
摘要： The invention provides a method of characterizing a target that binds to a ligand. The method comprises providing ligands, optionally attached to a support, and contacting the ligands with targets to allow at least one target to bind to at least one ligand. The method further comprises immobilizing the resulting complexes in a first matrix, such that each complex has a different position within the first matrix, and transferring the target of the complex to a second matrix. The position of the target within the second matrix corresponds to the position of the ligand-support complex within the first matrix. The target on the second matrix is then detected.
摘要翻译：本发明提供了表征与配体结合的靶的方法。该方法包括提供任选地连接到载体的配体，并使配体与靶标接触以使至少一个靶标与至少一个配体结合。所述方法还包括将所得的复合物固定在第一基质中，使得每个复合物在第一基质内具有不同的位置，并将复合物的靶转移到第二基质。第二个矩阵内靶的位置对应于第一个矩阵内配体 - 支持复合体的位置。然后检测第二矩阵上的目标。

9. 发明授权

US07863411B2 Prion protein ligands and methods of use 有权
标题翻译：朊蛋白配体及其使用方法
公开(公告)号：US07863411B2
公开(公告)日：2011-01-04
申请号：US10727335
申请日：2003-12-03
申请人： David J. Hammond , Julia T. Lathrop , Larisa Cervenakova , Ruben G. Carbonell
发明人： David J. Hammond , Julia T. Lathrop , Larisa Cervenakova , Ruben G. Carbonell
IPC分类号： C07K5/00
CPC分类号： G01N33/6896 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0819 , C07K5/0821 , C07K14/47 , G01N2800/2828
摘要： Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.
摘要翻译：与朊病毒蛋白结合的配体和使用配体检测或从样品例如生物液体或环境样品中除去朊病毒蛋白的方法。配体能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc）和重组朊蛋白（PrPr）。来自各种物种的朊病毒，包括人类和仓鼠，都被配体结合。还提供了治疗或延缓受试者中朊病毒相关病理学发展的方法。

10. 发明授权

US4994667A Sorting apparatus with controllable windows and fiber optics 失效
标题翻译：具有可控窗口和光纤的分拣设备
公开(公告)号：US4994667A
公开(公告)日：1991-02-19
申请号：US402817
申请日：1989-09-05
申请人： Neville E. Brown , David J. Hammond , Johannes H. Potgieter
发明人： Neville E. Brown , David J. Hammond , Johannes H. Potgieter
IPC分类号： B07C5/342
CPC分类号： B07C5/3425 , B07C5/3427
摘要： Particles are conveyed in a stream in a direction transverse to the width of the stream. Windows view individual width zones of the stream and optical fibres are associated with the windows to convey light passing through a window to a light detector. The windows are rapidly opened and closed and a processor is provided to determine which window passed light detected by the detector and accordingly which width zone of the stream the light emanated from. The windows preferably incorporate liquid crystal shutters which can be switched rapidly between light-transmitting and opaque states corresponding to open and closed states of the windows.

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