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1. 发明授权

US06750025B1 Method of detecting and isolating prion protein and variants thereof 失效
标题翻译：检测和分离朊病毒蛋白及其变体的方法
公开(公告)号：US06750025B1
公开(公告)日：2004-06-15
申请号：US09112956
申请日：1998-07-09
申请人： David J. Hammond , Emma L. Medina
发明人： David J. Hammond , Emma L. Medina
IPC分类号： A61K3514
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47 , G01N2800/2828
摘要： The present invention provides for a novel method of detecting the prion protein and variants thereof which utilizes specific amino acid binding sequences. Specifically, the present invention provides a method of detecting prion proteins, as well as isolating prion proteins, using an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Further provided by the present invention is a method of diagnosing prion diseases in a subject using an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Also provided are methods of treating and preventing prion diseases in a subject by administering an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Finally, a method of inhibiting the dissemination of prion diseases through ingestion or exposure to liquid or solid substances by treating of the liquid or solid substance with biotin is provided herein.
摘要翻译：本发明提供一种利用特异性氨基酸结合序列检测朊病毒蛋白及其变体的新方法。具体地，本发明提供了使用结合朊病毒蛋白质的氨基酸序列Gln-Pro-His的试剂检测朊病毒蛋白以及分离朊病毒蛋白的方法。本发明还提供了使用与朊病毒蛋白的氨基酸序列Gln-Pro-His结合的试剂来诊断受试者中的朊病毒疾病的方法。还提供了通过施用与朊病毒蛋白的氨基酸序列Gln-Pro-His结合的试剂来治疗和预防受试者中的朊病毒疾病的方法。最后，本文提供了通过用生物素处理液体或固体物质来摄取或暴露于液体或固体物质来抑制朊病毒疾病传播的方法。

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