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1. 发明授权

US07217507B2 Method for detecting ligands and targets in a mixture 失效
标题翻译：检测混合物中配体和靶标的方法
公开(公告)号：US07217507B2
公开(公告)日：2007-05-15
申请号：US10414523
申请日：2003-04-14
申请人： David J. Hammond , Julia Tait Lathrop
发明人： David J. Hammond , Julia Tait Lathrop
IPC分类号： C12Q1/70 , C12Q1/68 , C12Q1/46
CPC分类号： G01N33/54306 , C07K1/047 , C07K1/14 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C07K5/1008 , C07K7/06 , G01N33/54313 , G01N33/54386 , Y02P20/582
摘要： The invention provides a method of characterizing a target that binds to a ligand. The method comprises providing ligands, optionally attached to a support, and contacting the ligands with targets to allow at least one target to bind to at least one ligand. The method further comprises immobilizing the resulting complexes in a first matrix, such that each complex has a different position within the first matrix, and transferring the target of the complex to a second matrix. The position of the target within the second matrix corresponds to the position of the ligand-support complex within the first matrix. The target on the second matrix is then detected.
摘要翻译：本发明提供了表征与配体结合的靶的方法。该方法包括提供任选地连接到载体的配体，并使配体与靶标接触以使至少一个靶标与至少一个配体结合。所述方法还包括将所得的复合物固定在第一基质中，使得每个复合物在第一基质内具有不同的位置，并将复合物的靶转移到第二基质。第二个矩阵内靶的位置对应于第一个矩阵内配体 - 支持复合体的位置。然后检测第二矩阵上的目标。

2. 发明申请

US20090258834A1 Plasma protein-binding ligands 审中-公开
标题翻译：血浆蛋白结合配体
公开(公告)号：US20090258834A1
公开(公告)日：2009-10-15
申请号：US11802730
申请日：2007-05-24
申请人： David J. Hammond , Julia Tait Lathrop , Annemarie Ralston , Timothy K. Hayes , Iwona Fijalkowska
发明人： David J. Hammond , Julia Tait Lathrop , Annemarie Ralston , Timothy K. Hayes , Iwona Fijalkowska
IPC分类号： A61K38/06 , G01N33/573 , C12N9/14 , G01N33/566 , C07K7/06 , A61K38/08 , C07K5/08 , C07K14/435 , C07K14/75 , C07K14/575
CPC分类号： G01N33/54306 , C07K1/047 , C07K1/14 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C07K5/1008 , C07K7/06 , G01N33/54313 , G01N33/54386 , Y02P20/582
摘要： The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10 amino acids, and comprises an amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5, an amino acid sequence Gly-Xaa6-Arg-Xaa7, or an amino acid sequence selected from specific amino acid sequences provided herein. Alternatively, the isolated or purified protein binds to α1 proteinase inhibitor and/or a protein complex comprising Apo-A1 lipoprotein and paraoxonase. The peptide comprises no more than 10 amino acids and comprises an amino acid sequence Xaa8-Xaa8-Xaa1-His-Xaa1-Xaa3, and amino acid sequence His-Xaa8-Xaa9-Xaa1-Xaa10-Xaa2, or an amino acid sequence selected from specific amino acid sequences provided herein. In addition, the invention provides isolated or purified peptide that binds to von Willebrand Factor. The peptide comprises an amino acid sequence Xaa4-Xaa5-Xaa5, an amino acid sequence Tyr-Leu-Xaa11-Xaa4-Xaa12-Thr, or an amino acid sequence selected from specific amino acid sequences provided herein.
摘要翻译：本发明提供了结合至少一种血浆蛋白的分离或纯化的肽。在一个实施方案中，分离或纯化的肽结合纤维蛋白原，包含不超过10个氨基酸，并且包含氨基酸序列Xaa1-Xaa2-Xaa3-Xaa4-Xaa5，氨基酸序列Gly-Xaa6-Arg-Xaa7或选自本文提供的特定氨基酸序列的氨基酸序列。或者，分离或纯化的蛋白质结合α1蛋白酶抑制剂和/或包含Apo-A1脂蛋白和对氧磷酶的蛋白质复合物。该肽包含不超过10个氨基酸并且包含氨基酸序列Xaa8-Xaa8-Xaa1-His-Xaa1-Xaa3和氨基酸序列His-Xaa8-Xaa9-Xaa1-Xaa10-Xaa2或选自本文提供的特异性氨基酸序列。此外，本发明提供了与血管性血友病因子结合的分离或纯化的肽。肽包含氨基酸序列Xaa4-Xaa5-Xaa5，氨基酸序列Tyr-Leu-Xaa11-Xaa4-Xaa12-Thr或选自本文提供的特定氨基酸序列的氨基酸序列。

3. 发明授权

US07223734B2 Plasma protein-binding ligands 失效
标题翻译：血浆蛋白结合配体
公开(公告)号：US07223734B2
公开(公告)日：2007-05-29
申请号：US10414524
申请日：2003-04-14
申请人： David J. Hammond , Julia Tait Lathrop , Iwona Fijalkowska
发明人： David J. Hammond , Julia Tait Lathrop , Iwona Fijalkowska
IPC分类号： A61K38/08 , C07K7/04 , C07K2/00
CPC分类号： G01N33/54306 , C07K1/047 , C07K1/14 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C07K5/1008 , C07K7/06 , G01N33/54313 , G01N33/54386 , Y02P20/582
摘要： The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10 amino acids, and comprises an amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5, an amino acid sequence Gly-Xaa6-Arg-Xaa7, or an amino acid sequence selected from specific amino acid sequences provided herein. Alternatively, the isolated or purified protein binds to αl proteinase inhibitor and/or a protein complex comprising Apo-A1 lipoprotein and paraoxonase. The peptide comprises no more than 10 amino acids and comprises an amino acid sequence Xaa8-Xaa8-Xaa1-His-Xaa1-Xaa3, and amino acid sequence His-Xaa8-Xaa9-Xaa1-Xaa10-Xaa2, or an amino acid sequence selected from specific amino acid sequences provided herein. In addition, the invention provides isolated or purified peptide that binds to von Willebrand Factor. The peptide comprises an amino acid sequence Xaa4-Xaa5-Xaa5, an amino acid sequence Tyr-Leu-Xaa11-Xaa4-Xaa12-Thr, or an amino acid sequence selected from specific amino acid sequences provided herein.
摘要翻译：本发明提供了结合至少一种血浆蛋白的分离或纯化的肽。在一个实施方案中，分离或纯化的肽结合纤维蛋白原，包含不超过10个氨基酸，并且包含氨基酸序列Xaa 1 -Xaa 2 -Xaa＆lt; SUB 氨基酸序列Gly-Xaa 6 -Arg-Xaa 7（SEQ ID NO：3）或选自本文提供的特定氨基酸序列的氨基酸序列。或者，分离或纯化的蛋白质结合到α1-蛋白酶抑制剂和/或包含Apo-A1脂蛋白和对氧磷酶的蛋白质复合物。该肽包含不超过10个氨基酸，并且包含氨基酸序列Xaa 8 -Xaa 8 -Xaa 1-His-Xaa _{1个-Xaa 3个氨基酸序列，并且氨基酸序列His-Xaa 8 -Xaa 9 -Xaa 1}

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