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1. 发明授权

US5723579A Fibrinogen binding peptides 失效
标题翻译：纤维蛋白原结合肽
公开(公告)号：US5723579A
公开(公告)日：1998-03-03
申请号：US595718
申请日：1996-02-02
申请人： Joseph A. Buettner , Christopher A. Dadd , George A. Baumbach , David J. Hammond
发明人： Joseph A. Buettner , Christopher A. Dadd , George A. Baumbach , David J. Hammond
IPC分类号： C07K1/22 , C07K5/103 , C07K5/107 , C07K7/06 , C07K14/75 , C07K17/00 , A61K38/08 , C07K7/04
CPC分类号： C07K7/06 , C07K5/101 , C07K5/1016
摘要： Peptides which bind to fibrinogen are disclosed. These peptides have available fibrinogen binding domains having a Phe-Leu-Leu-Val or Leu-Leu-Val-Pro sequence. The preferred peptide is a 6-mer having the sequence Phe-Leu-Leu-Val-Pro-Leu (SEQ ID NO:1). A method of using these peptides in an affinity chromatography process to purify fibrinogen is described.
摘要翻译：公开了结合纤维蛋白原的肽。这些肽具有可用的具有Phe-Leu-Leu-Val或Leu-Leu-Val-Pro序列的纤维蛋白原结合结构域。优选的肽是具有序列Phe-Leu-Leu-Val-Pro-Leu（SEQ ID NO：1）的6聚体。描述了在亲和层析方法中使用这些肽以净化纤维蛋白原的方法。

2. 发明授权

US5831003A Peptides which bind to prothrombin and thrombin 失效
标题翻译：结合凝血酶原和凝血酶的肽
公开(公告)号：US5831003A
公开(公告)日：1998-11-03
申请号：US672805
申请日：1996-06-28
申请人： George A. Baumbach , Christopher A. Dadd , Joseph A. Buettner , David J. Hammond
发明人： George A. Baumbach , Christopher A. Dadd , Joseph A. Buettner , David J. Hammond
IPC分类号： C07K1/22 , C07K7/06 , C07K14/745 , C12N9/74 , C07K7/00
CPC分类号： C07K7/06 , C07K14/745 , C12N9/6429 , C12Y304/21005
摘要： Peptide ligands which bind to thrombin and prothrombin are disclosed. The sequences of these peptides are Gln-Leu-Trp-Gly-Ser-His, Arg-Gln-Leu-Trp-Gly-Ser-His, His-Gln-Leu-Trp-Gly-Ser-His, and Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. The preferred peptides have the sequence Gln-Leu-Trp-Gly-Ser-His or Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. A method of using these peptides in an affinity chromatography process to purify thrombin is described.
摘要翻译：公开了结合凝血酶和凝血酶原的肽配体。这些肽的序列是Gln-Leu-Trp-Gly-Ser-His，Arg-Gln-Leu-Trp-Gly-Ser-His，His-Gln-Leu-Trp-Gly-Ser-His和Tyr-Phe -Pro-Gly-Pro-Tyr-Leu。优选的肽具有序列Gln-Leu-Trp-Gly-Ser-His或Tyr-Phe-Pro-Gly-Pro-Tyr-Leu。描述了在亲和层析方法中使用这些肽以净化凝血酶的方法。

3. 发明授权

US5688912A Peptide ligands which bind to von willebrand factor 失效
标题翻译：结合血管性血友病因子的肽配体
公开(公告)号：US5688912A
公开(公告)日：1997-11-18
申请号：US537069
申请日：1995-09-22
申请人： Christopher A. Dadd , George A. Baumbach , David J. Hammond
发明人： Christopher A. Dadd , George A. Baumbach , David J. Hammond
IPC分类号： G01N33/53 , B01J20/281 , C07K1/22 , C07K14/00 , C07K14/475 , C07K14/745 , C12N9/00 , G01N30/88 , G01N33/566 , C07K7/04 , A61K35/14 , C07K17/00
CPC分类号： C07K14/745 , C07K14/001
摘要： Peptide ligands which bind to von Willebrand Factor (vWF) are disclosed. These peptides are selected from the group consisting of RLHSFY, RLKSFY, RLNSFY, RLQSFY, RFRSFY, RIRSFY, RVRSFY, RYRSFY, RLRSFY, HLRSFY, and KLRSFY. The preferred peptide ligand has the sequence RVRSFY. A method of using the disclosed peptides to purify vWF comprises binding the peptides to a support, then passing a solution containing vWF over the supports under condition such that the vWF will selectively bind to the peptides, and then eluting the vWF.
摘要翻译：公开了结合血管性血友病因子（vWFF）的肽配体。这些肽选自RLHSFY，RLKSFY，RLNSFY，RLQSFY，RFRSFY，RIRSFY，RVRSFY，RYRSFY，RLRSFY，HLRSFY和KLRSFY。优选的肽配体具有序列RVRSFY。使用所公开的肽来纯化vWF的方法包括将肽结合到载体上，然后在含有vWF的溶液中使含有vWF的溶液在条件下通过，使得vWF将选择性地结合肽，然后洗脱vWF。

4. 发明授权

US5844087A Method and device for delivering fibrin glue 失效
标题翻译：用于输送纤维蛋白胶的方法和装置
公开(公告)号：US5844087A
公开(公告)日：1998-12-01
申请号：US744488
申请日：1996-11-05
申请人： Thomas P. Zimmerman , Christopher A. Dadd , George A. Baumbach
发明人： Thomas P. Zimmerman , Christopher A. Dadd , George A. Baumbach
IPC分类号： A61J1/05 , A61B17/00 , A61B17/03 , A61L24/10 , A61K35/14 , A61M5/00 , B01D63/00
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495
摘要： A method and device for activating and applying a solution of fibrinogen to a desired site. The method includes contacting the solution of fibrinogen with immobilized thrombin resulting in an activated solution of polymerizable fibrin, and delivering the activated solution to the desired site. The device includes a housing having a compartment for a solution of fibrinogen, immobilized thrombin, a structure for bringing the solution of fibrinogen in contact with the immobilized thrombin under conditions which permit the activation of the fibrinogen resulting in polymerizable fibrin, and a structure for delivery of the activated solution to the desired site.
摘要翻译：用于激活和应用纤维蛋白原溶液到所需部位的方法和装置。该方法包括使纤维蛋白原溶液与固定的凝血酶接触，产生活化的可聚合纤维蛋白溶液，并将活化的溶液输送到所需位点。该装置包括具有用于纤维蛋白原溶液，固定化凝血酶的隔室的壳体，用于使纤维蛋白原溶液与固定的凝血酶接触的结构，所述结构在允许纤维蛋白原激活导致可聚合纤维蛋白的条件下，以及用于递送的结构的活化溶液。

5. 发明授权

US6121422A Method and device for delivering fibrin glue 有权
标题翻译：用于输送纤维蛋白胶的方法和装置
公开(公告)号：US6121422A
公开(公告)日：2000-09-19
申请号：US200636
申请日：1998-11-25
申请人： Thomas P. Zimmerman , Christopher A. Dadd , George A. Baumbach
发明人： Thomas P. Zimmerman , Christopher A. Dadd , George A. Baumbach
IPC分类号： A61J1/05 , A61B17/00 , A61B17/03 , A61L24/10 , A61K35/14 , A61M5/00 , B01D63/00
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495
摘要： A method and device for activating and applying a solution of fibrinogen to form fibrin glue at a desired site. The method includes contacting the solution of fibrinogen with immobilized thrombin under conditions that result in a solution of polymerizable fibrin and delivering the activated solution to the desired site. The device includes a housing having a compartment for a solution of fibrinogen, a container for immobilized thrombin, a structure following the solution of fibrinogen to be brought into contact with the immobilized thrombin under conditions which permit the activation of the fibrinogen to polymerizable fibrin, and a structure allowing for delivery of the activated solution to the desired site.
摘要翻译：用于在期望的位置激活和施加纤维蛋白原溶液以形成纤维蛋白胶的方法和装置。该方法包括在导致可聚合纤维蛋白溶液并将活化溶液输送到所需位点的条件下使纤维蛋白原溶液与固定化凝血酶接触。该装置包括具有用于纤维蛋白原溶液的隔室，用于固定化凝血酶的容器的结构，在允许纤维蛋白原激活到可聚合纤维蛋白的条件下，纤维蛋白原溶液与待固化的凝血酶接触的结构，以及允许将活化溶液输送到所需位置的结构。

6. 发明授权

US5786458A Selective stabilization of protein during viral inactivation 失效
标题翻译：病毒灭活期间蛋白质的选择性稳定
公开(公告)号：US5786458A
公开(公告)日：1998-07-28
申请号：US672255
申请日：1996-06-28
申请人： George A. Baumbach , David J. Hammond , John M. Lang , Cynthia J. Galloway
发明人： George A. Baumbach , David J. Hammond , John M. Lang , Cynthia J. Galloway
IPC分类号： C12N7/06 , A61L2/00 , C07K1/22 , C07K7/06 , C07K7/23 , C07K3/00
CPC分类号： A61L2/0023 , C07K1/22
摘要： A process for viral inactivation of a solution containing a biologically active protein, wherein the process comprises the steps of 1) contacting the solution with an immobilized ligand under conditions which allow protein to bind to the ligand, 2) subjecting the bound protein to a viral inactivation method under conditions which would result in substantial denaturation of the protein if it were not bound to the ligand, and 3) recovering the protein by washing the immobilized protein under conditions which favor the release of the protein into the solution under conditions in which the recovered protein retains its biological activity.
摘要翻译：用于病毒灭活含有生物活性蛋白质的溶液的方法，其中所述方法包括以下步骤：1）使所述溶液与固定的配体在允许蛋白质结合所述配体的条件下接触，2）使结合的蛋白质与病毒灭活方法，如果不结合配体会导致蛋白质的显着变性，以及3）在有利于将蛋白质释放到溶液中的条件下洗涤固定的蛋白质来回收蛋白质，其条件是回收的蛋白质保留其生物活性。

7. 发明授权

US5985836A Alpha-1 proteinase inhibitor binding peptides 失效
标题翻译： α-1蛋白酶抑制剂结合肽
公开(公告)号：US5985836A
公开(公告)日：1999-11-16
申请号：US127574
申请日：1998-07-31
申请人： Patrick D. Bastek , John M. Lang , George A. Baumbach , Ruben G. Carbonell
发明人： Patrick D. Bastek , John M. Lang , George A. Baumbach , Ruben G. Carbonell
IPC分类号： C07K7/06 , A61K38/00 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/06
摘要： Peptides which bind to alpha-1 Proteinase inhibitor (AlPI) are disclosed. The peptides have an available AlPI binding domain which may be any of the following preferred sequences: Val Ile Trp Leu Val Arg, Ile Ile Trp Leu Tyr Lys, Arg Tyr Arg Ile Phe Ile, Arg Ala Phe Trp Tyr Ile, Arg Phe Ile Tyr Tyr Thr, Tyr Lys Phe Arg Phe Trp, Leu Ile Val His Arg Trp, Pro Tyr Trp Ile Val Arg, Ala Arg Trp Tyr Ile His, Gln Tyr His Phe Trp Tyr, Arg Leu Trp Arg Tyr Gly, Val Ile Tyr Leu Val Arg, Val Ile Phe Leu Val Arg, Lys Ile Phe Leu Val Arg, Arg Ile Phe Leu Val Arg, His Ile Phe Leu Val Arg, Arg Val Leu Phe Ile Val, or Arg Val Leu Phe Ile His (SEQ ID NOS: 1-8, 10, 11, 15, 36, 37, 45, 46, 47, 61, and 62 respectively). A method of using peptides having these available binding domains in an affinity chromatography process to purify AlPI is described.
摘要翻译：公开了结合α-1蛋白酶抑制剂（AlPI）的肽。肽具有可用的AlPI结合结构域，其可以是以下优选的序列：Val Ile Trp Leu Val Arg，Ile Ile Trp Leu Tyr Lys，Arg Tyr Arg Ile Phe Ile，Arg Ala Phe Trp Tyr Ile，Arg Phe Ile Tyr Tyr Thr，Tyr Lys Phe Arg Phe Trp，Leu Ile Val His Arg Trp，Pro Tyr Trp Ile Val Arg，Ala Arg Trp Tyr Ile His，Gln Tyr His Phe Trp Tyr，Arg Leu Trp Arg Tyr Gly，Val Ile Tyr Leu Val Arg，Val Ile Phe Leu Val Arg，Lys Ile Phe Leu Val Arg，Arg Ile Phe Leu Val Arg，His Ile Phe Leu Val Arg，Arg Val Leu Phe Ile Val或Arg Val Leu Phe Ile His（SEQ ID NOS：1 分别为-8,10,11,15,36,37,45,46,47,61和62）。描述了在亲和层析方法中使用具有这些可用结合域的肽纯化AlPI的方法。

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