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    • 5. 发明申请
    • Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    • 使用组织荧光测定糖化终产物或疾病状态的测量
    • US20070088205A1
    • 2007-04-19
    • US11561380
    • 2006-11-17
    • Edward HullMarwood EdigerChristopher BrownJohn MaynardRobert Johnson
    • Edward HullMarwood EdigerChristopher BrownJohn MaynardRobert Johnson
    • A61B5/00
    • A61B5/1455A61B5/0059A61B5/0064A61B5/0066A61B5/0068A61B5/0071A61B5/0075A61B5/14532A61B5/412A61B5/441
    • A method of detefnnining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of waveliengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.
    • 确定个体中组织状态(例如,糖基化终产物或疾病状态)的量度的方法。 用激发光照射个体组织的一部分,然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光,激发光的扫描(以多个波长照射组织),单个波长的检测,检测波长的扫描(检测多个波长的发射光)及其组合。 本发明还可以包括校正技术,其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如,如果不采用适当的校正,组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型,包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用,有助于测定组织状态。 本发明还包括适于执行该方法的装置,包括用于检测荧光和组织状态测量的适当的光源,检测器和模型(例如,在计算机上实现)。
    • 8. 发明申请
    • Method and Apparatus to Compensate for Melanin and Hemoglobin Variation in Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    • 用于补偿黑色素和血红蛋白变化的方法和装置,用于测定糖化终产物或疾病状态的测量使用组织荧光
    • US20080103373A1
    • 2008-05-01
    • US11964665
    • 2007-12-26
    • Nathaniel MatterMarwood EdigerJohn Maynard
    • Nathaniel MatterMarwood EdigerJohn Maynard
    • A61B6/00
    • A61B5/0059A61B5/0071A61B5/14532A61B5/443A61B5/4875
    • A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual is disclosed. A portion of the skin of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can illuminate the skin and detect responsive light over a time that spans a plurality of cardiac cycles of the individual, which can, as an example, help mitigate the effects of time-varying signals such as those due to hemoglobin. The invention can also determine the amount of light to be directed to the skin, for example by controlling the time that a light source is energized. The amount of illumination light can be determined from a skin reflectance characteristic such as pigmentation or melanin in the skin. Controlling the amount of light directed to the tissue can reduce the dynamic range required of a corresponding optical system, for example by allowing a single system to accurately measure individuals with very light skin and individuals with very dark skin.
    • 公开了确定个体中组织状态(例如糖基化终产物或疾病状态)的测量方法。 用激发光照射个体皮肤的一部分,然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以照亮皮肤并且在跨越个体的多个心脏周期的时间内检测响应光,其可以作为示例有助于减轻诸如由于血红蛋白引起的时变信号的影响。 本发明还可以例如通过控制光源被激励的时间来确定要引导到皮肤的光量。 照明光的量可以根据皮肤的皮肤反射特性如皮肤中的色素沉着或黑色素来确定。 控制指向组织的光量可以减少相应光学系统所需的动态范围,例如通过允许单个系统准确地测量具有非常浅的皮肤的个体和具有非常暗的皮肤的个体。
    • 10. 发明授权
    • Handicap-accessible bath facility
    • 残疾人无障碍浴室
    • US4899402A
    • 1990-02-13
    • US251160
    • 1988-09-29
    • John MaynardDale Sexton
    • John MaynardDale Sexton
    • A47K1/04A47K3/28A47K17/02
    • A47K17/028A47K1/04A47K3/28
    • A handicap-accessible bath facility (10), and a method of making the same, involves a two piece modular wall (22) having a height and a length which are less than the height and length of an existing room (16) in which the bath facility is to be mounted. The modular wall comprises top and bottom wall assemblies (42, 44) which are placed parallel to a first existing wall (14) and abutting a second existing wall (16) to form a shower compartment (124). A factory molded shower base (24) is placed on an existing floor (21) in the shower compartment and defines a shower-base ramp (94) at an entrance to the compartment. A barrier line (98) at the top of the ramp, between the ramp and a drain depression (90) formed in the shower base prevents water from flowing out of the shower compartment. Wall panels (26, 28, 30) line the shower compartment and engage a vertical lip (100) of the shower base for preventing water from leaving the shower compartment at intersections of these panels with the shower base. A vanity top (32), with right angled edges (106, 108) forms a brace between the modular wall and the second existing wall. A commode (36), sink (34), and light (40) are mounted on an outside surface of the modular wall.
    • 残疾人无障碍浴室(10)及其制造方法涉及两件式的模块化壁(22),其高度和长度小于现有房间(16)的高度和长度,其中 洗澡设施将被安装。 所述模块化壁包括顶壁和底壁组件(42,44),其平行于第一现有壁(14)放置并邻接第二现有壁(16)以形成淋浴室(124)。 工厂模制的淋浴器底座(24)被放置在淋浴室的现有地板(21)上,并且在隔室的入口处限定了淋浴器基座斜坡(94)。 在斜坡顶部的斜坡和形成在淋浴器底座之间的排水口(90)之间的隔离线(98)防止水从淋浴室流出。 壁板(26,28,30)排列淋浴室并与淋浴底座的垂直唇缘(100)接合,以防止水在这些面板与淋浴器底座的交叉处离开淋浴室。 具有直角边缘(106,108)的梳妆台(32)在模块化壁和第二现有壁之间形成支柱。 在模块化墙体的外表面上安装有一个(36),水槽(34)和灯(40)。