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    • 3. 发明申请
    • Ballistic Guidance Control for Munitions
    • 弹道导弹控制弹药
    • US20070241227A1
    • 2007-10-18
    • US11629060
    • 2006-02-07
    • Paul ZemanyMark CarlsonJohn Maynard
    • Paul ZemanyMark CarlsonJohn Maynard
    • F41G7/00
    • F41G7/2293F41G7/222F41G7/226F42B10/06F42B10/64F42B15/01
    • A method and system for guiding and controlling an ordinance body having a trajectory and a bore sight angle including making corrections to the trajectory based on bore sight angle vs. time history. The system is incorporated with existing fuse components in a replacement kit for existing munitions. The method determines nominal time values of the ballistic trajectory of the munition in relation to launch time and determines deviation from the nominal time values by an algorithm by analyzing signals received from a source of radiation located at the target. A processor determines lateral (left/right) and range errors and provides steering commands to a plurality of flight control surfaces mounted on the munition.
    • 用于引导和控制具有轨迹和钻孔视角的条例体的方法和系统,包括基于钻孔视角对时间历史对轨迹进行校正。 该系统与现有的弹药更换套件中的现有保险丝组件相结合。 该方法确定弹药弹道轨迹与发射时间的标称时间值,并通过分析从位于目标位置的辐射源接收的信号,确定通过算法与标称时间值的偏差。 处理器确定侧向(左/右)和范围误差,并向安装在弹药上的多个飞行控制表面提供转向命令。
    • 6. 发明申请
    • Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    • 使用组织荧光测定糖化终产物或疾病状态的测量
    • US20070088205A1
    • 2007-04-19
    • US11561380
    • 2006-11-17
    • Edward HullMarwood EdigerChristopher BrownJohn MaynardRobert Johnson
    • Edward HullMarwood EdigerChristopher BrownJohn MaynardRobert Johnson
    • A61B5/00
    • A61B5/1455A61B5/0059A61B5/0064A61B5/0066A61B5/0068A61B5/0071A61B5/0075A61B5/14532A61B5/412A61B5/441
    • A method of detefnnining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of waveliengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.
    • 确定个体中组织状态(例如,糖基化终产物或疾病状态)的量度的方法。 用激发光照射个体组织的一部分,然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光,激发光的扫描(以多个波长照射组织),单个波长的检测,检测波长的扫描(检测多个波长的发射光)及其组合。 本发明还可以包括校正技术,其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如,如果不采用适当的校正,组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型,包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用,有助于测定组织状态。 本发明还包括适于执行该方法的装置,包括用于检测荧光和组织状态测量的适当的光源,检测器和模型(例如,在计算机上实现)。
    • 9. 发明申请
    • Method and Apparatus to Compensate for Melanin and Hemoglobin Variation in Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    • 用于补偿黑色素和血红蛋白变化的方法和装置,用于测定糖化终产物或疾病状态的测量使用组织荧光
    • US20080103373A1
    • 2008-05-01
    • US11964665
    • 2007-12-26
    • Nathaniel MatterMarwood EdigerJohn Maynard
    • Nathaniel MatterMarwood EdigerJohn Maynard
    • A61B6/00
    • A61B5/0059A61B5/0071A61B5/14532A61B5/443A61B5/4875
    • A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual is disclosed. A portion of the skin of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can illuminate the skin and detect responsive light over a time that spans a plurality of cardiac cycles of the individual, which can, as an example, help mitigate the effects of time-varying signals such as those due to hemoglobin. The invention can also determine the amount of light to be directed to the skin, for example by controlling the time that a light source is energized. The amount of illumination light can be determined from a skin reflectance characteristic such as pigmentation or melanin in the skin. Controlling the amount of light directed to the tissue can reduce the dynamic range required of a corresponding optical system, for example by allowing a single system to accurately measure individuals with very light skin and individuals with very dark skin.
    • 公开了确定个体中组织状态(例如糖基化终产物或疾病状态)的测量方法。 用激发光照射个体皮肤的一部分,然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以照亮皮肤并且在跨越个体的多个心脏周期的时间内检测响应光,其可以作为示例有助于减轻诸如由于血红蛋白引起的时变信号的影响。 本发明还可以例如通过控制光源被激励的时间来确定要引导到皮肤的光量。 照明光的量可以根据皮肤的皮肤反射特性如皮肤中的色素沉着或黑色素来确定。 控制指向组织的光量可以减少相应光学系统所需的动态范围,例如通过允许单个系统准确地测量具有非常浅的皮肤的个体和具有非常暗的皮肤的个体。