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1. 发明申请

US20070073118A1 Apparatus and method for noninvasively monitoring for the presence of alcohol or substances of abuse in controlled environments 有权
标题翻译：用于在受控环境中非侵入性地监测酒精或滥用物质的存在的装置和方法
公开(公告)号：US20070073118A1
公开(公告)日：2007-03-29
申请号：US11515565
申请日：2006-09-05
申请人： Trent Ridder , Ben Steeg , James McNally , John Maynard , Russell Abbink
发明人： Trent Ridder , Ben Steeg , James McNally , John Maynard , Russell Abbink
IPC分类号： A61B5/00
CPC分类号： G01J3/02 , A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/0088 , A61B5/117 , A61B5/14546 , A61B5/7264 , G01J3/0218 , G01J3/0291 , G01N21/274 , G01N21/359 , G01N21/474 , G01N2201/129
摘要： The present invention relates generally to non-invasive methods and apparatuses for determining analyte properties of a subject and identity characteristics of a subject. Embodiments of the present invention provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely that in systems that include separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.
摘要翻译：本发明一般涉及用于确定受试者的分析物特性和受试者身份特征的非侵入性方法和装置。本发明的实施方案提供了来自相同光谱信息的分析物质性质确定和鉴别确认或验证，使得在包括单独的分析物和身份确定的系统中不太可能使用未经授权的使用或误导结果。本发明可用于控制和监视访问受控环境的个人。

2. 发明授权

US08174394B2 System for noninvasive determination of analytes in tissue 失效
标题翻译：非侵入性测定组织中分析物的系统
公开(公告)号：US08174394B2
公开(公告)日：2012-05-08
申请号：US12562050
申请日：2009-09-17
申请人： Trent Ridder , Ben ver Steeg , Mike Mills , Bentley Laaksonen , James McNally , John Maynard , Russell Abbink
发明人： Trent Ridder , Ben ver Steeg , Mike Mills , Bentley Laaksonen , James McNally , John Maynard , Russell Abbink
IPC分类号： G08B13/14 , A61B5/1455
CPC分类号： A61B5/4845 , A61B5/0075 , A61B5/0088 , A61B5/117 , A61B5/14546 , A61B5/1455 , A61B5/1495 , A61B5/6826 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0229 , G01J3/0291 , G01J3/14 , G01J2003/1286 , G01N21/274 , G01N21/359 , G01N21/474 , G01N2201/129
摘要： An apparatus and method for noninvasive determination of analyte properties of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems can include an illumination/modulation subsystem, a tissue sampling subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The invention can provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely than in systems that use separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.
摘要翻译：一种用于通过定量红外光谱法非临床确定人体组织的分析物质的临床相关水平的精确度和准确度的装置和方法。该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。子系统可以包括照明/调制子系统，组织采样子系统，数据采集子系统，计算子系统和校准子系统。本发明可以提供来自相同光谱信息的分析物质性质确定和鉴别确定或验证，使得未经授权的使用或误导结果比使用单独的分析物和身份确定的系统更不可能。本发明可用于控制和监视访问受控环境的个人。

3. 发明申请

US20100010325A1 System for Noninvasive Determination of Analytes in Tissue 失效
标题翻译：无创测定组织中分析物的系统
公开(公告)号：US20100010325A1
公开(公告)日：2010-01-14
申请号：US12562050
申请日：2009-09-17
申请人： Trent Ridder , Ben ver Steeg , James McNally , John Maynard , Russell Abbink , Mike Mills , Bentley Laaksonen
发明人： Trent Ridder , Ben ver Steeg , James McNally , John Maynard , Russell Abbink , Mike Mills , Bentley Laaksonen
IPC分类号： A61B5/1455 , A61B5/117 , G06F7/04
CPC分类号： A61B5/4845 , A61B5/0075 , A61B5/0088 , A61B5/117 , A61B5/14546 , A61B5/1455 , A61B5/1495 , A61B5/6826 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0229 , G01J3/0291 , G01J3/14 , G01J2003/1286 , G01N21/274 , G01N21/359 , G01N21/474 , G01N2201/129
摘要： An apparatus and method for noninvasive determination of analyte properties of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems can include an illumination/modulation subsystem, a tissue sampling subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The invention can provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely than in systems that use separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.
摘要翻译：一种用于通过定量红外光谱法非临床确定人体组织的分析物质的临床相关水平的精确度和准确度的装置和方法。该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。子系统可以包括照明/调制子系统，组织采样子系统，数据采集子系统，计算子系统和校准子系统。本发明可以提供来自相同光谱信息的分析物质性质确定和鉴别确定或验证，使得未经授权的使用或误导结果比使用单独的分析物和身份确定的系统更不可能。本发明可用于控制和监视访问受控环境的个人。

4. 发明申请

US20050261560A1 Noninvasive determination of alcohol in tissue 有权
标题翻译：无创测定组织中的酒精
公开(公告)号：US20050261560A1
公开(公告)日：2005-11-24
申请号：US10852415
申请日：2004-05-24
申请人： Trent Ridder , John Maynard , Russell Abbink
发明人： Trent Ridder , John Maynard , Russell Abbink
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0075 , A61B5/14546
摘要： An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, and a processing subsystem. The invention is applicable, as examples, to determining the concentration or change of concentration of alcohol in human tissue.
摘要翻译：一种用于通过定量红外光谱非侵入式确定人体组织属性的装置和方法。该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。子系统包括照明子系统，组织采样子系统，光谱仪子系统，数据采集子系统和处理子系统。作为实例，本发明可用于确定人体组织中酒精浓度或浓度的变化。

5. 发明申请

US20050073690A1 Optical spectroscopy incorporating a vertical cavity surface emitting laser (VCSEL) 审中-公开
标题翻译：结合垂直腔表面发射激光器（VCSEL）的光学光谱
公开(公告)号：US20050073690A1
公开(公告)日：2005-04-07
申请号：US10678843
申请日：2003-10-03
申请人： Russell Abbink , John Maynard , Trent Ridder
发明人： Russell Abbink , John Maynard , Trent Ridder
IPC分类号： G01J3/26 , G01J3/45 , G01J9/02 , G01B9/02
CPC分类号： G01J3/26 , G01J3/0286 , G01J3/45 , G01J9/02
摘要： A vertical cavity surface-emitting laser (VCSEL) package useful in interferometry. The present invention comprises methods and apparatuses that allow use of multimode VCSELS, and that provide for wavelength control and stability. The present invention contemplates the use of a defined response element, such as an etalon, in combination with control of the operating environment of the VCSEL to monitor and control the output wavelength of the VCSEL.
摘要翻译：用于干涉测量的垂直腔表面发射激光器（VCSEL）封装。本发明包括允许使用多模VCSELS并提供波长控制和稳定性的方法和装置。本发明考虑使用诸如标准具的定义的响应元件与VCSEL的操作环境的控制相结合来监视和控制VCSEL的输出波长。

6. 发明申请

US20080171924A9 NONINVASIVE DETERMINATION OF ALCOHOL IN TISSUE 有权
标题翻译：非酒精组织中酒精的测定
公开(公告)号：US20080171924A9
公开(公告)日：2008-07-17
申请号：US10852415
申请日：2004-05-24
申请人： Trent Ridder , John Maynard , Russell Abbink , Robert Johnson , Edward Hull , Andrew Meigs , Alan Ross , Dashiell Birnkrant
发明人： Trent Ridder , John Maynard , Russell Abbink , Robert Johnson , Edward Hull , Andrew Meigs , Alan Ross , Dashiell Birnkrant
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0075 , A61B5/14546
摘要： An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, and a processing subsystem. The invention is applicable, as examples, to determining the concentration or change of concentration of alcohol in human tissue.
摘要翻译：一种用于通过定量红外光谱非侵入式确定人体组织属性的装置和方法。该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。子系统包括照明子系统，组织采样子系统，光谱仪子系统，数据采集子系统和处理子系统。作为实例，本发明可用于确定人体组织中酒精浓度或浓度的变化。

7. 发明申请

US20080208018A1 Apparatuses for Noninvasive Determination of in vivo Alcohol Concentration using Raman Spectroscopy 有权
标题翻译：使用拉曼光谱法无创测定体内酒精浓度的仪器
公开(公告)号：US20080208018A1
公开(公告)日：2008-08-28
申请号：US12107764
申请日：2008-04-23
申请人： Trent Ridder , Rob Johnson , Russell Abbink , John D. Maynard
发明人： Trent Ridder , Rob Johnson , Russell Abbink , John D. Maynard
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/0075 , A61B5/14546 , A61B5/1455
摘要： Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined non-invasively. A portion of the tissue is illuminated with light, the light propagates into the tissue where it is Raman scattered within the tissue. The Raman scattered light is then detected and can be combined with a model relating Raman spectra to alcohol concentration in order to determine the alcohol concentration in the blood or tissue of the individual. Correction techniques can be used to reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used in combination with the Raman spectral properties to aid in the determination of alcohol concentration, for example age of the individual, height of the individual, weight of the individual, medical history of the individual and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be highly optimized to provide reproducible and, preferably, uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra from the tissue, high optical throughput, high photometric accuracy, large dynamic range, excellent thermal stability, effective calibration maintenance, effective calibration transfer, built-in quality control, and ease-of-use.
摘要翻译：用于确定个体使用非侵入性拉曼光谱的组织属性的方法和装置。例如，可以非侵入性地确定个体的血液或组织中的酒精浓度。组织的一部分用光照射，光传播到组织中，其中拉曼散布在组织内。然后检测拉曼散射光，并且可以将与拉曼光谱相关的模型与酒精浓度组合以确定个体的血液或组织中的酒精浓度。校正技术可用于减少除了来自组织中的醇的拉曼散射以外的光的检测的测定误差。其他生物信息可以与拉曼光谱性质结合使用，以帮助确定酒精浓度，例如个体的年龄，个体的身高，个体的体重，个体及其家人的病史，种族，皮肤黑色素含量或其组合。该方法和装置可以被高度优化以提供组织的可再现的，优选地均匀的辐射，低组织取样误差，组织层的深度瞄准或包含感兴趣属性的样本位置，从组织中有效收集拉曼光谱，光学吞吐量高，光度精度高，动态范围大，热稳定性好，有效的校准维护，有效的校准传输，内置的质量控制和易于使用。

8. 发明申请

US20090234204A1 Methods for Noninvasive Determination of in vivo Alcohol Concentration using Raman Spectroscopy 有权
标题翻译：使用拉曼光谱法非侵入性测定体内酒精浓度的方法
公开(公告)号：US20090234204A1
公开(公告)日：2009-09-17
申请号：US12107765
申请日：2008-04-23
申请人： Trent Ridder , Rob Johnson , Russell Abbink , John D. Maynard
发明人： Trent Ridder , Rob Johnson , Russell Abbink , John D. Maynard
IPC分类号： A61B5/1455
CPC分类号： A61B5/0075 , A61B5/0059 , A61B5/14546 , A61B5/1455
摘要： Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined non-invasively. A portion of the tissue is illuminated with light, the light propagates into the tissue where it is Raman scattered within the tissue. The Raman scattered light is then detected and can be combined with a model relating Raman spectra to alcohol concentration in order to determine the alcohol concentration in the blood or tissue of the individual. Correction techniques can be used to reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used in combination with the Raman spectral properties to aid in the determination of alcohol concentration, for example age of the individual, height of the individual, weight of the individual, medical history of the individual and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be highly optimized to provide reproducible and, preferably, uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra from the tissue, high optical throughput, high photometric accuracy, large dynamic range, excellent thermal stability, effective calibration maintenance, effective calibration transfer, built-in quality control, and ease-of-use.
摘要翻译：用于确定个体使用非侵入性拉曼光谱的组织属性的方法和装置。例如，可以非侵入性地确定个体的血液或组织中的酒精浓度。组织的一部分用光照射，光传播到组织中，其中拉曼散布在组织内。然后检测拉曼散射光，并且可以将与拉曼光谱相关的模型与酒精浓度组合以确定个体的血液或组织中的酒精浓度。校正技术可用于减少除了来自组织中的醇的拉曼散射以外的光的检测的测定误差。其他生物信息可以与拉曼光谱性质结合使用，以帮助确定酒精浓度，例如个体的年龄，个体的身高，个体的体重，个体及其家人的病史，种族，皮肤黑色素含量或其组合。该方法和装置可以被高度优化以提供组织的可再现的，优选地均匀的辐射，低组织取样误差，组织层的深度瞄准或包含感兴趣属性的样本位置，从组织中有效收集拉曼光谱，光学吞吐量高，光度精度高，动态范围大，热稳定性好，有效的校准维护，有效的校准传输，内置的质量控制和易于使用。

9. 发明授权

US08581697B2 Apparatuses for noninvasive determination of in vivo alcohol concentration using raman spectroscopy 有权
标题翻译：使用拉曼光谱法无创测定体内酒精浓度的装置
公开(公告)号：US08581697B2
公开(公告)日：2013-11-12
申请号：US12107764
申请日：2008-04-23
申请人： Trent D Ridder , Rob Johnson , Russell Abbink , John D Maynard
发明人： Trent D Ridder , Rob Johnson , Russell Abbink , John D Maynard
IPC分类号： G05B23/00
CPC分类号： A61B5/0059 , A61B5/0075 , A61B5/14546 , A61B5/1455
摘要： Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined non-invasively. A portion of the tissue is illuminated with light, the light propagates into the tissue where it is Raman scattered within the tissue. The Raman scattered light is then detected and can be combined with a model relating Raman spectra to alcohol concentration in order to determine the alcohol concentration in the blood or tissue of the individual. Correction techniques can be used to reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used in combination with the Raman spectral properties to aid in the determination of alcohol concentration, for example age of the individual, height of the individual, weight of the individual, medical history of the individual and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be highly optimized to provide reproducible and, preferably, uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra from the tissue, high optical throughput, high photometric accuracy, large dynamic range, excellent thermal stability, effective calibration maintenance, effective calibration transfer, built-in quality control, and ease-of-use.
摘要翻译：用于确定个体使用非侵入性拉曼光谱的组织属性的方法和装置。例如，可以非侵入性地确定个体的血液或组织中的酒精浓度。组织的一部分用光照射，光传播到组织中，其中拉曼散布在组织内。然后检测拉曼散射光，并且可以将与拉曼光谱相关的模型与酒精浓度组合以确定个体的血液或组织中的酒精浓度。校正技术可用于减少除了来自组织中的醇的拉曼散射以外的光的检测的测定误差。其他生物信息可以与拉曼光谱性质结合使用，以帮助确定酒精浓度，例如个体的年龄，个体的身高，个体的体重，个体及其家人的病史，种族，皮肤黑色素含量或其组合。该方法和装置可以被高度优化以提供组织的可再现的，优选地均匀的辐射，低组织取样误差，组织层的深度瞄准或包含感兴趣属性的样本位置，从组织中有效收集拉曼光谱，光学吞吐量高，光度精度高，动态范围大，热稳定性好，有效的校准维护，有效的校准传输，内置的质量控制和易于使用。

10. 发明授权

US08515506B2 Methods for noninvasive determination of in vivo alcohol concentration using Raman spectroscopy 有权
标题翻译：使用拉曼光谱法无创测定体内酒精浓度的方法
公开(公告)号：US08515506B2
公开(公告)日：2013-08-20
申请号：US12107765
申请日：2008-04-23
申请人： Trent D Ridder , Rob Johnson , Russell Abbink , John D Maynard
发明人： Trent D Ridder , Rob Johnson , Russell Abbink , John D Maynard
IPC分类号： A61B5/1455 , G06F7/04 , G05B19/00
CPC分类号： A61B5/0075 , A61B5/0059 , A61B5/14546 , A61B5/1455
摘要： Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined non-invasively. A portion of the tissue is illuminated with light, the light propagates into the tissue where it is Raman scattered within the tissue. The Raman scattered light is then detected and can be combined with a model relating Raman spectra to alcohol concentration in order to determine the alcohol concentration in the blood or tissue of the individual. Correction techniques can be used to reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used in combination with the Raman spectral properties to aid in the determination of alcohol concentration, for example age of the individual, height of the individual, weight of the individual, medical history of the individual and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be highly optimized to provide reproducible and, preferably, uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra from the tissue, high optical throughput, high photometric accuracy, large dynamic range, excellent thermal stability, effective calibration maintenance, effective calibration transfer, built-in quality control, and ease-of-use.
摘要翻译：用于确定个体使用非侵入性拉曼光谱的组织属性的方法和装置。例如，可以非侵入性地确定个体的血液或组织中的酒精浓度。组织的一部分用光照射，光传播到组织中，其中拉曼散布在组织内。然后检测拉曼散射光，并且可以将与拉曼光谱相关的模型与酒精浓度组合以确定个体的血液或组织中的酒精浓度。校正技术可用于减少除了来自组织中的醇的拉曼散射以外的光的检测的测定误差。其他生物信息可以与拉曼光谱性质结合使用，以帮助确定酒精浓度，例如个体的年龄，个体的身高，个体的体重，个体及其家人的病史，种族，皮肤黑色素含量或其组合。该方法和装置可以被高度优化以提供组织的可再现的，优选地均匀的辐射，低组织取样误差，组织层的深度瞄准或包含感兴趣属性的样本位置，从组织中有效收集拉曼光谱，光学吞吐量高，光度精度高，动态范围大，热稳定性好，有效的校准维护，有效的校准传输，内置的质量控制和易于使用。

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